{"id":"https://openalex.org/W7124178385","doi":"https://doi.org/10.1038/s41420-025-02924-9","title":"SOHLH2-RAD54L axis induces radioresistance by promoting homologous recombination repair in non-small cell lung cancer","display_name":"SOHLH2-RAD54L axis induces radioresistance by promoting homologous recombination repair in non-small cell lung cancer","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7124178385","doi":"https://doi.org/10.1038/s41420-025-02924-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/41535248"},"language":"en","primary_location":{"id":"doi:10.1038/s41420-025-02924-9","doi":"https://doi.org/10.1038/s41420-025-02924-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-025-02924-9","pdf_url":"https://www.nature.com/articles/s41420-025-02924-9_reference.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41420-025-02924-9_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5123005752","display_name":"Jia-Xue Yang","orcid":"https://orcid.org/0000-0002-7217-3520","observed_orcids":["https://orcid.org/0000-0002-7217-3520"]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]},{"id":"https://openalex.org/I4210115141","display_name":"Third Hospital of Nanchang","ror":"https://ror.org/01h439d80","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115141"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia-Xue Yang","raw_affiliation_strings":["Department of Oncology, Yangxin People's Hospital, Yangxin, Hubei, China","Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0000-0002-7217-3520","affiliations":[{"raw_affiliation_string":"Department of Oncology, Yangxin People's Hospital, Yangxin, Hubei, China","institution_ids":[]},{"raw_affiliation_string":"Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210114086","https://openalex.org/I4210115141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033687654","display_name":"W X Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107571","display_name":"Jiangxi Provincial People's Hospital","ror":"https://ror.org/01dspcb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107571"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Hua Zhang","raw_affiliation_strings":["Integrated Traditional Chinese and Western Medicine Oncology Department, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Integrated Traditional Chinese and Western Medicine Oncology Department, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China","institution_ids":["https://openalex.org/I4210107571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054279172","display_name":"Jin-Ju Lei","orcid":"https://orcid.org/0009-0004-2884-2573","observed_orcids":["https://orcid.org/0009-0004-2884-2573"]},"institutions":[{"id":"https://openalex.org/I4210140357","display_name":"Renmin Hospital of Wuhan University","ror":"https://ror.org/03ekhbz91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140357"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Ju Lei","raw_affiliation_strings":["Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I4210140357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110732197","display_name":"Chun Cheng","orcid":"https://orcid.org/0009-0000-2172-8111","observed_orcids":["https://orcid.org/0009-0000-2172-8111"]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]},{"id":"https://openalex.org/I4210115141","display_name":"Third Hospital of Nanchang","ror":"https://ror.org/01h439d80","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115141"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Cheng","raw_affiliation_strings":["Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":"https://orcid.org/0009-0000-2172-8111","affiliations":[{"raw_affiliation_string":"Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210114086","https://openalex.org/I4210115141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136912771","display_name":"Meng Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]},{"id":"https://openalex.org/I4210115141","display_name":"Third Hospital of Nanchang","ror":"https://ror.org/01h439d80","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115141"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Yu","raw_affiliation_strings":["Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I4210114086","https://openalex.org/I4210115141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146675949","display_name":"Ping Zhang","orcid":"https://orcid.org/0009-0003-4630-3664","observed_orcids":["https://orcid.org/0009-0003-4630-3664"]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]},{"id":"https://openalex.org/I4210115141","display_name":"Third Hospital of Nanchang","ror":"https://ror.org/01h439d80","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115141"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Zhang","raw_affiliation_strings":["Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China. zhangping0808@ncu.edu.cn"],"raw_orcid":"https://orcid.org/0009-0003-4630-3664","affiliations":[{"raw_affiliation_string":"Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China. zhangping0808@ncu.edu.cn","institution_ids":["https://openalex.org/I4210114086","https://openalex.org/I4210115141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123006072","display_name":"Yi Sang","orcid":"https://orcid.org/0000-0001-6534-0741","observed_orcids":["https://orcid.org/0000-0001-6534-0741"]},"institutions":[{"id":"https://openalex.org/I4210114086","display_name":"Third Affiliated Hospital of Nanchang University","ror":"https://ror.org/02g9jg318","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114086"]},{"id":"https://openalex.org/I4210115141","display_name":"Third Hospital of Nanchang","ror":"https://ror.org/01h439d80","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115141"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Sang","raw_affiliation_strings":["Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China. ndsfy001889@ncu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-6534-0741","affiliations":[{"raw_affiliation_string":"Jiangxi Key Laboratory of Oncology, Department of Center Laboratory, The Third Affiliated Hospital of Nanchang University, Nanchang, China. ndsfy001889@ncu.edu.cn","institution_ids":["https://openalex.org/I4210114086","https://openalex.org/I4210115141"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5123006072","https://openalex.org/A5146675949"],"corresponding_institution_ids":["https://openalex.org/I4210114086","https://openalex.org/I4210115141"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.9386,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.78931574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"12","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sohlh2","display_name":"SOHLH2","score":0.996999979019165},{"id":"https://openalex.org/keywords/rad54l","display_name":"RAD54L","score":1.0},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.7799999713897705},{"id":"https://openalex.org/keywords/homologous-recombination-repair","display_name":"homologous recombination repair","score":0.9290000200271606},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.953000009059906},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9829999804496765},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/radiotherapy-resistance","display_name":"radiotherapy resistance","score":0.7829999923706055},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.9721999764442444},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.7657999992370605},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.7627000212669373},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6621000170707703},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5435000061988831},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5321000218391418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5105999708175659},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.43799999356269836},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42809998989105225},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.37560001015663147},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.36820000410079956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36340001225471497},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3499999940395355},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2909513124","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA Damage Repair","level":4,"score":0.2922999858856201},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2777999937534332},{"id":"https://openalex.org/C145803527","wikidata":"https://www.wikidata.org/wiki/Q18032396","display_name":"DNA repair protein XRCC4","level":5,"score":0.2660999894142151},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.257999986410141},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2549999952316284},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.25029999017715454}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1038/s41420-025-02924-9","doi":"https://doi.org/10.1038/s41420-025-02924-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-025-02924-9","pdf_url":"https://www.nature.com/articles/s41420-025-02924-9_reference.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},{"id":"pmid:41535248","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41535248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death discovery","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11684648","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12876998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12876998","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12876998/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Death Discov","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41420-025-02924-9","doi":"https://doi.org/10.1038/s41420-025-02924-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41420-025-02924-9","pdf_url":"https://www.nature.com/articles/s41420-025-02924-9_reference.pdf","source":{"id":"https://openalex.org/S2764515074","display_name":"Cell Death Discovery","issn_l":"2058-7716","issn":["2058-7716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8143696188926697,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G283172370","display_name":null,"funder_award_id":"8216110654","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124178385.pdf","grobid_xml":"https://content.openalex.org/works/W7124178385.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W127046385","https://openalex.org/W1502716441","https://openalex.org/W1980440773","https://openalex.org/W1981974065","https://openalex.org/W2066883074","https://openalex.org/W2077316753","https://openalex.org/W2090444328","https://openalex.org/W2111313313","https://openalex.org/W2125790701","https://openalex.org/W2127911142","https://openalex.org/W2414165668","https://openalex.org/W2461826907","https://openalex.org/W2466033276","https://openalex.org/W2586810147","https://openalex.org/W2776208190","https://openalex.org/W2790921095","https://openalex.org/W2802832662","https://openalex.org/W2892340304","https://openalex.org/W2903988391","https://openalex.org/W2942115509","https://openalex.org/W2962996956","https://openalex.org/W3108339828","https://openalex.org/W3130852911","https://openalex.org/W3139057214","https://openalex.org/W3175110581","https://openalex.org/W3213542757","https://openalex.org/W3214357320","https://openalex.org/W4205521436","https://openalex.org/W4206090238","https://openalex.org/W4295079305","https://openalex.org/W4320724635","https://openalex.org/W4388461192","https://openalex.org/W4393115143","https://openalex.org/W4396955535","https://openalex.org/W4402816273","https://openalex.org/W4404252677","https://openalex.org/W4404970306","https://openalex.org/W4409302229","https://openalex.org/W4410469070","https://openalex.org/W4413680442"],"related_works":[],"abstract_inverted_index":{"Radiation":[0],"resistance":[1,49],"is":[2,26],"the":[3,19,42,57,61,83,111,118,127,143],"major":[4],"cause":[5],"of":[6,21,44,60,86,120,129,145],"non-small":[7],"cell":[8,101],"lung":[9],"cancer":[10,130],"(NSCLC)":[11],"treatment":[12],"failure.":[13],"Homologous":[14],"recombination":[15],"(HR),":[16],"which":[17],"mediates":[18],"repair":[20,46,76,125,148],"DNA":[22],"double-strand":[23],"breaks":[24],"(DSB),":[25],"crucial":[27],"for":[28,165],"maintaining":[29],"genomic":[30],"integrity":[31],"and":[32,65,77,103,126,149],"enhancing":[33],"survival":[34,128],"in":[35,39,47,73,89,132,168],"response":[36,133],"to":[37,134,141],"radiotherapy":[38],"NSCLC.":[40,169],"However,":[41],"mechanisms":[43],"HR":[45,75,124,147],"radiation":[48,104],"remains":[50],"unclear.":[51],"In":[52],"this":[53],"study,":[54],"we":[55],"investigated":[56],"functional":[58],"role":[59],"transcription":[62,69],"factor":[63,70],"Spermatogenesis":[64],"oogenesis":[66],"basic":[67],"helix-loop-helix":[68],"2":[71],"(SOHLH2)":[72],"NSCLC":[74,90,100,146],"radioresistance.":[78],"Our":[79],"research":[80],"unveiled":[81],"that":[82],"expression":[84,98,119],"levels":[85],"SOHLH2":[87,97,109,115,153],"increased":[88],"compared":[91],"with":[92],"adjacent":[93],"non-tumor":[94],"tissues.":[95],"Elevated":[96],"promotes":[99],"proliferation":[102],"resistance,":[105],"while":[106],"knocking":[107],"down":[108],"has":[110],"opposite":[112],"effect.":[113],"Mechanistically,":[114],"transcriptionally":[116],"activated":[117],"RAD54L,":[121],"thereby":[122],"promoting":[123],"cells":[131],"radiation.":[135],"Notably,":[136],"RAD54L":[137],"overexpression":[138],"was":[139],"able":[140],"rescue":[142],"suppression":[144],"radioresistance":[150,167],"induced":[151],"by":[152],"knockdown.":[154],"Therefore,":[155],"SOHLH2-RAD54L":[156],"axis":[157],"may":[158],"serve":[159],"as":[160],"a":[161],"potential":[162],"therapeutic":[163],"target":[164],"overcoming":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-04T09:36:47.201465","created_date":"2026-01-15T00:00:00"}