{"id":"https://openalex.org/W7120675016","doi":null,"title":"Vitamin D deficiency induces acute kidney injury in rats treated with lipid formulation of amphotericin B","display_name":"Vitamin D deficiency induces acute kidney injury in rats treated with lipid formulation of amphotericin B","publication_year":2019,"publication_date":"2019-06-24","ids":{"openalex":"https://openalex.org/W7120675016"},"language":"pt","primary_location":{"id":"pmh:oai:teses.usp.br:tde-03092019-120216","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.11606/T.5.2019.tde-03092019-120216","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-03092019-120216/","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-03092019-120216/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122617560","display_name":"Daniela Gomes de Albuquerque Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Ferreira, Daniela","raw_affiliation_strings":["Laboratorio de Investigacao Medica 12 (LIM12) , Faculdade de Medicina , Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Investigacao Medica 12 (LIM12) , Faculdade de Medicina , Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5122617560"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.08900000154972076,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.08560000360012054,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.9729999899864197},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8809999823570251},{"id":"https://openalex.org/keywords/amphotericin-b","display_name":"amphotericin B","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hyperphosphatemia","display_name":"hyperphosphatemia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hypermagnesemia","display_name":"hypermagnesemia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9480000138282776},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.4309999942779541},{"id":"https://openalex.org/keywords/urine-concentrating-mechanism","display_name":"urine concentrating mechanism","score":0.5249999761581421},{"id":"https://openalex.org/keywords/kidney-histopathology","display_name":"kidney histopathology","score":0.6259999871253967},{"id":"https://openalex.org/keywords/drug-induced-nephrotoxicity","display_name":"drug-induced nephrotoxicity","score":0.4020000100135803},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.46799999475479126},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.5929999947547913},{"id":"https://openalex.org/keywords/renal-hemodynamics","display_name":"renal hemodynamics","score":0.30399999022483826}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6646000146865845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3971000015735626},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3571000099182129},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3458999991416931},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.3433000147342682},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3384000062942505},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32120001316070557},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.3100999891757965},{"id":"https://openalex.org/C2779629538","wikidata":"https://www.wikidata.org/wiki/Q412223","display_name":"Amphotericin B","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C2780880258","wikidata":"https://www.wikidata.org/wiki/Q3771629","display_name":"Magnesium deficiency (plants)","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C2909587778","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Kidney tubules","level":3,"score":0.259799987077713},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.25949999690055847},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2581000030040741}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:teses.usp.br:tde-03092019-120216","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.11606/T.5.2019.tde-03092019-120216","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-03092019-120216/","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:teses.usp.br:tde-03092019-120216","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.11606/T.5.2019.tde-03092019-120216","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-03092019-120216/","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7120675016.pdf","grobid_xml":"https://content.openalex.org/works/W7120675016.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2961061133","https://openalex.org/W2971750621","https://openalex.org/W2899266773","https://openalex.org/W7120736877","https://openalex.org/W7120898729","https://openalex.org/W1927838852","https://openalex.org/W3041748064","https://openalex.org/W1839598466","https://openalex.org/W1508018197","https://openalex.org/W7119993925"],"abstract_inverted_index":{"As":[0],"infec\u00e7\u00f5es":[1],"f\u00fangicas":[2],"invasivas":[3],"(IFIs)":[4],"s\u00e3o":[5],"um":[6,281],"problema":[7],"de":[8,16,27,51,70,93,95,121,167,203,211,235,255,265,284],"sa\u00fade":[9],"p\u00fablica":[10],"e":[11,18,59,86,114,164,186,199,214,230,251],"representam":[12],"uma":[13,79,90,273],"importante":[14],"causa":[15],"morbidade":[17],"mortalidade.":[19],"A":[20,233],"Anfotericina":[21],"B":[22],"(AnfB)":[23],"\u00e9":[24,260,280],"a":[25,37,45,62,75,104,109,128,135,200,220,227,238,242,276],"droga":[26,225],"escolha":[28],"no":[29],"tratamento":[30],"das":[31],"IFIs.":[32],"Apesar":[33],"da":[34,111,130,137,224,289],"sua":[35],"efic\u00e1cia,":[36],"AnfB":[38,76],"est\u00e1":[39],"associada":[40,286],"com":[41,237,271],"efeitos":[42,223],"adversos":[43],"como":[44],"nefrotoxicidade.":[46,122],"Com":[47],"o":[48],"n\u00famero":[49],"elevado":[50],"pacientes":[52,269],"suscet\u00edveis":[53],"\u00e0s":[54],"IFIs,":[55],"estudos":[56],"foram":[57,141,217],"desenvolvidos":[58],"demonstraram":[60],"que":[61,148,157,176,189,275],"nefrotoxicidade":[63,136,285],"pode":[64,107,133],"ser":[65],"prevenida":[66],"atrav\u00e9s":[67],"do":[68,253],"uso":[69,288],"AnfBs":[71],"modificadas.":[72],"Dessas":[73],"modifica\u00e7\u00f5es,":[74],"incorporada":[77],"\u00e0":[78],"emuls\u00e3o":[80],"lip\u00eddica":[81],"(AnfB/EL)":[82],"apresenta":[83],"baixo":[84],"custo":[85],"similar":[87],"efic\u00e1cia.":[88],"Existe":[89],"alta":[91],"preval\u00eancia":[92],"defici\u00eancia":[94,129,277],"vitamina":[96,131,181,194,266,279],"D":[97,106,132,182,195,240,267],"(dVD)":[98],"na":[99],"popula\u00e7\u00e3o":[100],"mundial.":[101],"Sendo":[102],"assim,":[103],"hipovitaminose":[105,239],"acelerar":[108],"progress\u00e3o":[110],"doen\u00e7a":[112],"renal":[113,216],"refletir":[115],"em":[116,119,143,180,193,268],"mau":[117],"progn\u00f3stico":[118],"casos":[120],"Esse":[123],"trabalho":[124],"visa":[125],"analisar":[126],"se":[127],"induzir":[134],"AnfB/EL.":[138],"Ratos":[139],"Wistar":[140],"divididos":[142],"quatro":[144],"grupos:":[145],"controle,":[146],"animais":[147,156,175,188],"receberam":[149,158,177,190],"dieta":[150,159,178,191],"padr\u00e3o":[151,160],"por":[152,161,183,196],"34":[153,162,184,197],"dias;":[154,173,185],"AnfB/EL,":[155,272],"dias":[163,198],"inje\u00e7\u00e3o":[165,201],"intraperitoneal":[166,202],"AnfB/EL":[168,204,236,290],"(5mg/kg/dia)":[169,205],"nos":[170,206],"\u00faltimos":[171,207],"4":[172,208],"dVD,":[174],"depletada":[179,192],"dVD+AnfB/EL,":[187],"dias.":[209],"Amostras":[210],"sangue,":[212],"urina":[213],"tecido":[215],"coletadas":[218],"para":[219],"an\u00e1lise":[221],"dos":[222],"sobre":[226],"fun\u00e7\u00e3o,":[228],"hemodin\u00e2mica":[229],"morfologia":[231],"renal.":[232],"associa\u00e7\u00e3o":[234],"levou":[241],"inj\u00faria":[243],"renal,":[244],"les\u00e3o":[245],"tubular":[246],"discreta,":[247],"hiperfosfat\u00faria,":[248],"hipermagnesi\u00faria,":[249],"hipertens\u00e3o":[250],"comprometimento":[252],"mecanismo":[254],"concentra\u00e7\u00e3o":[256],"urin\u00e1ria.":[257],"Dessa":[258],"forma,":[259],"essencial":[261],"monitorar":[262],"os":[263],"n\u00edveis":[264],"tratados":[270],"vez":[274],"dessa":[278],"fator":[282],"indutor":[283],"ao":[287]},"counts_by_year":[],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2026-01-10T00:00:00"}
