{"id":"https://openalex.org/W7122553969","doi":"https://doi.org/10.1038/s41598-025-34187-w","title":"Pulmonary vein isolation with a pulsed field system leads to lower levels of miR-23a-3p in the left atrial blood compared to a cryoballoon","display_name":"Pulmonary vein isolation with a pulsed field system leads to lower levels of miR-23a-3p in the left atrial blood compared to a cryoballoon","publication_year":2026,"publication_date":"2026-01-11","ids":{"openalex":"https://openalex.org/W7122553969","doi":"https://doi.org/10.1038/s41598-025-34187-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41521185","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12796457"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-34187-w","doi":"https://doi.org/10.1038/s41598-025-34187-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-34187-w","pdf_url":"https://www.nature.com/articles/s41598-025-34187-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-34187-w_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022432066","display_name":"Andreas Zietzer","orcid":"https://orcid.org/0000-0001-5759-7627","observed_orcids":["https://orcid.org/0000-0001-5759-7627"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Zietzer","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany. andreas.zietzer@ukbonn.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany. andreas.zietzer@ukbonn.de","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019578163","display_name":"Vincent Knappe","orcid":"https://orcid.org/0000-0002-8921-9134","observed_orcids":["https://orcid.org/0000-0002-8921-9134"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vincent Knappe","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122824523","display_name":"Frederick Braun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frederick Braun","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090776991","display_name":"Philip D\u00fcsing","orcid":"https://orcid.org/0000-0003-1394-6471","observed_orcids":["https://orcid.org/0000-0003-1394-6471"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philip D\u00fcsing","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122797320","display_name":"Sophia Grunewald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sophia Grunewald","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005009402","display_name":"Ansgar Ackerschott","orcid":"https://orcid.org/0000-0001-6473-2399","observed_orcids":["https://orcid.org/0000-0001-6473-2399"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ansgar Ackerschott","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038533337","display_name":"Laurine Reese","orcid":"https://orcid.org/0000-0003-4810-3976","observed_orcids":["https://orcid.org/0000-0003-4810-3976"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Laurine Reese","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110958200","display_name":"Marko Bulic","orcid":"https://orcid.org/0009-0003-2752-3477","observed_orcids":["https://orcid.org/0009-0003-2752-3477"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marko Bulic","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001331817","display_name":"Maximilian Funken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maximilian Funken","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047420352","display_name":"Christopher Gestrich","orcid":"https://orcid.org/0000-0002-4180-1037","observed_orcids":["https://orcid.org/0000-0002-4180-1037"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher Gestrich","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008177500","display_name":"Georg Nickenig","orcid":"https://orcid.org/0000-0003-2944-6033","observed_orcids":["https://orcid.org/0000-0003-2944-6033"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georg Nickenig","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050294762","display_name":"Thomas Beiert","orcid":"https://orcid.org/0000-0001-5398-403X","observed_orcids":["https://orcid.org/0000-0001-5398-403X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Beiert","raw_affiliation_strings":["Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022432066"],"corresponding_institution_ids":["https://openalex.org/I135140700","https://openalex.org/I2799391451"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":"1324","last_page":"1324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-vein-isolation","display_name":"pulmonary vein isolation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pulsed-field-ablation","display_name":"pulsed field ablation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/cryoballoon-ablation","display_name":"cryoballoon ablation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mir-23a-3p","display_name":"miR-23a-3p","score":0.9419999718666077},{"id":"https://openalex.org/keywords/microrna-biomarkers","display_name":"microRNA biomarkers","score":0.765999972820282},{"id":"https://openalex.org/keywords/ablation-outcome-prediction","display_name":"ablation outcome prediction","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2780689522","wikidata":"https://www.wikidata.org/wiki/Q535352","display_name":"Pulmonary vein","level":3,"score":0.8858000040054321},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8217999935150146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7627000212669373},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7572000026702881},{"id":"https://openalex.org/C2777615863","wikidata":"https://www.wikidata.org/wiki/Q1074839","display_name":"Left atrium","level":3,"score":0.7376999855041504},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.7346000075340271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7177000045776367},{"id":"https://openalex.org/C114021368","wikidata":"https://www.wikidata.org/wiki/Q189265","display_name":"Atrium (architecture)","level":3,"score":0.4578999876976013},{"id":"https://openalex.org/C2776131983","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Catheter ablation","level":3,"score":0.3901999890804291},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.37130001187324524},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.33379998803138733},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.3037000000476837},{"id":"https://openalex.org/C2777611987","wikidata":"https://www.wikidata.org/wiki/Q436572","display_name":"Ablation of atrial fibrillation","level":4,"score":0.29510000348091125},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C2777202286","wikidata":"https://www.wikidata.org/wiki/Q9609","display_name":"Vein","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.25600001215934753}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D003452","descriptor_name":"Cryosurgery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011667","descriptor_name":"Pulmonary Veins","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D017115","descriptor_name":"Catheter Ablation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-025-34187-w","doi":"https://doi.org/10.1038/s41598-025-34187-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-34187-w","pdf_url":"https://www.nature.com/articles/s41598-025-34187-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:41521185","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41521185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12796457","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12796457/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:026a5a7885734f6c86b0eeb7e16a41ac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/026a5a7885734f6c86b0eeb7e16a41ac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1, Pp 1-6 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-34187-w","doi":"https://doi.org/10.1038/s41598-025-34187-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-34187-w","pdf_url":"https://www.nature.com/articles/s41598-025-34187-w_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3268375241","display_name":"Die Rolle der MIR3142HG bei der Niereninsuffizienzassoziierten Endothelsch\u00e4digung","funder_award_id":"514976099","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G6094172880","display_name":null,"funder_award_id":"01EO2107","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8336812760","display_name":null,"funder_award_id":"01EO2107","funder_id":"https://openalex.org/F4320324900","funder_display_name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324900","display_name":"Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn","ror":"https://ror.org/041nas322"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7122553969.pdf","grobid_xml":"https://content.openalex.org/works/W7122553969.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2063144090","https://openalex.org/W2073175477","https://openalex.org/W2148056560","https://openalex.org/W2333001326","https://openalex.org/W2805382413","https://openalex.org/W2886514991","https://openalex.org/W3082188176","https://openalex.org/W3096791720","https://openalex.org/W3134407919","https://openalex.org/W4220661130","https://openalex.org/W4281666082","https://openalex.org/W4286493085","https://openalex.org/W4292237406","https://openalex.org/W4386203333","https://openalex.org/W4391844066","https://openalex.org/W4398140826","https://openalex.org/W4399327830","https://openalex.org/W4401657526","https://openalex.org/W4404343406"],"related_works":["https://openalex.org/W2169988621","https://openalex.org/W4391238824","https://openalex.org/W2130530789","https://openalex.org/W4321107464","https://openalex.org/W2805382413","https://openalex.org/W2789335591","https://openalex.org/W3167744353","https://openalex.org/W4412855628","https://openalex.org/W2360485830","https://openalex.org/W4409739674"],"abstract_inverted_index":{"Atrial":[0],"fibrillation":[1],"(AF)":[2],"is":[3,38,171],"the":[4,16,30,47,53,124,128,155,168,183],"most":[5],"common":[6],"arrhythmic":[7],"disease":[8],"in":[9,74,133,152,154,167],"humans,":[10],"with":[11,127],"its":[12],"incidence":[13],"rising":[14],"over":[15],"past":[17],"decade.":[18],"Novel":[19],"treatment":[20],"options":[21],"for":[22,189],"AF":[23],"include":[24],"pulsed":[25],"field":[26],"ablation":[27,79,107],"(PFA)":[28],"of":[29,50,61,123,185,191],"pulmonary":[31],"veins":[32],"through":[33],"electroporation.":[34],"While":[35],"this":[36,110],"technique":[37],"thought":[39],"to":[40,44,72,76,147,161,177],"be":[41,148],"less":[42,150],"damaging":[43],"surrounding":[45],"tissue,":[46],"acute":[48],"effects":[49],"PFA":[51,101,135,159,175],"on":[52,92],"atrium":[54,157,170],"are":[55],"only":[56],"incompletely":[57],"understood.":[58],"An":[59],"analysis":[60,89],"circulating":[62,164],"microRNAs":[63],"(miRs)":[64],"potentially":[65,181],"released":[66],"by":[67,174],"local":[68],"tissue":[69],"damage":[70],"due":[71],"PFA,":[73],"comparison":[75],"other":[77],"standard":[78],"procedures,":[80],"has":[81],"not":[82],"yet":[83],"been":[84],"performed.":[85],"Small":[86],"RNA":[87],"sequencing":[88],"was":[90,131],"performed":[91],"left":[93,156,169],"atrial":[94],"blood":[95],"samples":[96],"from":[97],"four":[98],"patients":[99,104],"after":[100,105,158,193],"and":[102],"five":[103],"cryoballoon":[106],"(CBA).":[108],"In":[109],"pilot":[111],"analysis,":[112],"154":[113],"miRs":[114,126,186],"were":[115],"stably":[116],"detected":[117],"across":[118],"all":[119],"samples.":[120],"The":[121,163],"expression":[122],"two":[125],"lowest":[129],"p-values":[130],"validated":[132],"20":[134],"cases":[136,140],"versus":[137],"25":[138],"CBA":[139],"via":[141],"real-time":[142],"PCR.":[143],"We":[144],"found":[145],"hsa-miR-23a-3p":[146],"significantly":[149],"abundant":[151],"plasma":[153],"compared":[160,176],"CBA.":[162,178],"miR":[165],"signature":[166],"differentially":[172],"affected":[173],"This":[179],"finding":[180],"influences":[182],"use":[184],"as":[187],"biomarkers":[188],"prediction":[190],"outcomes":[192],"ablation.":[194]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-01-13T00:00:00"}