{"id":"https://openalex.org/W7124309152","doi":"https://doi.org/10.7554/elife.109350.1.sa0","title":"Author response: A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania","display_name":"Author response: A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania","publication_year":2026,"publication_date":"2026-01-15","ids":{"openalex":"https://openalex.org/W7124309152","doi":"https://doi.org/10.7554/elife.109350.1.sa0"},"language":"en","primary_location":{"id":"doi:10.7554/elife.109350.1.sa0","doi":"https://doi.org/10.7554/elife.109350.1.sa0","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.109350.1.sa0","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"volume":null,"type":"peer-review","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.109350.1.sa0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028026701","display_name":"Gabriel H. Negreira","orcid":"https://orcid.org/0000-0003-4867-8892","observed_orcids":["https://orcid.org/0000-0003-4867-8892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel H Negreira","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4867-8892","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053515122","display_name":"Pieter Monsieurs","orcid":"https://orcid.org/0000-0003-2214-6652","observed_orcids":["https://orcid.org/0000-0003-2214-6652"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter Monsieurs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2214-6652","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054138064","display_name":"Jean\u2010Claude Dujardin","orcid":"https://orcid.org/0000-0002-9217-5240","observed_orcids":["https://orcid.org/0000-0002-9217-5240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Claude Dujardin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9217-5240","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038788635","display_name":"Malgorzata A. Domagalska","orcid":"https://orcid.org/0000-0003-0839-0325","observed_orcids":["https://orcid.org/0000-0003-0839-0325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malgorzata A Domagalska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0839-0325","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.3142000138759613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.2045000046491623,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania","display_name":"Leishmania","score":0.9049999713897705},{"id":"https://openalex.org/keywords/single-cell-dna-sequencing","display_name":"single-cell DNA sequencing","score":0.8610000014305115},{"id":"https://openalex.org/keywords/genomic-heterogeneity","display_name":"genomic heterogeneity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/unicellular-eukaryotes","display_name":"unicellular eukaryotes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8611000180244446},{"id":"https://openalex.org/C2779413310","wikidata":"https://www.wikidata.org/wiki/Q19088","display_name":"Eukaryote","level":4,"score":0.739300012588501},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6607999801635742},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.567799985408783},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5569999814033508},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.552299976348877},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.5023000240325928},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5005000233650208},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47350001335144043},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4129999876022339},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.41200000047683716},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.3646000027656555},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.3637000024318695},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.3549000024795532},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3504999876022339},{"id":"https://openalex.org/C2779040068","wikidata":"https://www.wikidata.org/wiki/Q7229807","display_name":"Population genomics","level":5,"score":0.3305000066757202},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.30979999899864197},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.2809000015258789},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2784999907016754}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.109350.1.sa0","doi":"https://doi.org/10.7554/elife.109350.1.sa0","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.109350.1.sa0","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"}],"best_oa_location":{"id":"doi:10.7554/elife.109350.1.sa0","doi":"https://doi.org/10.7554/elife.109350.1.sa0","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.109350.1.sa0","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"peer-review"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7860493651","display_name":"Exploring the adaptive role of genomic instability in Trypanosoma cruzi.","funder_award_id":"MR/Y001338/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320319128","display_name":"Vlaams Supercomputer Centrum","ror":"https://ror.org/05sqppn31"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7124250438","https://openalex.org/W2101904205","https://openalex.org/W7213874984","https://openalex.org/W3009569614","https://openalex.org/W4221052783","https://openalex.org/W4409989567","https://openalex.org/W2522391962","https://openalex.org/W3175604029","https://openalex.org/W7115178894","https://openalex.org/W2900120366"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-01-16T00:00:00"}