{"id":"https://openalex.org/W7124288290","doi":"https://doi.org/10.7554/elife.106439.2","title":"map3k1 is required for spatial restriction of progenitor differentiation in planarians","display_name":"map3k1 is required for spatial restriction of progenitor differentiation in planarians","publication_year":2026,"publication_date":"2026-01-15","ids":{"openalex":"https://openalex.org/W7124288290","doi":"https://doi.org/10.7554/elife.106439.2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.106439.2","doi":"https://doi.org/10.7554/elife.106439.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106439.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.106439.2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071930811","display_name":"Bryanna Isela-Inez Canales","orcid":"https://orcid.org/0000-0002-0693-3632","observed_orcids":["https://orcid.org/0000-0002-0693-3632"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryanna Isela-Inez Canales","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology","Whitehead Institute for Biomedical Research"],"raw_orcid":"https://orcid.org/0000-0002-0693-3632","affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064678742","display_name":"Hunter O. King","orcid":"https://orcid.org/0009-0001-9823-1856","observed_orcids":["https://orcid.org/0009-0001-9823-1856"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hunter O King","raw_affiliation_strings":["Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology","Whitehead Institute for Biomedical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011162507","display_name":"Peter W. Reddien","orcid":"https://orcid.org/0000-0002-5569-333X","observed_orcids":["https://orcid.org/0000-0002-5569-333X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W Reddien","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology","Howard Hughes Medical Institute, Massachusetts Institute of Technology","Whitehead Institute for Biomedical Research"],"raw_orcid":"https://orcid.org/0000-0002-5569-333X","affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Massachusetts Institute of Technology","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12789","display_name":"Planarian Biology and Electrostimulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/map3k1","display_name":"MAP3K1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/planarian-regeneration","display_name":"planarian regeneration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neoblasts","display_name":"neoblasts","score":0.8939999938011169},{"id":"https://openalex.org/keywords/progenitor-cell-differentiation","display_name":"progenitor cell differentiation","score":0.906000018119812},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.5799999833106995},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.7179999947547913},{"id":"https://openalex.org/keywords/pharynx","display_name":"pharynx","score":0.675000011920929},{"id":"https://openalex.org/keywords/teratoma","display_name":"teratoma","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tissue-patterning","display_name":"tissue patterning","score":0.5680000185966492},{"id":"https://openalex.org/keywords/map3k-signaling","display_name":"MAP3K signaling","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8309000134468079},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.8222000002861023},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.7267000079154968},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.7116000056266785},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6176000237464905},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5521000027656555},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.51910001039505},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5109999775886536},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4779999852180481},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.38100001215934753},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3799999952316284},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3596000075340271},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.35409998893737793},{"id":"https://openalex.org/C2777117487","wikidata":"https://www.wikidata.org/wiki/Q18811569","display_name":"Directed differentiation","level":5,"score":0.34950000047683716},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.33649998903274536},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3327000141143799},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30399999022483826},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.29649999737739563},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.2919999957084656},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2721000015735626},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.26899999380111694}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.106439.2","doi":"https://doi.org/10.7554/elife.106439.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106439.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.106439.2","doi":"https://doi.org/10.7554/elife.106439.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.106439.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000881880","display_name":"Stem cell and regeneration regulatory mechanisms in planarians","funder_award_id":"R35GM145345","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320314070","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1539627793","https://openalex.org/W1585102759","https://openalex.org/W1586268327","https://openalex.org/W1902811474","https://openalex.org/W1980060975","https://openalex.org/W1982205033","https://openalex.org/W1985661051","https://openalex.org/W1990750863","https://openalex.org/W2015621557","https://openalex.org/W2023265934","https://openalex.org/W2024940343","https://openalex.org/W2031108838","https://openalex.org/W2040723453","https://openalex.org/W2041203438","https://openalex.org/W2045097086","https://openalex.org/W2046496749","https://openalex.org/W2049284181","https://openalex.org/W2056965916","https://openalex.org/W2074658822","https://openalex.org/W2081015430","https://openalex.org/W2087776754","https://openalex.org/W2091966685","https://openalex.org/W2093162194","https://openalex.org/W2098719212","https://openalex.org/W2106740149","https://openalex.org/W2111865215","https://openalex.org/W2123959605","https://openalex.org/W2124984017","https://openalex.org/W2136653559","https://openalex.org/W2144375779","https://openalex.org/W2153476462","https://openalex.org/W2161617000","https://openalex.org/W2162345239","https://openalex.org/W2170116626","https://openalex.org/W2324706171","https://openalex.org/W2587163858","https://openalex.org/W2588736002","https://openalex.org/W2776817882","https://openalex.org/W2793615990","https://openalex.org/W2794159961","https://openalex.org/W2799796757","https://openalex.org/W2801443765","https://openalex.org/W2808131763","https://openalex.org/W2808684992","https://openalex.org/W2895635508","https://openalex.org/W2940861781","https://openalex.org/W2981317314","https://openalex.org/W3082044402","https://openalex.org/W4200139160","https://openalex.org/W4388728568","https://openalex.org/W4392119392","https://openalex.org/W4405307058","https://openalex.org/W4408537513"],"related_works":["https://openalex.org/W4408537513","https://openalex.org/W7033632974","https://openalex.org/W4388728568","https://openalex.org/W1902811474","https://openalex.org/W2605142920","https://openalex.org/W7128939443","https://openalex.org/W2920863448","https://openalex.org/W4210501465","https://openalex.org/W6989639443","https://openalex.org/W4379197193"],"abstract_inverted_index":{"Planarian":[0],"regeneration":[1],"and":[2,33,56,72,93,137,147,154,173],"tissue":[3,205],"turnover":[4],"involve":[5],"fate":[6],"specification":[7],"in":[8,77,109,132,156,182,197,202],"pluripotent":[9],"stem":[10],"cells":[11,136,150,162],"called":[12],"neoblasts.":[13,27],"Neoblasts":[14],"select":[15],"fates":[16],"through":[17],"the":[18,69,105,167,184,203],"expression":[19],"of":[20,49,74,90,119,124,187],"fate-specific":[21],"transcription":[22],"factors":[23],"(FSTFs),":[24],"generating":[25],"specialized":[26],"Specialized":[28],"neoblasts":[29],"are":[30,163],"spatially":[31],"intermingled":[32],"can":[34,54],"be":[35],"dispersed":[36,152],"broadly,":[37],"frequently":[38],"being":[39],"present":[40],"far":[41],"from":[42],"their":[43,128],"target":[44],"tissue.":[45],"The":[46],"post-mitotic":[47,112],"progeny":[48],"neoblasts,":[50],"serving":[51],"as":[52,84],"progenitors,":[53],"migrate":[55],"differentiate":[57],"into":[58],"mature":[59],"cell":[60],"types.":[61],"Pattern":[62],"formation":[63],"is":[64,96],"thus":[65],"strongly":[66],"influenced":[67],"by":[68],"migratory":[70,129],"assortment":[71],"differentiation":[73,114,123,146,193],"fate-specified":[75],"progenitors":[76,126],"precise":[78,116],"locations,":[79],"which":[80],"we":[81,100],"refer":[82],"to":[83,115,194,199],"progenitor":[85,113,188,192],"targeting.":[86],"This":[87],"central":[88],"step":[89],"pattern":[91],"maintenance":[92],"formation,":[94],"however,":[95],"poorly":[97],"understood.":[98],"Here,":[99],"describe":[101],"a":[102],"requirement":[103],"for":[104],"conserved":[106],"map3k1":[107,120,157,171,180],"gene":[108],"targeting,":[110],"restricting":[111,191],"locations.":[117],"RNAi":[118,158],"causes":[121],"ectopic":[122,134,144,148],"eye":[125,135],"along":[127],"path,":[130],"resulting":[131],"dispersed,":[133],"eyes.":[138],"Other":[139],"neural":[140],"tissues":[141],"similarly":[142],"display":[143],"posterior":[145],"pharynx":[149],"emerge":[151],"laterally":[153],"anteriorly":[155],"animals.":[159],"Ectopic":[160],"differentiated":[161],"also":[164],"found":[165],"within":[166],"incorrect":[168],"organs":[169],"after":[170],"RNAi,":[172],"ultimately,":[174],"teratomas":[175],"form.":[176],"These":[177],"findings":[178],"implicate":[179],"signaling":[181],"controlling":[183],"positional":[185],"regulation":[186],"behavior":[189],"\u2013":[190],"targeted":[195],"locations":[196],"response":[198],"external":[200],"cues":[201],"local":[204],"environment.":[206]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-01-16T00:00:00"}