{"id":"https://openalex.org/W7122405552","doi":"https://doi.org/10.18008/1816-5095-2025-4-919-929","title":"The Importance of Nutraceutical Support According to the AREDS2 Protocol in Age-related Macular Degeneration. Clinical observation","display_name":"The Importance of Nutraceutical Support According to the AREDS2 Protocol in Age-related Macular Degeneration. Clinical observation","publication_year":2025,"publication_date":"2025-12-28","ids":{"openalex":"https://openalex.org/W7122405552","doi":"https://doi.org/10.18008/1816-5095-2025-4-919-929"},"language":"en","primary_location":{"id":"doi:10.18008/1816-5095-2025-4-919-929","doi":"https://doi.org/10.18008/1816-5095-2025-4-919-929","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2025-4-919-929","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18008/1816-5095-2025-4-919-929","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032128237","display_name":"\u0410 \u0418 \u041c\u0430\u043b\u0430\u0445\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-0181-9873","observed_orcids":["https://orcid.org/0000-0002-0181-9873"]},"institutions":[{"id":"https://openalex.org/I4210094660","display_name":"Regional State Budgetary Healthcare Institution \"Smolensk Regional Clinical Hospital\"","ror":"https://ror.org/00p75zw90","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210094660"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. I. Malakhova","raw_affiliation_strings":["Care Smolensk Regional Clinical Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Care Smolensk Regional Clinical Hospital","institution_ids":["https://openalex.org/I4210094660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032128237"],"corresponding_institution_ids":["https://openalex.org/I4210094660"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"4","first_page":"919","last_page":"929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/areds2","display_name":"AREDS2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vitamin-and-mineral-complexes","display_name":"vitamin and mineral complexes","score":0.7990000247955322},{"id":"https://openalex.org/keywords/lutein","display_name":"lutein","score":0.9330000281333923},{"id":"https://openalex.org/keywords/zeaxanthin","display_name":"zeaxanthin","score":1.0},{"id":"https://openalex.org/keywords/carotenoids","display_name":"carotenoids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/macular-pigment","display_name":"macular pigment","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.8069999814033508},{"id":"https://openalex.org/keywords/multifocal-electroretinography","display_name":"multifocal electroretinogram","score":0.9599999785423279},{"id":"https://openalex.org/keywords/retinal-function","display_name":"retinal function","score":0.9649999737739563},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.5550000071525574},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7967000007629395},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.744700014591217},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6593000292778015},{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.65829998254776},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.5806000232696533},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3880000114440918},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.34940001368522644},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32760000228881836},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.3190999925136566},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3165999948978424},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.29280000925064087},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.2924000024795532},{"id":"https://openalex.org/C2780929884","wikidata":"https://www.wikidata.org/wiki/Q737460","display_name":"Blindness","level":2,"score":0.26330000162124634}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.18008/1816-5095-2025-4-919-929","doi":"https://doi.org/10.18008/1816-5095-2025-4-919-929","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2025-4-919-929","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:3feeeceab89e48268862bfa29ad04186","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/3feeeceab89e48268862bfa29ad04186","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Oftal\u02b9mologi\u00e2, Vol 22, Iss 4, Pp 919-929 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18008/1816-5095-2025-4-919-929","doi":"https://doi.org/10.18008/1816-5095-2025-4-919-929","is_oa":true,"landing_page_url":"https://doi.org/10.18008/1816-5095-2025-4-919-929","pdf_url":null,"source":{"id":"https://openalex.org/S4210233720","display_name":"Ophthalmology in Russia","issn_l":"1816-5095","issn":["1816-5095","2500-0845"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312650","host_organization_name":"Ophthalmology Publishing Group","host_organization_lineage":["https://openalex.org/P4310312650"],"host_organization_lineage_names":["Ophthalmology Publishing Group"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ophthalmology in Russia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W43722312","https://openalex.org/W850564675","https://openalex.org/W1969581472","https://openalex.org/W1972642682","https://openalex.org/W2001730904","https://openalex.org/W2001779931","https://openalex.org/W2017091087","https://openalex.org/W2030877659","https://openalex.org/W2048515880","https://openalex.org/W2050504762","https://openalex.org/W2051456678","https://openalex.org/W2052260720","https://openalex.org/W2073256286","https://openalex.org/W2098555483","https://openalex.org/W2138902069","https://openalex.org/W2150279590","https://openalex.org/W2154864949","https://openalex.org/W2201164157","https://openalex.org/W2214658362","https://openalex.org/W2329780587","https://openalex.org/W2415088879","https://openalex.org/W2597267452","https://openalex.org/W2598520882","https://openalex.org/W2603560165","https://openalex.org/W2605454194","https://openalex.org/W2734721636","https://openalex.org/W2752317959","https://openalex.org/W2807577713","https://openalex.org/W2888323593","https://openalex.org/W2898549572","https://openalex.org/W2944418641","https://openalex.org/W2999122995","https://openalex.org/W3025522265","https://openalex.org/W3038313001","https://openalex.org/W3044563645","https://openalex.org/W3089151264","https://openalex.org/W3174188786","https://openalex.org/W3203848552","https://openalex.org/W4223413646","https://openalex.org/W4284899850","https://openalex.org/W4307501022","https://openalex.org/W4376890989","https://openalex.org/W4386029106","https://openalex.org/W4396856947","https://openalex.org/W4406864206","https://openalex.org/W4408311938","https://openalex.org/W4409806529"],"related_works":["https://openalex.org/W7152653630","https://openalex.org/W114864780","https://openalex.org/W1984944437","https://openalex.org/W4404460440","https://openalex.org/W7211920263","https://openalex.org/W2955897409","https://openalex.org/W2087579356","https://openalex.org/W7140126942","https://openalex.org/W3048801885","https://openalex.org/W4235244632"],"abstract_inverted_index":{"Carotenoids,":[0],"which":[1],"are":[2],"part":[3],"of":[4,24,57,69,74,77,83,87,91,99,102,111],"macular":[5],"pigment,":[6],"play":[7],"a":[8,72],"key":[9],"role":[10],"in":[11,17,33,52,107],"maintaining":[12],"visual":[13,19],"functions.":[14],"Age-related":[15],"changes":[16],"the":[18,34,55,84,92,100,103,109],"organ":[20],"necessitate":[21],"increased":[22],"intake":[23],"vitamins":[25],"and":[26,37,44,80,89],"minerals":[27],"to":[28,49],"slow":[29],"down":[30,54],"degenerative":[31],"processes":[32],"retina.":[35],"Vitamin":[36],"mineral":[38],"complexes":[39],"(VMC)":[40],"containing":[41],"lutein,":[42],"zeaxanthin,":[43],"antioxidants":[45],"have":[46],"been":[47],"proven":[48],"be":[50],"effective":[51],"slowing":[53],"progression":[56,90],"advanced":[58],"AMD,":[59],"as":[60,71],"evidenced":[61],"by":[62],"international":[63],"studies.":[64],"Multifocal":[65],"electroretinogram":[66],"(mFERG)":[67],"is":[68,81],"interest":[70],"method":[73],"objective":[75,104],"assessment":[76],"retinal":[78,114],"function":[79],"one":[82],"sensitive":[85],"biomarkers":[86],"severity":[88],"disease.":[93],"The":[94],"article":[95],"presents":[96],"clinical":[97],"examples":[98],"use":[101],"mFERG":[105],"technique":[106],"assessing":[108],"effect":[110],"VMC":[112],"on":[113],"cells.":[115]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-13T00:00:00"}