{"id":"https://openalex.org/W7122575222","doi":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","title":"A single institutional analysis of missed opportunities in Lynch syndrome diagnosis.","display_name":"A single institutional analysis of missed opportunities in Lynch syndrome diagnosis.","publication_year":2026,"publication_date":"2026-01-10","ids":{"openalex":"https://openalex.org/W7122575222","doi":"https://doi.org/10.1200/jco.2026.44.2_suppl.95"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2026.44.2_suppl.95","doi":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2026.44.2_suppl.95","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2026.44.2_suppl.95","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072225779","display_name":"Gideon T. Dosunmu","orcid":"https://orcid.org/0009-0001-2071-0216","observed_orcids":["https://orcid.org/0009-0001-2071-0216"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Gideon T. Dosunmu","raw_affiliation_strings":["Winship Cancer Institute of Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092875358","display_name":"Fabienne Ehivet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabienne Ehivet","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147341962","display_name":"LePaige R. Godfrey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LePaige R. Godfrey","raw_affiliation_strings":["Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023483564","display_name":"Hasiya Eihuri Yusuf","orcid":"https://orcid.org/0000-0002-6948-8652","observed_orcids":["https://orcid.org/0000-0002-6948-8652"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hasiya Yusuf","raw_affiliation_strings":["Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050924701","display_name":"Mosunmoluwa Oyenuga","orcid":"https://orcid.org/0000-0001-8106-0483","observed_orcids":["https://orcid.org/0000-0001-8106-0483"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Mosunmoluwa Oyenuga","raw_affiliation_strings":["Winship Cancer Institute of Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045527493","display_name":"Oluwadunni Eunice Emiloju","orcid":"https://orcid.org/0009-0003-1173-7593","observed_orcids":["https://orcid.org/0009-0003-1173-7593","https://orcid.org/0000-0002-6884-4010"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Oluwadunni Eunice Emiloju","raw_affiliation_strings":["Winship Cancer Institute of Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103639156","display_name":"Lindsay Marie Hannan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Lindsay Marie Hannan","raw_affiliation_strings":["Winship Cancer Institute of Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031310041","display_name":"Patrick Sean Sullivan","orcid":"https://orcid.org/0000-0002-7728-0587","observed_orcids":["https://orcid.org/0000-0002-7728-0587"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick S. Sullivan","raw_affiliation_strings":["Winship Cancer Institute of Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042183981","display_name":"Christine L. Stanislaw","orcid":"https://orcid.org/0000-0002-5191-6479","observed_orcids":["https://orcid.org/0000-0002-5191-6479"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine L. Stanislaw","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047220835","display_name":"Olatunji Boladale Alese","orcid":"https://orcid.org/0000-0001-8079-4725","observed_orcids":["https://orcid.org/0000-0001-8079-4725"]},"institutions":[{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Olatunji B. Alese","raw_affiliation_strings":["Winship Cancer Institute of Emory University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Winship Cancer Institute of Emory University, Atlanta, GA","institution_ids":["https://openalex.org/I4390039307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"2_suppl","first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lynch-syndrome","display_name":"Lynch syndrome","score":0.9980000257492065},{"id":"https://openalex.org/keywords/missed-opportunities","display_name":"missed opportunities","score":0.5550000071525574},{"id":"https://openalex.org/keywords/immunohistochemistry-screening","display_name":"immunohistochemistry screening","score":0.7910000085830688},{"id":"https://openalex.org/keywords/mismatch-repair-deficiency","display_name":"mismatch repair deficiency","score":0.8550000190734863},{"id":"https://openalex.org/keywords/germline-testing","display_name":"germline genetic testing","score":0.8330000042915344},{"id":"https://openalex.org/keywords/genetic-counseling","display_name":"genetic counseling","score":0.6970000267028809},{"id":"https://openalex.org/keywords/early-onset-colorectal-cancer","display_name":"early-onset colorectal cancer","score":0.8840000033378601},{"id":"https://openalex.org/keywords/reflex-testing","display_name":"reflex testing","score":0.527999997138977},{"id":"https://openalex.org/keywords/pathogenic-variants","display_name":"pathogenic variants","score":0.6209999918937683},{"id":"https://openalex.org/keywords/nccn-guidelines","display_name":"NCCN guidelines","score":0.4339999854564667},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.4230000078678131},{"id":"https://openalex.org/keywords/hereditary-colorectal-cancer","display_name":"hereditary colorectal cancer","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C2776559941","wikidata":"https://www.wikidata.org/wiki/Q783644","display_name":"Lynch syndrome","level":5,"score":0.9620000123977661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8130000233650208},{"id":"https://openalex.org/C111425858","wikidata":"https://www.wikidata.org/wiki/Q14911708","display_name":"MLH1","level":5,"score":0.6198999881744385},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.6100000143051147},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.6065000295639038},{"id":"https://openalex.org/C2779115348","wikidata":"https://www.wikidata.org/wiki/Q14911688","display_name":"MSH2","level":5,"score":0.5422999858856201},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.5159000158309937},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.5078999996185303},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4848000109195709},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.45410001277923584},{"id":"https://openalex.org/C141496672","wikidata":"https://www.wikidata.org/wiki/Q14883437","display_name":"MUTYH","level":5,"score":0.40639999508857727},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4059000015258789},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.36629998683929443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36469998955726624},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C2779840525","wikidata":"https://www.wikidata.org/wiki/Q484827","display_name":"Anal cancer","level":3,"score":0.3111000061035156},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C2776674815","wikidata":"https://www.wikidata.org/wiki/Q14911717","display_name":"MSH6","level":5,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2026.44.2_suppl.95","doi":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2026.44.2_suppl.95","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1200/jco.2026.44.2_suppl.95","doi":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2026.44.2_suppl.95","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2026.44.2_suppl.95","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7122575222.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"95":[0],"Background:":[1],"The":[2],"National":[3],"Comprehensive":[4],"Cancer":[5],"Network":[6,73],"(NCCN)":[7],"recommended":[8],"germline":[9,132,227,233,300,339],"testing":[10,133,192,228,253],"for":[11,60,131,205,226,299,321],"all":[12],"patients":[13,79,143,203,214,249,285,327,355],"with":[14,80,92,111,144,292,346],"early":[15],"onset":[16],"colorectal":[17],"cancer":[18],"(EOCRC)":[19],"in":[20,53,150,162,168,196,256,280,306,326,343,353],"2017.":[21],"Older":[22],"adults":[23,345],"continued":[24],"to":[25,39,157,272,359],"rely":[26],"on":[27,103,125],"other":[28],"pathways":[29],"such":[30],"as":[31,98,134,136],"family":[32],"history":[33],"and":[34,180,229,259,294,349,364],"universal":[35,57,351],"immunohistochemistry":[36],"(IHC)":[37],"screening":[38,59],"identify":[40],"Lynch":[41,70,85,322,361],"syndrome":[42,86,323],"(LS)":[43],"carriers.":[44],"Here,":[45],"we":[46],"describe":[47],"cascade":[48,366],"completion":[49,342],"after":[50],"abnormal":[51,347],"IHC":[52,58,90,159,348],"the":[54,68,151,208,317],"era":[55],"of":[56,100,198,237,309],"CRC.":[61],"Methods:":[62],"We":[63,88],"reviewed":[64],"deidentified":[65],"data":[66],"from":[67,207],"Emory":[69],"Syndrome":[71],"Screening":[72],"(LSSN)":[74],"database.":[75],"This":[76],"database":[77,153],"tracks":[78],"cancers":[81],"that":[82],"are":[83,356],"considered":[84],"associated.":[87],"evaluated":[89],"results":[91],"deficient":[93],"mismatch":[94],"repair":[95],"(dMMR);":[96],"defined":[97],"loss":[99,113,116,175,178],"\u22651":[101],"protein":[102,183],"complete":[104,338],"IHC.":[105],"LS":[106,206,216,219],"suspicious":[107,204,220],"cases":[108],"were":[109,215,224,270,278,297],"those":[110,238,310],"MSH2/MSH6":[112,177],"or":[114,120,187],"MLH1/PMS2":[115,174,199,209],"without":[117],"BRAF":[118],"mutation":[119,303],"MLH1":[121],"promoter":[122],"methylation":[123],"(obtained":[124],"reflex":[126],"testing).":[127],"Outcomes":[128],"included":[129],"referral":[130],"well":[135],"completed":[137,161,195,232,255],"genetic":[138],"counseling/testing.":[139],"Results:":[140],"Among":[141,171,218],"565":[142],"CRC":[145],"(450":[146],"colon,":[147],"115":[148],"rectal)":[149],"LSSN":[152],"diagnosed":[154],"between":[155],"2013":[156],"2023,":[158],"was":[160,166,193,254,304,325],"99.5%":[163],"(562/565).":[164],"dMMR":[165,172,273],"identified":[167,305],"17.8%":[169],"(100/562).":[170],"tumors,":[173,274],"(n=73),":[176],"(n=17),":[179],"rare":[181],"single":[182],"losses":[184],"(MSH6,":[185],"PMS2,":[186],"MSH2":[188],"only)":[189],"(n=10).":[190],"Reflex":[191],"not":[194,337],"20%":[197],"cases,":[200,221],"leaving":[201],"41":[202],"cohort.":[210],"In":[211,244,284,314],"total,":[212],"62":[213],"suspicious.":[217],"40%":[222],"(25/62)":[223],"referred":[225],"29%":[230],"(18/62)":[231],"testing.":[234,340,367],"61%":[235],"(11/18)":[236],"tested":[239,298],"carried":[240,262],"a":[241,263,331],"pathogenic":[242,264,268,333],"variant.":[243,265],"age":[245],"stratified":[246],"analysis,":[247],"100":[248],"had":[250,290],"EOCRC.":[251],"Germline":[252],"27%":[257],"(27/100)":[258],"19%":[260],"(5/27)":[261],"All":[266],"5":[267],"variants":[269,277],"confined":[271],"while":[275],"no":[276],"detected":[279],"pMMR":[281],"tumors":[282],"(0/19).":[283],"\u226550":[286,311,328],"years":[287],"(n=461),":[288],"83":[289],"tumor":[291],"dMMR,":[293],"11%":[295],"(9/83)":[296],"mutations.":[301],"Pathogenic":[302],"44%":[307,332],"(4/9)":[308],"years.":[312,329],"Conclusions:":[313],"this":[315],"cohort,":[316],"greatest":[318],"missed":[319],"opportunity":[320],"diagnosis":[324],"Despite":[330],"yield,":[334],"most":[335],"did":[336],"Improving":[341],"older":[344],"ensuring":[350],"uptake":[352],"younger":[354],"both":[357],"essential":[358],"maximize":[360],"carrier":[362],"detection":[363],"enable":[365]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2026-01-13T00:00:00"}