{"id":"https://openalex.org/W7120635758","doi":null,"title":"Assessment of complement activation in SARS-CoV-2 (COVID-19) infection with D-dimer greater than 3,000 ng/mL FEU","display_name":"Assessment of complement activation in SARS-CoV-2 (COVID-19) infection with D-dimer greater than 3,000 ng/mL FEU","publication_year":2025,"publication_date":"2025-05-07","ids":{"openalex":"https://openalex.org/W7120635758"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/74137","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11600/74137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11600/74137","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017465007","display_name":"Daniela Ghidetti Mangas Catarino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Catarino, Daniela Ghidetti Mangas [UNIFESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5017465007"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9340000152587891},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.972000002861023},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mechanical-ventilation","display_name":"mechanical ventilation","score":0.5479999780654907},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6859999895095825},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.5899999737739563},{"id":"https://openalex.org/keywords/c5a","display_name":"C5a","score":0.3319999873638153},{"id":"https://openalex.org/keywords/c3a","display_name":"C3a","score":0.6169999837875366},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.6150000095367432},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.4690000116825104},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.3009999990463257},{"id":"https://openalex.org/keywords/c5","display_name":"C5","score":0.5059999823570251},{"id":"https://openalex.org/keywords/c4","display_name":"C4","score":0.4869999885559082},{"id":"https://openalex.org/keywords/c1r","display_name":"C1r","score":0.36399999260902405},{"id":"https://openalex.org/keywords/c1s","display_name":"C1s","score":0.8389999866485596},{"id":"https://openalex.org/keywords/c2","display_name":"C2","score":0.3700000047683716},{"id":"https://openalex.org/keywords/c3b","display_name":"C3b","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6183000206947327},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3456000089645386},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2955999970436096},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.2912999987602234},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27320000529289246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24160000681877136},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.24079999327659607},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.23720000684261322},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23690000176429749}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repositorio.unifesp.br:11600/74137","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11600/74137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/74137","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11600/74137","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403554833","https://openalex.org/W4403554257","https://openalex.org/W4387730178","https://openalex.org/W4306321028","https://openalex.org/W3208442617","https://openalex.org/W3211449608","https://openalex.org/W4306321439","https://openalex.org/W7117960816","https://openalex.org/W3195364089","https://openalex.org/W3196788695"],"abstract_inverted_index":{"Introdu\u00e7\u00e3o:":[0],"O":[1,488],"sistema":[2,512],"complemento":[3,34,48,550],"e":[4,11,30,65,79,90,114,119,134,188,250,279,289,326,333,343,353,358,379,414,442,445,450,459,462,475,477,480,482,485,578],"de":[5,16,28,63,73,76,96,104,111,136,150,153,165,172,193,199,216,220,223,244,251,265,270,297,303,317,330,391,408,427,494,534,544,554,593],"coagula\u00e7\u00e3o":[6],"compartilham":[7],"algumas":[8],"proteases":[9],"ativas":[10],"h\u00e1":[12],"uma":[13],"grande":[14],"quantidade":[15],"evid\u00eancias":[17],"mostrando":[18],"sua":[19,66],"interconex\u00e3o.":[20],"Na":[21],"COVID19,":[22],"o":[23,143,268,440,542],"D-d\u00edmero":[24,55,91,441,449,495,583],"\u00e9":[25],"um":[26,504],"marcador":[27,505],"gravidade,":[29],"a":[31,43,102,107,148,431,492,507,527],"ativa\u00e7\u00e3o":[32,44,127,271,286,296,510,567],"do":[33,47,109,128,167,272,287,340,511,549,568],"tem":[35],"sido":[36],"associada":[37],"\u00e0":[38,375,389,467],"insufici\u00eancia":[39],"respirat\u00f3ria.":[40],"Objetivo:":[41],"Avaliar":[42],"da":[45,126,197,238,509],"via":[46,528],"em":[49,204,208,214,228,246,253,262,349,373,387,418,465,517,561,580],"pacientes":[50,83,166,520,524,581],"com":[51,68,85,190,267,299,521,546,582],"COVID-19":[52],"que":[53,57,93,491,514,525,541,565],"apresentaram":[54,526],"maior":[56,92,532],"3.000":[58,94,497],"ng/mL":[59,95,498,585],"FEU":[60,97,499,586],"(unidade":[61],"equivalente":[62],"fibrinog\u00eanio)":[64],"correla\u00e7\u00e3o":[67,428,434],"desfechos":[69],"cl\u00ednicos,":[70,117],"como":[71,503,590],"presen\u00e7a":[72],"trombose,":[74],"necessidade":[75,390,533],"suporte":[77,392,535],"ventilat\u00f3rio":[78,536],"mortalidade.":[80],"M\u00e9todo:":[81],"Cinquenta":[82],"internados":[84,203],"COVID-19,":[86],"confirmados":[87],"por":[88,163],"RT-PCR,":[89],"foram":[98,122,360],"recrutados":[99],"entre":[100,142,309,439,448,457,478],"fevereiro":[101],"junho":[103],"2021":[105],"ap\u00f3s":[106],"assinatura":[108],"termo":[110],"consentimento":[112],"livre":[113],"esclarecido.":[115],"Dados":[116],"epidemiol\u00f3gicos":[118],"amostras":[120],"laboratoriais":[121],"coletados":[123],"para":[124,506],"avalia\u00e7\u00e3o":[125],"complemento,":[129,513],"marcadores":[130],"inflamat\u00f3rios,":[131],"fenotipagem":[132],"ABO":[133],"teste":[135],"antiglobulina":[137],"direta.":[138],"Resultados:":[139],"A":[140,159,257,337,362],"mediana":[141,171,339],"in\u00edcio":[144],"dos":[145,255],"sintomas":[146],"at\u00e9":[147],"coleta":[149,198],"sangue":[151],"foi":[152,161,259,345,364,401,424],"15":[154],"dias":[155],"(13,0;":[156],"19,0":[157],"dias).":[158],"amostra":[160,258,399],"composta":[162],"72%":[164,230],"sexo":[168],"masculino,":[169],"idade":[170],"62":[173],"anos":[174],"(53,8;":[175],"68,0),":[176],"sendo":[177],"52%":[178],"hipertensos,":[179],"46%":[180],"obesos,":[181],"34%":[182],"diab\u00e9ticos,":[183],"26%":[184],"cardiopatas,":[185],"10%":[186],"asm\u00e1ticos":[187],"6%":[189,226],"diagn\u00f3stico":[191,232],"pr\u00e9vio":[192],"neoplasia.":[194],"No":[195],"momento":[196],"sangue,":[200],"94%":[201],"estavam":[202,207,213,227],"UTI,":[205],"64%":[206],"ventila\u00e7\u00e3o":[209],"mec\u00e2nica":[210],"invasiva,":[211],"98%":[212],"uso":[215],"medica\u00e7\u00e3o":[217],"anticoagulante,":[218],"100%":[219],"corticosteroides,":[221],"37%":[222],"drogas":[224],"vasoativas,":[225],"di\u00e1lise,":[229],"tinham":[231],"infeccioso":[233],"presumido":[234],"ou":[235,300],"confirmado":[236],"al\u00e9m":[237,329],"COVID-19.":[239,522,596],"Foi":[240],"observado":[241],"dosagem":[242,338,407,493],"alterada":[243],"CH50":[245,278,288,318,458],"21":[247],"participantes":[248],"(42%)":[249],"AH50":[252,280,290,298,321],"25%":[254],"pacientes.":[256],"ent\u00e3o":[260],"dividida":[261],"3":[263,293,311],"grupos":[264,312],"acordo":[266],"perfil":[269],"SC:":[273],"grupo":[274,282,292],"1":[275],"(G1)":[276],"-":[277,285,295],"normais;":[281],"2":[283],"(G2)":[284],"normal;":[291],"(G3)":[294],"sem":[301],"altera\u00e7\u00e3o":[302],"CH50.":[304],"Observou-se":[305,433],"diferen\u00e7a":[306,372,384,403],"estatisticamente":[307,385,404,437,455],"significativa":[308,386,405,438,447,456],"os":[310,519],"independentes":[313],"nas":[314],"dosagens":[315],"medianas":[316],"(p<":[319,322,335],"0,001),":[320],"0,001);":[323],"C3":[324,464],"(p=0,023)":[325],"C4":[327],"(p=0,041)":[328],"leuc\u00f3citos":[331],"(p<0,001)":[332],"neutr\u00f3filos":[334],"0,001).":[336],"D-d\u00edmero,":[341],"ferritina":[342,479],"haptoglobina":[344,411,574],"menor":[346],"no":[347,367],"G2":[348],"rela\u00e7\u00e3o":[350,374,388,419,466],"ao":[351,420],"G1":[352],"G3,":[354],"enquanto":[355],"fibrinog\u00eanio,":[356],"IL-6":[357],"plaquetas":[359],"maiores.":[361],"linfopenia":[363,579],"mais":[365,556],"pronunciada":[366],"G3.":[368],"N\u00e3o":[369],"se":[370],"observou":[371],"trombose":[376],"confirmada":[377],"(p=0.353)":[378],"mortalidade":[380,594],"(p=0.5021),":[381],"mas":[382],"houve":[383,531],"respirat\u00f3rio":[393],"invasivo":[394],"(p=0.0109).":[395],"Al\u00e9m":[396,570],"disso,":[397,571],"na":[398,406,595],"total,":[400],"observada":[402],"fibrinog\u00eanio":[409,576],"(p=0.0093);":[410],"(p=":[412,416],"0.0082)":[413],"linf\u00f3citos":[415],"0.0244)":[417],"desfecho":[421],"vital.":[422],"Oportunamente,":[423],"realizada":[425],"an\u00e1lise":[426],"considerando":[429],"toda":[430],"amostra.":[432],"linear":[435],"inversa":[436],"trombomodulina":[443],"(TM)":[444],"marginalmente":[446],"C2.":[451],"Correla\u00e7\u00e3o":[452],"proporcional":[453],"positiva":[454],"AH50;":[460],"TM":[461],"fibrinog\u00eanio;":[463],"AH50,":[468],"CH50,":[469],"C2,":[470],"C4,":[471],"C5,":[472],"fator":[473,483],"H":[474,484],"haptoglobina,":[476,481],"fibrinog\u00eanio.":[486],"Conclus\u00e3o:":[487],"estudo":[489],"sugere":[490],"\u2265":[496],"pode":[500],"ser":[501,552,588],"utilizada":[502],"pesquisa":[508],"n\u00e3o":[515],"ocorre":[516],"todos":[518],"Nos":[523],"alternativa":[529],"ativada,":[530],"invasivo.":[537],"Dessa":[538],"forma,":[539],"acreditamos":[540],"emprego":[543],"terapias":[545],"medicamentos":[547],"inibidores":[548],"poderia":[551],"utilizado":[553],"modo":[555],"assertivo":[557],"nessa":[558],"e,":[559],"possivelmente,":[560],"outras":[562],"infe\u00e7\u00f5es":[563],"virais":[564],"apresentam":[566],"complemento.":[569],"dados":[572],"sobre":[573],"aumentada,":[575],"normal":[577],"\u22653.000":[584],"podem":[587],"\u00fateis":[589],"poss\u00edveis":[591],"preditores":[592]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-01-10T00:00:00"}