{"id":"https://openalex.org/W7124265317","doi":"https://doi.org/10.3390/diagnostics16020276","title":"The Value of HALP Score in Predicting Adverse In-Hospital Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement","display_name":"The Value of HALP Score in Predicting Adverse In-Hospital Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement","publication_year":2026,"publication_date":"2026-01-15","ids":{"openalex":"https://openalex.org/W7124265317","doi":"https://doi.org/10.3390/diagnostics16020276","pmid":"https://pubmed.ncbi.nlm.nih.gov/41594252"},"language":"en","primary_location":{"id":"doi:10.3390/diagnostics16020276","doi":"https://doi.org/10.3390/diagnostics16020276","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diagnostics16020276","pdf_url":"https://www.mdpi.com/2075-4418/16/2/276/pdf?version=1768470033","source":{"id":"https://openalex.org/S4210172076","display_name":"Diagnostics","issn_l":"2075-4418","issn":["2075-4418"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2075-4418/16/2/276/pdf?version=1768470033","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102780232","display_name":"\u00d6mer Faruk \u00c7i\u00e7ek","orcid":"https://orcid.org/0000-0001-8912-674X","observed_orcids":["https://orcid.org/0000-0001-8912-674X"]},"institutions":[{"id":"https://openalex.org/I4210125526","display_name":"\u015eanl\u0131urfa Mehmet Akif \u0130nan E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02zv5qf81","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210125526"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"\u00d6mer Faruk \u00c7i\u00e7ek","raw_affiliation_strings":["Department of Cardiology, Mehmet Akif Inan Education and Research Hospital, Sanliurfa 63300, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-8912-674X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Mehmet Akif Inan Education and Research Hospital, Sanliurfa 63300, Turkey","institution_ids":["https://openalex.org/I4210125526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121243587","display_name":"Mustafa \u00c7etin","orcid":"https://orcid.org/0000-0003-1167-4644","observed_orcids":["https://orcid.org/0000-0003-1167-4644"]},"institutions":[{"id":"https://openalex.org/I4210125526","display_name":"\u015eanl\u0131urfa Mehmet Akif \u0130nan E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02zv5qf81","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210125526"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa \u00c7etin","raw_affiliation_strings":["Department of Cardiology, Mehmet Akif Inan Education and Research Hospital, Sanliurfa 63300, Turkey"],"raw_orcid":"https://orcid.org/0000-0003-1167-4644","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Mehmet Akif Inan Education and Research Hospital, Sanliurfa 63300, Turkey","institution_ids":["https://openalex.org/I4210125526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004655522","display_name":"Ali Palice","orcid":"https://orcid.org/0000-0001-6560-8031","observed_orcids":["https://orcid.org/0000-0001-6560-8031"]},"institutions":[{"id":"https://openalex.org/I1303077703","display_name":"Ministry of Health","ror":"https://ror.org/00pkvys92","country_code":"TR","type":"government","lineage":["https://openalex.org/I1303077703"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Palice","raw_affiliation_strings":["Ak\u00e7akale State Hospital, Sanliurfa 63500, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ak\u00e7akale State Hospital, Sanliurfa 63500, Turkey","institution_ids":["https://openalex.org/I1303077703"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102780232"],"corresponding_institution_ids":["https://openalex.org/I4210125526"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":9.6475,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.96580281,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"16","issue":"2","first_page":"276","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/halp-score","display_name":"HALP score","score":0.8009999990463257},{"id":"https://openalex.org/keywords/transcatheter-aortic-valve-replacement","display_name":"transcatheter aortic valve implantation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/severe-aortic-stenosis","display_name":"severe aortic stenosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.8579999804496765},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.996999979019165},{"id":"https://openalex.org/keywords/in-hospital-mortality","display_name":"in-hospital mortality","score":0.8550000190734863},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.5910000205039978},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prognostic-score","display_name":"prognostic score","score":0.8510000109672546},{"id":"https://openalex.org/keywords/preoperative-risk-stratification","display_name":"preoperative risk stratification","score":0.6129999756813049},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.574999988079071},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.828000009059906},{"id":"https://openalex.org/keywords/lymphocyte-count","display_name":"lymphocyte count","score":0.8679999709129333},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5979999899864197},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9186000227928162},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6553000211715698},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5340999960899353},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5202999711036682},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4717999994754791},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4530999958515167},{"id":"https://openalex.org/C2776570981","wikidata":"https://www.wikidata.org/wiki/Q4413093","display_name":"Aortic valve replacement","level":3,"score":0.4207000136375427},{"id":"https://openalex.org/C2780026749","wikidata":"https://www.wikidata.org/wiki/Q7912830","display_name":"Valve replacement","level":3,"score":0.4147999882698059},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.34790000319480896},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3472000062465668},{"id":"https://openalex.org/C2780714102","wikidata":"https://www.wikidata.org/wiki/Q616071","display_name":"Aortic valve","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C200457457","wikidata":"https://www.wikidata.org/wiki/Q584049","display_name":"Ventilation (architecture)","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.28760001063346863},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2533000111579895}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/diagnostics16020276","doi":"https://doi.org/10.3390/diagnostics16020276","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diagnostics16020276","pdf_url":"https://www.mdpi.com/2075-4418/16/2/276/pdf?version=1768470033","source":{"id":"https://openalex.org/S4210172076","display_name":"Diagnostics","issn_l":"2075-4418","issn":["2075-4418"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostics","raw_type":"journal-article"},{"id":"pmid:41594252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41594252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostics (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a6f634b2abfb4cd2a6e4a25c1bb504a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a6f634b2abfb4cd2a6e4a25c1bb504a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diagnostics, Vol 16, Iss 2, p 276 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12840431","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12840431/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diagnostics (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/diagnostics16020276","doi":"https://doi.org/10.3390/diagnostics16020276","is_oa":true,"landing_page_url":"https://doi.org/10.3390/diagnostics16020276","pdf_url":"https://www.mdpi.com/2075-4418/16/2/276/pdf?version=1768470033","source":{"id":"https://openalex.org/S4210172076","display_name":"Diagnostics","issn_l":"2075-4418","issn":["2075-4418"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diagnostics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124265317.pdf","grobid_xml":"https://content.openalex.org/works/W7124265317.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W432037510","https://openalex.org/W1809056726","https://openalex.org/W1972706572","https://openalex.org/W2007486557","https://openalex.org/W2048471256","https://openalex.org/W2061677561","https://openalex.org/W2087291640","https://openalex.org/W2105391691","https://openalex.org/W2129975031","https://openalex.org/W2277097529","https://openalex.org/W2557490708","https://openalex.org/W2905246806","https://openalex.org/W2914545533","https://openalex.org/W2924944506","https://openalex.org/W2949228322","https://openalex.org/W3007816896","https://openalex.org/W3020013745","https://openalex.org/W3094601613","https://openalex.org/W3115258265","https://openalex.org/W3120772173","https://openalex.org/W3142637981","https://openalex.org/W3195842247","https://openalex.org/W3210181814","https://openalex.org/W4281662353","https://openalex.org/W4376598178","https://openalex.org/W4387393063","https://openalex.org/W4388627456","https://openalex.org/W4414380347"],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Transcatheter":[1],"aortic":[2,13],"valve":[3],"replacement":[4],"(TAVR)":[5],"is":[6,23,264],"widely":[7],"used":[8],"in":[9,272,289],"patients":[10,43,273],"with":[11,133,194,208,267],"severe":[12],"stenosis.":[14],"The":[15,261],"HALP":[16,64,106,122,135,203,221,262],"(hemoglobin,":[17],"albumin,":[18],"lymphocyte,":[19],"and":[20,33,51,70,98,108,117,163,249,276,282],"platelet)":[21],"score":[22,65,107,204,222,263],"an":[24],"easily":[25],"obtainable":[26],"composite":[27],"index":[28],"that":[29],"reflects":[30],"nutritional":[31],"status":[32],"systemic":[34],"inflammation.":[35],"Methods:":[36],"In":[37,198],"this":[38,290],"single-center":[39],"retrospective":[40],"study,":[41],"140":[42],"who":[44],"underwent":[45],"TAVR":[46,275],"between":[47,104],"1":[48],"April":[49],"2021,":[50],"31":[52],"October":[53],"2024,":[54],"were":[55,58,76,111],"included.":[56],"Patients":[57,132],"stratified":[59],"according":[60],"to":[61],"the":[62,105,118,195,220,227],"median":[63],"(32.65)":[66],"into":[67],"low":[68,134],"(<32.65)-":[69],"high":[71],"(\u226532.65)-HALP":[72],"groups.":[73],"In-hospital":[74],"outcomes":[75,110,271],"mortality,":[77],"bleeding":[78,149,235],"requiring":[79],"transfusion":[80],"of":[81,84,100,121,140,219],">5":[82],"units":[83],"red":[85],"blood":[86],"cells,":[87],"acute":[88],"kidney":[89],"injury":[90],"(AKI),":[91],"need":[92,164,250],"for":[93,165,223,251,285],"mechanical":[94,166,252],"ventilation":[95,167,253],">24":[96,168],"h,":[97],"length":[99],"hospital":[101,180],"stay.":[102],"Associations":[103],"clinical":[109,270],"evaluated":[112],"using":[113,125],"multivariable":[114,199],"regression":[115],"analyses,":[116],"discriminatory":[119,217],"performance":[120],"was":[123],"assessed":[124],"receiver":[126],"operating":[127],"characteristic":[128],"(ROC)":[129],"curves.":[130],"Results:":[131],"scores":[136],"had":[137],"higher":[138],"rates":[139],"in-hospital":[141,211,269],"mortality":[142,224],"(11.4%":[143,157],"vs.":[144,151,158,171,185],"4.2%;":[145],"p":[146,153,160,173,190],"=":[147,174,191,230,233,237,240,244,247,255,258],"0.002),":[148,175],"(28.6%":[150],"5.7%;":[152],"<":[154,161],"0.001),":[155,162],"AKI":[156,242],"2.9%;":[159],"h":[169],"(25.7%":[170],"14.4%;":[172],"as":[176,178,279],"well":[177],"longer":[179],"stay":[181],"(4.82":[182],"\u00b1":[183,187],"1.50":[184],"3.62":[186],"1.94":[188],"days;":[189],"0.001)":[192],"compared":[193],"high-HALP":[196],"group.":[197],"models,":[200],"a":[201,280],"lower":[202],"remained":[205],"independently":[206,265],"associated":[207,266],"all":[209],"adverse":[210,268],"outcomes.":[212],"ROC":[213],"analysis":[214],"showed":[215],"good":[216],"ability":[218],"(area":[225],"under":[226],"curve":[228],"[AUC]":[229],"0.816;":[231],"cut-off":[232,239,246,257],"20.16),":[234],"(AUC":[236,243,254],"0.798;":[238],"24.94),":[241],"0.737;":[245],"26.21),":[248],"0.735;":[256],"27.36).":[259],"Conclusions:":[260],"undergoing":[274],"may":[277],"serve":[278],"simple":[281],"practical":[283],"tool":[284],"early":[286],"risk":[287],"stratification":[288],"population.":[291]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-16T00:00:00"}
