{"id":"https://openalex.org/W7123561002","doi":"https://doi.org/10.1021/acs.macromol.5c03008","title":"pH-Triggered Swelling and Disassembly of Tertiary Amine-Containing Block Copolymer Self-Assemblies: Role of Molecular Weight in Nanocarrier Design","display_name":"pH-Triggered Swelling and Disassembly of Tertiary Amine-Containing Block Copolymer Self-Assemblies: Role of Molecular Weight in Nanocarrier Design","publication_year":2026,"publication_date":"2026-01-13","ids":{"openalex":"https://openalex.org/W7123561002","doi":"https://doi.org/10.1021/acs.macromol.5c03008"},"language":"en","primary_location":{"id":"doi:10.1021/acs.macromol.5c03008","doi":"https://doi.org/10.1021/acs.macromol.5c03008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.macromol.5c03008","pdf_url":null,"source":{"id":"https://openalex.org/S177196338","display_name":"Macromolecules","issn_l":"0024-9297","issn":["0024-9297","1520-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004242655","display_name":"Juthi Pal","orcid":"https://orcid.org/0000-0003-4746-7129","observed_orcids":["https://orcid.org/0000-0003-4746-7129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juthi Pal","raw_affiliation_strings":["Department of Chemistry","Indian Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0003-4746-7129","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rishabh Maity","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rishabh Maity","raw_affiliation_strings":["Department of Chemistry","Indian Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115805060","display_name":"Manisha Khamrai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manisha Khamrai","raw_affiliation_strings":["Department of Chemistry","Indian Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082151065","display_name":"Dibakar Dhara","orcid":"https://orcid.org/0000-0003-2574-5378","observed_orcids":["https://orcid.org/0000-0003-2574-5378"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dibakar Dhara","raw_affiliation_strings":["Department of Chemistry","Indian Institute of Technology"],"raw_orcid":"https://orcid.org/0000-0003-2574-5378","affiliations":[{"raw_affiliation_string":"Department of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Indian Institute of Technology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082151065"],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01507359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":"2","first_page":"879","last_page":"893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ph-sensitive-polymers","display_name":"pH-responsive polymers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/polymer-self-assembly","display_name":"polymer self-assembly","score":0.6919999718666077},{"id":"https://openalex.org/keywords/nanoparticle-swelling","display_name":"nanoparticle swelling","score":0.7900000214576721},{"id":"https://openalex.org/keywords/molecular-weight-effects","display_name":"molecular weight effects","score":0.8889999985694885},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7789999842643738},{"id":"https://openalex.org/keywords/nanocarriers","display_name":"nanocarriers","score":0.7269999980926514},{"id":"https://openalex.org/keywords/2-diethylamino-ethyl-methacrylate","display_name":"2-(diethylamino)ethyl methacrylate","score":0.8790000081062317},{"id":"https://openalex.org/keywords/thermoresponsive-polymers","display_name":"thermoresponsive polymers","score":0.7459999918937683},{"id":"https://openalex.org/keywords/dual-stimuli-responsive-materials","display_name":"dual stimuli-responsive materials","score":0.5899999737739563},{"id":"https://openalex.org/keywords/raft-polymerization","display_name":"RAFT polymerization","score":0.6959999799728394},{"id":"https://openalex.org/keywords/post-polymerization-modification","display_name":"post-polymerization modification","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.9108999967575073},{"id":"https://openalex.org/C2778540859","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Swelling","level":2,"score":0.8561999797821045},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.7215999960899353},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.7010999917984009},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6624000072479248},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6556000113487244},{"id":"https://openalex.org/C132050475","wikidata":"https://www.wikidata.org/wiki/Q736232","display_name":"Methacrylate","level":4,"score":0.6047000288963318},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.5157999992370605},{"id":"https://openalex.org/C9132879","wikidata":"https://www.wikidata.org/wiki/Q17100313","display_name":"Raft","level":4,"score":0.5076000094413757},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.5016999840736389},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.47769999504089355},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.39640000462532043},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3856000006198883},{"id":"https://openalex.org/C121120078","wikidata":"https://www.wikidata.org/wiki/Q3737603","display_name":"Chain transfer","level":5,"score":0.364300012588501},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.32190001010894775},{"id":"https://openalex.org/C188109995","wikidata":"https://www.wikidata.org/wiki/Q1645085","display_name":"Lower critical solution temperature","level":4,"score":0.31859999895095825},{"id":"https://openalex.org/C34594497","wikidata":"https://www.wikidata.org/wiki/Q639983","display_name":"Reversible addition\u2212fragmentation chain-transfer polymerization","level":5,"score":0.30559998750686646},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30329999327659607},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2946999967098236},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C62773188","wikidata":"https://www.wikidata.org/wiki/Q425113","display_name":"Smart polymer","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C51115888","wikidata":"https://www.wikidata.org/wiki/Q7226568","display_name":"Polymersome","level":5,"score":0.2689000070095062},{"id":"https://openalex.org/C134424308","wikidata":"https://www.wikidata.org/wiki/Q4119000","display_name":"Nanogel","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.26010000705718994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.macromol.5c03008","doi":"https://doi.org/10.1021/acs.macromol.5c03008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.macromol.5c03008","pdf_url":null,"source":{"id":"https://openalex.org/S177196338","display_name":"Macromolecules","issn_l":"0024-9297","issn":["0024-9297","1520-5835"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-3","ki-jl-1","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Macromolecules","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4736649990081787,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2866873809","display_name":null,"funder_award_id":"CRG/2023/006124","funder_id":"https://openalex.org/F4320334771","funder_display_name":"Science and Engineering Research Board"}],"funders":[{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320325536","display_name":"Indian Institute of Technology Kharagpur","ror":"https://ror.org/03w5sq511"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1988155694","https://openalex.org/W2003390427","https://openalex.org/W2013982530","https://openalex.org/W2014414042","https://openalex.org/W2015593851","https://openalex.org/W2016252278","https://openalex.org/W2027001623","https://openalex.org/W2036725443","https://openalex.org/W2064370290","https://openalex.org/W2070836823","https://openalex.org/W2090438105","https://openalex.org/W2163970592","https://openalex.org/W2171936962","https://openalex.org/W2214947942","https://openalex.org/W2288268375","https://openalex.org/W2318144700","https://openalex.org/W2328572315","https://openalex.org/W2471312355","https://openalex.org/W2491078374","https://openalex.org/W2535626139","https://openalex.org/W2549125599","https://openalex.org/W2552739997","https://openalex.org/W2553034650","https://openalex.org/W2619114252","https://openalex.org/W2623661023","https://openalex.org/W2753988495","https://openalex.org/W2769927701","https://openalex.org/W2808667306","https://openalex.org/W2918733447","https://openalex.org/W2950742071","https://openalex.org/W3003425423","https://openalex.org/W3004826148","https://openalex.org/W3008855879","https://openalex.org/W3008871374","https://openalex.org/W3009701618","https://openalex.org/W3115341634","https://openalex.org/W3182117133","https://openalex.org/W3215029072","https://openalex.org/W4221030462","https://openalex.org/W4223557203","https://openalex.org/W4280567827","https://openalex.org/W4293463061","https://openalex.org/W4321795760","https://openalex.org/W4324101995","https://openalex.org/W4372346323","https://openalex.org/W4381951193","https://openalex.org/W4386092596","https://openalex.org/W4388705474","https://openalex.org/W4400956300"],"related_works":[],"abstract_inverted_index":{"pH-responsive":[0,115],"polymers":[1,40,182,231],"constitute":[2],"an":[3],"important":[4],"nanocarrier":[5],"system":[6],"for":[7,67,109,219],"tumor-targeted":[8,224],"drug":[9,14,69,226],"delivery":[10,227],"as":[11],"they":[12],"enable":[13],"release":[15],"either":[16],"through":[17],"nanoparticle":[18],"swelling":[19,84,200],"or":[20,46,201],"by":[21,235],"complete":[22],"disintegration":[23],"in":[24],"response":[25],"to":[26,56],"the":[27,110,220,230],"acidic":[28,191],"environment":[29],"of":[30,99,113,125,157,169,222],"cancer":[31],"cells":[32],"and":[33,64,142,164,172,187,214,237],"tissues.":[34],"Within":[35],"this":[36,119],"class,":[37],"tertiary":[38],"amine-containing":[39],"bearing":[41],"2-(diethylamino)":[42],"ethyl":[43,48],"methacrylate":[44,49],"(DEAEMA)":[45],"2-(azepan-1-yl)":[47],"(AEMA)":[50],"units":[51],"are":[52],"widely":[53],"used":[54],"due":[55],"their":[57,72,170,241],"physiologically":[58],"relevant":[59],"p":[60],"K":[61],"a":[62,106,123,207],"values":[63],"strong":[65],"potential":[66],"size-tunable":[68],"delivery.":[70],"Despite":[71],"popularity,":[73],"inconsistent":[74],"behaviors":[75],"have":[76],"been":[77],"reported,":[78],"with":[79],"some":[80],"systems":[81],"exhibiting":[82],"predominant":[83],"at":[85,190],"tumor":[86],"extracellular":[87],"pH":[88,236],"levels":[89],"(6.5\u20136.8),":[90],"while":[91],"others":[92],"undergo":[93,183],"spontaneous":[94],"disassembly.":[95,203],"The":[96],"mechanistic":[97],"origins":[98],"these":[100],"contrasting":[101],"responses":[102],"remain":[103],"unclear,":[104],"posing":[105],"critical":[107],"challenge":[108],"rational":[111],"design":[112,217],"reproducible,":[114],"nanocarriers.":[116],"To":[117],"address":[118],"gap,":[120],"we":[121],"synthesized":[122],"series":[124],"[poly(ethylene":[126,143],"glycol)":[127,144],"monoethyl":[128,145],"ether]":[129,146],"5k":[130,138,147,153],"-":[131,139,148,154],"b":[132,140,149,155],"-poly[(2-(azepan-1-yl)ethyl":[133],"acrylate)":[134],"x":[135],"]":[136],"(PEG":[137,152],"-PAEA)":[141],"-poly[(2-(diethylamino)ethyl":[150],"methacrylate)y]":[151],"-PDEAEMA)":[156],"varying":[158],"molecular":[159,208,238],"weights":[160],"via":[161],"RAFT":[162],"polymerization":[163],"postpolymerization":[165],"modification.":[166],"Systematic":[167],"evaluation":[168],"transmittance":[171],"hydrodynamic":[173],"diameter":[174],"revealed":[175],"that":[176,211],"self-assembled":[177],"nanostructures":[178],"from":[179],"higher":[180],"molecular-weight":[181,195],"rapid":[184],"structural":[185],"reorganization":[186],"efficient":[188],"disassembly":[189],"pH,":[192],"whereas":[193],"lower":[194],"analogs":[196],"exhibit":[197],"only":[198],"limited":[199],"partial":[202],"These":[204],"results":[205],"implied":[206],"weight":[209],"threshold":[210],"governs":[212],"pH-responsiveness":[213],"provides":[215],"fundamental":[216],"strategies":[218],"manufacturing":[221],"size-tunable,":[223],"polymeric":[225],"systems.":[228],"Additionally,":[229],"showed":[232],"thermoresponsiveness":[233],"modulated":[234],"weight,":[239],"highlighting":[240],"dual":[242],"stimuli-responsive":[243],"capability.":[244]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-01-14T00:00:00"}
