{"id":"https://openalex.org/W7124300710","doi":"https://doi.org/10.1093/etojnl/vgag010","title":"Beyond acute toxicity: evolutionary response by rapid polygenic adaptation to a complex environmental stressor in Chironomus riparius","display_name":"Beyond acute toxicity: evolutionary response by rapid polygenic adaptation to a complex environmental stressor in Chironomus riparius","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7124300710","doi":"https://doi.org/10.1093/etojnl/vgag010","pmid":"https://pubmed.ncbi.nlm.nih.gov/41537247"},"language":"en","primary_location":{"id":"doi:10.1093/etojnl/vgag010","doi":"https://doi.org/10.1093/etojnl/vgag010","is_oa":false,"landing_page_url":"https://doi.org/10.1093/etojnl/vgag010","pdf_url":null,"source":{"id":"https://openalex.org/S136710263","display_name":"Environmental Toxicology and Chemistry","issn_l":"0730-7268","issn":["0730-7268","1552-8618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/27/2025.05.23.655730.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5095744227","display_name":"Lorenzo Rigano","orcid":"https://orcid.org/0009-0005-5330-3499","observed_orcids":["https://orcid.org/0009-0005-5330-3499"]},"institutions":[{"id":"https://openalex.org/I4210112860","display_name":"Senckenberg Biodiversity and Climate Research Centre","ror":"https://ror.org/01amp2a31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802697327","https://openalex.org/I315704651","https://openalex.org/I4210112860"]},{"id":"https://openalex.org/I4210122504","display_name":"LOEWE Centre for Translational Biodiversity Genomics","ror":"https://ror.org/0396gab88","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210122504"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Lorenzo Rigano","raw_affiliation_strings":["Department of Molecular Ecology, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","LOEWE Centre of Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,"],"raw_orcid":"https://orcid.org/0009-0005-5330-3499","affiliations":[{"raw_affiliation_string":"Department of Molecular Ecology, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","institution_ids":["https://openalex.org/I4210112860"]},{"raw_affiliation_string":"LOEWE Centre of Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","institution_ids":["https://openalex.org/I4210112860","https://openalex.org/I4210122504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108971090","display_name":"Markus Schmitz","orcid":"https://orcid.org/0000-0003-0522-6351","observed_orcids":["https://orcid.org/0000-0003-0522-6351"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Schmitz","raw_affiliation_strings":["Department of Evolutionary Ecology & Environmental Toxicology (E3T), Institute for Ecology, Evolution and Diversity, Faculty 15 Biological Sciences, Goethe University , Frankfurt am Main,"],"raw_orcid":"https://orcid.org/0000-0003-0522-6351","affiliations":[{"raw_affiliation_string":"Department of Evolutionary Ecology & Environmental Toxicology (E3T), Institute for Ecology, Evolution and Diversity, Faculty 15 Biological Sciences, Goethe University , Frankfurt am Main,","institution_ids":["https://openalex.org/I114090438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089154321","display_name":"Henner Hollert","orcid":"https://orcid.org/0000-0001-5776-5619","observed_orcids":["https://orcid.org/0000-0001-5776-5619"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210112860","display_name":"Senckenberg Biodiversity and Climate Research Centre","ror":"https://ror.org/01amp2a31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802697327","https://openalex.org/I315704651","https://openalex.org/I4210112860"]},{"id":"https://openalex.org/I4210122504","display_name":"LOEWE Centre for Translational Biodiversity Genomics","ror":"https://ror.org/0396gab88","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210122504"]},{"id":"https://openalex.org/I4210134473","display_name":"Fraunhofer Institute for Molecular Biology and Applied Ecology","ror":"https://ror.org/03j85fc72","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210134473","https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henner Hollert","raw_affiliation_strings":["Department Environmental Media Related Ecotoxicology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME , Schmallenberg,","Department of Evolutionary Ecology & Environmental Toxicology (E3T), Institute for Ecology, Evolution and Diversity, Faculty 15 Biological Sciences, Goethe University , Frankfurt am Main,","LOEWE Centre of Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,"],"raw_orcid":"https://orcid.org/0000-0001-5776-5619","affiliations":[{"raw_affiliation_string":"Department Environmental Media Related Ecotoxicology, Fraunhofer Institute for Molecular Biology and Applied Ecology IME , Schmallenberg,","institution_ids":["https://openalex.org/I4210134473"]},{"raw_affiliation_string":"Department of Evolutionary Ecology & Environmental Toxicology (E3T), Institute for Ecology, Evolution and Diversity, Faculty 15 Biological Sciences, Goethe University , Frankfurt am Main,","institution_ids":["https://openalex.org/I114090438"]},{"raw_affiliation_string":"LOEWE Centre of Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","institution_ids":["https://openalex.org/I4210112860","https://openalex.org/I4210122504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089417026","display_name":"Markus Pfenninger","orcid":"https://orcid.org/0000-0002-1547-7245","observed_orcids":["https://orcid.org/0000-0002-1547-7245"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]},{"id":"https://openalex.org/I4210112860","display_name":"Senckenberg Biodiversity and Climate Research Centre","ror":"https://ror.org/01amp2a31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802697327","https://openalex.org/I315704651","https://openalex.org/I4210112860"]},{"id":"https://openalex.org/I4210122504","display_name":"LOEWE Centre for Translational Biodiversity Genomics","ror":"https://ror.org/0396gab88","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210122504"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Pfenninger","raw_affiliation_strings":["Department of Molecular Ecology, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","Institute for Molecular and Organismic Evolution, Johannes Gutenberg University , Mainz,","LOEWE Centre of Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,"],"raw_orcid":"https://orcid.org/0000-0002-1547-7245","affiliations":[{"raw_affiliation_string":"Department of Molecular Ecology, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","institution_ids":["https://openalex.org/I4210112860"]},{"raw_affiliation_string":"Institute for Molecular and Organismic Evolution, Johannes Gutenberg University , Mainz,","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"LOEWE Centre of Translational Biodiversity Genomics, Senckenberg Biodiversity and Climate Research Centre , Frankfurt am Main,","institution_ids":["https://openalex.org/I4210112860","https://openalex.org/I4210122504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5095744227"],"corresponding_institution_ids":["https://openalex.org/I4210112860","https://openalex.org/I4210122504"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":7.5933,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.95313913,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"45","issue":"4","first_page":"1006","last_page":"1017"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.1932000070810318,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chironomus-riparius","display_name":"Chironomus riparius","score":0.9419999718666077},{"id":"https://openalex.org/keywords/polygenic-adaptation","display_name":"polygenic adaptation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/transgenerational-effects","display_name":"transgenerational effects","score":0.6190000176429749},{"id":"https://openalex.org/keywords/life-history-trade-offs","display_name":"life-history trade-offs","score":0.8970000147819519},{"id":"https://openalex.org/keywords/genomic-signatures-of-selection","display_name":"genomic signatures of selection","score":0.8199999928474426},{"id":"https://openalex.org/keywords/allele-frequency-change","display_name":"allele frequency change","score":0.6539999842643738},{"id":"https://openalex.org/keywords/stress-response-pathways","display_name":"stress response pathways","score":0.5249999761581421},{"id":"https://openalex.org/keywords/environmental-risk-assessment","display_name":"environmental risk assessment","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7472000122070312},{"id":"https://openalex.org/C2910387474","wikidata":"https://www.wikidata.org/wiki/Q331710","display_name":"Genetic Fitness","level":3,"score":0.7002999782562256},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6450999975204468},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.5407999753952026},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.5315999984741211},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.5286999940872192},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.5234000086784363},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5109999775886536},{"id":"https://openalex.org/C135811302","wikidata":"https://www.wikidata.org/wiki/Q1382557","display_name":"Evolutionary ecology","level":3,"score":0.4984999895095825},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.45210000872612},{"id":"https://openalex.org/C2780354846","wikidata":"https://www.wikidata.org/wiki/Q24962946","display_name":"Local adaptation","level":3,"score":0.3896999955177307},{"id":"https://openalex.org/C115346097","wikidata":"https://www.wikidata.org/wiki/Q1412144","display_name":"Ecotoxicology","level":2,"score":0.37709999084472656},{"id":"https://openalex.org/C167683757","wikidata":"https://www.wikidata.org/wiki/Q5937774","display_name":"Human evolutionary genetics","level":4,"score":0.37119999527931213},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.3711000084877014},{"id":"https://openalex.org/C16989226","wikidata":"https://www.wikidata.org/wiki/Q16934857","display_name":"Environmental change","level":3,"score":0.36469998955726624},{"id":"https://openalex.org/C2779040068","wikidata":"https://www.wikidata.org/wiki/Q7229807","display_name":"Population genomics","level":5,"score":0.3474999964237213},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.3077999949455261},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.3000999987125397},{"id":"https://openalex.org/C85721925","wikidata":"https://www.wikidata.org/wiki/Q31151","display_name":"Population genetics","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C18832751","wikidata":"https://www.wikidata.org/wiki/Q295031","display_name":"Ecological genetics","level":3,"score":0.29670000076293945},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.2913999855518341},{"id":"https://openalex.org/C130947863","wikidata":"https://www.wikidata.org/wiki/Q5533121","display_name":"Gene\u2013environment interaction","level":4,"score":0.2833999991416931},{"id":"https://openalex.org/C2909468537","wikidata":"https://www.wikidata.org/wiki/Q58734","display_name":"Environmental pollution","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C110872660","wikidata":"https://www.wikidata.org/wiki/Q37813","display_name":"Ecosystem","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C65201436","wikidata":"https://www.wikidata.org/wiki/Q5333255","display_name":"Ecological selection","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C93642007","wikidata":"https://www.wikidata.org/wiki/Q5422399","display_name":"Extreme environment","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C132651083","wikidata":"https://www.wikidata.org/wiki/Q7942","display_name":"Climate change","level":2,"score":0.25119999051094055},{"id":"https://openalex.org/C205458427","wikidata":"https://www.wikidata.org/wiki/Q206912","display_name":"Extremophile","level":4,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002683","descriptor_name":"Chironomidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019015","descriptor_name":"Geologic Sediments","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/etojnl/vgag010","doi":"https://doi.org/10.1093/etojnl/vgag010","is_oa":false,"landing_page_url":"https://doi.org/10.1093/etojnl/vgag010","pdf_url":null,"source":{"id":"https://openalex.org/S136710263","display_name":"Environmental Toxicology and Chemistry","issn_l":"0730-7268","issn":["0730-7268","1552-8618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Chemistry","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.23.655730","doi":"https://doi.org/10.1101/2025.05.23.655730","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.23.655730","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/27/2025.05.23.655730.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41537247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41537247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology and chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/504977","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/504977","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1101/2025.05.23.655730","doi":"https://doi.org/10.1101/2025.05.23.655730","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.23.655730","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/27/2025.05.23.655730.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2259858095","display_name":null,"funder_award_id":"519/03/03.001\u2014","funder_id":"https://openalex.org/F4320321961","funder_display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst"}],"funders":[{"id":"https://openalex.org/F4320321961","display_name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","ror":"https://ror.org/00zd5gr55"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124300710.pdf","grobid_xml":"https://content.openalex.org/works/W7124300710.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1598363147","https://openalex.org/W1822410214","https://openalex.org/W1957752345","https://openalex.org/W1991943452","https://openalex.org/W2077751281","https://openalex.org/W2082013423","https://openalex.org/W2096260958","https://openalex.org/W2101037833","https://openalex.org/W2103441770","https://openalex.org/W2105543480","https://openalex.org/W2108234281","https://openalex.org/W2116360795","https://openalex.org/W2116668053","https://openalex.org/W2131271579","https://openalex.org/W2140768759","https://openalex.org/W2144410236","https://openalex.org/W2161950199","https://openalex.org/W2265596685","https://openalex.org/W2466937571","https://openalex.org/W2511662209","https://openalex.org/W2529761341","https://openalex.org/W2529873061","https://openalex.org/W2640569185","https://openalex.org/W2765443904","https://openalex.org/W2896268397","https://openalex.org/W2897475259","https://openalex.org/W2903733180","https://openalex.org/W2913676002","https://openalex.org/W2953164954","https://openalex.org/W2987820647","https://openalex.org/W2997902498","https://openalex.org/W3020558917","https://openalex.org/W3037488002","https://openalex.org/W3046886955","https://openalex.org/W3076056390","https://openalex.org/W3106054463","https://openalex.org/W4206650635","https://openalex.org/W4220925763","https://openalex.org/W4248023687","https://openalex.org/W4283325664","https://openalex.org/W4290793046","https://openalex.org/W4292663605","https://openalex.org/W4295021942","https://openalex.org/W4322388308","https://openalex.org/W4382537098","https://openalex.org/W4400079170","https://openalex.org/W4401662454","https://openalex.org/W4407606288","https://openalex.org/W4407755816","https://openalex.org/W4409816582","https://openalex.org/W6702740663"],"related_works":[],"abstract_inverted_index":{"Anthropogenic":[0],"stressors,":[1],"such":[2],"as":[3,67],"pollution":[4],"and":[5,56,69,81,101,115,123,134,140,156,168,184,225,235],"climate":[6],"change,":[7],"are":[8],"altering":[9],"selective":[10],"pressures":[11],"on":[12,189],"natural":[13],"populations,":[14,205],"but":[15],"the":[16,37,87,99,207,223,226,237],"evolutionary":[17,41,95,208,218,241],"consequences":[18],"of":[19,25,40,118,150,166,170,198,210,228,239],"chronic":[20],"exposure":[21,49,78],"to":[22,36,45,50,74,110,146,231],"complex":[23,68],"mixtures":[24],"contaminants":[26,52],"remain":[27],"poorly":[28],"understood.":[29],"Addressing":[30],"this":[31,60],"knowledge":[32],"gap":[33],"is":[34],"critical":[35],"emerging":[38],"field":[39],"ecotoxicology,":[42],"which":[43],"aims":[44],"understand":[46],"how":[47,76,217],"long-term":[48],"environmental":[51,233],"shapes":[53],"adaptive":[54],"evolution":[55],"genome-wide":[57],"variation.":[58],"In":[59],"study,":[61],"we":[62],"used":[63],"urban":[64,119],"runoff":[65,120],"sediment":[66,121],"environmentally":[70],"realistic":[71,232],"model":[72],"stressor":[73],"investigate":[75],"multigenerational":[77],"affects":[79],"fitness":[80,126,158],"potentially":[82],"drives":[83],"genomic":[84,148],"adaptation":[85,230],"in":[86,180,203],"freshwater":[88],"midge":[89],"Chironomus":[90],"riparius.":[91],"We":[92],"combined":[93],"an":[94],"life-cycle":[96],"test":[97],"with":[98,194],"evolve":[100],"resequence":[102],"approach,":[103],"exposing":[104],"replicate":[105],"populations":[106],"over":[107],"seven":[108],"generations":[109],"three":[111],"treatments:":[112],"a":[113],"control":[114,204],"two":[116],"concentrations":[117],"(0.5%":[122],"10%).":[124],"Key":[125],"traits,":[127],"including":[128,162],"mortality,":[129],"mean":[130],"emergence":[131],"time,":[132],"fertility,":[133],"population":[135],"growth":[136],"rate,":[137],"were":[138,144,175,200],"measured,":[139],"allele":[141],"frequency":[142],"changes":[143],"tracked":[145],"identify":[147],"signatures":[149],"selection.":[151],"The":[152],"results":[153],"revealed":[154],"distinct":[155],"nonlinear":[157],"responses":[159],"across":[160],"treatments,":[161],"transgenerational":[163],"effects,":[164],"recovery":[165],"performance,":[167],"evidence":[169],"life-history":[171],"trade-offs.":[172],"Candidate":[173],"haplotypes":[174],"enriched":[176],"for":[177],"genes":[178],"involved":[179],"membrane":[181],"transport,":[182],"metabolism,":[183],"gene":[185],"regulation,":[186],"suggesting":[187],"selection":[188,199],"general":[190],"stress-response":[191],"pathways":[192],"consistent":[193],"polygenic":[195],"adaptation.":[196],"Signals":[197],"also":[201],"detected":[202],"underscoring":[206],"influence":[209],"laboratory":[211],"conditions.":[212],"Overall,":[213],"our":[214],"findings":[215],"demonstrate":[216],"ecotoxicology":[219],"can":[220],"reveal":[221],"both":[222],"potential":[224],"constraints":[227],"rapid":[229],"stressors":[234],"highlight":[236],"importance":[238],"integrating":[240],"perspectives":[242],"into":[243],"ecological":[244],"risk":[245],"assessment.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-01-16T00:00:00"}