{"id":"https://openalex.org/W7120650679","doi":null,"title":"Characterization of photodamaged skin, development and clinical efficacy of dermocosmetic formulations by biophysical and skin imaging techniques","display_name":"Characterization of photodamaged skin, development and clinical efficacy of dermocosmetic formulations by biophysical and skin imaging techniques","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W7120650679"},"language":"pt","primary_location":{"id":"pmh:oai:teses.usp.br:tde-02052016-152624","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","pdf_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080329968","display_name":"Daiane Garcia Merc\u00fario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Mercurio, Daiane Garcia","raw_affiliation_strings":["Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto - Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto , 2015"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto - Universidade de S\u00e3o Paulo , Ribeir\u00e3o Preto , 2015","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080329968"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-photodamage","display_name":"photodamaged skin","score":0.8050000071525574},{"id":"https://openalex.org/keywords/photoaging","display_name":"photoaging","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dermocosmetic-formulation","display_name":"dermocosmetic formulation","score":0.859000027179718},{"id":"https://openalex.org/keywords/d-alpha-tocopherol","display_name":"D-alpha-tocopherol","score":0.7020000219345093},{"id":"https://openalex.org/keywords/retinyl-palmitate","display_name":"retinyl palmitate","score":0.9160000085830688},{"id":"https://openalex.org/keywords/alpha-tocopheryl-acetate","display_name":"alpha-tocopherol acetate","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anti-aging-cosmetics","display_name":"anti-aging cosmetics","score":0.753000020980835},{"id":"https://openalex.org/keywords/formulation-stability","display_name":"formulation stability","score":0.7749999761581421},{"id":"https://openalex.org/keywords/skin-imaging","display_name":"skin imaging","score":0.3840000033378601},{"id":"https://openalex.org/keywords/skin-biophysics","display_name":"skin biophysics","score":0.796999990940094},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.3720000088214874},{"id":"https://openalex.org/keywords/skin-elasticity","display_name":"skin elasticity","score":0.44999998807907104},{"id":"https://openalex.org/keywords/skin-roughness","display_name":"skin roughness","score":0.5210000276565552},{"id":"https://openalex.org/keywords/skin-autofluorescence","display_name":"skin autofluorescence","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4634000062942505},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.3391000032424927},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.33410000801086426},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.29280000925064087},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2870999872684479},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.22540000081062317},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.21559999883174896},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.19820000231266022},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.1876000016927719},{"id":"https://openalex.org/C175933922","wikidata":"https://www.wikidata.org/wiki/Q3344895","display_name":"Artificial skin","level":2,"score":0.1873999983072281}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:teses.usp.br:tde-02052016-152624","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","pdf_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:teses.usp.br:tde-02052016-152624","doi":null,"is_oa":true,"landing_page_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","pdf_url":"http://www.teses.usp.br/teses/disponiveis/60/60137/tde-02052016-152624/","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7120650679.pdf","grobid_xml":"https://content.openalex.org/works/W7120650679.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2345592564","https://openalex.org/W4386826015","https://openalex.org/W1484730753","https://openalex.org/W2336462770","https://openalex.org/W2281291527","https://openalex.org/W7017224695","https://openalex.org/W2941769742","https://openalex.org/W6981654925","https://openalex.org/W7120886273","https://openalex.org/W7120468951"],"abstract_inverted_index":{"O":[0,491],"fotoenvelhecimento":[1,309],"tem":[2,45],"sido":[3],"um":[4,60,337],"assunto":[5],"de":[6,26,34,66,112,120,124,137,139,163,165,170,174,207,211,213,218,234,238,250,254,261,267,282,301,319,330,339,352,354,430,461,469,473,482,485],"grande":[7],"interesse":[8],"na":[9,81,190,365,386,388,398,437,502,526],"\u00e1rea":[10],"cosm\u00e9tica":[11],"e":[12,30,40,42,69,104,108,149,172,194,215,220,232,252,257,291,317,327,349,361,368,377,413,419,433,440,471,509],"dermatol\u00f3gica.":[13,528],"Portanto,":[14],"\u00e9":[15],"relevante":[16,513],"a":[17,106,109,181,240,273,350,373,478,495],"caracteriza\u00e7\u00e3o":[18,185,464],"da":[19,85,153,186,222,280,312,346,396,400,406,408,411,415,417,421,443,447,450,453,465,497,506],"pele":[20,86,187,366,466,507],"fotoenvelhecida,":[21,508],"bem":[22,278],"como":[23,48,279,525],"o":[24,63,90,131,515],"desenvolvimento":[25],"formula\u00e7\u00f5es":[27,113,158,244,294,427],"dermocosm\u00e9ticas":[28],"adequadas":[29],"direcionadas":[31],"\u00e0":[32],"finalidade":[33],"uso":[35,262,516],"proposta.":[36],"As":[37,243,293,426],"vitaminas":[38,431],"A":[39,184,224,270,381,432,463],"E":[41,434],"seus":[43],"derivados":[44,429],"se":[46],"destacado":[47],"subst\u00e2ncias":[49],"ativas":[50],"para":[51,79,144,477,514],"tal":[52],"finalidade,":[53],"e,":[54],"baseado":[55],"nesse":[56],"conceito,":[57],"foi":[58,95,129,142,199,227,335,475],"proposto":[59],"composto":[61],"inovador,":[62],"Tocoretinate":[64,117,384,501],"(\u00e9ster":[65],"all-trans-\u00e1cido":[67],"retinoico":[68,78],"D-?-tocoferol),":[70],"uma":[71],"potencial":[72],"subst\u00e2ncia":[73],"ativa":[74],"alternativa":[75],"ao":[76,308],"\u00e1cido":[77],"atuar":[80],"melhoria":[82,410,503],"das":[83,151,197,423,504],"condi\u00e7\u00f5es":[84,505],"fotoenvelhecida.":[87],"Nesse":[88],"contexto,":[89],"objetivo":[91],"do":[92,101,168,393,402,480],"presente":[93],"projeto":[94],"caracterizar":[96],"as":[97,176,488],"altera\u00e7\u00f5es":[98],"cut\u00e2neas":[99],"decorrentes":[100],"fotoenvelhecimento,":[102],"desenvolver":[103],"avaliar":[105,145],"estabilidade":[107,302],"efic\u00e1cia":[110,486,496],"cl\u00ednica":[111,527],"cosm\u00e9ticas":[114],"antienvelhecimento":[115],"contendo":[116,383,428,500],"(TR),":[118],"palmitato":[119,164],"retinila":[121],"ou":[122,160],"acetato":[123,169],"tocoferila.":[125],"Para":[126],"tal,":[127],"inicialmente":[128],"feito":[130],"planejamento":[132],"experimental":[133],"Box-Behnken":[134],"com":[135],"metodologia":[136],"superf\u00edcie":[138],"resposta":[140],"(MSR)":[141],"executado":[143],"os":[146,456],"principais":[147,305],"efeitos":[148,276,306],"intera\u00e7\u00f5es":[150],"mat\u00e9rias-primas":[152],"formula\u00e7\u00e3o.":[154],"Foram":[155],"selecionadas":[156],"tr\u00eas":[157],"contendo,":[159],"n\u00e3o,":[161],"0,5%":[162],"retinila,":[166],"5%":[167],"tocoferila":[171],"0,1%":[173],"Tocoretinate,":[175],"quais":[177],"foram":[178,246,296,363],"avaliadas":[179,247],"quanto":[180],"sua":[182],"estabilidade.":[183],"fotoenvelhecida":[188],"brasileira":[189,367],"face,":[191],"nos":[192],"antebra\u00e7os":[193],"no":[195,229,391,445],"dorso":[196],"m\u00e3os":[198],"realizada":[200,228],"em":[201,204,285,522],"80":[202],"volunt\u00e1rias":[203,236,264],"dois":[205],"grupos":[206],"idade":[208],"por":[209,216,248,467],"meio":[210],"question\u00e1rios":[212],"autoavalia\u00e7\u00e3o":[214],"t\u00e9cnicas":[217,249,468],"biof\u00edsica":[219,251,470],"imagem":[221,255,474],"pele.":[223],"mesma":[225],"avalia\u00e7\u00e3o":[226,274],"antebra\u00e7o":[230],"volar":[231],"face":[233],"41":[235],"francesas":[237],"40":[239,268],"65":[241],"anos.":[242,269],"desenvolvidas":[245,295],"an\u00e1lise":[253,333,472],"antes":[256],"ap\u00f3s":[258,458],"84":[259,459],"dias":[260,460],"pelas":[263],"brasileiras":[265],"acima":[266],"MSR":[271],"permitiu":[272],"dos":[275],"isolados":[277],"intera\u00e7\u00e3o":[281],"mat\u00e9rias":[283],"primas":[284],"respostas":[286],"como:":[287],"par\u00e2metros":[288],"reol\u00f3gicos,":[289],"sensorial":[290],"hidrata\u00e7\u00e3o.":[292],"consideradas":[297],"est\u00e1veis":[298],"pelos":[299],"testes":[300],"realizados.":[303],"Os":[304],"relacionados":[307],"foram:":[310],"perda":[311],"qualidade":[313],"el\u00e1stica,":[314],"maior":[315,323,328],"n\u00famero":[316],"largura":[318],"rugas,":[320],"menor":[321],"ecogenicidade,":[322],"\u00e2ngulo":[324],"tipol\u00f3gico":[325],"individual":[326],"tamanho":[329],"corne\u00f3citos.":[331],"Na":[332],"morfol\u00f3gica,":[334],"observado":[336],"padr\u00e3o":[338],"pigmenta\u00e7\u00e3o":[340,416],"irregular,":[341],"queratin\u00f3citos":[342,457],"distribu\u00eddos":[343],"irregularmente,":[344],"achatamento":[345],"jun\u00e7\u00e3o":[347],"dermoepid\u00e9rmica":[348],"presen\u00e7a":[351],"fibras":[353],"col\u00e1geno":[355],"deterioradas.":[356],"Diferentes":[357],"caracter\u00edsticas":[358],"morfol\u00f3gicas,":[359],"estruturais":[360],"biof\u00edsicas":[362],"encontradas":[364],"francesa,":[369],"que":[370],"s\u00e3o":[371],"submetidas":[372],"diferentes":[374],"fatores":[375],"ambientais":[376],"apresentam":[378],"h\u00e1bitos":[379],"distintos.":[380],"formula\u00e7\u00e3o":[382,498],"atuou":[385],"hidrata\u00e7\u00e3o,":[387],"elasticidade":[389],"l\u00edquida,":[390],"aumento":[392,405,420,446,452],"componente":[394],"viscoso":[395],"pele,":[397,444],"redu\u00e7\u00e3o":[399,414],"espessura":[401,407],"estrato":[403],"c\u00f3rneo,":[404],"epiderme,":[409],"homogeneidade":[412],"epiderme":[418],"profundidade":[422],"papilas":[424],"d\u00e9rmicas.":[425],"apresentaram":[435],"efeito":[436],"hidrata\u00e7\u00e3o":[438],"cut\u00e2nea":[439],"fun\u00e7\u00e3o":[441],"barreira":[442],"por\u00e7\u00e3o":[448],"viscoel\u00e1stica":[449],"curva,":[451],"reflect\u00e2ncia":[454],"entre":[455],"estudo.":[462],"fundamental":[476],"defini\u00e7\u00e3o":[479],"protocolo":[481],"estudo":[483,492],"cl\u00ednico":[484,493],"aplicando":[487],"referidas":[489],"t\u00e9cnicas.":[490],"mostrou":[494],"desenvolvida":[499],"fornece":[510],"embasamento":[511],"cient\u00edfico":[512],"deste":[517],"ingrediente":[518],"ativo":[519],"inovador":[520],"tanto":[521],"produtos":[523],"cosm\u00e9ticos":[524]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-01-10T00:00:00"}
