{"id":"https://openalex.org/W7124305256","doi":"https://doi.org/10.5281/zenodo.18255287","title":"ZEBRAFISH AS A MODEL FOR HERBAL TOXICOLOGY: A SCIENTIFIC REVIEW ON ASHWAGANDHA (WITHANIA SOMNIFERA) AND ITS SAFETY PROFILE","display_name":"ZEBRAFISH AS A MODEL FOR HERBAL TOXICOLOGY: A SCIENTIFIC REVIEW ON ASHWAGANDHA (WITHANIA SOMNIFERA) AND ITS SAFETY PROFILE","publication_year":2026,"publication_date":"2026-01-15","ids":{"openalex":"https://openalex.org/W7124305256","doi":"https://doi.org/10.5281/zenodo.18255287"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.18255287","doi":"https://doi.org/10.5281/zenodo.18255287","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18255287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.18255287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123084743","display_name":"Dr. K. Shruthi Murali*","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153931","display_name":"D.Y. Patil University","ror":"https://ror.org/045qb5273","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210153931"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dr. K. Shruthi Murali*","raw_affiliation_strings":["PG Scholar, Department of Rasa Shastra & Bhaishajya Kalpana, D.Y. Patil Deemed to Be University, Nerul, Navi Mumbai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PG Scholar, Department of Rasa Shastra & Bhaishajya Kalpana, D.Y. Patil Deemed to Be University, Nerul, Navi Mumbai","institution_ids":["https://openalex.org/I4210153931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061089755","display_name":"Ekta Tomar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153931","display_name":"D.Y. Patil University","ror":"https://ror.org/045qb5273","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210153931"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Dr. Ekta Tomar","raw_affiliation_strings":["Associate professor, Department of Rasa Shastra & Bhaishajya Kalpana, D.Y. Patil Deemed to Be University, Nerul, Navi Mumbai"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate professor, Department of Rasa Shastra & Bhaishajya Kalpana, D.Y. Patil Deemed to Be University, Nerul, Navi Mumbai","institution_ids":["https://openalex.org/I4210153931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210153931"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02890954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ashwagandha","display_name":"Withania somnifera","score":1.0},{"id":"https://openalex.org/keywords/herbal-medicine-safety","display_name":"herbal medicine safety","score":0.9559999704360962},{"id":"https://openalex.org/keywords/herb-drug-interactions","display_name":"herb-drug interactions","score":0.9580000042915344},{"id":"https://openalex.org/keywords/embryotoxicity","display_name":"embryotoxicity","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytochrome-p450-interactions","display_name":"cytochrome P450 interactions","score":0.953000009059906},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.828000009059906},{"id":"https://openalex.org/keywords/adaptogens","display_name":"adaptogens","score":0.6019999980926514},{"id":"https://openalex.org/keywords/dose-dependent-toxicity","display_name":"dose-dependent toxicity","score":0.609000027179718},{"id":"https://openalex.org/keywords/translational-toxicology","display_name":"translational toxicology","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8220000267028809},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5055000185966492},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48989999294281006},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.48080000281333923},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.41040000319480896},{"id":"https://openalex.org/C520753416","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal testing","level":2,"score":0.40220001339912415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3887999951839447},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.36970001459121704},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.36730000376701355},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36000001430511475},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3467000126838684},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C3019038264","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug candidate","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.26159998774528503},{"id":"https://openalex.org/C2780500402","wikidata":"https://www.wikidata.org/wiki/Q13023682","display_name":"Non-human","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.2540000081062317},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.25049999356269836}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.18255287","doi":"https://doi.org/10.5281/zenodo.18255287","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18255287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.18255288","doi":"https://doi.org/10.5281/zenodo.18255288","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18255288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.18255287","doi":"https://doi.org/10.5281/zenodo.18255287","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18255287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Responsible consumption and production","score":0.42857998609542847,"id":"https://metadata.un.org/sdg/12"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Herbal":[0],"medicines":[1],"remain":[2],"integral":[3],"to":[4,41,45,71,80],"traditional":[5],"and":[6,23,30,47,68,87,98,117,127,133,142,158,169,183],"modern":[7],"healthcare,":[8],"with":[9,111,131,156],"Ashwagandha":[10,105,196],"(Withania":[11],"somnifera)":[12],"being":[13],"one":[14],"of":[15,189,195],"the":[16,146,187,193],"most":[17],"widely":[18],"utilised":[19],"for":[20,148,173],"its":[21],"adaptogenic":[22],"neuroprotective":[24],"properties.":[25],"However,":[26],"concerns":[27],"regarding":[28],"safety":[29,74,109,190],"herb\u2013drug":[31],"interactions":[32],"necessitate":[33],"systematic":[34],"toxicological":[35,176],"evaluation.":[36],"Zebrafish":[37,151,164],"(Danio":[38],"rerio),":[39],"owing":[40],"their":[42],"genetic":[43],"similarity":[44],"humans":[46],"high-throughput":[48],"potential,":[49],"have":[50],"emerged":[51],"as":[52,197],"powerful":[53],"models":[54,113],"in":[55],"preclinical":[56],"toxicology.":[57],"This":[58],"review":[59],"synthesises":[60],"recent":[61],"evidence":[62],"from":[63],"zebrafish-based":[64],"assays,":[65,89],"rodent":[66,157],"studies,":[67],"clinical":[69,134],"trials":[70],"evaluate":[72],"Ashwagandha\u2019s":[73,175],"profile.":[75,177],"Literature":[76],"was":[77],"critically":[78],"analysed":[79],"highlight":[81],"experimental":[82],"approaches,":[83],"including":[84],"embryotoxicity,":[85],"neurotoxicity,":[86],"cardiotoxicity":[88],"alongside":[90],"molecular":[91],"insights":[92],"into":[93,180],"oxidative":[94],"stress,":[95],"mitochondrial":[96],"dysfunction,":[97],"cytochrome":[99],"P450":[100],"interactions.":[101],"Findings":[102],"indicate":[103],"that":[104],"demonstrates":[106],"a":[107,198],"broad":[108],"margin,":[110],"zebrafish":[112],"revealing":[114],"dose-dependent":[115],"therapeutic":[116],"toxic":[118],"effects.":[119],"At":[120],"optimal":[121],"concentrations,":[122],"extracts":[123],"confer":[124],"neuroprotection,":[125],"immunomodulation,":[126],"stress":[128],"resilience,":[129],"consistent":[130],"mammalian":[132],"outcomes.":[135],"Conversely,":[136],"excessive":[137],"dosing":[138],"may":[139],"induce":[140],"developmental":[141],"metabolic":[143],"disturbances,":[144],"underscoring":[145],"need":[147],"standardised":[149,199],"protocols.":[150],"data":[152],"also":[153],"align":[154],"closely":[155],"human":[159],"evidence,":[160],"reinforcing":[161],"translational":[162],"validity.":[163],"provide":[165],"an":[166],"efficient,":[167],"predictive,":[168],"ethically":[170],"sustainable":[171],"platform":[172],"assessing":[174],"Their":[178],"integration":[179],"drug":[181],"discovery":[182],"regulatory":[184],"pipelines":[185],"enhances":[186],"reliability":[188],"assessments,":[191],"supporting":[192],"advancement":[194],"therapeutic.":[200]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2026-01-16T00:00:00"}