{"id":"https://openalex.org/W7124322276","doi":"https://doi.org/10.1097/js9.0000000000004814","title":"Letter to the Editor on \u201cIndividualized structural network deviations predict surgical outcome in mesial temporal lobe epilepsy: a multicenter validation study\u201d","display_name":"Letter to the Editor on \u201cIndividualized structural network deviations predict surgical outcome in mesial temporal lobe epilepsy: a multicenter validation study\u201d","publication_year":2026,"publication_date":"2026-01-13","ids":{"openalex":"https://openalex.org/W7124322276","doi":"https://doi.org/10.1097/js9.0000000000004814","pmid":"https://pubmed.ncbi.nlm.nih.gov/41537401"},"language":"en","primary_location":{"id":"doi:10.1097/js9.0000000000004814","doi":"https://doi.org/10.1097/js9.0000000000004814","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000004814","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1097/js9.0000000000004814","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083020117","display_name":"Jingjing Zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingjing Zhong","raw_affiliation_strings":["Reproductive Medicine Center, Hainan Women and Children's Medical Center, Haikou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reproductive Medicine Center, Hainan Women and Children's Medical Center, Haikou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123164785","display_name":"Weiying Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiying Lu","raw_affiliation_strings":["Published online 13 January 2026","Reproductive Medicine Center, Hainan Women and Children\u2019s Medical Center, Haikou, China","Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Published online 13 January 2026","institution_ids":[]},{"raw_affiliation_string":"Reproductive Medicine Center, Hainan Women and Children\u2019s Medical Center, Haikou, China","institution_ids":[]},{"raw_affiliation_string":"Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"5","first_page":"12421","last_page":"12422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesial-temporal-lobe-epilepsy","display_name":"mesial temporal lobe epilepsy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/surgical-outcome-prediction","display_name":"surgical outcome prediction","score":0.8009999990463257},{"id":"https://openalex.org/keywords/anterior-temporal-lobectomy","display_name":"anterior temporal lobectomy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/seizure-outcome","display_name":"seizure outcome","score":0.5040000081062317},{"id":"https://openalex.org/keywords/network-biomarkers","display_name":"network biomarkers","score":0.5400000214576721},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.3449999988079071},{"id":"https://openalex.org/keywords/t1-weighted-mri","display_name":"T1-weighted imaging","score":0.6449999809265137},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/generalizability","display_name":"generalizability","score":0.6110000014305115},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"default mode network","score":0.6050000190734863},{"id":"https://openalex.org/keywords/frontoparietal-network","display_name":"frontoparietal network","score":0.9539999961853027},{"id":"https://openalex.org/keywords/network-hubs","display_name":"network hubs","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.729200005531311},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.6819999814033508},{"id":"https://openalex.org/C2780803581","wikidata":"https://www.wikidata.org/wiki/Q1347108","display_name":"Epilepsy surgery","level":3,"score":0.59579998254776},{"id":"https://openalex.org/C2779513729","wikidata":"https://www.wikidata.org/wiki/Q4771405","display_name":"Anterior temporal lobectomy","level":4,"score":0.5771999955177307},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.5339999794960022},{"id":"https://openalex.org/C2994116697","wikidata":"https://www.wikidata.org/wiki/Q616667","display_name":"Mesial temporal lobe epilepsy","level":4,"score":0.4453999996185303},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.43290001153945923},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.42730000615119934},{"id":"https://openalex.org/C44725695","wikidata":"https://www.wikidata.org/wiki/Q288156","display_name":"Normative","level":2,"score":0.4214000105857849},{"id":"https://openalex.org/C2777876421","wikidata":"https://www.wikidata.org/wiki/Q1637174","display_name":"Lobe","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.34779998660087585},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3467999994754791},{"id":"https://openalex.org/C2779370443","wikidata":"https://www.wikidata.org/wiki/Q1776627","display_name":"Surgical planning","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3255000114440918},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C3020562746","wikidata":"https://www.wikidata.org/wiki/Q7446275","display_name":"Surgical resection","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C12770488","wikidata":"https://www.wikidata.org/wiki/Q188449","display_name":"Neurosurgery","level":2,"score":0.25060001015663147}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/js9.0000000000004814","doi":"https://doi.org/10.1097/js9.0000000000004814","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000004814","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:41537401","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41537401","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of surgery (London, England)","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1097/js9.0000000000004814","doi":"https://doi.org/10.1097/js9.0000000000004814","is_oa":true,"landing_page_url":"https://doi.org/10.1097/js9.0000000000004814","pdf_url":null,"source":{"id":"https://openalex.org/S67965910","display_name":"International Journal of Surgery","issn_l":"1743-9159","issn":["1743-9159","1743-9191"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2126727507","https://openalex.org/W3002061926","https://openalex.org/W3081299376","https://openalex.org/W4288723200","https://openalex.org/W4411980276"],"related_works":[],"abstract_inverted_index":{"Dear":[0],"Editor,":[1],"Feng":[2,122],"et":[3,123],"al":[4],"report":[5],"a":[6,30,49,92,101,108,112,118,247,261],"multicenter":[7],"MRI-based":[8],"machine":[9],"learning":[10],"model":[11,238,329],"that":[12,126,162,352,368],"uses":[13],"individualized":[14,426],"structural":[15,427],"covariance":[16],"networks":[17,165,216],"(iSCN)":[18],"to":[19,75,219,253,278,283,423],"predict":[20],"surgical":[21,172,288],"outcome":[22,156,185],"in":[23,68,135,194,208,439],"mesial":[24],"temporal":[25,40,229,378],"lobe":[26,230,379],"epilepsy":[27,231,388],"(mTLE)[1].":[28],"In":[29],"field":[31],"where":[32],"30\u201340%":[33],"of":[34,81,91,189,202,437],"patients":[35,129],"remain":[36],"non\u2013seizure-free":[37,127],"after":[38],"anterior":[39],"lobectomy":[41],"despite":[42],"optimal":[43],"candidate":[44,433],"selection[2,3],":[45],"the":[46,71,89,136,149,160,167,195,234,320,328,366],"shift":[47],"from":[48,95,250],"purely":[50],"focal":[51],"\u201cepileptogenic":[52],"zone\u201d":[53],"concept":[54,367],"toward":[55],"network-level":[56],"biomarkers":[57,429],"is":[58,66,88,260,274,295,330,346],"both":[59],"timely":[60],"and":[61,78,111,145,191,204,214,228,256,276,287,324,370,390,435],"clinically":[62],"relevant.":[63],"This":[64,158],"commentary":[65],"prepared":[67],"accordance":[69],"with":[70,186,198,334],"TITAN":[72],"2025":[73],"guidance":[74],"ensure":[76],"transparent":[77],"responsible":[79],"reporting":[80],"AI-related":[82],"methods[4].":[83],"The":[84,272,407],"key":[85],"methodological":[86],"advance":[87],"derivation":[90],"patient-specific":[93,314],"iSCN":[94,133,180],"routine":[96,270],"preoperative":[97,251],"T1-weighted":[98],"MRI":[99,252],"using":[100],"normative":[102],"template,":[103],"then":[104],"partitioning":[105],"it":[106],"into":[107,239,420],"\u201csurgery":[109],"network\u201d":[110,115],"\u201csurgically":[113],"spared":[114,137,179,325,371],"based":[116],"on":[117],"standardized":[119],"resection":[120,168,255,308,359,438],"mask.":[121],"al.":[124],"show":[125],"(NSF)":[128],"exhibit":[130],"significantly":[131],"greater":[132],"abnormalities":[134,227],"network,":[138],"particularly":[139],"within":[140],"contralateral":[141,178,369],"frontal,":[142],"temporal,":[143],"insular":[144],"limbic":[146],"modules,":[147],"whereas":[148],"surgery":[150],"network":[151,225,372,428],"does":[152],"not":[153,331,401],"differ":[154],"between":[155,322],"groups[1].":[157],"supports":[159],"notion":[161],"persistent":[163],"epileptogenic":[164],"outside":[166],"zone":[169],"critically":[170],"determine":[171,424],"failure.":[173],"Using":[174],"support":[175],"vector":[176],"machines,":[177],"features":[181],"predicted":[182],"1-year":[183],"seizure":[184,385],"an":[187,240,348],"accuracy":[188],"82%":[190],"AUC":[192],"0.81":[193],"primary":[196],"cohort,":[197],"external":[199,293],"validation":[200],"accuracies":[201],"80":[203],"88%":[205],"(AUC":[206],"0.80\u20130.82)":[207],"two":[209],"independent":[210],"centers[1].":[211],"Default":[212],"mode":[213],"frontoparietal":[215],"contributed":[217],"most":[218],"classification,":[220],"echoing":[221],"prior":[222],"work":[223,363],"linking":[224],"hub":[226],"outcome[5\u20137].":[232],"Importantly,":[233],"authors":[235],"package":[236],"their":[237],"open-source":[241],"\u201cEpilepsy":[242],"Surgical":[243],"Prediction":[244],"Toolbox,\u201d":[245],"outlining":[246],"realistic":[248],"workflow":[249],"virtual":[254],"prognostic":[257],"readout,":[258],"which":[259,317],"major":[262],"translational":[263],"strength.":[264],"Several":[265],"caveats":[266],"warrant":[267],"caution":[268],"before":[269],"adoption.":[271],"study":[273],"retrospective":[275],"restricted":[277],"three":[279],"Chinese":[280],"centers;":[281],"generalizability":[282],"other":[284],"populations,":[285],"scanners":[286],"practices":[289],"remains":[290],"uncertain.":[291],"One":[292],"cohort":[294],"small":[296],"(n":[297],"=":[298],"17),":[299],"so":[300],"performance":[301],"estimates":[302],"there":[303,347],"are":[304,395],"imprecise.":[305],"A":[306],"group-level":[307],"mask":[309],"was":[310],"used":[311],"rather":[312,375],"than":[313,376],"postoperative":[315,384],"masks,":[316],"may":[318],"blur":[319],"distinction":[321],"resected":[323],"tissue.":[326],"Moreover,":[327],"compared":[332],"head-to-head":[333],"simpler":[335],"predictors":[336],"(clinical":[337],"variables,":[338],"standard":[339,421],"MRI,":[340],"or":[341,357],"established":[342],"connectomic":[343],"scores),":[344],"nor":[345],"impact":[349],"analysis":[350],"showing":[351],"model-guided":[353],"decisions":[354],"improve":[355],"outcomes":[356],"change":[358],"strategy.":[360],"Nonetheless,":[361],"this":[362],"meaningfully":[364],"advances":[365],"pathology":[373],"\u2013":[374,382],"local":[377],"damage":[380],"alone":[381],"drives":[383],"persistence.":[386],"For":[387],"surgeons":[389],"multidisciplinary":[391],"teams,":[392],"iSCN-based":[393],"tools":[394],"best":[396],"viewed":[397],"as":[398],"adjuncts":[399],"to,":[400],"replacements":[402],"for,":[403],"comprehensive":[404],"presurgical":[405],"evaluation.":[406],"next":[408],"step":[409],"should":[410],"be":[411],"prospective,":[412],"ideally":[413],"multicenter,":[414],"studies":[415],"embedding":[416],"iSCN-guided":[417],"risk":[418],"stratification":[419],"work-up":[422],"whether":[425],"can":[430],"safely":[431],"refine":[432],"selection":[434],"tailoring":[436],"mTLE.":[440]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2026-01-16T00:00:00"}
