{"id":"https://openalex.org/W7124189595","doi":"https://doi.org/10.1038/s41598-026-35189-y","title":"Extracellular vesicle-derived miR-760 as a novel promising candidate biomarker differentiating stable RRMS from SPMS","display_name":"Extracellular vesicle-derived miR-760 as a novel promising candidate biomarker differentiating stable RRMS from SPMS","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7124189595","doi":"https://doi.org/10.1038/s41598-026-35189-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41535347"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-35189-y","doi":"https://doi.org/10.1038/s41598-026-35189-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-35189-y","pdf_url":"https://www.nature.com/articles/s41598-026-35189-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-35189-y_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074351187","display_name":"Karina Maciak","orcid":"https://orcid.org/0000-0003-3098-1113","observed_orcids":["https://orcid.org/0000-0003-3098-1113"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Karina Wasilewska","raw_affiliation_strings":["Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland. karina.wasilewska@edu.uni.lodz.pl"],"raw_orcid":"https://orcid.org/0000-0003-3098-1113","affiliations":[{"raw_affiliation_string":"Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland. karina.wasilewska@edu.uni.lodz.pl","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088826366","display_name":"Angela Dziedzic","orcid":"https://orcid.org/0000-0001-5962-4721","observed_orcids":["https://orcid.org/0000-0001-5962-4721"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Angela Dziedzic","raw_affiliation_strings":["Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland"],"raw_orcid":"https://orcid.org/0000-0001-5962-4721","affiliations":[{"raw_affiliation_string":"Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058418852","display_name":"Shamundeeswari Anandan","orcid":"https://orcid.org/0000-0002-0106-794X","observed_orcids":["https://orcid.org/0000-0002-0106-794X"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Shamundeeswari Anandan","raw_affiliation_strings":["Department of Clinical Medicine, University of Bergen, 5021, Bergen, Norway","Neuro-SysMed, Department of Neurology, Haukeland University Hospital, 5021, Bergen, Norway"],"raw_orcid":"https://orcid.org/0000-0002-0106-794X","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, University of Bergen, 5021, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Neuro-SysMed, Department of Neurology, Haukeland University Hospital, 5021, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123006458","display_name":"El\u017cbieta Miller","orcid":"https://orcid.org/0000-0002-7029-1857","observed_orcids":["https://orcid.org/0000-0002-7029-1857"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"El\u017cbieta Miller","raw_affiliation_strings":["Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, Lodz, 93-113, Poland"],"raw_orcid":"https://orcid.org/0000-0002-7029-1857","affiliations":[{"raw_affiliation_string":"Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, Lodz, 93-113, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047186402","display_name":"\u0141ukasz \u0141aczma\u0144ski","orcid":"https://orcid.org/0000-0002-0874-5483","observed_orcids":["https://orcid.org/0000-0002-0874-5483","https://orcid.org/0000-0003-1063-2821"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"\u0141ukasz \u0141aczma\u0144ski","raw_affiliation_strings":["Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland"],"raw_orcid":"https://orcid.org/0000-0002-0874-5483","affiliations":[{"raw_affiliation_string":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland","institution_ids":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059263757","display_name":"Rados\u0142aw Zajdel","orcid":"https://orcid.org/0000-0002-1654-8957","observed_orcids":["https://orcid.org/0000-0002-1654-8957"]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rados\u0142aw Zajdel","raw_affiliation_strings":["Department of AI in HealthCare Monitoring, Medical University of Lodz, Lodz, 90-645, Poland"],"raw_orcid":"https://orcid.org/0000-0002-1654-8957","affiliations":[{"raw_affiliation_string":"Department of AI in HealthCare Monitoring, Medical University of Lodz, Lodz, 90-645, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050091992","display_name":"Sylwia Michlewska","orcid":"https://orcid.org/0000-0002-8952-469X","observed_orcids":["https://orcid.org/0000-0002-8952-469X"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Sylwia Michlewska","raw_affiliation_strings":["Faculty of Biology and Environmental Protection, Laboratory of Microscopic Imaging and Specialized Biological Techniques, University of Lodz, Banacha 12/16, Lodz, 90-237, Poland"],"raw_orcid":"https://orcid.org/0000-0002-8952-469X","affiliations":[{"raw_affiliation_string":"Faculty of Biology and Environmental Protection, Laboratory of Microscopic Imaging and Specialized Biological Techniques, University of Lodz, Banacha 12/16, Lodz, 90-237, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087695298","display_name":"Dorota Kujawa","orcid":"https://orcid.org/0000-0003-0340-7167","observed_orcids":["https://orcid.org/0000-0003-0340-7167"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dorota Kujawa","raw_affiliation_strings":["Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland","institution_ids":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123039763","display_name":"Marta Gancarek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Gancarek","raw_affiliation_strings":["Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland","institution_ids":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083886543","display_name":"Justyna Raczkowska","orcid":"https://orcid.org/0000-0002-3863-4944","observed_orcids":["https://orcid.org/0000-0002-3863-4944"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Justyna Raczkowska","raw_affiliation_strings":["Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Genomics and Bioinformatics, Polish Academy of Sciences, Weigla 12, Wroclaw, 53-114, Poland","institution_ids":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002645703","display_name":"Lidia W\u0142odarczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122071","display_name":"Medical University of Lodz","ror":"https://ror.org/02t4ekc95","country_code":"PL","type":"education","lineage":["https://openalex.org/I4210122071"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Lidia W\u0142odarczyk","raw_affiliation_strings":["Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, Lodz, 93-113, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Rehabilitation, Medical University of Lodz, Milionowa 14, Lodz, 93-113, Poland","institution_ids":["https://openalex.org/I4210122071"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123007557","display_name":"Patrycja Nowak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Patrycja Nowak","raw_affiliation_strings":["Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland","institution_ids":["https://openalex.org/I34250744"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060187731","display_name":"Joanna Saluk","orcid":"https://orcid.org/0000-0002-1197-1713","observed_orcids":["https://orcid.org/0000-0002-1197-1713"]},"institutions":[{"id":"https://openalex.org/I34250744","display_name":"University of \u0141\u00f3d\u017a","ror":"https://ror.org/05cq64r17","country_code":"PL","type":"education","lineage":["https://openalex.org/I34250744"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna Saluk","raw_affiliation_strings":["Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland"],"raw_orcid":"https://orcid.org/0000-0002-1197-1713","affiliations":[{"raw_affiliation_string":"Faculty of Biology and Environmental Protection, Department of General Biochemistry, University of Lodz, Pomorska 141/143, Lodz, 90-236, Poland","institution_ids":["https://openalex.org/I34250744"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074351187"],"corresponding_institution_ids":["https://openalex.org/I34250744"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":5.6163,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.94776906,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"5208","last_page":"5208"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.3091000020503998,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":1.0},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7599999904632568},{"id":"https://openalex.org/keywords/mir-760","display_name":"miR-760","score":0.9959999918937683},{"id":"https://openalex.org/keywords/mir-98-5p","display_name":"miR-98-5p","score":0.9980000257492065},{"id":"https://openalex.org/keywords/circulating-biomarkers","display_name":"circulating biomarkers","score":0.7820000052452087},{"id":"https://openalex.org/keywords/immune-regulation","display_name":"immune regulation","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7627999782562256},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7031000256538391},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5819000005722046},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.5720999836921692},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5365999937057495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47269999980926514},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4490000009536743},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.3824999928474426},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35760000348091125},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.35749998688697815},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3504999876022339},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.3165000081062317},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.3075000047683716},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.30660000443458557},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.304500013589859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2759999930858612},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2662000060081482},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.258899986743927}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020528","descriptor_name":"Multiple Sclerosis, Chronic Progressive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D020529","descriptor_name":"Multiple Sclerosis, Relapsing-Remitting","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-026-35189-y","doi":"https://doi.org/10.1038/s41598-026-35189-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-35189-y","pdf_url":"https://www.nature.com/articles/s41598-026-35189-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:41535347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41535347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11689184","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12881579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:59326b4866d447d792c6f6ac849f2b1e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/59326b4866d447d792c6f6ac849f2b1e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1, Pp 1-21 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12881579","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12881579/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-35189-y","doi":"https://doi.org/10.1038/s41598-026-35189-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-35189-y","pdf_url":"https://www.nature.com/articles/s41598-026-35189-y_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.5777984261512756,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5927664819","display_name":null,"funder_award_id":"65/2021","funder_id":"https://openalex.org/F4320323344","funder_display_name":"Uniwersytet \u0141\u00f3dzki"},{"id":"https://openalex.org/G5947229791","display_name":null,"funder_award_id":"UMO-2018/31/B/NZ4/02688","funder_id":"https://openalex.org/F4320322511","funder_display_name":"Narodowe Centrum Nauki"}],"funders":[{"id":"https://openalex.org/F4320322511","display_name":"Narodowe Centrum Nauki","ror":"https://ror.org/03ha2q922"},{"id":"https://openalex.org/F4320323344","display_name":"Uniwersytet \u0141\u00f3dzki","ror":"https://ror.org/05cq64r17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124189595.pdf","grobid_xml":"https://content.openalex.org/works/W7124189595.grobid-xml"},"referenced_works_count":85,"referenced_works":["https://openalex.org/W1965075131","https://openalex.org/W1972898510","https://openalex.org/W1999319492","https://openalex.org/W2017749666","https://openalex.org/W2035618305","https://openalex.org/W2049663084","https://openalex.org/W2057082801","https://openalex.org/W2078621743","https://openalex.org/W2105423509","https://openalex.org/W2106596862","https://openalex.org/W2123372486","https://openalex.org/W2176271034","https://openalex.org/W2327450924","https://openalex.org/W2342290396","https://openalex.org/W2413665674","https://openalex.org/W2468923595","https://openalex.org/W2511350458","https://openalex.org/W2559588208","https://openalex.org/W2576494783","https://openalex.org/W2605842649","https://openalex.org/W2754463724","https://openalex.org/W2765115586","https://openalex.org/W2767162546","https://openalex.org/W2769421609","https://openalex.org/W2792692975","https://openalex.org/W2895666204","https://openalex.org/W2939031356","https://openalex.org/W2955767697","https://openalex.org/W2983166786","https://openalex.org/W2984562828","https://openalex.org/W2990252095","https://openalex.org/W2990955852","https://openalex.org/W3001679005","https://openalex.org/W3004344486","https://openalex.org/W3010184049","https://openalex.org/W3012427530","https://openalex.org/W3044432427","https://openalex.org/W3048887029","https://openalex.org/W3093751863","https://openalex.org/W3119238477","https://openalex.org/W3153146293","https://openalex.org/W3153846402","https://openalex.org/W3157816897","https://openalex.org/W3161450396","https://openalex.org/W3188386001","https://openalex.org/W3208303884","https://openalex.org/W4200147867","https://openalex.org/W4210617599","https://openalex.org/W4211048507","https://openalex.org/W4225006102","https://openalex.org/W4226208516","https://openalex.org/W4242289937","https://openalex.org/W4281693219","https://openalex.org/W4281851321","https://openalex.org/W4281939026","https://openalex.org/W4282053186","https://openalex.org/W4283692078","https://openalex.org/W4285157634","https://openalex.org/W4293523115","https://openalex.org/W4294216483","https://openalex.org/W4295693891","https://openalex.org/W4310457402","https://openalex.org/W4322487774","https://openalex.org/W4353015157","https://openalex.org/W4360976321","https://openalex.org/W4367056702","https://openalex.org/W4376875787","https://openalex.org/W4377090813","https://openalex.org/W4379055779","https://openalex.org/W4381108625","https://openalex.org/W4381839228","https://openalex.org/W4385064560","https://openalex.org/W4390082379","https://openalex.org/W4390545143","https://openalex.org/W4390691496","https://openalex.org/W4391798283","https://openalex.org/W4392167284","https://openalex.org/W4393342446","https://openalex.org/W4399387653","https://openalex.org/W4399576480","https://openalex.org/W4400260606","https://openalex.org/W4401804595","https://openalex.org/W4402635605","https://openalex.org/W4403329727","https://openalex.org/W4405201360"],"related_works":[],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3],"a":[4],"chronic":[5],"autoimmune":[6],"disease":[7,220],"of":[8,40,122,198,236],"the":[9,112,175],"central":[10],"nervous":[11],"system":[12,114],"with":[13,159,219,227],"heterogenous":[14],"clinical":[15,250],"course,":[16],"lacking":[17],"non-invasive":[18],"biomarkers":[19,108],"for":[20,179],"phenotype":[21,221],"differentiation.":[22],"This":[23],"study":[24],"aimed":[25],"to":[26,131,194],"explore":[27,132],"circulating":[28],"extracellular":[29],"vesicle":[30],"(EV)-derived":[31],"microRNA":[32],"(miRNA)":[33],"signatures":[34],"and":[35,65,77,86,94,102,105,115,119,152,191,212,244],"related":[36],"molecular":[37,216],"profiles":[38,96],"capable":[39],"distinguishing":[41,134],"stable":[42,56,150,180,189],"relapsing-remitting":[43],"MS":[44,49,206,237],"(RRMS)":[45],"from":[46,55,92],"secondary":[47],"progressive":[48],"(SPMS).":[50],"Plasma":[51,208],"samples":[52],"were":[53,97,109,125],"collected":[54],"RRMS":[57,151,190],"(n":[58,62,69],"=":[59,63,70,171],"30),":[60,64,71],"SPMS":[61,192],"healthy":[66],"controls":[67],"(HC)":[68],"followed":[72],"by":[73],"total":[74],"EVs":[75],"isolation":[76],"characterization":[78],"using":[79,111],"transmission":[80],"electron":[81],"microscopy,":[82],"dynamic":[83],"light":[84],"scattering,":[85],"flow":[87],"cytometry.":[88],"RNA":[89,100],"was":[90,184],"extracted":[91],"EVs,":[93],"miRNA":[95,123,199],"analyzed":[98],"via":[99],"sequencing":[101],"RT-qPCR.":[103],"Cytokines":[104],"neuronal/astroglial":[106],"injury":[107],"quantified":[110],"BioPlex":[113],"ELISA.":[116],"Functional":[117],"enrichment":[118],"network":[120],"analyses":[121],"targets":[124,200],"performed,":[126],"alongside":[127],"logistic":[128],"regression":[129],"modeling":[130],"potential":[133,214],"features.":[135],"Four":[136],"EV-derived":[137,209],"miRNAs":[138,158],"(miR-760,":[139],"miR-98-5p,":[140],"miR-301a-3p,":[141],"miR-223-3p)":[142],"showed":[143,174],"significant":[144],"differences":[145],"(p":[146],"<":[147],"0.05)":[148],"between":[149],"SPMS.":[153],"An":[154],"integrative":[155],"model":[156],"combining":[157],"fibroblast":[160],"growth":[161],"factor":[162],"(FGF)":[163],"basic":[164],"protein":[165,228],"enabled":[166],"accurate":[167],"phenotypic":[168],"differentiation":[169],"(AUC":[170],"0.942).":[172],"miR-760":[173],"strongest":[176],"distinctive":[177],"capacity":[178],"RRMS.":[181],"Additionally,":[182],"miR-98-5p":[183],"markedly":[185],"up-regulated":[186],"in":[187,222,241],"both":[188],"compared":[193],"HC.":[195],"Network":[196],"analysis":[197],"suggested":[201],"distinct":[202],"immunoregulatory":[203],"patterns":[204],"across":[205],"phenotypes.":[207],"miRNAs\u2014particularly":[210],"miR-760,":[211],"miR-98-5p\u2014showed":[213],"as":[215],"indicators":[217],"associated":[218],"MS.":[223],"Integrating":[224],"EV-miRNA":[225],"profiling":[226],"markers":[229],"support":[230],"efforts":[231],"toward":[232],"more":[233],"precise":[234],"stratification":[235],"patients.":[238],"Further":[239],"studies":[240],"independent":[242],"cohorts":[243],"functional":[245],"validation":[246],"are":[247],"warranted":[248],"before":[249],"translation.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-01-15T00:00:00"}
