{"id":"https://openalex.org/W7123614535","doi":"https://doi.org/10.1038/s41440-025-02534-z","title":"Cumulative blood pressure exposure and cognition: the potential mediating role of brain volume","display_name":"Cumulative blood pressure exposure and cognition: the potential mediating role of brain volume","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7123614535","doi":"https://doi.org/10.1038/s41440-025-02534-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41530464"},"language":"en","primary_location":{"id":"doi:10.1038/s41440-025-02534-z","doi":"https://doi.org/10.1038/s41440-025-02534-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41440-025-02534-z","pdf_url":"https://www.nature.com/articles/s41440-025-02534-z.pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/s41440-025-02534-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xiaoshuai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoshuai Li","raw_affiliation_strings":["Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122934820","display_name":"Zejun Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zejun Zhu","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121844264","display_name":"Ying Hui","orcid":"https://orcid.org/0009-0009-0534-210X","observed_orcids":["https://orcid.org/0009-0009-0534-210X"]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Hui","raw_affiliation_strings":["Department of MR, Kailuan General Hospital, Tangshan, China. huiyingct@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of MR, Kailuan General Hospital, Tangshan, China. huiyingct@163.com","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122946183","display_name":"Huijing Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijing Shi","raw_affiliation_strings":["Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiacheng Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiacheng Fan","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wei Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Hong","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaohui Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohui Hu","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121413001","display_name":"Xianyu Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianyu Zhu","raw_affiliation_strings":["Precision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision and Intelligence Medical Imaging Lab, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404038","display_name":"Haitao Li","orcid":"https://orcid.org/0000-0001-9160-8334","observed_orcids":["https://orcid.org/0000-0001-9160-8334","https://orcid.org/0000-0002-5835-6590","https://orcid.org/0009-0002-2490-6889"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haitao Li","raw_affiliation_strings":["Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074242090","display_name":"Lingmei Yue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingmei Yue","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060933285","display_name":"S Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shun Zhang","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122929085","display_name":"Xiaoliang Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoliang Liang","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039932216","display_name":"S. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuohua Chen","raw_affiliation_strings":["Department of MR, Kailuan General Hospital, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of MR, Kailuan General Hospital, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024638516","display_name":"Han Lv","orcid":"https://orcid.org/0000-0001-9559-4777","observed_orcids":["https://orcid.org/0000-0001-9559-4777"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Lv","raw_affiliation_strings":["Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100627241","display_name":"Pengfei Zhao","orcid":"https://orcid.org/0000-0002-9210-6544","observed_orcids":["https://orcid.org/0000-0002-9210-6544"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Zhao","raw_affiliation_strings":["Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024638516","display_name":"Han Lv","orcid":"https://orcid.org/0000-0001-9559-4777","observed_orcids":["https://orcid.org/0000-0001-9559-4777"]},"institutions":[{"id":"https://openalex.org/I4210153550","display_name":"Beijing Tsinghua Chang Gung Hospital","ror":"https://ror.org/050nfgr37","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153550"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Li","raw_affiliation_strings":["Beijing Tsinghua Changgung Hospital, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Tsinghua Changgung Hospital, Beijing, China","institution_ids":["https://openalex.org/I4210153550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130373259","display_name":"Y T Wu","orcid":"https://orcid.org/0000-0003-0331-0285","observed_orcids":["https://orcid.org/0000-0003-0331-0285"]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuntao Wu","raw_affiliation_strings":["Department of Cardiology, Kailuan General Hospital, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Kailuan General Hospital, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016220519","display_name":"Zhenjian Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenjian Yu","raw_affiliation_strings":["Kailuan Mental Health Center, Tangshan, China. yuzhenjian68@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kailuan Mental Health Center, Tangshan, China. yuzhenjian68@163.com","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146722013","display_name":"Shouling Wu","orcid":"https://orcid.org/0000-0001-7095-6022","observed_orcids":["https://orcid.org/0000-0001-7095-6022","https://orcid.org/0000-0002-2921-7583"]},"institutions":[{"id":"https://openalex.org/I4210109698","display_name":"Kailuan General Hospital","ror":"https://ror.org/01kwdp645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109698"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shouling Wu","raw_affiliation_strings":["Department of Cardiology, Kailuan General Hospital, Tangshan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Kailuan General Hospital, Tangshan, China","institution_ids":["https://openalex.org/I4210109698"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115595037","display_name":"Zhenchang Wang","orcid":"https://orcid.org/0000-0001-8190-6469","observed_orcids":["https://orcid.org/0000-0001-8190-6469"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenchang Wang","raw_affiliation_strings":["Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. cjr.wzhch@vip.163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. cjr.wzhch@vip.163.com","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016220519","https://openalex.org/A5115595037","https://openalex.org/A5121844264"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210109698","https://openalex.org/I4210147433"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0298455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"49","issue":"4","first_page":"1361","last_page":"1370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7749999761581421},{"id":"https://openalex.org/keywords/brain-volume","display_name":"brain volume","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.5389999747276306},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8500000238418579},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":1.0},{"id":"https://openalex.org/keywords/grey-matter-volume","display_name":"gray matter volume","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8889999985694885},{"id":"https://openalex.org/keywords/frontal-lobe","display_name":"frontal lobe","score":0.9710000157356262},{"id":"https://openalex.org/keywords/temporal-lobe","display_name":"temporal lobe","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.5070000290870667},{"id":"https://openalex.org/keywords/brain-structure","display_name":"brain structure","score":0.5529999732971191},{"id":"https://openalex.org/keywords/kailuan-study","display_name":"Kailuan Study","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.6223000288009644},{"id":"https://openalex.org/C2777127467","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal lobe","level":2,"score":0.6054999828338623},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5436999797821045},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5357999801635742},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.508899986743927},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5006999969482422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4921000003814697},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.47929999232292175},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4578000009059906},{"id":"https://openalex.org/C2776632958","wikidata":"https://www.wikidata.org/wiki/Q6906262","display_name":"Montreal Cognitive Assessment","level":4,"score":0.4350000023841858},{"id":"https://openalex.org/C2777230293","wikidata":"https://www.wikidata.org/wiki/Q23579818","display_name":"Cumulative effects","level":2,"score":0.40070000290870667},{"id":"https://openalex.org/C88879693","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative incidence","level":3,"score":0.3959999978542328},{"id":"https://openalex.org/C151032500","wikidata":"https://www.wikidata.org/wiki/Q5194182","display_name":"Cumulative dose","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3589000105857849},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3571999967098236},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.33340001106262207},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30320000648498535},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2752000093460083},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C2994039464","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative risk","level":2,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1038/s41440-025-02534-z","doi":"https://doi.org/10.1038/s41440-025-02534-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41440-025-02534-z","pdf_url":"https://www.nature.com/articles/s41440-025-02534-z.pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},{"id":"pmid:41530464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41530464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension research : official journal of the Japanese Society of Hypertension","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13050639","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13050639/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hypertens Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41440-025-02534-z","doi":"https://doi.org/10.1038/s41440-025-02534-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41440-025-02534-z","pdf_url":"https://www.nature.com/articles/s41440-025-02534-z.pdf","source":{"id":"https://openalex.org/S67902008","display_name":"Hypertension Research","issn_l":"0916-9636","issn":["0916-9636","1348-4214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2339577280","display_name":null,"funder_award_id":"2021-135","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6665831267","display_name":null,"funder_award_id":"82202109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320317799","display_name":"Health Commission of Hebei Province","ror":"https://ror.org/02g4yc525"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7123614535.pdf","grobid_xml":"https://content.openalex.org/works/W7123614535.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1719320297","https://openalex.org/W1783216802","https://openalex.org/W1982891394","https://openalex.org/W1997298866","https://openalex.org/W2006035554","https://openalex.org/W2007211407","https://openalex.org/W2045637250","https://openalex.org/W2048273899","https://openalex.org/W2053680366","https://openalex.org/W2056985030","https://openalex.org/W2061353398","https://openalex.org/W2072203364","https://openalex.org/W2076459510","https://openalex.org/W2092359565","https://openalex.org/W2095100741","https://openalex.org/W2098747356","https://openalex.org/W2104591424","https://openalex.org/W2104897414","https://openalex.org/W2111562675","https://openalex.org/W2117463741","https://openalex.org/W2134832377","https://openalex.org/W2143537130","https://openalex.org/W2150204018","https://openalex.org/W2157533062","https://openalex.org/W2603112182","https://openalex.org/W2616216465","https://openalex.org/W2619207017","https://openalex.org/W2698307513","https://openalex.org/W2747497136","https://openalex.org/W2968527306","https://openalex.org/W2969832889","https://openalex.org/W2990330896","https://openalex.org/W2994871395","https://openalex.org/W3022712746","https://openalex.org/W3083733923","https://openalex.org/W3094376925","https://openalex.org/W3186385567","https://openalex.org/W4212996371","https://openalex.org/W4220850473","https://openalex.org/W4221044947","https://openalex.org/W4241875855","https://openalex.org/W4283277507","https://openalex.org/W4311714681","https://openalex.org/W4315436353","https://openalex.org/W4377826841","https://openalex.org/W4384925383"],"related_works":[],"abstract_inverted_index":{"Elevated":[0],"blood":[1,35],"pressure":[2],"(BP)":[3],"has":[4],"been":[5],"linked":[6],"to":[7,76,97,114],"brain":[8,32,47,104,119,150,247],"structure":[9,248],"changes":[10],"and":[11,38,49,57,81,107,121,129,169,174,192,201,208,211,223,236,249],"cognitive":[12,39,58,108,130,224],"decline.":[13,40,59,131],"However,":[14],"few":[15],"studies":[16],"have":[17],"accounted":[18],"for":[19],"long-term":[20],"cumulative":[21,29,55,102,127,141,179,199,221,242],"BP":[22,30,56,70,128,243],"exposure.":[23],"We":[24,60],"investigated":[25],"the":[26,52,66,82,99,124,134,137,175,229],"association":[27,53,125],"between":[28,54,101,126,220],"exposure,":[31],"volume,":[33,105],"cerebral":[34],"flow":[36],"(CBF),":[37],"Furthermore,":[41],"we":[42],"explored":[43],"whether":[44,116],"alterations":[45,117],"in":[46,89,118,148,186,231,241],"volume":[48,120,185],"CBF":[50,122,210],"mediated":[51,123,227],"included":[61],"1012":[62],"adult":[63],"participants":[64],"from":[65,74],"Kailuan":[67],"study.":[68],"Cumulative":[69],"exposure":[71],"was":[72,112],"calculated":[73],"2006":[75],"2020.":[77,90],"Brain":[78],"MRI":[79],"scans":[80],"Montreal":[83],"Cognitive":[84],"Assessment":[85],"(MoCA)":[86],"were":[87,95,143,181,203,226],"performed":[88,113],"Generalized":[91],"linear":[92],"regression":[93],"models":[94],"used":[96],"investigate":[98],"associations":[100,219],"BP,":[103],"CBF,":[106],"function.":[109,250],"Mediation":[110],"analysis":[111],"examine":[115],"Compared":[132],"with":[133,145,183,205],"lowest":[135],"tertiles,":[136],"highest":[138,176],"tertiles":[139,177],"of":[140,178],"SBP":[142,200],"associated":[144,182,204],"lower":[146,184,206],"volumes":[147,230],"total":[149,154,207,232],"(-9.11":[151],"[-16.25,":[152],"-1.97]),":[153],"GM":[155],"(-5.53":[156],"[-10.02,":[157],"-1.04]),":[158],"frontal":[159,187,234],"lobe":[160,165,188,194,235],"(-2.46":[161],"[-4.15,":[162],"-0.78]),":[163],"temporal":[164,193,237],"(-1.37":[166],"[-2.51,":[167],"-0.23])":[168],"hippocampus":[170],"(-0.15":[171],"[-0.26,":[172],"-0.03]),":[173],"DBP":[180,202,222],"(-2.33":[189],"[-3.98,":[190],"-0.68])":[191],"(-1.15":[195],"[-2.27,":[196],"-0.04]).":[197],"Higher":[198],"regional":[209],"MoCA":[212],"scores":[213],"(all":[214],"P":[215],"<":[216],"0.05).":[217],"The":[218],"decline":[225],"by":[228],"GM,":[233],"lobe.":[238],"Early":[239],"intervention":[240],"may":[244],"help":[245],"preserve":[246]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-14T00:00:00"}