{"id":"https://openalex.org/W7120594098","doi":null,"title":"CHRONIC SODIUM FLUORIDE INTAKE PROMOTES CHANGES IN INSULIN SIGNALING AND INFLAMMATORY PATHWAYS IN THE SKELETAL MUSCLE OF RATS","display_name":"CHRONIC SODIUM FLUORIDE INTAKE PROMOTES CHANGES IN INSULIN SIGNALING AND INFLAMMATORY PATHWAYS IN THE SKELETAL MUSCLE OF RATS","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W7120594098"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.unesp.br:11449/237758","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/237758","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11449/237758","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000118523","display_name":"Fernando Yamamoto Chiba","orcid":"https://orcid.org/0000-0003-4406-405X","observed_orcids":["https://orcid.org/0000-0003-4406-405X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yamamoto Chiba, Fernando[UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122450190","display_name":"Thais Veronica Saori [UNESP] Tsosura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsosura, Thais Veronica Saori [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016056699","display_name":"Maria Sara de Lima Coutinho Mattera","orcid":"https://orcid.org/0000-0003-2288-708X","observed_orcids":["https://orcid.org/0000-0003-2288-708X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mattera, Maria Sara de Lima Coutinho[UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122616264","display_name":"Renato Augusto Pamplona [UNESP] Pereira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pereira, Renato Felipe [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122465317","display_name":"Rodrigo Martins [UNESP] Dos Santos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santos, Rodrigo Martins dos [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091366716","display_name":"Renan Furlan de Oliveira","orcid":"https://orcid.org/0000-0002-1361-0356","observed_orcids":["https://orcid.org/0000-0002-1361-0356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliveira, Renan Akira Fujii de [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031424690","display_name":"Cl\u00e9a Adas Sal\u00edba Garbin","orcid":"https://orcid.org/0000-0001-5069-8812","observed_orcids":["https://orcid.org/0000-0001-5069-8812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garbin, Clea Adas Saliba [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061747414","display_name":"Bianca Elvira Belardi","orcid":"https://orcid.org/0000-0002-5564-8256","observed_orcids":["https://orcid.org/0000-0002-5564-8256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Belardi, Bianca Elvira [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035013332","display_name":"Sandra Cristina de Oliveira","orcid":"https://orcid.org/0000-0002-0968-0108","observed_orcids":["https://orcid.org/0000-0002-0968-0108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Penha de Oliveira, Sandra Helena [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062855165","display_name":"D\u00f3ris Hissako Matsushita","orcid":"https://orcid.org/0000-0003-3753-229X","observed_orcids":["https://orcid.org/0000-0003-3753-229X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matsushita, Doris Hissako [UNESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11969","display_name":"Fluoride Effects and Removal","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2312","display_name":"Water Science and Technology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-fluoride","display_name":"sodium fluoride","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fluoride-toxicity","display_name":"fluoride toxicity","score":0.8560000061988831},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7350000143051147},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nf-kappab-phosphorylation","display_name":"NF-\u03baB phosphorylation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8709999918937683},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.7409999966621399},{"id":"https://openalex.org/keywords/glut4-translocation","display_name":"GLUT4 translocation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.9110000133514404},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.9169999957084656},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8152999877929688},{"id":"https://openalex.org/C2776188179","wikidata":"https://www.wikidata.org/wiki/Q24768727","display_name":"GLUT4","level":4,"score":0.8109999895095825},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8029999732971191},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7412999868392944},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6747999787330627},{"id":"https://openalex.org/C88216763","wikidata":"https://www.wikidata.org/wiki/Q4652205","display_name":"AKT2","level":5,"score":0.5976999998092651},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5784000158309937},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5296000242233276},{"id":"https://openalex.org/C2779234887","wikidata":"https://www.wikidata.org/wiki/Q407520","display_name":"Sodium fluoride","level":3,"score":0.5212000012397766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5126000046730042},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.48539999127388},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4756999909877777},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.4496000111103058},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41940000653266907},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.31700000166893005},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C161573976","wikidata":"https://www.wikidata.org/wiki/Q420277","display_name":"Glucose transporter","level":3,"score":0.3037000000476837},{"id":"https://openalex.org/C2780828025","wikidata":"https://www.wikidata.org/wiki/Q44793182","display_name":"Fluoride","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.2540999948978424},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.unesp.br:11449/237758","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/237758","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:repositorio.unesp.br:11449/248734","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/248734","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:repositorio.unesp.br:11449/237758","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11449/237758","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UNESP","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1992860496","https://openalex.org/W947408688","https://openalex.org/W796636787","https://openalex.org/W2604913481","https://openalex.org/W7217960894","https://openalex.org/W2337241499","https://openalex.org/W7064394760","https://openalex.org/W7054998848","https://openalex.org/W1977259956","https://openalex.org/W2344785002"],"abstract_inverted_index":{"This":[0],"study":[1],"aimed":[2],"to":[3,212,244],"investigate":[4],"the":[5,12,15,23,83,88,148,162,185,203,215,223,245],"final":[6,216],"step":[7,217],"of":[8,27,91,97,121,134,195,218,232,247],"insulin":[9,19,219],"signaling":[10,249],"and":[11,18,55,65,110,127,132,157,166,169,175,188,192,198,205,221,227],"relationship":[13],"between":[14,202],"inflammatory":[16,248],"pathway":[17],"signal":[20],"attenuation":[21],"in":[22,68,87,147,161,179,184,214,230],"gastrocnemius":[24],"muscle":[25],"(GM)":[26],"rats":[28,37,142],"chronically":[29],"treated":[30,49],"with":[31,50,63],"NaF.":[32],"Thirty-two":[33],"seven-week-old":[34],"male":[35],"Wistar":[36],"were":[38,85,200],"randomly":[39],"distributed":[40],"into":[41],"2":[42],"groups:":[43],"a":[44,56,144],"control":[45,206],"group,":[46,58],"which":[47,59],"was":[48],"drinking":[51,61],"water":[52,62],"without":[53],"fluoride;":[54],"fluoride":[57,73,239],"received":[60],"NaF":[64,209],"F":[66],"present":[67],"their":[69],"food":[70],"pellets":[71],"(total":[72],"intake=":[74],"4.0":[75],"mg/":[76],"kg":[77],"body":[78],"weight/day).":[79],"After":[80],"six":[81],"weeks,":[82],"following":[84],"measured":[86],"GM:":[89],"content":[90,160,178,229],"protein":[92,159,177,193],"kinase":[93,100,108],"B":[94,99],"(Akt),":[95],"inhibitor":[96],"kappa":[98],"(I\u03ba\u039a\u03b1/\u03b2),":[101],"tumor":[102],"necrosis":[103],"factor\u03b1":[104],"(TNF-\u03b1),":[105],"c-Jun":[106],"N-terminal":[107],"(JNK),":[109],"glucose":[111],"transporter":[112],"type":[113],"4":[114],"(GLUT4)":[115],"by":[116,129,137,237],"western":[117,130],"blotting;":[118,131],"phosphorylation":[119,152,173,190,225],"status":[120,174,226],"Akt":[122,124,150,186],"threonine,":[123],"serine,":[125],"I\u03ba\u039a\u03b1/\u03b2,":[126,197],"JNK":[128,189,199],"expression":[133,156],"GLUT4":[135,154],"mRNA":[136],"real-time":[138],"PCR.":[139],"The":[140],"fluoride-treated":[141,204],"showed":[143],"decrease":[145],"(p<0.05)":[146,171],"insulin-stimulated":[149],"serine":[151],"status,":[153,191],"gene":[155],"its":[158],"plasma":[163],"membrane":[164],"fraction":[165],"translocation":[167],"index;":[168],"increased":[170,222],"I\u03ba\u039a\u03b1/\u03b2":[172,224],"TNF-\u03b1":[176,228],"GM.":[180],"No":[181],"significant":[182],"differences":[183],"threonine":[187],"contents":[194],"Akt,":[196],"observed":[201],"rats.":[207,233],"Chronic":[208],"intake":[210,240],"led":[211],"alterations":[213],"signaling,":[220],"GM":[231],"Insulin":[234],"resistance":[235],"induced":[236],"excessive":[238],"might":[241],"be":[242],"related":[243],"activation":[246],"pathways.":[250]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-01-10T00:00:00"}