{"id":"https://openalex.org/W7122778773","doi":"https://doi.org/10.1038/s41596-025-01279-w","title":"Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level","display_name":"Hydrogen/deuterium exchange mass spectrometry analysis of ribosome-nascent chain complexes to study protein biogenesis at the peptide level","publication_year":2026,"publication_date":"2026-01-12","ids":{"openalex":"https://openalex.org/W7122778773","doi":"https://doi.org/10.1038/s41596-025-01279-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41526491","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7619191"},"language":"en","primary_location":{"id":"doi:10.1038/s41596-025-01279-w","doi":"https://doi.org/10.1038/s41596-025-01279-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41596-025-01279-w","pdf_url":null,"source":{"id":"https://openalex.org/S109387254","display_name":"Nature Protocols","issn_l":"1750-2799","issn":["1750-2799","1754-2189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Protocols","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7619191/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067137748","display_name":"Al\u017eb\u011bta Roeselov\u00e1","orcid":"https://orcid.org/0000-0002-0175-6462","observed_orcids":["https://orcid.org/0000-0002-0175-6462"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Al\u017eb\u011bta Roeselov\u00e1","raw_affiliation_strings":["Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":"https://orcid.org/0000-0002-0175-6462","affiliations":[{"raw_affiliation_string":"Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036887188","display_name":"Aleksandra Pajak","orcid":"https://orcid.org/0000-0001-8294-9620","observed_orcids":["https://orcid.org/0000-0001-8294-9620"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aleksandra Pajak","raw_affiliation_strings":["Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071831434","display_name":"Thomas E. Wales","orcid":"https://orcid.org/0000-0001-6133-5689","observed_orcids":["https://orcid.org/0000-0001-6133-5689"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Wales","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-6133-5689","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036493039","display_name":"Grant A. Pellowe","orcid":"https://orcid.org/0000-0003-4314-5261","observed_orcids":["https://orcid.org/0000-0003-4314-5261"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]},{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Grant A. Pellowe","raw_affiliation_strings":["Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-4314-5261","affiliations":[{"raw_affiliation_string":"Aston Institute for Membrane Excellence, Aston University, Birmingham, UK","institution_ids":["https://openalex.org/I169199633"]},{"raw_affiliation_string":"Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105406755","display_name":"Svend Kj\u00e6r","orcid":"https://orcid.org/0000-0001-9767-8683","observed_orcids":["https://orcid.org/0000-0001-9767-8683"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Svend Kj\u00e6r","raw_affiliation_strings":["Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK","institution_ids":["https://openalex.org/I2801081054"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082763070","display_name":"John R. Engen","orcid":"https://orcid.org/0000-0002-6918-9476","observed_orcids":["https://orcid.org/0000-0002-6918-9476"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John R. Engen","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA. j.engen@northeastern.edu"],"raw_orcid":"https://orcid.org/0000-0002-6918-9476","affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA. j.engen@northeastern.edu","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025989758","display_name":"David Balchin","orcid":"https://orcid.org/0000-0002-5000-0995","observed_orcids":["https://orcid.org/0000-0002-5000-0995"]},"institutions":[{"id":"https://openalex.org/I2801081054","display_name":"The Francis Crick Institute","ror":"https://ror.org/04tnbqb63","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David Balchin","raw_affiliation_strings":["Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK. david.balchin@crick.ac.uk"],"raw_orcid":"https://orcid.org/0000-0002-5000-0995","affiliations":[{"raw_affiliation_string":"Protein Biogenesis Laboratory, The Francis Crick Institute, London, UK. david.balchin@crick.ac.uk","institution_ids":["https://openalex.org/I2801081054"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025989758","https://openalex.org/A5082763070"],"corresponding_institution_ids":["https://openalex.org/I12912129","https://openalex.org/I2801081054"],"apc_list":null,"apc_paid":null,"fwci":5.6667,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.95819113,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"21","issue":"5","first_page":"2271","last_page":"2300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ribosome-nascent-chain-complex","display_name":"ribosome-nascent chain complex","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ribosomal-proteins","display_name":"ribosomal proteins","score":0.8659999966621399},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7670000195503235},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.6579999923706055},{"id":"https://openalex.org/keywords/ribosome-stalling","display_name":"ribosome stalling","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pepsin-digestion","display_name":"pepsin digestion","score":0.6230000257492065},{"id":"https://openalex.org/keywords/internal-control","display_name":"internal control","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6061000227928162},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.5740000009536743},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5640000104904175},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.5472999811172485},{"id":"https://openalex.org/C38062823","wikidata":"https://www.wikidata.org/wiki/Q3408228","display_name":"Ribosomal protein","level":5,"score":0.49079999327659607},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.4855000078678131},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46309998631477356},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4595000147819519},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43389999866485596},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.415800005197525},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C184185385","wikidata":"https://www.wikidata.org/wiki/Q6085263","display_name":"Isobaric labeling","level":5,"score":0.3741999864578247},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3549000024795532},{"id":"https://openalex.org/C54689828","wikidata":"https://www.wikidata.org/wiki/Q2029259","display_name":"Ultracentrifuge","level":2,"score":0.3544999957084656},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.35190001130104065},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.33550000190734863},{"id":"https://openalex.org/C192772702","wikidata":"https://www.wikidata.org/wiki/Q2583975","display_name":"Structural genomics","level":3,"score":0.32710000872612},{"id":"https://openalex.org/C121745418","wikidata":"https://www.wikidata.org/wiki/Q585536","display_name":"Quenching (fluorescence)","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3151000142097473},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.2992999851703644},{"id":"https://openalex.org/C190431759","wikidata":"https://www.wikidata.org/wiki/Q6710242","display_name":"Lysis buffer","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2874000072479248},{"id":"https://openalex.org/C2779419633","wikidata":"https://www.wikidata.org/wiki/Q7322423","display_name":"Ribosome biogenesis","level":5,"score":0.28049999475479126},{"id":"https://openalex.org/C27420735","wikidata":"https://www.wikidata.org/wiki/Q5968721","display_name":"Peptide mass fingerprinting","level":4,"score":0.2761000096797943},{"id":"https://openalex.org/C2910425616","wikidata":"https://www.wikidata.org/wiki/Q85741465","display_name":"Analytical Ultracentrifugation","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C2778471508","wikidata":"https://www.wikidata.org/wiki/Q425310","display_name":"Proteinase K","level":3,"score":0.2671999931335449},{"id":"https://openalex.org/C177462420","wikidata":"https://www.wikidata.org/wiki/Q7531731","display_name":"Site-directed spin labeling","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.2529999911785126},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.2515999972820282},{"id":"https://openalex.org/C199185054","wikidata":"https://www.wikidata.org/wiki/Q552299","display_name":"Chain (unit)","level":2,"score":0.25119999051094055},{"id":"https://openalex.org/C36674120","wikidata":"https://www.wikidata.org/wiki/Q370228","display_name":"Isotopic labeling","level":2,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000080307","descriptor_name":"Hydrogen Deuterium Exchange-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014461","descriptor_name":"Ultracentrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41596-025-01279-w","doi":"https://doi.org/10.1038/s41596-025-01279-w","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41596-025-01279-w","pdf_url":null,"source":{"id":"https://openalex.org/S109387254","display_name":"Nature Protocols","issn_l":"1750-2799","issn":["1750-2799","1754-2189"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Protocols","raw_type":"journal-article"},{"id":"pmid:41526491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41526491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature protocols","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7619191","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7619191/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Protoc","raw_type":"Text"},{"id":"pmh:oai:publications.aston.ac.uk:48577","doi":null,"is_oa":false,"landing_page_url":"https://publications.aston.ac.uk/id/eprint/48577/1/Hydrogen_deuterium_exchange_mass_spectrometry_analysis_of_ribosome-nascent_chain_complexes_AAM.pdf","pdf_url":"https://publications.aston.ac.uk/id/eprint/48577/1/Hydrogen_deuterium_exchange_mass_spectrometry_analysis_of_ribosome-nascent_chain_complexes_AAM.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7619191","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7619191/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Protoc","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G13733811","display_name":null,"funder_award_id":"FC001985","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5658496674","display_name":"Conformational Regulation and Therapeutic Targeting of Oncogenic KRAS","funder_award_id":"R01CA233978","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5761084948","display_name":null,"funder_award_id":"FC001985","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G6103113220","display_name":null,"funder_award_id":"FC001985","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1597525592","https://openalex.org/W1910438362","https://openalex.org/W1969633341","https://openalex.org/W1975255230","https://openalex.org/W1980346780","https://openalex.org/W2003129326","https://openalex.org/W2008818819","https://openalex.org/W2026814176","https://openalex.org/W2027864165","https://openalex.org/W2030899314","https://openalex.org/W2033662167","https://openalex.org/W2037314282","https://openalex.org/W2039911942","https://openalex.org/W2052300440","https://openalex.org/W2057553906","https://openalex.org/W2059003438","https://openalex.org/W2071804506","https://openalex.org/W2080113742","https://openalex.org/W2080144642","https://openalex.org/W2083174976","https://openalex.org/W2085981159","https://openalex.org/W2086402782","https://openalex.org/W2091905411","https://openalex.org/W2092985726","https://openalex.org/W2102324590","https://openalex.org/W2106246537","https://openalex.org/W2122964499","https://openalex.org/W2125865850","https://openalex.org/W2130079299","https://openalex.org/W2142482793","https://openalex.org/W2145317409","https://openalex.org/W2148789926","https://openalex.org/W2157436515","https://openalex.org/W2170004934","https://openalex.org/W2184623063","https://openalex.org/W2220104844","https://openalex.org/W2277212569","https://openalex.org/W2292015557","https://openalex.org/W2316113687","https://openalex.org/W2343251287","https://openalex.org/W2476763007","https://openalex.org/W2551865142","https://openalex.org/W2604381779","https://openalex.org/W2608956179","https://openalex.org/W2617303727","https://openalex.org/W2622241102","https://openalex.org/W2770566660","https://openalex.org/W2771199102","https://openalex.org/W2783275555","https://openalex.org/W2805624672","https://openalex.org/W2887692611","https://openalex.org/W2896163603","https://openalex.org/W2917382201","https://openalex.org/W2960982755","https://openalex.org/W2976500897","https://openalex.org/W3000413147","https://openalex.org/W3036600652","https://openalex.org/W3036620924","https://openalex.org/W3039075502","https://openalex.org/W3096800638","https://openalex.org/W3163411493","https://openalex.org/W3165617216","https://openalex.org/W3197273087","https://openalex.org/W3205085227","https://openalex.org/W3208691473","https://openalex.org/W4200177889","https://openalex.org/W4205984030","https://openalex.org/W4224290112","https://openalex.org/W4245504988","https://openalex.org/W4284709305","https://openalex.org/W4285492665","https://openalex.org/W4286559954","https://openalex.org/W4289783501","https://openalex.org/W4389512726","https://openalex.org/W4392663182","https://openalex.org/W4392956063","https://openalex.org/W4399886364","https://openalex.org/W4400503241","https://openalex.org/W4406688626","https://openalex.org/W4414358293","https://openalex.org/W4416183001"],"related_works":["https://openalex.org/W2476763007","https://openalex.org/W7221645672","https://openalex.org/W4366822184","https://openalex.org/W2511829957","https://openalex.org/W2102324590","https://openalex.org/W3197273087","https://openalex.org/W4285226021","https://openalex.org/W3097471373","https://openalex.org/W2963440633","https://openalex.org/W2316462688"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-13T00:00:00"}