{"id":"https://openalex.org/W7122708331","doi":"https://doi.org/10.1093/ofid/ofaf695.439","title":"P-217. Neurocognitive Effects of Transitioning to Dolutegravir-based Antiretroviral Therapy in People with HIV in sub-Saharan Africa","display_name":"P-217. Neurocognitive Effects of Transitioning to Dolutegravir-based Antiretroviral Therapy in People with HIV in sub-Saharan Africa","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7122708331","doi":"https://doi.org/10.1093/ofid/ofaf695.439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12791820"},"language":"en","primary_location":{"id":"doi:10.1093/ofid/ofaf695.439","doi":"https://doi.org/10.1093/ofid/ofaf695.439","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofaf695.439","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/ofid/ofaf695.439","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044603427","display_name":"Henry Ukachukwu Michael","orcid":"https://orcid.org/0000-0002-1944-0650","observed_orcids":["https://orcid.org/0000-0002-1944-0650"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Henry Michael","raw_affiliation_strings":["University of KwaZulu-Natal , Durban, KwaZulu-Natal ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of KwaZulu-Natal , Durban, KwaZulu-Natal ,","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137969225","display_name":"Hannah Kibuuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800255189","display_name":"Makerere University Walter Reed Project","ror":"https://ror.org/02mgm5r23","country_code":"UG","type":"nonprofit","lineage":["https://openalex.org/I2800255189"]}],"countries":["UG"],"is_corresponding":false,"raw_author_name":"Hannah Kibuuka","raw_affiliation_strings":["Makerere University Walter Reed Project , Kampala, Kampala ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Makerere University Walter Reed Project , Kampala, Kampala ,","institution_ids":["https://openalex.org/I2800255189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037033610","display_name":"John Owuoth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Owuoth","raw_affiliation_strings":["Henry M. Jackson Medical Research International , Kisumu, Western ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Medical Research International , Kisumu, Western ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069193306","display_name":"Valentine Sing\u2019oei","orcid":"https://orcid.org/0000-0001-9434-9630","observed_orcids":["https://orcid.org/0000-0001-9434-9630"]},"institutions":[{"id":"https://openalex.org/I4210154500","display_name":"HJF Medical Research International","ror":"https://ror.org/0492b0q60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210154500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valentine Sing\u2019oei","raw_affiliation_strings":["HJF Medical Research International , Kisumu, Western ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HJF Medical Research International , Kisumu, Western ,","institution_ids":["https://openalex.org/I4210154500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000644503","display_name":"Jonah Maswai","orcid":"https://orcid.org/0000-0002-1882-3297","observed_orcids":["https://orcid.org/0000-0002-1882-3297"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonah K Maswai","raw_affiliation_strings":["Walter Reed Army Institute of Research - Africa , Kericho, Rift Valley ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research - Africa , Kericho, Rift Valley ,","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075910318","display_name":"Reginald R Gervas","orcid":"https://orcid.org/0000-0002-8403-9601","observed_orcids":["https://orcid.org/0000-0002-8403-9601"]},"institutions":[{"id":"https://openalex.org/I4210154500","display_name":"HJF Medical Research International","ror":"https://ror.org/0492b0q60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210154500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reginald R Gervas","raw_affiliation_strings":["HJF Medical Research International , , Mbeya, Mbeya,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HJF Medical Research International , , Mbeya, Mbeya,","institution_ids":["https://openalex.org/I4210154500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011706582","display_name":"Abdulwasiu Bolaji Tiamiyu","orcid":"https://orcid.org/0000-0003-0101-5004","observed_orcids":["https://orcid.org/0000-0003-0101-5004"]},"institutions":[{"id":"https://openalex.org/I4210154500","display_name":"HJF Medical Research International","ror":"https://ror.org/0492b0q60","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210154500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdulwasiu Tiamiyu","raw_affiliation_strings":["HJF Medical Research International , Kisumu, Western ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HJF Medical Research International , Kisumu, Western ,","institution_ids":["https://openalex.org/I4210154500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035800937","display_name":"Zahra Parker","orcid":"https://orcid.org/0009-0005-7605-5889","observed_orcids":["https://orcid.org/0009-0005-7605-5889"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zahra Parker","raw_affiliation_strings":["U.S. Military HIV Research Program, Walter Reed Army Institute of Research AfricaHenry M. Jackson Foundation for the Advancement of Military Medicine , Lagos, Lagos ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research AfricaHenry M. Jackson Foundation for the Advancement of Military Medicine , Lagos, Lagos ,","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062901582","display_name":"Trevor A. Crowell","orcid":"https://orcid.org/0000-0001-5947-265X","observed_orcids":["https://orcid.org/0000-0001-5947-265X"]},"institutions":[{"id":"https://openalex.org/I1280259254","display_name":"Henry M. Jackson Foundation","ror":"https://ror.org/04q9tew83","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1280259254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor A Crowell","raw_affiliation_strings":["Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry M. Jackson Foundation for the Advancement of Military Medicine , Bethesda, Maryland","institution_ids":["https://openalex.org/I1280259254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057274213","display_name":"Victor Valcour","orcid":"https://orcid.org/0000-0003-1981-4832","observed_orcids":["https://orcid.org/0000-0003-1981-4832"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor Valcour","raw_affiliation_strings":["University of California , San Francisco, San Francisco, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California , San Francisco, San Francisco, California","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052150473","display_name":"Julie A. Ake","orcid":"https://orcid.org/0000-0003-3831-5828","observed_orcids":["https://orcid.org/0000-0003-3831-5828"]},"institutions":[{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A Ake","raw_affiliation_strings":["Walter Reed Army Institute of Research , Silver Spring, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter Reed Army Institute of Research , Silver Spring, Maryland","institution_ids":["https://openalex.org/I92664306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030130199","display_name":"Frasia Oosthuizen","orcid":"https://orcid.org/0000-0003-3691-7446","observed_orcids":["https://orcid.org/0000-0003-3691-7446","https://orcid.org/0000-0002-7971-4270"]},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Frasia Oosthuizen","raw_affiliation_strings":["University of Kwazulu-Natal , Durban, KwaZulu-Natal ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kwazulu-Natal , Durban, KwaZulu-Natal ,","institution_ids":["https://openalex.org/I95023434"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4053,"currency":"USD","value_usd":4053},"apc_paid":{"value":4053,"currency":"USD","value_usd":4053},"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.05389999970793724,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dolutegravir","display_name":"dolutegravir","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antiretroviral-therapy-switching","display_name":"antiretroviral therapy switching","score":0.871999979019165},{"id":"https://openalex.org/keywords/neurocognitive-function","display_name":"neurocognitive function","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7710000276565552},{"id":"https://openalex.org/keywords/efavirenz","display_name":"efavirenz","score":0.9660000205039978},{"id":"https://openalex.org/keywords/first-line-antiretroviral-therapy","display_name":"first-line antiretroviral therapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cognitive-monitoring","display_name":"cognitive monitoring","score":0.5070000290870667},{"id":"https://openalex.org/keywords/sub-saharan-africa","display_name":"sub-Saharan Africa","score":0.7210000157356262},{"id":"https://openalex.org/keywords/practice-effects","display_name":"practice effects","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.9275000095367432},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8810999989509583},{"id":"https://openalex.org/C2781432083","wikidata":"https://www.wikidata.org/wiki/Q422645","display_name":"Efavirenz","level":5,"score":0.7455000281333923},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5758000016212463},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5619000196456909},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5547000169754028},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.489300012588501},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.4629000127315521},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.42899999022483826},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3831999897956848},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.3808000087738037},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C2779502633","wikidata":"https://www.wikidata.org/wiki/Q937224","display_name":"Dolutegravir","level":5,"score":0.3635999858379364},{"id":"https://openalex.org/C2994444459","wikidata":"https://www.wikidata.org/wiki/Q133500","display_name":"Verbal learning","level":3,"score":0.361299991607666},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.32600000500679016},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3199999928474426},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.3190000057220459},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.31540000438690186},{"id":"https://openalex.org/C2778451633","wikidata":"https://www.wikidata.org/wiki/Q5629934","display_name":"HIV drug resistance","level":5,"score":0.3066999912261963},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3066999912261963},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3034000098705292},{"id":"https://openalex.org/C53084192","wikidata":"https://www.wikidata.org/wiki/Q1485121","display_name":"Gee","level":3,"score":0.2921999990940094},{"id":"https://openalex.org/C134290984","wikidata":"https://www.wikidata.org/wiki/Q5141241","display_name":"Cognitive skill","level":3,"score":0.2775999903678894},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2773999869823456},{"id":"https://openalex.org/C111278954","wikidata":"https://www.wikidata.org/wiki/Q17069312","display_name":"Minimal clinically important difference","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.26249998807907104}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/ofid/ofaf695.439","doi":"https://doi.org/10.1093/ofid/ofaf695.439","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofaf695.439","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12791820","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12791820/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/ofid/ofaf695.439","doi":"https://doi.org/10.1093/ofid/ofaf695.439","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ofid/ofaf695.439","pdf_url":null,"source":{"id":"https://openalex.org/S2735126445","display_name":"Open Forum Infectious Diseases","issn_l":"2328-8957","issn":["2328-8957"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Forum Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7116969230","https://openalex.org/W4402503741","https://openalex.org/W3001389296","https://openalex.org/W4387185128","https://openalex.org/W3094380756","https://openalex.org/W4283329207","https://openalex.org/W4281900226","https://openalex.org/W4308372396","https://openalex.org/W4393055849","https://openalex.org/W1964114641"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"In":[2],"2018,":[3],"dolutegravir":[4],"(DTG)":[5],"was":[6,207,232],"recommended":[7],"by":[8],"the":[9,14,261],"World":[10],"Health":[11],"Organization":[12],"as":[13],"preferred":[15],"first-line":[16],"antiretroviral":[17],"therapy":[18],"(ART)":[19],"due":[20],"to":[21,126,263,278],"its":[22,32],"favourable":[23],"safety,":[24],"high":[25],"resistance":[26],"barrier,":[27],"and":[28,48,68,80,98,103,107,133,149,165,221,254,282],"viral":[29,145],"suppression.":[30],"However,":[31],"long-term":[33,268],"neurocognitive":[34],"impact":[35],"is":[36],"unclear,":[37],"especially":[38,250],"in":[39,52,64,251],"low-resource":[40],"settings.":[41],"We":[42,120],"assessed":[43],"cognitive":[44,75,84,129,265],"performance":[45,226],"trajectories":[46],"before":[47,132],"after":[49,134],"DTG":[50],"transition":[51],"adults":[53],"with":[54,225,234],"HIV.":[55],"Methods":[56],"Data":[57],"were":[58,112,182,223],"from":[59,88,155],"AFRICOS,":[60],"a":[61,122,275],"multicountry":[62],"cohort":[63],"Uganda,":[65],"Kenya,":[66],"Nigeria,":[67],"Tanzania.":[69],"Eligible":[70],"participants":[71,168],"had":[72],"\u22656":[73],"annual":[74],"assessments":[76],"(\u2265":[77],"3":[78],"pre-":[79],"post-transition).":[81],"A":[82],"composite":[83],"Z-score":[85,130],"averaged":[86],"z-scores":[87],"five":[89],"tests:":[90],"WHO":[91],"Auditory":[92],"Verbal":[93],"Learning":[94],"Test":[95],"(Trials":[96],"1\u20135,":[97],"Delayed":[99],"Recall),":[100],"Trails":[101],"A,":[102],"Grooved":[104],"Pegboard":[105],"(dominant":[106],"non-dominant":[108],"hands).":[109],"Reverse-scored":[110],"tests":[111],"adjusted":[113,138],"so":[114],"higher":[115],"scores":[116,189],"reflected":[117],"better":[118],"performance.":[119],"used":[121],"discontinuous":[123],"growth":[124],"model":[125],"longitudinally":[127],"estimate":[128],"slopes":[131],"regimen":[135],"switch.":[136],"Models":[137],"for":[139,172],"age,":[140],"sex,":[141],"education,":[142,219],"country,":[143],"BMI,":[144,220],"load,":[146],"nadir":[147],"CD4,":[148],"practice":[150],"effect":[151],"(i.e.,":[152],"score":[153],"improvement":[154],"repeated":[156],"testing":[157],"rather":[158],"than":[159],"true":[160],"change).":[161],"Results":[162],"Between":[163],"2013":[164],"2024,":[166],"1,159":[167],"met":[169],"eligibility":[170],"criteria":[171],"this":[173],"analysis":[174],"(mean":[175],"age":[176],"41.3":[177],"years;":[178],"55.2%":[179],"female);":[180],"66.7%":[181],"previously":[183],"on":[184],"efavirenz":[185,230],"(Table":[186,227],"1).":[187,217],"Cognitive":[188,246],"improved":[190],"pre-transition":[191,237],"(slope":[192,201],"=":[193,210],"0.04;":[194],"95%":[195,212],"CI:":[196,213],"0.03\u20130.05)":[197],"but":[198,238],"plateaued":[199],"post-transition":[200,241],"\u2248":[202],"\u20130.01).":[203],"The":[204],"slope":[205],"change":[206],"significant":[208,240],"(interaction":[209],"\u20130.047;":[211],"\u20130.06,":[214],"\u20130.03)":[215],"(Figure":[216,243],"Age,":[218],"country":[222],"associated":[224,233],"2).":[228,244],"Prior":[229],"use":[231],"greater":[235],"gains":[236,247],"no":[239],"advantage":[242],"Conclusion":[245],"slowed":[248],"post-DTG,":[249],"older,":[252],"underweight,":[253],"less":[255],"educated":[256],"individuals.":[257],"These":[258],"findings":[259],"underscore":[260],"need":[262],"integrate":[264],"monitoring":[266],"into":[267],"HIV":[269],"care.":[270],"ART":[271],"transitions":[272],"may":[273],"offer":[274],"timely":[276],"opportunity":[277],"identify":[279],"subtle":[280],"changes":[281],"guide":[283],"supportive":[284],"care":[285],"planning.":[286],"Disclosures":[287],"All":[288],"Authors:":[289],"No":[290],"reported":[291],"disclosures":[292]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-01-13T00:00:00"}