{"id":"https://openalex.org/W7123599526","doi":"https://doi.org/10.5500/wjt.v16.i1.114044","title":"Preformed vs de novo anti-human leukocyte antigens-DQ antibodies in kidney transplantation: A retrospective study","display_name":"Preformed vs de novo anti-human leukocyte antigens-DQ antibodies in kidney transplantation: A retrospective study","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7123599526","doi":"https://doi.org/10.5500/wjt.v16.i1.114044","pmid":"https://pubmed.ncbi.nlm.nih.gov/41607818"},"language":"en","primary_location":{"id":"doi:10.5500/wjt.v16.i1.114044","doi":"https://doi.org/10.5500/wjt.v16.i1.114044","is_oa":true,"landing_page_url":"https://doi.org/10.5500/wjt.v16.i1.114044","pdf_url":"https://rcastoragev2.blob.core.windows.net/164bfe08804af53a0d1768f22698b420/PMC4407941.pdf","source":{"id":"https://openalex.org/S2764518715","display_name":"World Journal of Transplantation","issn_l":"2220-3230","issn":["2220-3230"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rcastoragev2.blob.core.windows.net/164bfe08804af53a0d1768f22698b420/PMC4407941.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122937312","display_name":"Oumaima Guissouss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151823","display_name":"Institut Pasteur du Maroc","ror":"https://ror.org/04yb4j419","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210151823"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Oumaima Guissouss","raw_affiliation_strings":["Faculty of Sciences Ain Chock, Laboratory of Integrative Biology, University Hassan II, Casablanca 20100, Morocco","Histocompatibility Laboratory, Institute Pasteur of Morocco, Casablanca 20360, Morocco. oumayma.guissouss1@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Sciences Ain Chock, Laboratory of Integrative Biology, University Hassan II, Casablanca 20100, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"Histocompatibility Laboratory, Institute Pasteur of Morocco, Casablanca 20360, Morocco. oumayma.guissouss1@gmail.com","institution_ids":["https://openalex.org/I4210151823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122970004","display_name":"Khalid Achiaou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151823","display_name":"Institut Pasteur du Maroc","ror":"https://ror.org/04yb4j419","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210151823"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Khalid Achiaou","raw_affiliation_strings":["Histocompatibility Laboratory, Institute Pasteur of Morocco, Casablanca 20360, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histocompatibility Laboratory, Institute Pasteur of Morocco, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I4210151823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085244362","display_name":"Joumana El Turk","orcid":"https://orcid.org/0009-0007-8134-206X","observed_orcids":["https://orcid.org/0009-0007-8134-206X"]},"institutions":[{"id":"https://openalex.org/I4210095535","display_name":"Universit\u00e9 Internationale de Casablanca","ror":"https://ror.org/00nvwb533","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210095535"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Joumana El Turk","raw_affiliation_strings":["Faculty of Health Sciences, Health Sciences Research Laboratory, International University of Casablanca, Casablanca 50169, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Health Sciences Research Laboratory, International University of Casablanca, Casablanca 50169, Morocco","institution_ids":["https://openalex.org/I4210095535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117662730","display_name":"Asmaa Mourachid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Asmaa Mourachid","raw_affiliation_strings":["Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093466624","display_name":"Abdelhadi Cheggali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Abdelhadi Cheggali","raw_affiliation_strings":["Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040683238","display_name":"G. Medkouri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ghislaine Medkouri","raw_affiliation_strings":["Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020500016","display_name":"B. Ramdani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Benyounes Ramdani","raw_affiliation_strings":["Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091265366","display_name":"Mohammed Benghanem Gharbi","orcid":"https://orcid.org/0000-0003-2209-4071","observed_orcids":["https://orcid.org/0000-0003-2209-4071"]},"institutions":[{"id":"https://openalex.org/I4210138534","display_name":"Centre Hospitalier Universitaire Ibn Rochd","ror":"https://ror.org/03sbc8x80","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210138534"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mohammed Benghanem Gharbi","raw_affiliation_strings":["Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Dialysis, and Kidney Transplantation, Ibn Rochd University Hospital Center, Casablanca 20250, Morocco","institution_ids":["https://openalex.org/I4210138534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059424437","display_name":"Majda Taoudi Benchekroun","orcid":"https://orcid.org/0009-0001-8940-8787","observed_orcids":["https://orcid.org/0009-0001-8940-8787"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Majda Taoudi Benchekroun","raw_affiliation_strings":["Faculty of Sciences Ain Chock, Laboratory of Integrative Biology, University Hassan II, Casablanca 20100, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Sciences Ain Chock, Laboratory of Integrative Biology, University Hassan II, Casablanca 20100, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001819626","display_name":"Siham Bennani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151823","display_name":"Institut Pasteur du Maroc","ror":"https://ror.org/04yb4j419","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210151823"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Siham Bennani","raw_affiliation_strings":["Histocompatibility Laboratory, Institute Pasteur of Morocco, Casablanca 20360, Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Histocompatibility Laboratory, Institute Pasteur of Morocco, Casablanca 20360, Morocco","institution_ids":["https://openalex.org/I4210151823"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.969,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.92141163,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"16","issue":"1","first_page":"114044","last_page":"114044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11163","display_name":"Organ Donation and Transplantation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donor-specific-antibodies","display_name":"donor-specific antibodies","score":0.8479999899864197},{"id":"https://openalex.org/keywords/hla-dq","display_name":"HLA-DQ","score":0.8460000157356262},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antibody-mediated-rejection","display_name":"antibody-mediated rejection","score":0.9210000038146973},{"id":"https://openalex.org/keywords/preformed-antibodies","display_name":"preformed antibodies","score":0.5759999752044678},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.550000011920929},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7649999856948853},{"id":"https://openalex.org/keywords/graft-function","display_name":"graft function","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8707000017166138},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7893000245094299},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5274999737739563},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5070000290870667},{"id":"https://openalex.org/C3019514911","wikidata":"https://www.wikidata.org/wiki/Q48928650","display_name":"Donor specific antibodies","level":4,"score":0.5034000277519226},{"id":"https://openalex.org/C2994498544","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplant","level":4,"score":0.4999000132083893},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.48559999465942383},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4607999920845032},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4401000142097473},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.38350000977516174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38260000944137573},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3070000112056732},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.301800012588501},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2856999933719635},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C2778430493","wikidata":"https://www.wikidata.org/wiki/Q6085242","display_name":"Isoantibodies","level":3,"score":0.2563999891281128}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5500/wjt.v16.i1.114044","doi":"https://doi.org/10.5500/wjt.v16.i1.114044","is_oa":true,"landing_page_url":"https://doi.org/10.5500/wjt.v16.i1.114044","pdf_url":"https://rcastoragev2.blob.core.windows.net/164bfe08804af53a0d1768f22698b420/PMC4407941.pdf","source":{"id":"https://openalex.org/S2764518715","display_name":"World Journal of Transplantation","issn_l":"2220-3230","issn":["2220-3230"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Transplantation","raw_type":"journal-article"},{"id":"pmid:41607818","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41607818","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12836199","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41607818/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World J Transplant","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.5500/wjt.v16.i1.114044","doi":"https://doi.org/10.5500/wjt.v16.i1.114044","is_oa":true,"landing_page_url":"https://doi.org/10.5500/wjt.v16.i1.114044","pdf_url":"https://rcastoragev2.blob.core.windows.net/164bfe08804af53a0d1768f22698b420/PMC4407941.pdf","source":{"id":"https://openalex.org/S2764518715","display_name":"World Journal of Transplantation","issn_l":"2220-3230","issn":["2220-3230"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4737076163291931}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7123599526.pdf","grobid_xml":"https://content.openalex.org/works/W7123599526.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W133101211","https://openalex.org/W1970684747","https://openalex.org/W1975206040","https://openalex.org/W1995815906","https://openalex.org/W2042021216","https://openalex.org/W2051792863","https://openalex.org/W2089851051","https://openalex.org/W2135867242","https://openalex.org/W2299693824","https://openalex.org/W2402722787","https://openalex.org/W2591904632","https://openalex.org/W2592185057","https://openalex.org/W2859605380","https://openalex.org/W3027708783","https://openalex.org/W3040717224","https://openalex.org/W3092222556","https://openalex.org/W4315630222","https://openalex.org/W4377565225","https://openalex.org/W4385237772","https://openalex.org/W4388002801"],"related_works":[],"abstract_inverted_index":{"BACKGROUND":[0],"Donor-specific":[1],"antibodies":[2,65,80],"(DSAs)":[3],"against":[4],"human":[5],"leukocyte":[6],"antigen":[7,86],"(HLA)-DQ":[8],"are":[9,188],"increasingly":[10],"recognized":[11],"as":[12],"major":[13],"contributors":[14],"to":[15,117,168,190],"antibody-mediated":[16],"rejection":[17],"(AMR)":[18],"and":[19,38,55,68,89,98,130,178,276,287],"graft":[20,93,133,230,281],"failure":[21],"in":[22,31,43,140,173,182,248],"kidney":[23,45,59,250],"transplantation.":[24,78],"However,":[25],"their":[26],"clinical":[27,56,90,193,243],"impact":[28,194],"remains":[29],"understudied":[30],"Morocco.":[32],"AIM":[33],"To":[34],"evaluate":[35],"the":[36,52,104,141,151,192,242],"presence":[37],"implications":[39],"of":[40,58,100,153,175,180,195,245],"anti-HLA-DQ":[41,72,123,156,246],"DSAs":[42,73,124,157,247,255,265],"Moroccan":[44,249],"transplant":[46,60,251],"recipients.":[47,252],"METHODS":[48],"We":[49],"retrospectively":[50],"analyzed":[51],"immunological":[53],"profiles":[54],"outcomes":[57,282],"recipients":[61],"screened":[62],"for":[63],"anti-HLA":[64],"between":[66],"2015":[67],"2020,":[69],"who":[70],"developed":[71,200,216],"either":[74],"before":[75],"or":[76],"after":[77,211,222,232],"Anti-HLA":[79],"were":[81],"identified":[82],"using":[83],"Luminex\u00ae":[84],"single":[85],"bead":[87],"technology,":[88],"follow-up":[91],"included":[92],"function":[94,134,231],"assessment,":[95],"biopsy":[96],"interpretation,":[97],"evaluation":[99],"immunosuppression.":[101,137],"RESULTS":[102],"In":[103,138],"pre-transplant":[105],"group":[106,143],"(n":[107,144],"=":[108,145],"6":[109,146,176],"with":[110,115,147,161,163,170,208,256,268],"confirmed":[111,148],"donor":[112,149,289],"typing),":[113,150],"patients":[114],"low":[116,257],"moderate":[118],"median":[119],"fluorescence":[120],"intensity":[121],"(MFI)":[122],"(MFI":[125,206],"561-1581)":[126],"underwent":[127],"successful":[128,261],"transplantation":[129],"maintained":[131,228],"stable":[132,229],"under":[135],"optimized":[136],"contrast,":[139],"post-transplant":[142],"emergence":[152],"de":[154,203,219,263],"novo":[155,204,220,264],"was":[158],"consistently":[159],"associated":[160],"AMR,":[162],"MFI":[164],"values":[165],"reaching":[166],"up":[167],"19473,":[169],"biopsy-proven":[171],"AMR":[172,181,210,225],"5":[174,212,233],"cases":[177,187],"suspicion":[179],"1":[183],"case.":[184],"Two":[185],"representative":[186],"detailed":[189],"illustrate":[191],"DQ":[196],"DSAs:":[197],"one":[198],"patient":[199],"high-level":[201],"anti-DQB1*02":[202],"DSA":[205,221,274],"12029)":[207],"persistent":[209],"years,":[213],"while":[214],"another":[215],"anti-DQA1*05:":[217],"01":[218],"an":[223],"early":[224,285],"episode":[226],"but":[227],"years":[234],"(creatinine":[235],"1.48":[236],"mg/dL).":[237],"CONCLUSION":[238],"Our":[239],"findings":[240],"underscore":[241],"significance":[244],"While":[253],"preformed":[254],"immunogenicity":[258],"may":[259],"permit":[260],"transplantation,":[262],"strongly":[266],"correlate":[267],"AMR.":[269],"Proactive":[270],"monitoring,":[271],"including":[272],"routine":[273],"screening":[275],"HLA-DQ":[277],"typing,":[278],"could":[279],"improve":[280],"by":[283],"enabling":[284],"intervention":[286],"better":[288],"selection.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-01-14T00:00:00"}