{"id":"https://openalex.org/W7123418367","doi":"https://doi.org/10.3389/fruro.2025.1720445","title":"A hybrid combination of in vitro cultured buccal mucosal cells using two different methodologies, complementing each other in successfully repairing a stricture-inflicted human male urethral epithelium","display_name":"A hybrid combination of in vitro cultured buccal mucosal cells using two different methodologies, complementing each other in successfully repairing a stricture-inflicted human male urethral epithelium","publication_year":2026,"publication_date":"2026-01-14","ids":{"openalex":"https://openalex.org/W7123418367","doi":"https://doi.org/10.3389/fruro.2025.1720445","pmid":"https://pubmed.ncbi.nlm.nih.gov/41613370","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12846977"},"language":"en","primary_location":{"id":"doi:10.3389/fruro.2025.1720445","doi":"https://doi.org/10.3389/fruro.2025.1720445","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fruro.2025.1720445","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/urology/articles/10.3389/fruro.2025.1720445/pdf","source":{"id":"https://openalex.org/S4210224467","display_name":"Frontiers in Urology","issn_l":"2673-9828","issn":["2673-9828"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/urology/articles/10.3389/fruro.2025.1720445/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039473258","display_name":"Akio Horiguchi","orcid":"https://orcid.org/0000-0002-7678-6375","observed_orcids":["https://orcid.org/0000-0002-7678-6375"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akio Horiguchi","raw_affiliation_strings":["Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103054717","display_name":"Toshihiro Kushibiki","orcid":"https://orcid.org/0000-0002-1705-1467","observed_orcids":["https://orcid.org/0000-0002-1705-1467"]},"institutions":[{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshihiro Kushibiki","raw_affiliation_strings":["Department of Medical Engineering, National Defence Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Engineering, National Defence Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071733151","display_name":"Yoshine Mayumi","orcid":"https://orcid.org/0000-0003-1741-8385","observed_orcids":["https://orcid.org/0000-0003-1741-8385"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayumi Yoshine","raw_affiliation_strings":["Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003716933","display_name":"Masayuki Shinchi","orcid":"https://orcid.org/0000-0002-5860-6318","observed_orcids":["https://orcid.org/0000-0002-5860-6318"]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Shinchi","raw_affiliation_strings":["Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086157165","display_name":"Kenichiro Ojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenichiro Ojima","raw_affiliation_strings":["Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108813378","display_name":"Yusuke Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087193","display_name":"National Defense Medical College Hospital","ror":"https://ror.org/004ej3g52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087193"]},{"id":"https://openalex.org/I53888640","display_name":"National Defense Medical College","ror":"https://ror.org/02e4qbj88","country_code":"JP","type":"education","lineage":["https://openalex.org/I53888640"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Hirano","raw_affiliation_strings":["Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, National Defence Medical College, Tokorozawa, Saitama, Japan","institution_ids":["https://openalex.org/I4210087193","https://openalex.org/I53888640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085716436","display_name":"Shojiro Katoh","orcid":"https://orcid.org/0000-0002-8355-9074","observed_orcids":["https://orcid.org/0000-0002-8355-9074"]},"institutions":[{"id":"https://openalex.org/I4210146857","display_name":"Edogawa Hospital","ror":"https://ror.org/05gw5ee29","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210146857"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shojiro Katoh","raw_affiliation_strings":["Edogawa Evolutionary Lab of Science (EELS), 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan","Edogawa Hospital, 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Edogawa Evolutionary Lab of Science (EELS), 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"Edogawa Hospital, 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan","institution_ids":["https://openalex.org/I4210146857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101549134","display_name":"Masaru Iwasaki","orcid":"https://orcid.org/0000-0003-3766-8744","observed_orcids":["https://orcid.org/0000-0003-3766-8744"]},"institutions":[{"id":"https://openalex.org/I4210112011","display_name":"University of Yamanashi Hospital","ror":"https://ror.org/022tqjv17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112011"]},{"id":"https://openalex.org/I66906201","display_name":"University of Yamanashi","ror":"https://ror.org/059x21724","country_code":"JP","type":"education","lineage":["https://openalex.org/I66906201"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Iwasaki","raw_affiliation_strings":["Center for Advancing Clinical Research (CACR), University of Yamanashi - Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi 409-3898, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advancing Clinical Research (CACR), University of Yamanashi - Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi 409-3898, Japan","institution_ids":["https://openalex.org/I4210112011","https://openalex.org/I66906201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034076820","display_name":"Vaddi Surya Prakash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129842","display_name":"Yashoda Hospital","ror":"https://ror.org/03gd0pk10","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210129842"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vaddi Surya Prakash","raw_affiliation_strings":["Department of Urology, Yashoda Hospitals, Raj Bhavan Rd, Matha Nagar, Somajiguda, Hyderabad, Telangana 500082, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Yashoda Hospitals, Raj Bhavan Rd, Matha Nagar, Somajiguda, Hyderabad, Telangana 500082, India","institution_ids":["https://openalex.org/I4210129842"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042443133","display_name":"Koji Ichiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koji Ichiyama","raw_affiliation_strings":["Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan","R&D Division, JBM Inc., 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan","institution_ids":[]},{"raw_affiliation_string":"R&D Division, JBM Inc., 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088537100","display_name":"Rajappa Senthilkumar","orcid":"https://orcid.org/0000-0002-9568-7639","observed_orcids":["https://orcid.org/0000-0002-9568-7639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajappa Senthilkumar","raw_affiliation_strings":["Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan","R&D Division, JBM Inc., 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan","The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Chennai 600034, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan","institution_ids":[]},{"raw_affiliation_string":"R&D Division, JBM Inc., 2-24-18, Higashi-Koiwa, Edogawa, Tokyo 133-0052, Japan","institution_ids":[]},{"raw_affiliation_string":"The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Chennai 600034, Tamil Nadu, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043676052","display_name":"Senthilkumar Preethy","orcid":"https://orcid.org/0000-0002-9333-0361","observed_orcids":["https://orcid.org/0000-0002-9333-0361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senthilkumar Preethy","raw_affiliation_strings":["The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Chennai 600034, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), PB 1262, Chennai 600034, Tamil Nadu, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122933119","display_name":"Samuel J. K. Abraham","orcid":"https://orcid.org/0000-0003-2646-2687","observed_orcids":["https://orcid.org/0000-0003-2646-2687"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Samuel JK Abraham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2646-2687","affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5122933119"],"corresponding_institution_ids":[],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":4.3566,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.87548015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"5","issue":null,"first_page":"1720445","last_page":"1720445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.1454000025987625,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urethral-stricture","display_name":"urethral stricture","score":0.9620000123977661},{"id":"https://openalex.org/keywords/thermosensitive-hydrogel","display_name":"thermosensitive hydrogel","score":0.6299999952316284},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.8859999775886536},{"id":"https://openalex.org/keywords/monolayer-culture","display_name":"monolayer culture","score":0.8880000114440918},{"id":"https://openalex.org/keywords/fibroblast-like-cells","display_name":"fibroblast-like cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/epithelial-phenotype","display_name":"epithelial phenotype","score":0.8180000185966492},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9089999794960022},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.871999979019165},{"id":"https://openalex.org/keywords/autologous-cell-therapy","display_name":"autologous cell therapy","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7128999829292297},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.6229000091552734},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6046000123023987},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5166000127792358},{"id":"https://openalex.org/C195735259","wikidata":"https://www.wikidata.org/wiki/Q16963239","display_name":"Buccal administration","level":2,"score":0.4765999913215637},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4505999982357025},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44850000739097595},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39890000224113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39629998803138733},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36399999260902405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34630000591278076},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3248000144958496},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2736000120639801}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fruro.2025.1720445","doi":"https://doi.org/10.3389/fruro.2025.1720445","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fruro.2025.1720445","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/urology/articles/10.3389/fruro.2025.1720445/pdf","source":{"id":"https://openalex.org/S4210224467","display_name":"Frontiers in Urology","issn_l":"2673-9828","issn":["2673-9828"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Urology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.08.29.555240","doi":"https://doi.org/10.1101/2023.08.29.555240","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.08.29.555240","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/30/2023.08.29.555240.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41613370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41613370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in urology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12846977","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12846977/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Urol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e0ad032eda1148b99a00042aa172e69b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e0ad032eda1148b99a00042aa172e69b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Urology, Vol 5 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fruro.2025.1720445","doi":"https://doi.org/10.3389/fruro.2025.1720445","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fruro.2025.1720445","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/urology/articles/10.3389/fruro.2025.1720445/pdf","source":{"id":"https://openalex.org/S4210224467","display_name":"Frontiers in Urology","issn_l":"2673-9828","issn":["2673-9828"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Urology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334647","display_name":"ESRC National Centre for Research Methods, University of Southampton","ror":"https://ror.org/027q2tw68"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7123418367.pdf","grobid_xml":"https://content.openalex.org/works/W7123418367.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1524363703","https://openalex.org/W1939325234","https://openalex.org/W2002280796","https://openalex.org/W2019759781","https://openalex.org/W2062847462","https://openalex.org/W2072641766","https://openalex.org/W2100171779","https://openalex.org/W2118007244","https://openalex.org/W2118596455","https://openalex.org/W2119491151","https://openalex.org/W2123630792","https://openalex.org/W2127296180","https://openalex.org/W2140184205","https://openalex.org/W2185622766","https://openalex.org/W2260036449","https://openalex.org/W2746323662","https://openalex.org/W2810158158","https://openalex.org/W2810278363","https://openalex.org/W2901474568","https://openalex.org/W2904465258","https://openalex.org/W2917046652","https://openalex.org/W2953976941","https://openalex.org/W2975094058","https://openalex.org/W3021540403","https://openalex.org/W3138477069","https://openalex.org/W3168859317","https://openalex.org/W4200232884","https://openalex.org/W4220899727","https://openalex.org/W4307454555","https://openalex.org/W4322617164","https://openalex.org/W4366527119","https://openalex.org/W4383368651","https://openalex.org/W4416770075","https://openalex.org/W7117243028"],"related_works":["https://openalex.org/W3168859317","https://openalex.org/W4200232884","https://openalex.org/W4225254923","https://openalex.org/W3110703468","https://openalex.org/W1997027614","https://openalex.org/W2901474568","https://openalex.org/W2407857930","https://openalex.org/W7161994582","https://openalex.org/W2010321350","https://openalex.org/W2072641766"],"abstract_inverted_index":{"Background":[0],"Autologous":[1],"buccal":[2,44,91],"mucosa":[3],"cell":[4,24,234],"transplantation":[5,218],"has":[6,19],"emerged":[7],"as":[8,179],"a":[9,162,190,216],"promising":[10],"treatment":[11],"strategy":[12],"for":[13,115,120,242],"urethral":[14,32,53,62],"stricture":[15,54],"disease.":[16],"However,":[17],"ambiguity":[18],"persisted":[20],"regarding":[21],"the":[22,43,71,102,107,169,184,196,207,222],"optimal":[23],"type":[25],"and":[26,47,60,81,106,118,175,198,244,248],"culture":[27],"conditions":[28],"that":[29],"aid":[30],"successful":[31,180,223],"repair.":[33],"Clinical":[34],"study":[35],"of":[36,74,172,183,192,200,210],"our":[37],"previously":[38],"reported":[39,226],"cell-based":[40],"endoscopic":[41],"approach,":[42],"epithelium":[45],"expanded":[46],"encapsulated":[48],"in":[49,96,109,152,215,227],"scaffold-hybrid":[50],"approach":[51,73,241],"to":[52,137,238],"(BEES-HAUS),":[55],"demonstrated":[56],"durable":[57],"epithelial":[58,131,173,204],"regeneration":[59],"long-term":[61],"patency.":[63],"The":[64],"present":[65],"work":[66],"provides":[67],"mechanistic":[68],"insights":[69],"supporting":[70],"BEES-HAUS":[72,185],"combining":[75,201],"two-dimensional":[76],"(2D)":[77],"monolayer-cultured":[78],"fibroblast-like":[79,144,213],"cells":[80,128,205,214],"three-dimensional":[82],"(3D)":[83],"thermo-responsive":[84],"gelation":[85],"polymer":[86],"(Festigel)-cultured":[87],"cells.":[88,146],"Methods":[89],"Human":[90],"tissues":[92,247],"(n=22)":[93],"were":[94,122],"cultured":[95],"two":[97],"methods;":[98],"one":[99],"portion":[100],"using":[101,111],"monolayer":[103],"method":[104],"(2D),":[105],"other":[108,246],"3D":[110,126,156,202],"Festigel.":[112],"Flow":[113],"cytometry":[114],"phenotype":[116],"markers":[117],"ELISA":[119],"IGF-1":[121,147],"carried":[123],"out.":[124],"Results":[125],"Festigel-cultured":[127],"acquired":[129],"an":[130],"phenotype,":[132],"with":[133,206],"AE1/AE3":[134],"expression":[135],"up":[136],"day":[138],"21,":[139],"while":[140],"2D":[141,153,212],"cultures":[142,154],"yielded":[143],"CD140b-positive/AE1-AE3\u2013negative":[145],"secretion":[148],"was":[149],"significantly":[150],"higher":[151],"than":[155],"Festigel":[157],"(p":[158],"<":[159],"0.05),":[160],"indicating":[161],"supportive":[163],"paracrine":[164,208],"role.":[165],"These":[166],"findings":[167],"explain":[168],"complementary":[170],"contribution":[171],"integration":[174],"IGF-1\u2013mediated":[176],"support":[177],"observed":[178],"clinical":[181,224],"outcome":[182],"procedure.":[186],"Conclusion":[187],"This":[188],"study,":[189],"first":[191],"its":[193],"kind,":[194],"clarifies":[195],"rationale":[197],"advantages":[199],"Festigel-expanded":[203],"effect":[209],"IGF-1-secreting":[211],"single":[217],"strategy,":[219],"thereby":[220],"explaining":[221],"outcomes":[225],"BEES-HAUS.":[228],"Further":[229],"research":[230],"on":[231],"this":[232,240],"hybrid":[233],"combination":[235],"is":[236],"recommended":[237],"expand":[239],"regenerating":[243],"repairing":[245],"organs.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-01-14T00:00:00"}