{"id":"https://openalex.org/W7120871072","doi":null,"title":"Effects of plant sterols supplementation to lipidlowering therapy in familial hypercholesterolemia","display_name":"Effects of plant sterols supplementation to lipidlowering therapy in familial hypercholesterolemia","publication_year":2013,"publication_date":"2013-12-20","ids":{"openalex":"https://openalex.org/W7120871072"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/47570","doi":null,"is_oa":true,"landing_page_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=2474868","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=2474868","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113748383","display_name":"Valeria Arruda Machado","orcid":"https://orcid.org/0009-0002-6874-0657","observed_orcids":["https://orcid.org/0009-0002-6874-0657"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Machado, Valeria Arruda [UNIFESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113748383"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.008799999952316284,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.8899999856948853},{"id":"https://openalex.org/keywords/familial-hypercholesterolemia","display_name":"familial hypercholesterolemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/heterozygous-familial-hypercholesterolemia","display_name":"heterozygous familial hypercholesterolemia","score":0.9290000200271606},{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.699999988079071},{"id":"https://openalex.org/keywords/cholesterol-absorption","display_name":"cholesterol absorption","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/campesterol","display_name":"campesterol","score":0.8339999914169312},{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.9750000238418579},{"id":"https://openalex.org/keywords/desmosterol","display_name":"desmosterol","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apolipoproteins","display_name":"apolipoproteins","score":0.8159999847412109},{"id":"https://openalex.org/keywords/phytosterolemia","display_name":"phytosterolemia","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9257000088691711},{"id":"https://openalex.org/C2778657065","wikidata":"https://www.wikidata.org/wiki/Q417997","display_name":"Ezetimibe","level":3,"score":0.892799973487854},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.8549000024795532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6449000239372253},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.6337000131607056},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5778999924659729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.535099983215332},{"id":"https://openalex.org/C2909892341","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Plant sterols","level":4,"score":0.5338000059127808},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.503000020980835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4927999973297119},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.39259999990463257},{"id":"https://openalex.org/C2779718769","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Phytosterol","level":2,"score":0.3752000033855438},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.34450000524520874},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.3156999945640564},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.31470000743865967},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.2962999939918518},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2953000068664551},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28630000352859497},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.28349998593330383},{"id":"https://openalex.org/C104950815","wikidata":"https://www.wikidata.org/wiki/Q415607","display_name":"HMG-CoA reductase","level":4,"score":0.27129998803138733},{"id":"https://openalex.org/C2779152743","wikidata":"https://www.wikidata.org/wiki/Q7166854","display_name":"Pera","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.26109999418258667},{"id":"https://openalex.org/C2780022283","wikidata":"https://www.wikidata.org/wiki/Q3218465","display_name":"Lathosterol","level":5,"score":0.2533000111579895}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repositorio.unifesp.br:11600/47570","doi":null,"is_oa":true,"landing_page_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=2474868","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/47570","doi":null,"is_oa":true,"landing_page_url":"https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=2474868","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028710229","https://openalex.org/W2125241372","https://openalex.org/W2313580927","https://openalex.org/W2131855630","https://openalex.org/W2071045538","https://openalex.org/W2039504794","https://openalex.org/W2033044303","https://openalex.org/W2063421403","https://openalex.org/W2068783082","https://openalex.org/W2051543085"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Familial":[1],"hypercholesterolemia":[2],"(FH)":[3],"is":[4,297],"a":[5,44,110],"severe":[6],"inherited":[7],"dyslipidemia":[8],"often":[9],"requiring":[10],"high-dose":[11],"lipid-lowering":[12,58,118,203,293,322],"therapy":[13,59,119,225,266],"and":[14,32,72,84,120,167,169,183,208,211,257,278,285,315],"combined":[15,63,224,265],"therapy.":[16],"Plant":[17],"sterol":[18,54],"supplementation":[19,55],"can":[20,40,317],"improve":[21],"achievement":[22],"of":[23,52,69,90,98,115,133,145,163,232,234,290,321],"lipid":[24],"targets,":[25],"but":[26],"their":[27,258],"effects":[28,51],"on":[29,66,299,312],"cholesterol":[30,70,164,261,276,286,307,313],"synthesis":[31,71,171,314],"absorption":[33,165,269,308,316],"need":[34],"evaluation,":[35],"because":[36],"increase":[37,274],"in":[38,241,275,295],"phytosterolemia":[39],"be":[41],"associated":[42],"with":[43,60,64,93,222],"higher":[45],"cardiovascular":[46],"risk.":[47],"We":[48],"evaluted":[49],"the":[50,57,116,125,152,223,242,264,268,273,281,303,306,319],"plant":[53,235,251],"to":[56,129,151,260,292],"statin":[61],"or":[62,137,190],"ezetimibe":[65,141],"lipids,":[67],"markers":[68,162],"absorption.":[73],"METHODS:":[74],"A":[75],"prospective,":[76],"randomized,":[77],"open":[78],"label":[79],"study,":[80],"witl":[81],"parallel":[82],"arms":[83],"blinded":[85],"endpoints":[86],"included":[87],"42":[88],"individuals":[89],"both":[91],"genders":[92],"clinical":[94],"and/or":[95],"genetic":[96],"diagnosis":[97],"heterozygous":[99],"FH":[100,296],"(Med":[101],"Ped,":[102],"Dutch":[103],"Lipid":[104],"Clinics":[105],"Network,":[106],"Simon":[107],"Broome).":[108],"After":[109],"4-":[111],"week":[112],"washout":[113],"period":[114],"previous":[117,153],"under":[121],"NCEP/ATPIII":[122],"nutrition":[123],"counseling,":[124],"patients":[126],"were":[127,149,178,198],"randomized":[128],"receive":[130],"12":[131,182],"weeks":[132],"simvastatin":[134,138,228],"80":[135],"mg":[136],"80mg":[139],"plus":[140,250],"10mg.":[142],"Further,":[143],"2g/day":[144],"free":[146],"phytosterols":[147,291],"(Vegapure),":[148],"added":[150],"treatment":[154,304],"for":[155],"another":[156],"12-week":[157],"period.":[158],"Lipids,":[159],"apolipoproteins":[160],"(Apo),":[161],"(campesterol":[166],"?-sitosterol)":[168],"endogenous":[170],"(desmosterol)":[172],"(Ultra":[173],"Performance":[174],"Liquid":[175],"Chromatography/Mass":[176],"Spectrometry),":[177],"assessed":[179],"at":[180,200],"baseline,":[181],"24":[184],"weeks.":[185],"Statistical":[186],"analysis":[187],"used":[188],"parametric":[189],"non-parametric":[191],"tests,":[192],"as":[193],"appropriate.":[194],"RESULTS:":[195],"The":[196],"groups":[197],"comparable":[199],"baseline.":[201],"Both":[202],"therapies":[204,294],"effectively":[205],"reduced":[206,267,280],"total":[207],"LDL-c,":[209],"triglycerides":[210],"Apo":[212],"B":[213],"(P<0,001":[214],"vs.":[215,227],"baseline),":[216],"however,":[217],"greater":[218],"modification":[219],"was":[220],"observed":[221],"(P<0.05":[226],"(Student?s":[229],"t-test).":[230,248],"Addition":[231,289],"2g":[233],"sterols":[236,252,284],"further":[237],"decreased":[238],"LDL-c":[239,300],"only":[240,301],"group":[243],"receiving":[244],"simvastatin/ezetimibe":[245],"(P<0.05,":[246],"paired":[247],"Simvastatin":[249],"increased":[253],"campesterol,":[254],"?-sitosterol,":[255],"desmosterol":[256],"ratios":[259,282],"(P<0,05),":[262],"whereas":[263],"markers,":[270],"while":[271],"preventing":[272],"synthesis,":[277],"also":[279],"between":[283],"(P<0,05).":[287],"CONCLUSIONS:":[288],"beneficial":[298],"when":[302],"includes":[305],"inhibitor,":[309],"ezetimibe.":[310],"Changes":[311],"influence":[318],"results":[320],"interventions.":[323]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-01-10T00:00:00"}