{"id":"https://openalex.org/W7123335747","doi":"https://doi.org/10.22336/rjo.2025.89","title":"Lung metastasis with primary conjunctival mucoepidermoid carcinoma","display_name":"Lung metastasis with primary conjunctival mucoepidermoid carcinoma","publication_year":2025,"publication_date":"2025-12-29","ids":{"openalex":"https://openalex.org/W7123335747","doi":"https://doi.org/10.22336/rjo.2025.89","pmid":"https://pubmed.ncbi.nlm.nih.gov/41971202","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13065113"},"language":"en","primary_location":{"id":"doi:10.22336/rjo.2025.89","doi":"https://doi.org/10.22336/rjo.2025.89","is_oa":false,"landing_page_url":"https://doi.org/10.22336/rjo.2025.89","pdf_url":null,"source":{"id":"https://openalex.org/S4210175898","display_name":"Romanian Journal of Ophthalmology","issn_l":"2457-4325","issn":["2457-4325","2501-2533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40"],"host_organization":"https://openalex.org/P4310314538","host_organization_name":"Romanian Society of Ophthalmology","host_organization_lineage":["https://openalex.org/P4310314538"],"host_organization_lineage_names":["Romanian Society of Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"romanian journal of ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065113/pdf/RomJOphthalmol-69-580.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125428942","display_name":"Francisco Calleja-Casado","orcid":"https://orcid.org/0000-0002-0367-1446","observed_orcids":["https://orcid.org/0000-0002-0367-1446"]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Calleja-Casado","raw_affiliation_strings":["Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072492485","display_name":"Amparo Lanuza Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Amparo Lanuza-Garc\u00eda","raw_affiliation_strings":["Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079761864","display_name":"Gemma Ortega Prades","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gemma Ortega-Prades","raw_affiliation_strings":["Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090562580","display_name":"Sergio Maugard Tepper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Alfredo Maugard-Tepper","raw_affiliation_strings":["Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109739455","display_name":"Antonio Duch Samper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Duch Samper","raw_affiliation_strings":["Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","University of Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ophthalmology Department, Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I4210094406"]},{"raw_affiliation_string":"University of Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"69","issue":"4","first_page":"580","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11035","display_name":"Salivary Gland Tumors Diagnosis and Treatment","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mucoepidermoid-carcinoma","display_name":"mucoepidermoid carcinoma","score":0.9269999861717224},{"id":"https://openalex.org/keywords/conjunctiva","display_name":"conjunctiva","score":0.9589999914169312},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.968999981880188},{"id":"https://openalex.org/keywords/ocular-surface-squamous-neoplasia","display_name":"ocular surface squamous neoplasia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/orbital-invasion","display_name":"orbital invasion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/deep-biopsy","display_name":"deep biopsy","score":0.609000027179718},{"id":"https://openalex.org/keywords/histopathological-assessment","display_name":"histopathological assessment","score":0.621999979019165},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma-variant","display_name":"squamous cell carcinoma variant","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8586999773979187},{"id":"https://openalex.org/C2780859518","wikidata":"https://www.wikidata.org/wiki/Q2736268","display_name":"Mucoepidermoid carcinoma","level":3,"score":0.7129999995231628},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4717000126838684},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4681999981403351},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3993000090122223},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.3991999924182892},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3815999925136566},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3068000078201294},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.27459999918937683},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.2599000036716461},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.25619998574256897}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003228","descriptor_name":"Conjunctiva","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003230","descriptor_name":"Conjunctival Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003230","descriptor_name":"Conjunctival Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017809","descriptor_name":"Fatal Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018277","descriptor_name":"Carcinoma, Mucoepidermoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018277","descriptor_name":"Carcinoma, Mucoepidermoid","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.22336/rjo.2025.89","doi":"https://doi.org/10.22336/rjo.2025.89","is_oa":false,"landing_page_url":"https://doi.org/10.22336/rjo.2025.89","pdf_url":null,"source":{"id":"https://openalex.org/S4210175898","display_name":"Romanian Journal of Ophthalmology","issn_l":"2457-4325","issn":["2457-4325","2501-2533"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","medline","poland-40"],"host_organization":"https://openalex.org/P4310314538","host_organization_name":"Romanian Society of Ophthalmology","host_organization_lineage":["https://openalex.org/P4310314538"],"host_organization_lineage_names":["Romanian Society of Ophthalmology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"romanian journal of ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13065113","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065113/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065113/pdf/RomJOphthalmol-69-580.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rom J Ophthalmol","raw_type":"Text"},{"id":"pmid:41971202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41971202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of ophthalmology","raw_type":"Case Reports"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13065113","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065113/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13065113/pdf/RomJOphthalmol-69-580.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rom J Ophthalmol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7123335747.pdf","grobid_xml":"https://content.openalex.org/works/W7123335747.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1723723816","https://openalex.org/W2040898081","https://openalex.org/W2048969068","https://openalex.org/W2053736219","https://openalex.org/W2087175295","https://openalex.org/W2092549741","https://openalex.org/W2159965213","https://openalex.org/W2166262029","https://openalex.org/W2620176855","https://openalex.org/W3158582361","https://openalex.org/W4235884706"],"related_works":["https://openalex.org/W1723723816","https://openalex.org/W2062652767","https://openalex.org/W2568621773","https://openalex.org/W2066278999","https://openalex.org/W2334033947","https://openalex.org/W1979530414","https://openalex.org/W2399707462","https://openalex.org/W2532875887","https://openalex.org/W7100994453","https://openalex.org/W2081994551"],"abstract_inverted_index":{"Background:":[0],"Mucoepidermoid":[1,70],"carcinoma":[2,71,169],"of":[3,11,18,72,82,105,143],"the":[4,45,73,141],"conjunctiva":[5,74],"is":[6,75,121],"a":[7,28,112],"rare,":[8,123],"aggressive":[9,80,172],"variant":[10,81],"squamous":[12,85,98],"cell":[13,99],"carcinoma,":[14,100],"with":[15,27,96],"limited":[16],"reports":[17],"systemic":[19,158,175,184],"metastasis.":[20],"Case":[21],"presentation:":[22],"An":[23],"86-year-old":[24],"man":[25],"presented":[26],"suspicious":[29],"conjunctival":[30],"lesion.":[31],"Initial":[32],"biopsy":[33],"was":[34],"inconclusive,":[35],"but":[36,195],"excision":[37],"confirmed":[38,60],"moderately":[39],"differentiated":[40],"mucoepidermoid":[41,168],"carcinoma.":[42],"Despite":[43],"treatment,":[44],"tumor":[46,161],"showed":[47],"rapid":[48],"orbital":[49,109],"invasion.":[50],"Imaging":[51],"later":[52],"revealed":[53],"bilateral":[54],"lung":[55],"and":[56,78,111,133,155,174,183,192],"liver":[57],"metastases.":[58,197],"Cytology":[59],"metastatic":[61],"spread.":[62,117],"The":[63],"patient":[64],"died":[65],"two":[66],"months":[67],"later.":[68],"Discussion:":[69],"an":[76],"uncommon":[77],"particularly":[79],"ocular":[83],"surface":[84],"neoplasia,":[86],"often":[87],"underdiagnosed":[88],"due":[89],"to":[90,147,188],"its":[91],"mixed":[92],"histological":[93,181],"components.":[94],"Compared":[95],"classic":[97],"it":[101],"demonstrates":[102],"higher":[103],"rates":[104],"local":[106,173],"recurrence,":[107],"deeper":[108],"invasion,":[110],"greater":[113],"potential":[114],"for":[115],"regional":[116],"Although":[118],"distant":[119],"metastasis":[120],"exceedingly":[122],"our":[124],"case":[125],"illustrates":[126],"that":[127],"this":[128],"subtype":[129],"may":[130,170],"disseminate":[131],"rapidly":[132],"extensively":[134],"despite":[135],"early":[136,157],"intervention.":[137],"These":[138],"findings":[139],"highlight":[140],"importance":[142],"performing":[144],"deep":[145,178],"biopsies":[146],"avoid":[148],"sampling":[149],"error,":[150],"ensuring":[151],"complete":[152,180],"histopathological":[153],"assessment,":[154],"considering":[156],"imaging":[159,185],"when":[160],"behavior":[162],"appears":[163],"unusually":[164],"aggressive.":[165],"Conclusion:":[166],"Conjunctival":[167],"exhibit":[171],"behavior.":[176],"Early":[177],"biopsy,":[179],"analysis,":[182],"are":[186],"essential":[187],"guide":[189],"appropriate":[190],"management":[191],"detect":[193],"rare":[194],"fatal":[196]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-01-14T00:00:00"}