{"id":"https://openalex.org/W7120787266","doi":null,"title":"Neurogenesis and synaptic plasticity in the hippocampus of rats submitted to maternal separation and environmental enrichment","display_name":"Neurogenesis and synaptic plasticity in the hippocampus of rats submitted to maternal separation and environmental enrichment","publication_year":2014,"publication_date":"2014-10-23","ids":{"openalex":"https://openalex.org/W7120787266"},"language":"pt","primary_location":{"id":"pmh:oai:teses.usp.br:tde-17012015-134343","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.17.2017.tde-17012015-134343","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057158534","display_name":"Su\u00e9len Merlo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Merlo, Su\u00e9len","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057158534"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9063000082969666,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.07620000094175339,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-separation","display_name":"maternal separation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/environmental-enrichment","display_name":"environmental enrichment","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/postpartum-stress","display_name":"postpartum stress","score":0.7900000214576721},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/nr3c1","display_name":"NR3C1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/serotonin-receptor-1a","display_name":"serotonin receptor 1A","score":0.7179999947547913},{"id":"https://openalex.org/keywords/5-ht1a-receptor","display_name":"5-HT1A receptor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.6288999915122986},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.583299994468689},{"id":"https://openalex.org/C53927964","wikidata":"https://www.wikidata.org/wiki/Q3054611","display_name":"Environmental enrichment","level":2,"score":0.4691999852657318},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45089998841285706},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4381999969482422},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43160000443458557},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39559999108314514},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3711000084877014},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33970001339912415},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.33660000562667847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31790000200271606},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.298799991607666},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C2986039202","wikidata":"https://www.wikidata.org/wiki/Q123414","display_name":"Environmental stress","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.27000001072883606},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2651999890804291},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.257999986410141}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:teses.usp.br:tde-17012015-134343","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.11606/T.17.2017.tde-17012015-134343","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7049143662","https://openalex.org/W2081785842","https://openalex.org/W7120736734","https://openalex.org/W2790610233","https://openalex.org/W2046457031","https://openalex.org/W3100592582","https://openalex.org/W7065679202","https://openalex.org/W2974963042","https://openalex.org/W2255462709","https://openalex.org/W7058100626"],"abstract_inverted_index":{"Eventos":[0],"estressantes":[1],"durante":[2],"a":[3,12,52,104,110,115,138,145,167,171,177],"inf\u00e2ncia":[4],"promovem":[5],"altera\u00e7\u00f5es":[6,79,182],"comportamentais":[7],"e":[8,96,127,170],"encef\u00e1licas":[9],"persistentes,":[10,189],"aumentando":[11],"predisposi\u00e7\u00e3o":[13],"para":[14,119],"transtornos":[15],"psiqui\u00e1tricos.":[16],"A":[17,106],"separa\u00e7\u00e3o":[18,31,83,107,164,185],"materna":[19,32,84,108,186],"tem":[20],"sido":[21],"utilizada":[22],"como":[23,114],"modelo":[24],"de":[25,65,87,99,117,124,130,140,147,173],"estresse":[26],"p\u00f3s-natal.":[27],"Animais":[28],"submetidos":[29,162],"\u00e0":[30,163],"apresentam":[33],"uma":[34],"resposta":[35],"exacerbada":[36],"do":[37,57,197],"eixo":[38],"hipot\u00e1lamo-hip\u00f3fise-adrenal":[39],"ao":[40],"estresse.":[41],"Ao":[42],"contr\u00e1rio,":[43],"estudos":[44],"sugerem":[45],"que":[46],"o":[47,73],"ambiente":[48],"enriquecido,":[49],"por":[50,102],"aumentar":[51],"neurog\u00eanese":[53,111],"no":[54,85],"giro":[55],"denteado":[56],"hipocampo,":[58],"pode":[59],"ter":[60],"efeitos":[61],"ben\u00e9ficos":[62],"sobre":[63,149],"doen\u00e7as":[64],"dist\u00farbio":[66],"comportamental.":[67],"No":[68],"presente":[69],"projeto":[70],"questionamos":[71],"se":[72],"enriquecimento":[74,135,157,196],"ambiental":[75,136],"interfere":[76],"com":[77],"as":[78],"pl\u00e1sticas":[80],"promovidas":[81,183],"pela":[82,184],"hipocampo":[86],"ratos":[88],"jovens.":[89],"Utilizamos":[90],"imunofluoresc\u00eancia,":[91],"microscopia":[92,94],"confocal,":[93],"eletr\u00f4nica":[95],"qRT-":[97],"PCR":[98],"amostras":[100],"coletadas":[101],"microdissec\u00e7\u00e3o":[103],"laser.":[105],"reduziu":[109,137],"hipocampal,":[112],"bem":[113],"express\u00e3o":[116,139,172],"mRNA":[118],"os":[120],"genes":[121],"Nr3c1,":[122,174],"codificador":[123,129],"receptores":[125,131],"glicocortic\u00f3ides,":[126],"Htr1a,":[128],"serotonin\u00e9rgicos":[132],"(5TH-1A).":[133],"O":[134,156],"Htr1a.":[141],"Al\u00e9m":[142],"disso,":[143],"aumentou":[144,166],"propor\u00e7\u00e3o":[146],"sinapses":[148],"espinhos":[150],"dendr\u00edticos,":[151],"sugerindo":[152],"maior":[153],"plasticidade":[154],"sin\u00e1ptica.":[155],"ambiental,":[158],"nos":[159],"animais":[160],"previamente":[161],"materna,":[165],"sobreviv\u00eancia":[168],"celular":[169],"mas":[175,190],"n\u00e3o":[176],"diferencia\u00e7\u00e3o":[178],"neuronal":[179],"hipocampal.":[180],"As":[181],"parecem":[187],"ser":[188,192],"podem":[191],"parcialmente":[193],"revertidas":[194],"pelo":[195],"ambiente.":[198]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-10T00:00:00"}