{"id":"https://openalex.org/W7120844883","doi":null,"title":"Estudo de produ\u00e7\u00e3o, caracteriza\u00e7\u00e3o e biocompatibilidade in vitro de nanoc\u00e1psulas polim\u00e9ricas contendo \u00f3leo de copa\u00edba em c\u00e9lulas pulmonares","display_name":"Estudo de produ\u00e7\u00e3o, caracteriza\u00e7\u00e3o e biocompatibilidade in vitro de nanoc\u00e1psulas polim\u00e9ricas contendo \u00f3leo de copa\u00edba em c\u00e9lulas pulmonares","publication_year":2023,"publication_date":"2023-03-06","ids":{"openalex":"https://openalex.org/W7120844883"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.ufrn.br:123456789/52036","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/handle/123456789/52036","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorio.ufrn.br/handle/123456789/52036","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041665066","display_name":"Victor M. Rodrigues","orcid":"https://orcid.org/0000-0002-5413-8414","observed_orcids":["https://orcid.org/0000-0002-5413-8414"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rodrigues, Victor Moraes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041665066"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.23669999837875366,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.050599999725818634,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copaiba-oil","display_name":"copaiba oil","score":0.9909999966621399},{"id":"https://openalex.org/keywords/polymeric-nanocapsules","display_name":"polymeric nanocapsules","score":0.8700000047683716},{"id":"https://openalex.org/keywords/nanoprecipitation","display_name":"nanoprecipitation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/hemocompatibility","display_name":"hemocompatibility","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9240000247955322},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":1.0},{"id":"https://openalex.org/keywords/lung-cells","display_name":"lung cells","score":0.8270000219345093},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.8629999756813049},{"id":"https://openalex.org/keywords/physicochemical-stability","display_name":"physicochemical stability","score":0.734000027179718},{"id":"https://openalex.org/keywords/beta-bisabolene","display_name":"\u03b2-bisabolene","score":0.7789999842643738},{"id":"https://openalex.org/keywords/caryophyllene","display_name":"caryophyllene","score":0.9380000233650208},{"id":"https://openalex.org/keywords/caryophyllene-oxide","display_name":"caryophyllene oxide","score":0.8579999804496765},{"id":"https://openalex.org/keywords/pulmonary-drug-delivery","display_name":"pulmonary drug delivery","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C204399865","wikidata":"https://www.wikidata.org/wiki/Q17157402","display_name":"Nanocapsules","level":3,"score":0.7107999920845032},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6409000158309937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5809000134468079},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5659000277519226},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.5335999727249146},{"id":"https://openalex.org/C2779902561","wikidata":"https://www.wikidata.org/wiki/Q471706","display_name":"Hemolysis","level":2,"score":0.4065999984741211},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40400001406669617},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.34599998593330383},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.3433000147342682},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34130001068115234},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2621000111103058}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repositorio.ufrn.br:123456789/52036","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/handle/123456789/52036","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.ufrn.br:123456789/52036","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.ufrn.br/handle/123456789/52036","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UFRN","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313585124","https://openalex.org/W7125201269","https://openalex.org/W7120648194","https://openalex.org/W4387452013","https://openalex.org/W4406070180","https://openalex.org/W2908762620","https://openalex.org/W2735677640","https://openalex.org/W4321234682","https://openalex.org/W7215665879","https://openalex.org/W4402305798"],"abstract_inverted_index":{"Copaiba":[0,59],"oil":[1,48,60,101],"has":[2],"been":[3],"largely":[4],"used":[5],"due":[6,23],"to":[7,14,19,24,27,43,52,170,200],"its":[8],"therapeutic":[9],"properties.":[10,182],"Nanocapsules":[11],"were":[12,86,95],"revealed":[13],"be":[15],"a":[16,105,113,121,187],"great":[17],"nanosystem":[18],"carry":[20],"natural":[21],"oils":[22],"their":[25,54],"ability":[26],"improve":[28],"the":[29,32,72,82,98,164,198,205],"bioaccessibility":[30],"and":[31,45,51,57,66,79,92,120,157,180],"bioavailability":[33],"of":[34,39,81,108,116,124,143,166,207,214],"lipophilic":[35],"compounds.":[36],"The":[37,75,140],"aim":[38],"this":[40,184],"study":[41],"was":[42,61,69,145],"produce":[44],"characterize":[46],"copaiba":[47,100,215],"nanocapsules":[49],"(CopNc)":[50],"evaluate":[53],"hemocompatibility,":[55],"cytotoxicity,":[56],"genotoxicity.":[58],"chemically":[62],"characterized":[63],"by":[64],"GC-MS":[65],"FTIR.":[67],"CopNc":[68,103,144,149,176,203],"produced":[70],"using":[71],"nanoprecipitation":[73],"method.":[74],"physicochemical":[76,181],"stability,":[77],"toxicity,":[78],"biocompatibility":[80],"systems,":[83],"in":[84,153,160],"vitro,":[85],"then":[87],"evaluated.":[88],"\u03b2-bisabolene,":[89],"cis-\u03b1-bergamotene,":[90],"caryophyllene,":[91],"caryophyllene":[93],"oxide":[94],"identified":[96],"as":[97],"major":[99],"components.":[102],"showed":[104,177],"particle":[106],"size":[107],"215":[109],"\u00b1":[110,118,126,137,147],"10":[111],"nm,":[112],"polydispersity":[114],"index":[115],"0.15":[117],"0.01,":[119],"zeta":[122],"potential":[123],"\u221218":[125],"1.":[127],"These":[128,194],"parameters":[129],"remained":[130],"unchanged":[131],"over":[132],"30":[133],"days":[134],"at":[135,163],"25":[136],"2":[138],"\u00b0C.":[139],"encapsulation":[141],"efficiency":[142],"54":[146],"2%.":[148],"neither":[150],"induced":[151],"hemolysis":[152],"erythrocytes,":[154],"nor":[155],"cytotoxic":[156],"genotoxic":[158],"effects":[159],"lung":[161,192],"cells":[162],"range":[165],"concentrations":[167],"from":[168],"50":[169],"200":[171],"\u03bcg\u00b7mL\u22121":[172],".":[173],"In":[174],"conclusion,":[175],"suitable":[178],"stability":[179],"Moreover,":[183],"formulation":[185],"presented":[186],"remarkable":[188],"safety":[189],"profile":[190],"on":[191],"cells.":[193],"results":[195],"may":[196],"pave":[197],"way":[199],"further":[201],"use":[202],"for":[204,211],"development":[206],"phytotherapeutic":[208],"medicine":[209],"intended":[210],"pulmonary":[212],"delivery":[213],"oil.":[216]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2026-01-10T00:00:00"}