{"id":"https://openalex.org/W7124305012","doi":"https://doi.org/10.3390/jcm15020722","title":"Revisiting Abdominal Pain in IBS: From Pathophysiology to Targeted Management with Alverine Citrate/Simeticone","display_name":"Revisiting Abdominal Pain in IBS: From Pathophysiology to Targeted Management with Alverine Citrate/Simeticone","publication_year":2026,"publication_date":"2026-01-15","ids":{"openalex":"https://openalex.org/W7124305012","doi":"https://doi.org/10.3390/jcm15020722","pmid":"https://pubmed.ncbi.nlm.nih.gov/41598660"},"language":"en","primary_location":{"id":"doi:10.3390/jcm15020722","doi":"https://doi.org/10.3390/jcm15020722","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15020722","pdf_url":"https://www.mdpi.com/2077-0383/15/2/722/pdf?version=1768487582","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2077-0383/15/2/722/pdf?version=1768487582","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038697021","display_name":"Rodolfo Sacco","orcid":"https://orcid.org/0000-0002-9887-7315","observed_orcids":["https://orcid.org/0000-0002-9887-7315"]},"institutions":[{"id":"https://openalex.org/I106296451","display_name":"University of Foggia","ror":"https://ror.org/01xtv3204","country_code":"IT","type":"education","lineage":["https://openalex.org/I106296451"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rodolfo Sacco","raw_affiliation_strings":["Gastroenterology and Digestive Endoscopy Unit, Department of Surgical and Medical Sciences, University of Foggia, 71122 Foggia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Digestive Endoscopy Unit, Department of Surgical and Medical Sciences, University of Foggia, 71122 Foggia, Italy","institution_ids":["https://openalex.org/I106296451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010071655","display_name":"Antonio Facciorusso","orcid":"https://orcid.org/0000-0002-2107-2156","observed_orcids":["https://orcid.org/0000-0002-2107-2156"]},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Facciorusso","raw_affiliation_strings":["Gastroenterology Unit, Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2107-2156","affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy","institution_ids":["https://openalex.org/I142910587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014172694","display_name":"Edoardo Giovanni Giannini","orcid":"https://orcid.org/0000-0001-8526-837X","observed_orcids":["https://orcid.org/0000-0001-8526-837X"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Edoardo Giannini","raw_affiliation_strings":["Gastroenterology Unit, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, University of Genova, 16126 Genova, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8526-837X","affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale Policlinico San Martino, University of Genova, 16126 Genova, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021696777","display_name":"Massimo Bellini","orcid":"https://orcid.org/0000-0002-6387-6443","observed_orcids":["https://orcid.org/0000-0002-6387-6443"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Bellini","raw_affiliation_strings":["Gastroenterology Unit, University of Pisa, 56124 Pisa, Italy"],"raw_orcid":"https://orcid.org/0000-0002-6387-6443","affiliations":[{"raw_affiliation_string":"Gastroenterology Unit, University of Pisa, 56124 Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5038697021"],"corresponding_institution_ids":["https://openalex.org/I106296451"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":5.4437,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.91004159,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"15","issue":"2","first_page":"722","last_page":"722"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13289","display_name":"Infant Health and Development","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.9869999885559082},{"id":"https://openalex.org/keywords/visceral-hypersensitivity","display_name":"visceral hypersensitivity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/intestinal-distension","display_name":"intestinal distension","score":0.6520000100135803},{"id":"https://openalex.org/keywords/gas","display_name":"gases","score":0.6179999709129333},{"id":"https://openalex.org/keywords/smooth-muscle-relaxation","display_name":"smooth muscle relaxation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.9629999995231628},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8460000157356262},{"id":"https://openalex.org/keywords/ibs-subtypes","display_name":"IBS subtypes","score":0.7390000224113464},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.6840000152587891},{"id":"https://openalex.org/keywords/healthcare-resource-utilization","display_name":"healthcare resource utilization","score":0.5509999990463257},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9663000106811523},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8579000234603882},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6687999963760376},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.5931000113487244},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5623999834060669},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.5598000288009644},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.5070000290870667},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.44130000472068787},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4278999865055084},{"id":"https://openalex.org/C2779794527","wikidata":"https://www.wikidata.org/wiki/Q4116360","display_name":"Visceral pain","level":4,"score":0.3774999976158142},{"id":"https://openalex.org/C2984752397","wikidata":"https://www.wikidata.org/wiki/Q3259956","display_name":"Primary care","level":2,"score":0.3345000147819519},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.33410000801086426},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3215000033378601},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.31369999051094055},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3093000054359436},{"id":"https://openalex.org/C2983098980","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain management","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.29429998993873596},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C3019806175","wikidata":"https://www.wikidata.org/wiki/Q11974939","display_name":"Health professionals","level":3,"score":0.289000004529953},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2854999899864197},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C2988170871","wikidata":"https://www.wikidata.org/wiki/Q11000047","display_name":"Healthcare system","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C2989236134","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Patient care","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2646999955177307},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C2982889124","wikidata":"https://www.wikidata.org/wiki/Q107439039","display_name":"Disease management","level":4,"score":0.25099998712539673}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/jcm15020722","doi":"https://doi.org/10.3390/jcm15020722","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15020722","pdf_url":"https://www.mdpi.com/2077-0383/15/2/722/pdf?version=1768487582","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},{"id":"pmid:41598660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41598660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical medicine","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/1361291","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11568/1361291","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unisalento.it:11587/567707","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11587/567707","pdf_url":null,"source":{"id":"https://openalex.org/S7407055257","display_name":"AIRUS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12842271","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12842271/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Clin Med","raw_type":"Text"},{"id":"pmh:oai:unige.iris.cineca.it:11567/1284698","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11567/1284698","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/jcm15020722","doi":"https://doi.org/10.3390/jcm15020722","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jcm15020722","pdf_url":"https://www.mdpi.com/2077-0383/15/2/722/pdf?version=1768487582","source":{"id":"https://openalex.org/S2737969411","display_name":"Journal of Clinical Medicine","issn_l":"2077-0383","issn":["2077-0383"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124305012.pdf","grobid_xml":"https://content.openalex.org/works/W7124305012.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1534808289","https://openalex.org/W1567763106","https://openalex.org/W1981236357","https://openalex.org/W2007461840","https://openalex.org/W2013223817","https://openalex.org/W2013253837","https://openalex.org/W2063653508","https://openalex.org/W2064484958","https://openalex.org/W2065530845","https://openalex.org/W2069255677","https://openalex.org/W2097465425","https://openalex.org/W2316319365","https://openalex.org/W2330377679","https://openalex.org/W2419592887","https://openalex.org/W2495307074","https://openalex.org/W2530981261","https://openalex.org/W2590344642","https://openalex.org/W2625582958","https://openalex.org/W2768875022","https://openalex.org/W2775922728","https://openalex.org/W2799759998","https://openalex.org/W2897216914","https://openalex.org/W2904554638","https://openalex.org/W2905478753","https://openalex.org/W2999331904","https://openalex.org/W3011547682","https://openalex.org/W3016675340","https://openalex.org/W3121765154","https://openalex.org/W3135011130","https://openalex.org/W3159143441","https://openalex.org/W3162865300","https://openalex.org/W3192851081","https://openalex.org/W3212258323","https://openalex.org/W3216728382","https://openalex.org/W4210564580","https://openalex.org/W4211073917","https://openalex.org/W4211089299","https://openalex.org/W4282573953","https://openalex.org/W4283157307","https://openalex.org/W4283800685","https://openalex.org/W4296027136","https://openalex.org/W4311590220","https://openalex.org/W4385667571","https://openalex.org/W4387158615","https://openalex.org/W4391252325","https://openalex.org/W4391527551","https://openalex.org/W4391888630","https://openalex.org/W4394808474","https://openalex.org/W4396229361","https://openalex.org/W4398134263","https://openalex.org/W4405464485","https://openalex.org/W4406674671","https://openalex.org/W4408529239","https://openalex.org/W4409342737","https://openalex.org/W4409577270"],"related_works":[],"abstract_inverted_index":{"Abdominal":[0],"pain":[1,158],"is":[2,83],"the":[3,12,42,49,86],"cardinal":[4],"symptom":[5],"of":[6,15,51,89,120],"irritable":[7],"bowel":[8],"syndrome":[9],"(IBS)":[10],"and":[11,18,25,57,63,73,78,96,107,122,140],"primary":[13],"determinant":[14],"disease":[16],"burden":[17],"healthcare":[19,124],"utilization.":[20],"Despite":[21,127],"its":[22,102,113],"diagnostic":[23],"centrality":[24],"high":[26],"prevalence":[27],"across":[28],"all":[29],"IBS":[30],"subtypes,":[31],"effective":[32],"management":[33,159],"remains":[34],"a":[35,150,166],"clinical":[36],"challenge.":[37],"This":[38],"narrative":[39],"review":[40,147],"explores":[41],"pathophysiological":[43],"mechanisms":[44],"underlying":[45],"IBS-related":[46],"pain,":[47,117],"emphasizing":[48],"role":[50],"visceral":[52],"hypersensitivity,":[53],"altered":[54],"brain-gut":[55],"communication,":[56],"luminal":[58],"factors":[59],"such":[60],"as":[61],"gas":[62],"distension.":[64],"We":[65],"examine":[66],"current":[67],"guideline":[68],"recommendations,":[69],"real-world":[70],"treatment":[71,136],"patterns,":[72],"evidence":[74],"supporting":[75],"both":[76,94],"pharmacological":[77],"non-pharmacological":[79],"interventions.":[80],"Particular":[81],"focus":[82],"placed":[84],"on":[85],"fixed-dose":[87],"combination":[88],"alverine":[90,163],"citrate/simeticone,":[91],"which":[92],"targets":[93],"motor":[95],"sensory":[97],"pathways.":[98],"Mechanistic":[99],"studies":[100],"demonstrate":[101],"smooth":[103],"muscle":[104],"relaxant,":[105],"antinociceptive,":[106],"anti-inflammatory":[108],"actions.":[109],"Clinical":[110],"trials":[111],"support":[112],"efficacy":[114],"in":[115,160],"reducing":[116],"improving":[118],"quality":[119],"life,":[121],"lowering":[123],"resource":[125],"use.":[126],"these":[128],"advances,":[129],"several":[130],"unmet":[131],"needs":[132],"remain,":[133],"including":[134],"subtype-specific":[135],"strategies,":[137],"mechanistic":[138],"biomarkers,":[139],"broader":[141],"access":[142],"to":[143,157],"integrated":[144],"care.":[145],"The":[146],"concludes":[148],"with":[149,162],"call":[151],"for":[152],"more":[153],"personalized,":[154],"mechanism-based":[155],"approaches":[156],"IBS,":[161],"citrate/simeticone":[164],"offering":[165],"pragmatic":[167],"option":[168],"within":[169],"this":[170],"evolving":[171],"therapeutic":[172],"framework.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2026-01-16T00:00:00"}
