{"id":"https://openalex.org/W7124322972","doi":"https://doi.org/10.1039/d5ob01961c","title":"Palladium-catalyzed esterification reaction of arenes/heterocyclic carboxylic acids with difluoroallyl bromide for the efficient preparation of difluoroallyl esters","display_name":"Palladium-catalyzed esterification reaction of arenes/heterocyclic carboxylic acids with difluoroallyl bromide for the efficient preparation of difluoroallyl esters","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7124322972","doi":"https://doi.org/10.1039/d5ob01961c","pmid":"https://pubmed.ncbi.nlm.nih.gov/41556607"},"language":"en","primary_location":{"id":"doi:10.1039/d5ob01961c","doi":"https://doi.org/10.1039/d5ob01961c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d5ob01961c","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Li Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Chen","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100421304","display_name":"Yang Li","orcid":"https://orcid.org/0000-0001-7009-0871","observed_orcids":["https://orcid.org/0000-0001-7009-0871"]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":"https://orcid.org/0000-0001-7009-0871","affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113629519","display_name":"Yun Long Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-Long Hu","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123094516","display_name":"Xin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Chen","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113650177","display_name":"Mei Ru Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei-Ru Chen","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045369198","display_name":"Lan-Ting Shi","orcid":"https://orcid.org/0000-0001-9618-0795","observed_orcids":["https://orcid.org/0000-0001-9618-0795"]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan-Ting Shi","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123106121","display_name":"Hong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27599042","display_name":"Xi'an Polytechnic University","ror":"https://ror.org/03442p831","country_code":"CN","type":"education","lineage":["https://openalex.org/I27599042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Li","raw_affiliation_strings":["School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Environmental and Chemical Engineering, Xi'an Polytechnic University, Xi'an, 710048, China","institution_ids":["https://openalex.org/I27599042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I27599042"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"5","first_page":"1114","last_page":"1119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.3582000136375427,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10354","display_name":"Catalytic C\u2013H Functionalization Methods","score":0.048900000751018524,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/palladium-catalysis","display_name":"palladium catalysis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/esterification","display_name":"esterification","score":0.9449999928474426},{"id":"https://openalex.org/keywords/c-o-cross-coupling","display_name":"C\u2013O coupling","score":0.7450000047683716},{"id":"https://openalex.org/keywords/indole-carboxylic-acids","display_name":"indole carboxylic acids","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pyrrole-carboxylic-acids","display_name":"pyrrole carboxylic acids","score":0.9710000157356262},{"id":"https://openalex.org/keywords/difluoromethylene-group","display_name":"difluoromethylene group","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8525000214576721},{"id":"https://openalex.org/C2776254738","wikidata":"https://www.wikidata.org/wiki/Q81406","display_name":"Alkene","level":3,"score":0.7294999957084656},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.7003999948501587},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6403999924659729},{"id":"https://openalex.org/C2779074116","wikidata":"https://www.wikidata.org/wiki/Q134856","display_name":"Carboxylic acid","level":2,"score":0.6274999976158142},{"id":"https://openalex.org/C502130503","wikidata":"https://www.wikidata.org/wiki/Q1089","display_name":"Palladium","level":3,"score":0.4975999891757965},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.489300012588501},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.4625999927520752},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4368000030517578},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4307999908924103},{"id":"https://openalex.org/C192527728","wikidata":"https://www.wikidata.org/wiki/Q1465700","display_name":"Indole test","level":2,"score":0.423799991607666},{"id":"https://openalex.org/C2776300020","wikidata":"https://www.wikidata.org/wiki/Q422423","display_name":"Bromide","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C2777332933","wikidata":"https://www.wikidata.org/wiki/Q170409","display_name":"Functional group","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C48424934","wikidata":"https://www.wikidata.org/wiki/Q898912","display_name":"Coupling reaction","level":3,"score":0.37610000371932983},{"id":"https://openalex.org/C168382676","wikidata":"https://www.wikidata.org/wiki/Q900377","display_name":"Carbonylation","level":4,"score":0.32010000944137573},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.3111000061035156},{"id":"https://openalex.org/C505241676","wikidata":"https://www.wikidata.org/wiki/Q688","display_name":"Chlorine","level":2,"score":0.3068999946117401},{"id":"https://openalex.org/C168896768","wikidata":"https://www.wikidata.org/wiki/Q899916","display_name":"Heck reaction","level":4,"score":0.295199990272522},{"id":"https://openalex.org/C2994149032","wikidata":"https://www.wikidata.org/wiki/Q1089","display_name":"Palladium catalyst","level":4,"score":0.2870999872684479},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C175113610","wikidata":"https://www.wikidata.org/wiki/Q3394849","display_name":"Reaction rate","level":3,"score":0.25870001316070557}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1039/d5ob01961c","doi":"https://doi.org/10.1039/d5ob01961c","is_oa":false,"landing_page_url":"https://doi.org/10.1039/d5ob01961c","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & Biomolecular Chemistry","raw_type":"journal-article"},{"id":"pmid:41556607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41556607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3884947891","display_name":null,"funder_award_id":"2025ZG-JBGS-019","funder_id":"https://openalex.org/F4320336035","funder_display_name":"Shanxi Provincial Key Research and Development Project"},{"id":"https://openalex.org/G5351760482","display_name":null,"funder_award_id":"2022GY-195","funder_id":"https://openalex.org/F4320336035","funder_display_name":"Shanxi Provincial Key Research and Development Project"}],"funders":[{"id":"https://openalex.org/F4320336035","display_name":"Shanxi Provincial Key Research and Development Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1967456361","https://openalex.org/W2068912668","https://openalex.org/W2073293181","https://openalex.org/W2144869962","https://openalex.org/W2177146398","https://openalex.org/W2219733639","https://openalex.org/W2264719596","https://openalex.org/W2313348552","https://openalex.org/W2333129245","https://openalex.org/W2334452370","https://openalex.org/W2398180944","https://openalex.org/W2402770948","https://openalex.org/W2419534400","https://openalex.org/W2512094518","https://openalex.org/W2513456701","https://openalex.org/W2575131390","https://openalex.org/W2618634678","https://openalex.org/W2785609333","https://openalex.org/W2794791315","https://openalex.org/W2805344847","https://openalex.org/W2945041329","https://openalex.org/W2947413520","https://openalex.org/W2948766130","https://openalex.org/W2955134801","https://openalex.org/W2999311498","https://openalex.org/W3003221014","https://openalex.org/W3003809340","https://openalex.org/W3010565290","https://openalex.org/W3019266968","https://openalex.org/W3024525460","https://openalex.org/W3097562619","https://openalex.org/W3124454989","https://openalex.org/W3127562776","https://openalex.org/W3133550433","https://openalex.org/W3160802024","https://openalex.org/W3164214079","https://openalex.org/W3178071429","https://openalex.org/W3183228573","https://openalex.org/W4200388061","https://openalex.org/W4205758014","https://openalex.org/W4224248129","https://openalex.org/W4289793749","https://openalex.org/W4317937588","https://openalex.org/W4318466534","https://openalex.org/W4362578324","https://openalex.org/W4365457285","https://openalex.org/W4376604801","https://openalex.org/W4377939033","https://openalex.org/W4382010781","https://openalex.org/W4385548258","https://openalex.org/W4385840473","https://openalex.org/W4387542161","https://openalex.org/W4389570157","https://openalex.org/W4390024239","https://openalex.org/W4391221103","https://openalex.org/W4392001847","https://openalex.org/W4393223714","https://openalex.org/W4394853017","https://openalex.org/W4394934428","https://openalex.org/W4399547087","https://openalex.org/W4402761083","https://openalex.org/W4404549940","https://openalex.org/W4413007541","https://openalex.org/W7211992423"],"related_works":["https://openalex.org/W2968511948","https://openalex.org/W4237792964","https://openalex.org/W2466314252","https://openalex.org/W4289600970","https://openalex.org/W2999627639","https://openalex.org/W4283328284","https://openalex.org/W3044493806","https://openalex.org/W2170289328","https://openalex.org/W2114498410","https://openalex.org/W2408368684"],"abstract_inverted_index":{"We":[0],"report":[1],"a":[2,22,28,118],"palladium-catalyzed":[3],"esterification":[4],"reaction":[5,26,43,58],"involving":[6],"difluoroallyl":[7,84],"bromides.":[8],"This":[9],"synthetic":[10,123],"strategy":[11],"involves":[12],"the":[13,46,54,60,63,68,81,110],"activation":[14,50],"of":[15,41,51,62,67,83],"fluorinated":[16],"bromohydrocarbons":[17],"by":[18,53],"palladium":[19,55],"catalysis":[20],"and":[21,49,91,121],"direct":[23],"C-O":[24],"coupling":[25],"with":[27],"weakly":[29],"nucleophilic":[30],"indole":[31,36],"carboxylic":[32,37,112,128],"acid":[33],"to":[34,100],"obtain":[35],"esters.":[38,113,129],"The":[39,57],"key":[40],"this":[42,115],"lies":[44],"in":[45],"selective":[47],"coordination":[48],"3-bromo-3,3-difluoropropene":[52],"catalyst.":[56],"overcomes":[59],"influence":[61],"unique":[64],"electronic":[65],"effects":[66],"difluoromethylene":[69],"group":[70,94],"on":[71],"alkene":[72],"reactivity,":[73],"directly":[74],"establishing":[75],"an":[76],"efficient":[77],"new":[78],"method":[79],"for":[80,125],"synthesis":[82],"esters,":[85],"while":[86],"exhibiting":[87],"good":[88],"substrate":[89],"compatibility":[90],"moderate":[92],"functional":[93],"tolerance.":[95],"It":[96],"not":[97],"only":[98],"applies":[99],"indole-based":[101],"substrates":[102],"but":[103],"also":[104],"can":[105],"convert":[106],"pyrrole/aromatic":[107],"acids":[108],"into":[109],"corresponding":[111],"Overall,":[114],"study":[116],"provides":[117],"practic":[119],"al":[120],"straightforward":[122],"approach":[124],"difluoroallyl-substituted":[126],"indole/pyrrole/aromatic":[127]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-01-16T00:00:00"}