{"id":"https://openalex.org/W7124319700","doi":"https://doi.org/10.14744/hf.2025.01128","title":"Nivolumab and bevacizumab attenuate cisplatin-induced hepatic inflammation and apoptosis in rats","display_name":"Nivolumab and bevacizumab attenuate cisplatin-induced hepatic inflammation and apoptosis in rats","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7124319700","doi":"https://doi.org/10.14744/hf.2025.01128","pmid":"https://pubmed.ncbi.nlm.nih.gov/41589213","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12831985"},"language":"en","primary_location":{"id":"doi:10.14744/hf.2025.01128","doi":"https://doi.org/10.14744/hf.2025.01128","is_oa":true,"landing_page_url":"https://doi.org/10.14744/hf.2025.01128","pdf_url":"https://hepatologyforum.org/storage/upload/pdfs/1768478537-en.pdf","source":{"id":"https://openalex.org/S4210219018","display_name":"Hepatology forum/Hepatology forum (Online)","issn_l":"2757-7392","issn":["2757-7392","1307-5888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Forum","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://hepatologyforum.org/storage/upload/pdfs/1768478537-en.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003375619","display_name":"O\u011fur Karhan","orcid":"https://orcid.org/0000-0002-7140-8957","observed_orcids":["https://orcid.org/0000-0002-7140-8957"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ogur Karhan","raw_affiliation_strings":["Department of Medical Oncology, School of Medicine, Harran University, Sanliurfa, Turkiye"],"raw_orcid":"https://orcid.org/0000-0002-7140-8957","affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, School of Medicine, Harran University, Sanliurfa, Turkiye","institution_ids":["https://openalex.org/I80538482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002408206","display_name":"Sibel T\u00fcredi","orcid":"https://orcid.org/0000-0003-0946-0700","observed_orcids":["https://orcid.org/0000-0003-0946-0700"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sibel Turedi","raw_affiliation_strings":["Department of Histology and Embryology, School of Medicine, Harran University, Sanliurfa, Turkiye"],"raw_orcid":"https://orcid.org/0000-0003-0946-0700","affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, School of Medicine, Harran University, Sanliurfa, Turkiye","institution_ids":["https://openalex.org/I80538482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003375619"],"corresponding_institution_ids":["https://openalex.org/I80538482"],"apc_list":null,"apc_paid":null,"fwci":3.2241,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.82287709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"7","issue":"1","first_page":"45","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.6410999894142151,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.33959999680519104,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9570000171661377},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.925000011920929},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8600000143051147},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.968999981880188},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9909999966621399},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9350000023841858},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.46399998664855957},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7982000112533569},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7957000136375427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7131999731063843},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7103000283241272},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6273000240325928},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5182999968528748},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4433000087738037},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3747999966144562},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.2980000078678131},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2921999990940094},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28439998626708984},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2825999855995178},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27790001034736633},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.25870001316070557},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.2572000026702881},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2554999887943268}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.14744/hf.2025.01128","doi":"https://doi.org/10.14744/hf.2025.01128","is_oa":true,"landing_page_url":"https://doi.org/10.14744/hf.2025.01128","pdf_url":"https://hepatologyforum.org/storage/upload/pdfs/1768478537-en.pdf","source":{"id":"https://openalex.org/S4210219018","display_name":"Hepatology forum/Hepatology forum (Online)","issn_l":"2757-7392","issn":["2757-7392","1307-5888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Forum","raw_type":"journal-article"},{"id":"pmid:41589213","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41589213","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology forum","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12831985","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12831985/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatol Forum","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.14744/hf.2025.01128","doi":"https://doi.org/10.14744/hf.2025.01128","is_oa":true,"landing_page_url":"https://doi.org/10.14744/hf.2025.01128","pdf_url":"https://hepatologyforum.org/storage/upload/pdfs/1768478537-en.pdf","source":{"id":"https://openalex.org/S4210219018","display_name":"Hepatology forum/Hepatology forum (Online)","issn_l":"2757-7392","issn":["2757-7392","1307-5888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-4","tr-dizin"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hepatology Forum","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124319700.pdf","grobid_xml":"https://content.openalex.org/works/W7124319700.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1974762321","https://openalex.org/W1974913186","https://openalex.org/W1981175286","https://openalex.org/W2041053691","https://openalex.org/W2128035403","https://openalex.org/W2196610251","https://openalex.org/W2410958990","https://openalex.org/W2549481046","https://openalex.org/W2556393126","https://openalex.org/W2970139187","https://openalex.org/W3013347515","https://openalex.org/W3031327640","https://openalex.org/W3035301526","https://openalex.org/W3164529233","https://openalex.org/W3210474759","https://openalex.org/W4284674137","https://openalex.org/W4306155451","https://openalex.org/W4378468787","https://openalex.org/W4387048817","https://openalex.org/W4387364366","https://openalex.org/W4387384302","https://openalex.org/W4392459252","https://openalex.org/W4401991457","https://openalex.org/W4405974302","https://openalex.org/W4408648497","https://openalex.org/W4408685595","https://openalex.org/W4410206247","https://openalex.org/W4411437114"],"related_works":["https://openalex.org/W3170582721","https://openalex.org/W3176551685","https://openalex.org/W7161058658","https://openalex.org/W3164072903","https://openalex.org/W1974913186","https://openalex.org/W4408601000","https://openalex.org/W4401991457","https://openalex.org/W2529314307","https://openalex.org/W2084302626","https://openalex.org/W4400894104"],"abstract_inverted_index":{"Background":[0],"and":[1,26,34,63,76,79,96,123,143,217,231,235],"Aim:":[2],"Hepatotoxicity":[3],"represents":[4],"a":[5],"significant":[6],"adverse":[7],"effect":[8],"associated":[9],"with":[10,31,128,167,224],"cancer":[11],"treatment.":[12],"The":[13,193],"present":[14],"study":[15],"was":[16,72,85,159,180,189,202,207],"designed":[17],"to":[18],"evaluate":[19],"the":[20,92,155,162,168,172,177,185,197,211],"possible":[21],"hepatoprotective":[22,220],"effects":[23],"of":[24,38,69,104,112,141,154,233],"bevacizumab":[25,51,129],"nivolumab":[27,54,131,175,200,218],"when":[28,222],"administered":[29],"concomitantly":[30],"cisplatin.":[32],"Materials":[33],"Methods:":[35],"A":[36],"total":[37],"forty-two":[39],"male":[40],"Wistar":[41],"Albino":[42],"rats":[43],"were":[44,149],"randomly":[45],"allocated":[46],"into":[47],"six":[48],"groups:":[49],"control,":[50],"(10":[52],"mg/kg),":[53,56,59],"(3":[55],"cisplatin":[57,60,64,105,173,198,212],"(12":[58],"plus":[61,65],"bevacizumab,":[62],"nivolumab.":[66],"Histological":[67],"assessment":[68],"liver":[70],"tissues":[71],"performed":[73],"using":[74],"hematoxylin":[75],"eosin":[77],"(H&E)":[78],"Masson's":[80],"trichrome":[81],"staining.":[82],"Immunohistochemical":[83],"evaluation":[84],"conducted":[86],"for":[87],"inflammatory":[88,142,234],"markers":[89,98,145],"(TNF-\u03b1,":[90,146],"IL-6),":[91],"angiogenic":[93],"factor":[94],"VEGF,":[95],"apoptotic":[97,236],"(Bax,":[99],"Bcl-2,":[100],"Caspase-3).":[101],"Results:":[102],"Administration":[103],"resulted":[106],"in":[107,161,184,196,210],"hepatotoxic":[108],"changes,":[109],"including":[110],"disruption":[111],"normal":[113],"hepatic":[114],"cord":[115],"architecture,":[116],"cytoplasmic":[117],"vacuolization,":[118],"hemorrhage,":[119],"mononuclear":[120],"cell":[121],"infiltration,":[122],"enhanced":[124],"collagen":[125],"accumulation.":[126],"Co-treatment":[127],"or":[130],"significantly":[132],"alleviated":[133],"these":[134],"histopathological":[135],"changes":[136],"(p<0.001).":[137],"In":[138,171],"addition,":[139],"levels":[140],"pro-apoptotic":[144],"Bax,":[147],"Caspase-3)":[148],"markedly":[150],"reduced,":[151],"whereas":[152,183],"expression":[153],"anti-apoptotic":[156],"protein":[157],"Bcl-2":[158,194],"increased":[160],"combination":[163],"treatment":[164],"groups":[165],"compared":[166],"cisplatin-only":[169,186],"group.":[170],"+":[174,199],"group,":[176],"TNF-\u03b1":[178],"level":[179,195],"1.0":[181,203],"(0.8-1.2),":[182,204],"group":[187,201,213],"it":[188,206],"2.0":[190],"(1.8-2.0)":[191],"(p=0.03).":[192],"while":[205],"0.2":[208],"(0-0.6)":[209],"(p=0.04).":[214],"Conclusion:":[215],"Bevacizumab":[216],"exhibited":[219],"properties":[221],"combined":[223],"cisplatin,":[225],"as":[226],"demonstrated":[227],"by":[228],"histological":[229],"improvement":[230],"regulation":[232],"signaling":[237],"pathways.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-01-16T00:00:00"}