{"id":"https://openalex.org/W7124140288","doi":"https://doi.org/10.1111/cts.70450","title":"Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral TYK2 Inhibitor D\u20102570 in Healthy Subjects: A First\u2010in\u2010Human Phase I Study","display_name":"Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral TYK2 Inhibitor D\u20102570 in Healthy Subjects: A First\u2010in\u2010Human Phase I Study","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7124140288","doi":"https://doi.org/10.1111/cts.70450","pmid":"https://pubmed.ncbi.nlm.nih.gov/41532712","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12802081"},"language":"en","primary_location":{"id":"doi:10.1111/cts.70450","doi":"https://doi.org/10.1111/cts.70450","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.70450","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.70450","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.70450","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062485767","display_name":"Meng Wang","orcid":"https://orcid.org/0000-0001-6679-5166","observed_orcids":["https://orcid.org/0000-0001-6679-5166"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Wang","raw_affiliation_strings":["Department of Pharmacy The Second Affiliated Hospital of Soochow University  Suzhou Jiangsu Province People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-6679-5166","affiliations":[{"raw_affiliation_string":"Department of Pharmacy The Second Affiliated Hospital of Soochow University  Suzhou Jiangsu Province People's Republic of China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102808023","display_name":"Zhang Quan-ying","orcid":"https://orcid.org/0000-0001-9870-2972","observed_orcids":["https://orcid.org/0000-0001-9870-2972"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Quanying Zhang","raw_affiliation_strings":["Department of Pharmacy The Second Affiliated Hospital of Soochow University  Suzhou Jiangsu Province People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-9870-2972","affiliations":[{"raw_affiliation_string":"Department of Pharmacy The Second Affiliated Hospital of Soochow University  Suzhou Jiangsu Province People's Republic of China","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101886527","display_name":"Zhe Shi","orcid":"https://orcid.org/0000-0001-5308-6934","observed_orcids":["https://orcid.org/0000-0001-5308-6934"]},"institutions":[{"id":"https://openalex.org/I4405268094","display_name":"InventisBio Co., Ltd. (China)","ror":"https://ror.org/05s4wn714","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405268094"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Shi","raw_affiliation_strings":["InventisBio Co., Ltd.  Shanghai People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InventisBio Co., Ltd.  Shanghai People's Republic of China","institution_ids":["https://openalex.org/I4405268094"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268094","display_name":"InventisBio Co., Ltd. (China)","ror":"https://ror.org/05s4wn714","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405268094"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Zhang","raw_affiliation_strings":["InventisBio Co., Ltd.  Shanghai People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"InventisBio Co., Ltd.  Shanghai People's Republic of China","institution_ids":["https://openalex.org/I4405268094"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123019422","display_name":"Jie Pan","orcid":"https://orcid.org/0009-0000-0005-3442","observed_orcids":["https://orcid.org/0009-0000-0005-3442"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Pan","raw_affiliation_strings":["Department of Pharmacy The Second Affiliated Hospital of Soochow University  Suzhou Jiangsu Province People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0000-0005-3442","affiliations":[{"raw_affiliation_string":"Department of Pharmacy The Second Affiliated Hospital of Soochow University  Suzhou Jiangsu Province People's Republic of China","institution_ids":["https://openalex.org/I4210124971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5123019422"],"corresponding_institution_ids":["https://openalex.org/I4210124971"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":3.4715,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.85681058,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"19","issue":"1","first_page":"e70450","last_page":"e70450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.4293999969959259,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.13449999690055847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyk2-inhibitor","display_name":"TYK2 inhibitor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tyk2","display_name":"TYK2","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pseudokinase-domain","display_name":"pseudokinase domain","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9980000257492065},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.7099999785423279},{"id":"https://openalex.org/keywords/single-ascending-dose","display_name":"single ascending dose","score":0.7160000205039978},{"id":"https://openalex.org/keywords/multiple-ascending-dose","display_name":"multiple ascending dose","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interferon-gamma-release","display_name":"interferon-gamma release","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.7450000047683716},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7940000295639038},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/healthy-chinese-subjects","display_name":"healthy Chinese subjects","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8209999799728394},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.739300012588501},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6843000054359436},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6773999929428101},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6294000148773193},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5212000012397766},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.4440999925136566},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4392000138759613},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.43459999561309814},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.39570000767707825},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.36010000109672546},{"id":"https://openalex.org/C96529984","wikidata":"https://www.wikidata.org/wiki/Q286136","display_name":"EC50","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3330000042915344},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3280999958515167},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3276999890804291},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2759000062942505},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.27250000834465027},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C42533223","wikidata":"https://www.wikidata.org/wiki/Q1378064","display_name":"ED50","level":3,"score":0.2508000135421753},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D053634","descriptor_name":"TYK2 Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064368","descriptor_name":"Healthy Volunteers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/cts.70450","doi":"https://doi.org/10.1111/cts.70450","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.70450","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.70450","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},{"id":"pmid:41532712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41532712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12802081","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12802081/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:178dd21a39884ee0a30c60e217a93929","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/178dd21a39884ee0a30c60e217a93929","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Translational Science, Vol 19, Iss 1, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1111/cts.70450","doi":"https://doi.org/10.1111/cts.70450","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cts.70450","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cts.70450","source":{"id":"https://openalex.org/S106654227","display_name":"Clinical and Translational Science","issn_l":"1752-8054","issn":["1752-8054","1752-8062"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7124140288.pdf","grobid_xml":"https://content.openalex.org/works/W7124140288.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2040002852","https://openalex.org/W2593565645","https://openalex.org/W2890147164","https://openalex.org/W3008727737","https://openalex.org/W3174212996","https://openalex.org/W4284989117","https://openalex.org/W4295807681","https://openalex.org/W4308834504","https://openalex.org/W4319765269","https://openalex.org/W4323531056","https://openalex.org/W4324018025","https://openalex.org/W4387761919","https://openalex.org/W4388807301","https://openalex.org/W4392657203","https://openalex.org/W4401723588","https://openalex.org/W4403535987","https://openalex.org/W4404832637","https://openalex.org/W4412454913","https://openalex.org/W4414299657"],"related_works":["https://openalex.org/W3110971242","https://openalex.org/W4404832637","https://openalex.org/W4410769137","https://openalex.org/W7165544368","https://openalex.org/W7220830574","https://openalex.org/W7131277081","https://openalex.org/W2113988917","https://openalex.org/W3170807342","https://openalex.org/W2130440144","https://openalex.org/W4387204817"],"abstract_inverted_index":{"D-2570":[0,29,79,171,208,237],"selectively":[1],"binds":[2],"to":[3,112,122,142,164],"the":[4,13,96,134,154,173,183,198,225],"pseudokinase":[5],"domain":[6],"of":[7,28,48,170,175,185],"tyrosine":[8,248],"kinase":[9,249],"2,":[10],"which":[11],"mediates":[12],"downstream":[14],"cytokine":[15],"signaling":[16],"pathways":[17],"involved":[18],"in":[19,32,41,182,206,212,230],"immune":[20],"regulation.":[21],"The":[22,45,167],"safety,":[23],"tolerability,":[24],"pharmacokinetics,":[25],"and":[26,72,91,145,151,196,216,234],"pharmacodynamics":[27],"were":[30,201],"evaluated":[31],"a":[33,239],"randomized,":[34],"double-blind,":[35],"placebo-controlled":[36],"phase":[37],"I":[38],"study":[39,46],"conducted":[40],"healthy":[42,213],"Chinese":[43,214],"subjects.":[44],"consisted":[47],"three":[49],"parts:":[50],"single":[51],"ascending":[52,61],"dose":[53,62,97,126,228],"(D-2570:":[54,63,75],"3-48":[55],"mg":[56,65],"once":[57,66],"daily)":[58],"study,":[59,71],"multiple":[60,100],"6-36":[64,186],"daily":[67],"for":[68,153,227,243],"10":[69],"days)":[70],"food":[73],"effect":[74,160,169],"9":[76],"mg)":[77],"study.":[78],"was":[80,209,220],"rapidly":[81],"absorbed,":[82],"with":[83,115,157],"peak":[84],"plasma":[85,147],"concentration":[86,135,148],"at":[87,106],"around":[88],"4":[89],"h":[90],"exposure":[92],"increased":[93,131,180],"sub-proportional":[94],"across":[95],"groups.":[98],"Following":[99],"dosing,":[101],"mean":[102],"terminal":[103],"elimination":[104],"half-lives":[105],"steady":[107],"state":[108],"ranged":[109],"from":[110,138],"22.22":[111],"33.86":[113],"h,":[114],"modest":[116],"area":[117,132],"under":[118,133],"curve":[119,137],"accumulation":[120],"(1.74-":[121],"2.08-fold)":[123],"showing":[124],"no":[125,158],"dependence.":[127],"A":[128],"high-fat":[129],"meal":[130],"time":[136,139,144,163],"zero":[140],"extrapolated":[141],"infinite":[143],"maximum":[146,165],"by":[149,178,247],"33%":[150],"15%":[152],"9-mg":[155],"dose,":[156],"significant":[159],"on":[161,172],"median":[162],"concentration.":[166],"inhibitory":[168],"release":[174],"interferon-gamma":[176],"induced":[177],"interleukin-12/interleukin-18":[179],"dose-dependently":[181],"range":[184],"mg.":[187],"No":[188],"deaths":[189],"or":[190,204],"serious":[191],"treatment-emergent":[192],"adverse":[193,199],"events":[194,200],"occurred,":[195],"all":[197],"Grade":[202],"1":[203],"2":[205],"severity.":[207],"well":[210],"tolerated":[211],"subjects,":[215],"its":[217],"pharmacokinetic":[218],"profile":[219],"characterized.":[221],"These":[222],"results":[223],"provide":[224],"rationale":[226],"selection":[229],"future":[231],"clinical":[232],"trials":[233],"support":[235],"advancing":[236],"as":[238],"potential":[240],"treatment":[241],"option":[242],"autoimmune":[244],"diseases":[245],"mediated":[246],"2.":[250],"Trial":[251],"Registration:":[252],"Chinadrugtrials.org.cn":[253],"(CTR20222168).":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-01-15T00:00:00"}
