{"id":"https://openalex.org/W7120700129","doi":null,"title":"Avalia\u00e7\u00e3o do potencial citot\u00f3xico de complexos in\u00e9ditos de Ru (II) contendo tiomidas em diferentes linhagens de c\u00e9lulas cancer\u00edgenas","display_name":"Avalia\u00e7\u00e3o do potencial citot\u00f3xico de complexos in\u00e9ditos de Ru (II) contendo tiomidas em diferentes linhagens de c\u00e9lulas cancer\u00edgenas","publication_year":2022,"publication_date":"2022-09-30","ids":{"openalex":"https://openalex.org/W7120700129"},"language":"pt","primary_location":{"id":"pmh:oai:saberaberto.uneb.br:20.500.11896/3790","doi":null,"is_oa":true,"landing_page_url":"https://saberaberto.uneb.br/handle/20.500.11896/3790","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNEB","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://saberaberto.uneb.br/handle/20.500.11896/3790","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028768275","display_name":"Luciano Vasconcellos Pacheco","orcid":"https://orcid.org/0000-0002-6210-3828","observed_orcids":["https://orcid.org/0000-0002-6210-3828"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pacheco, Luciano Vasconcellos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5028768275"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruthenium-ii-complexes","display_name":"ruthenium(II) complexes","score":0.9909999966621399},{"id":"https://openalex.org/keywords/thiourea-ligands","display_name":"thiourea ligands","score":0.6150000095367432},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.796999990940094},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.5910000205039978},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.906000018119812},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.6740000247955322},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hemolysis","display_name":"hemolysis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anticancer-metal-complexes","display_name":"anticancer metal complexes","score":0.48100000619888306},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5860000252723694},{"id":"https://openalex.org/keywords/cytotoxicity-screening","display_name":"cytotoxicity screening","score":0.3619999885559082},{"id":"https://openalex.org/keywords/hemolytic-toxicity","display_name":"hemolytic toxicity","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8001000285148621},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4505000114440918},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.35920000076293945},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.26669999957084656},{"id":"https://openalex.org/C2779433975","wikidata":"https://www.wikidata.org/wiki/Q40417805","display_name":"Cyclodextrin","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.2303999960422516},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.22259999811649323},{"id":"https://openalex.org/C49852136","wikidata":"https://www.wikidata.org/wiki/Q906487","display_name":"Depolymerization","level":2,"score":0.1996999979019165},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.19859999418258667}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:saberaberto.uneb.br:20.500.11896/3790","doi":null,"is_oa":true,"landing_page_url":"https://saberaberto.uneb.br/handle/20.500.11896/3790","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNEB","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:saberaberto.uneb.br:20.500.11896/3790","doi":null,"is_oa":true,"landing_page_url":"https://saberaberto.uneb.br/handle/20.500.11896/3790","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNEB","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6991018733","https://openalex.org/W2602632701","https://openalex.org/W2621069522","https://openalex.org/W7120612939","https://openalex.org/W7017411989","https://openalex.org/W2955362244","https://openalex.org/W7119319403","https://openalex.org/W7063957477","https://openalex.org/W7064393410","https://openalex.org/W7120397680"],"abstract_inverted_index":{"c\u00e2ncer":[0],"\u00e9":[1],"definido":[2],"como":[3,236,250,510],"uma":[4,130],"doen\u00e7a":[5],"multifatorial":[6],"sendo":[7,163,323],"iniciada":[8],"por":[9,175,225,257,451],"muta\u00e7\u00f5es":[10],"gen\u00e9ticas":[11],"que":[12,296,394],"causam":[13],"um":[14,26,511],"descontrole":[15],"em":[16,156,286],"v\u00e1rios":[17],"aspectos":[18],"celulares,":[19],"incluindo":[20],"a":[21,78,154,232,293,315,348,358,365,368,383,396,426,489],"prolifera\u00e7\u00e3o.":[22],"As":[23],"leucemias":[24],"constituem":[25],"grupo":[27],"de":[28,34,62,72,80,82,97,99,113,122,125,167,188,195,200,205,223,230,246,264,267,281,288,326,340,350,378,398,410,416,430,437,446,459,508,515],"tumores":[29],"malignos":[30],"caracterizadas":[31],"pelo":[32,165,193,449],"ac\u00famulo":[33],"leuc\u00f3citos":[35],"disfuncionais":[36],"no":[37,49,494],"tecido":[38],"sangu\u00edneo":[39],"e":[40,59,75,106,129,161,177,185,212,216,239,284,299,331,357,367,405,420,477,504],"na":[41,408,428,457],"medula":[42],"\u00f3ssea.":[43],"A":[44,108,228,311],"quimioterapia":[45],"apresenta":[46,54],"papel":[47],"fundamental":[48],"tratamento":[50,450,495],"dos":[51,110,512],"c\u00e2nceres,":[52],"entretanto":[53],"limita\u00e7\u00f5es":[55],"associadas":[56],"\u00e0":[57],"toxicidade":[58],"casos":[60],"emergentes":[61],"resist\u00eancia":[63],"ao":[64],"tratamento.":[65],"Dessa":[66],"forma,":[67],"faz-se":[68],"necess\u00e1rio":[69],"o":[70,94,186,198,203,240,275,297,300,385,393,455,475,479],"desenvolvimento":[71],"novos":[73],"f\u00e1rmacos,":[74],"nesse":[76],"contexto":[77],"utiliza\u00e7\u00e3o":[79],"complexos":[81,98,112,208,321,403],"rut\u00eanio":[83,100,114],"(Ru)":[84],"tem":[85],"demonstrado":[86,338],"resultados":[87],"promissores.":[88],"Objetivos:":[89],"O":[90,140,253,464],"trabalho":[91],"visa":[92],"avaliar":[93],"potencial":[95],"citot\u00f3xico":[96,470],"Ru(II)":[101],"contendo":[102,115,243],"tioamidas":[103,116],"in\u00e9ditos.":[104],"Materiais":[105],"M\u00e9todos:":[107],"citotoxicidade":[109,351],"quatro":[111],"foram":[117,173,219,272],"testados":[118],"contra":[119],"10":[120],"linhagens":[121,308],"c\u00e9lulas":[123,171,189,271,354],"cancer\u00edgenas":[124,309],"diferentes":[126,157,181],"tipos":[127],"histol\u00f3gicos":[128],"linhagem":[131,312],"n\u00e3o":[132],"cancer\u00edgena":[133,360],"atrav\u00e9s":[134],"do":[135,137,144,151,183,278,485],"ensaio":[136,141,166,194,204,254],"Alamar":[138,168],"Blue.":[139,169],"para":[142,305,318,474,478],"avalia\u00e7\u00e3o":[143],"sinergismo":[145,363],"foi":[146,191,234,248,255,314,441],"realizado":[147],"dispondo":[148,277],"da":[149,343,390,444,496,506],"associa\u00e7\u00e3o":[150],"FOR0212A":[152,184,276,298,344,366,404,456,476,487],"com":[153,180,197,221,274,373,454,471,488],"doxorrubicina":[155],"propor\u00e7\u00f5es":[158],"(1:1,":[159],"2:1":[160],"1:2)":[162],"mensurado":[164],"Posteriormente,":[170],"HL-60":[172,313],"incubadas":[174],"24":[176],"48":[178],"horas":[179],"concentra\u00e7\u00f5es":[182,502],"n\u00famero":[187],"vi\u00e1veis":[190],"determinado":[192],"exclus\u00e3o":[196],"azul":[199],"tripam.":[201],"Para":[202,260],"hem\u00f3lise,":[206],"os":[207,262,319,402],"FOR0212A,":[209],"FOR0012A,":[210,406],"FOR020":[211],"FOR000":[213],"(12,5;":[214],"25":[215],"50":[217,411],"\u00b5M),":[218],"incubados":[220],"suspens\u00e3o":[222],"eritr\u00f3citos":[224],"1":[226,452],"hora.":[227],"solu\u00e7\u00e3o":[229],"saponina":[231],"1%":[233],"utilizada":[235],"controle":[237,251],"positivo,":[238],"PBS":[241],"1x":[242],"0,5%":[244],"(v/v)":[245],"DMSO":[247],"utilizado":[249,493],"negativo.":[252],"quantificado":[256],"espectrofotometria":[258],"(540nm).":[259],"quantificar":[261],"n\u00edveis":[263],"esp\u00e9cies":[265],"reativas":[266],"oxig\u00eanio":[268],"(ERO),":[269],"as":[270,307,353],"tratadas":[273],"reagente":[279],"diacetato":[280],"2,7-diclorodihidrofluoresce\u00edna":[282],"(H2-DCF-DA)":[283],"adquiridas":[285],"citometro":[287],"fluxo.":[289],"Resultados:":[290],"Quando":[291],"avaliada":[292,347],"citotoxicidade,":[294],"observou-se":[295],"FOR0012A":[301,480],"apresentaram":[302],"atividade":[303,414,499],"citot\u00f3xica":[304],"todas":[306],"testadas.":[310],"mais":[316],"sens\u00edvel":[317],"dois":[320],"met\u00e1licos,":[322],"obtidos":[324],"CI50":[325],"1,5":[327],"\u00b5M":[328,333,432,461],"(\u00b1":[329,334,380,418,435],"0,3)":[330],"5,7":[332],"0,9),":[335],"respectivamente.":[336,423],"Foi":[337],"\u00edndice":[339,376],"seletividade":[341,473],"relevante":[342],"(6,6)":[345],"quando":[346],"raz\u00e3o":[349],"entre":[352,364],"normais":[355],"(MRC-5)":[356],"c\u00e9lula":[359],"(HL-60).":[361],"Observou-se":[362],"doxorrubicina,":[369,427,490],"frente":[370],"modelo":[371],"celular":[372],"HL-60,":[374],"apresentando":[375],"combinat\u00f3rio":[377],"0,27":[379],"0,09).":[381],"Associado":[382],"isso,":[384,425],"isobolograma":[386],"evidenciou":[387],"pontos":[388],"abaixo":[389],"linha":[391],"isobologr\u00e1fica,":[392],"sugere":[395],"ocorr\u00eancia":[397],"efeito":[399,469,483],"sin\u00e9rgico.":[400],"Ademais,":[401,481],"ambas":[407],"concentra\u00e7\u00e3o":[409,429,458],"\u00b5M,":[412],"evidenciaram":[413],"hemol\u00edtica":[415,500],"21%":[417],"1,0)":[419],"1%(\u00b1":[421],"0,8),":[422],"Enquanto":[424],"20":[431],"apresentou":[433],"13%":[434],"0,8)":[436],"hem\u00f3lise.":[438],"Por":[439],"fim,":[440],"observada":[442],"eleva\u00e7\u00e3o":[443],"produ\u00e7\u00e3o":[445,507],"ERO\u00b4s,":[447],"induzida":[448],"hora,":[453],"3":[460],"(p<0,05).":[462],"Conclus\u00e3o:":[463],"presente":[465],"estudo":[466],"permitiu":[467],"observar":[468],"boa":[472],"visualizou-se":[482],"sin\u00e9rgico":[484],"complexo":[486],"f\u00e1rmaco":[491],"j\u00e1":[492],"LPA,":[497],"baixa":[498],"nas":[501],"citot\u00f3xicas":[503],"aumento":[505],"ERO":[509],"prov\u00e1veis":[513],"mecanismos":[514],"morte":[516],"celular.":[517]},"counts_by_year":[],"updated_date":"2026-07-02T06:18:51.028212","created_date":"2026-01-10T00:00:00"}
