{"id":"https://openalex.org/W7123686459","doi":"https://doi.org/10.1080/14786419.2026.2613758","title":"Histone deacetylase 6 (HDAC 6) inhibition by mangrove-derived fat and fatty acids","display_name":"Histone deacetylase 6 (HDAC 6) inhibition by mangrove-derived fat and fatty acids","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7123686459","doi":"https://doi.org/10.1080/14786419.2026.2613758","pmid":"https://pubmed.ncbi.nlm.nih.gov/41532165"},"language":"en","primary_location":{"id":"doi:10.1080/14786419.2026.2613758","doi":"https://doi.org/10.1080/14786419.2026.2613758","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2026.2613758","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051836395","display_name":"Meran Keshawa Ediriweera","orcid":"https://orcid.org/0000-0001-9393-9516","observed_orcids":["https://orcid.org/0000-0001-9393-9516"]},"institutions":[{"id":"https://openalex.org/I90678064","display_name":"University of Colombo","ror":"https://ror.org/02phn5242","country_code":"LK","type":"education","lineage":["https://openalex.org/I90678064"]}],"countries":["LK"],"is_corresponding":true,"raw_author_name":"Meran Keshawa Ediriweera","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo","institution_ids":["https://openalex.org/I90678064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047744238","display_name":"W.M. Gayashani Sandamalika","orcid":"https://orcid.org/0000-0002-9519-0518","observed_orcids":["https://orcid.org/0000-0002-9519-0518"]},"institutions":[{"id":"https://openalex.org/I175606534","display_name":"Wayamba University of Sri Lanka","ror":"https://ror.org/043yykt67","country_code":"LK","type":"education","lineage":["https://openalex.org/I175606534"]}],"countries":["LK"],"is_corresponding":false,"raw_author_name":"W. M. Gayashani Sandamalika","raw_affiliation_strings":["Department of Aquaculture and Fisheries, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Aquaculture and Fisheries, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka","institution_ids":["https://openalex.org/I175606534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078509022","display_name":"Jayanath Gopi","orcid":"https://orcid.org/0000-0002-4028-2028","observed_orcids":["https://orcid.org/0000-0002-4028-2028"]},"institutions":[{"id":"https://openalex.org/I134085113","display_name":"King Fahd University of Petroleum and Minerals","ror":"https://ror.org/03yez3163","country_code":"SA","type":"education","lineage":["https://openalex.org/I134085113"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Jayanath Gopi","raw_affiliation_strings":["Applied Research Center for Environment and Marine Studies, Research and Innovation, King Fahd University of Petroleum and Minerals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research Center for Environment and Marine Studies, Research and Innovation, King Fahd University of Petroleum and Minerals","institution_ids":["https://openalex.org/I134085113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015538346","display_name":"Seerangan Manokaran","orcid":"https://orcid.org/0000-0001-5482-5866","observed_orcids":["https://orcid.org/0000-0001-5482-5866"]},"institutions":[{"id":"https://openalex.org/I134085113","display_name":"King Fahd University of Petroleum and Minerals","ror":"https://ror.org/03yez3163","country_code":"SA","type":"education","lineage":["https://openalex.org/I134085113"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Seerangan Manokaran","raw_affiliation_strings":["Applied Research Center for Environment and Marine Studies, Research and Innovation, King Fahd University of Petroleum and Minerals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research Center for Environment and Marine Studies, Research and Innovation, King Fahd University of Petroleum and Minerals","institution_ids":["https://openalex.org/I134085113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061144117","display_name":"Thadickal V. Joydas","orcid":"https://orcid.org/0000-0002-6725-4094","observed_orcids":["https://orcid.org/0000-0002-6725-4094"]},"institutions":[{"id":"https://openalex.org/I134085113","display_name":"King Fahd University of Petroleum and Minerals","ror":"https://ror.org/03yez3163","country_code":"SA","type":"education","lineage":["https://openalex.org/I134085113"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Thadickal Viswanathan Joydas","raw_affiliation_strings":["Applied Research Center for Environment and Marine Studies, Research and Innovation, King Fahd University of Petroleum and Minerals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Research Center for Environment and Marine Studies, Research and Innovation, King Fahd University of Petroleum and Minerals","institution_ids":["https://openalex.org/I134085113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122914505","display_name":"Devaki Sethi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devaki Sethi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067128501","display_name":"Thyageshwar Chandran","orcid":"https://orcid.org/0000-0002-7504-1371","observed_orcids":["https://orcid.org/0000-0002-7504-1371"]},"institutions":[{"id":"https://openalex.org/I4210107052","display_name":"Instituto Nacional de Tecnologia","ror":"https://ror.org/012ang229","country_code":"BR","type":"government","lineage":["https://openalex.org/I4210107052","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I4210120810","display_name":"National Institute of Technology","ror":"https://ror.org/02xqkcw08","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210120810"]}],"countries":["BR","JP"],"is_corresponding":false,"raw_author_name":"Thyageshwar Chandran","raw_affiliation_strings":["Biomolecular Structure and Dynamics Group, Department of Biotechnology, National Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomolecular Structure and Dynamics Group, Department of Biotechnology, National Institute of Technology","institution_ids":["https://openalex.org/I4210107052","https://openalex.org/I4210120810"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051836395","https://openalex.org/A5061144117"],"corresponding_institution_ids":["https://openalex.org/I134085113","https://openalex.org/I90678064"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02560521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.972000002861023},{"id":"https://openalex.org/keywords/avicennia-marina","display_name":"Avicennia marina","score":0.921999990940094},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/heptadecanoic-acid","display_name":"heptadecanoic acid","score":0.8960000276565552},{"id":"https://openalex.org/keywords/alpha-linolenic-acid","display_name":"alpha-linolenic acid","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.996999979019165},{"id":"https://openalex.org/keywords/oleamide","display_name":"oleamide","score":0.9419999718666077},{"id":"https://openalex.org/keywords/myristic-acid","display_name":"myristic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/epigenetic-enzymes","display_name":"epigenetic enzymes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/natural-product-inhibitors","display_name":"natural product inhibitors","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.723800003528595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6697999835014343},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6614000201225281},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.6564000248908997},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5491999983787537},{"id":"https://openalex.org/C2778483698","wikidata":"https://www.wikidata.org/wiki/Q422658","display_name":"Myristic acid","level":4,"score":0.475600004196167},{"id":"https://openalex.org/C68874143","wikidata":"https://www.wikidata.org/wiki/Q19756","display_name":"Mangrove","level":2,"score":0.3846000134944916},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.3725999891757965},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.3231000006198883},{"id":"https://openalex.org/C4951695","wikidata":"https://www.wikidata.org/wiki/Q18046437","display_name":"HDAC11","level":5,"score":0.2824000120162964},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.2685000002384186},{"id":"https://openalex.org/C27253355","wikidata":"https://www.wikidata.org/wiki/Q18034954","display_name":"Histone deacetylase 5","level":5,"score":0.26809999346733093},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/14786419.2026.2613758","doi":"https://doi.org/10.1080/14786419.2026.2613758","is_oa":false,"landing_page_url":"https://doi.org/10.1080/14786419.2026.2613758","pdf_url":null,"source":{"id":"https://openalex.org/S205999849","display_name":"Natural Product Research","issn_l":"1478-6419","issn":["1478-6419","1478-6427"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Research","raw_type":"journal-article"},{"id":"pmid:41532165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41532165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural product research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","score":0.412080317735672,"display_name":"Life below water"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3528637619","display_name":null,"funder_award_id":"22\u2013140 RG/BIO/AS_I","funder_id":"https://openalex.org/F4320321078","funder_display_name":"The World Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321078","display_name":"The World Academy of Sciences","ror":"https://ror.org/00twbd828"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1487532570","https://openalex.org/W1971883851","https://openalex.org/W1979800875","https://openalex.org/W2003189290","https://openalex.org/W2034503181","https://openalex.org/W2058127448","https://openalex.org/W2058644993","https://openalex.org/W2107733280","https://openalex.org/W2119133472","https://openalex.org/W2129635356","https://openalex.org/W2162407754","https://openalex.org/W2171759299","https://openalex.org/W2482664294","https://openalex.org/W2499955277","https://openalex.org/W2530993461","https://openalex.org/W2745845107","https://openalex.org/W2805686942","https://openalex.org/W2914648344","https://openalex.org/W2946244649","https://openalex.org/W3011179511","https://openalex.org/W3121682185","https://openalex.org/W3162250118","https://openalex.org/W3169149268","https://openalex.org/W3176937375","https://openalex.org/W3195696863","https://openalex.org/W4225133915","https://openalex.org/W4229069568","https://openalex.org/W4255691026","https://openalex.org/W4285802382","https://openalex.org/W4290989580","https://openalex.org/W4306831195","https://openalex.org/W4320732441","https://openalex.org/W4360999434","https://openalex.org/W4387190566","https://openalex.org/W4387734997","https://openalex.org/W4390227028","https://openalex.org/W4391135119","https://openalex.org/W4406730868"],"related_works":[],"abstract_inverted_index":{"Mangroves":[0],"are":[1,62],"rich":[2],"in":[3,57,89,133],"various":[4],"phytochemicals,":[5],"including":[6,31],"fatty":[7,26,79,122],"acids.":[8],"This":[9,140],"study":[10],"investigated":[11],"the":[12,41,90,134,143],"effects":[13,84],"of":[14,25,43,67,92,137,146],"fat":[15,148],"extracted":[16,71],"from":[17,28,34,110],"Avicennia":[18],"marina":[19],"leaves":[20],"and":[21,38,60,127],"a":[22,52,65],"selected":[23],"group":[24],"acids":[27,80,123],"mangrove":[29,36],"ecosystems,":[30],"those":[32],"derived":[33,109],"both":[35],"flora":[37],"fauna,":[39],"on":[40,85],"inhibition":[42],"Histone":[44],"Deacetylase":[45],"6":[46,50,75,87,151],"(HDAC":[47],"6).":[48],"HDAC":[49,74,86,138,150],"is":[51],"key":[53,131],"epigenetic":[54],"enzyme.":[55],"Irregularities":[56],"its":[58],"expression":[59],"activity":[61,88],"linked":[63],"to":[64],"number":[66],"human":[68],"diseases.":[69],"Fat":[70],"demonstrated":[72],"significant":[73],"inhibitory":[76,83],"effects.":[77],"The":[78],"tested":[81],"showed":[82],"order":[91],"docosahexaenoic":[93],"acid":[94,98,101,104],"(DHA)":[95],">":[96,99,102,105,113],"heptadecanoic":[97],"\u03b1-linoleic":[100],"oleic":[103,111],"oleamide":[106],"(an":[107],"amide":[108],"acid)":[112],"myristic":[114],"acid.":[115],"In":[116],"silico":[117],"analysis":[118],"revealed":[119],"that":[120],"these":[121],"make":[124],"hydrophobic":[125],"interactions":[126],"hydrogen":[128],"bonds":[129],"with":[130],"residues":[132],"catalytic":[135],"domain":[136],"6.":[139],"research":[141],"supports":[142],"potential":[144],"use":[145],"mangrove-derived":[147],"as":[149],"inhibitors.":[152]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-01-14T00:00:00"}
