{"id":"https://openalex.org/W7120486396","doi":null,"title":"Analysis of the incorporation of omega-3 fatty acids (EPA and DHA) in the cell membrane of C2C12 myoblasts: evaluation of the effects on cell proliferation and differentiation","display_name":"Analysis of the incorporation of omega-3 fatty acids (EPA and DHA) in the cell membrane of C2C12 myoblasts: evaluation of the effects on cell proliferation and differentiation","publication_year":2023,"publication_date":"2023-09-11","ids":{"openalex":"https://openalex.org/W7120486396"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/70957","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11600/70957","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11600/70957","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122607825","display_name":"Daniela Carvalho [UNIFESP] Monteiro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monteiro, Daniela Carvalho [UNIFESP]","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5122607825"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9860000014305115},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/resolvin-e1","display_name":"resolvin E1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/blt1-receptor","display_name":"BLT1 receptor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.8130000233650208},{"id":"https://openalex.org/keywords/myod","display_name":"MyoD","score":0.6129999756813049},{"id":"https://openalex.org/keywords/myf5","display_name":"Myf5","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.7908999919891357},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6492999792098999},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5550000071525574},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.45170000195503235},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40459999442100525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3846000134944916},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.3635999858379364},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.3434999883174896},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.3416000008583069},{"id":"https://openalex.org/C2778106681","wikidata":"https://www.wikidata.org/wiki/Q416095","display_name":"MyoD","level":4,"score":0.3328999876976013},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3179999887943268},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.3154999911785126},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.3034000098705292},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.29580000042915344},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.28600001335144043},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.2840000092983246},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.2648000121116638},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2615000009536743},{"id":"https://openalex.org/C97816823","wikidata":"https://www.wikidata.org/wiki/Q166726","display_name":"Myogenin","level":4,"score":0.25769999623298645}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repositorio.unifesp.br:11600/70957","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11600/70957","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.unifesp.br:11600/70957","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11600/70957","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:UNIFESP","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060068262","https://openalex.org/W2905298741","https://openalex.org/W2792977868","https://openalex.org/W3035489514","https://openalex.org/W2742771661","https://openalex.org/W3109821907","https://openalex.org/W4389018996","https://openalex.org/W3017324700","https://openalex.org/W3109043235","https://openalex.org/W7120360423"],"abstract_inverted_index":{"Objetivo:":[0],"Analisar":[1],"o":[2,188,438,577],"grau":[3,87,189],"de":[4,20,31,33,58,66,75,88,90,103,118,129,138,145,155,171,190,196,198,220,239,256,260,267,278,288,300,317,323,326,349,358,373,387,403,424,449,465,483,485,512,528,535,543,550,556,567,611],"incorpora\u00e7\u00e3o":[5,89,197,409,429,542],"dos":[6,574,597],"\u00e1cidos":[7],"graxos":[8],"do":[9,86,116,131,153,410,430,440,560],"tipo":[10],"\u00f4mega-3":[11],"\u00e1cido":[12],"eicosapentaeinoico":[13],"(EPA)":[14],"e":[15,27,42,92,176,179,181,222,225,236,269,273,295,311,319,328,340,379,405,426,437,451,477,545,559,572,600,606],"docosahexaenoico":[16],"(DHA)":[17],"em":[18,24,73,79,96,212,306,335,354,377,456,472,519],"membrana":[19],"mioblastos":[21,245,376,536,575],"C2C12":[22,56,521,537,583],"cultivados":[23],"cultura":[25,289],"celular":[26],"suplementado":[28],"com":[29,47,62,114,124,210,250,286,309,313,338,343,366,381,394,417,418,435,458,475,495,502,523,538,604],"nanoemuls\u00e3o":[30],"\u00f3leo":[32],"peixe":[34],"(NOP).":[35],"Avaliar":[36],"esse":[37],"efeito":[38],"sobre":[39,569],"a":[40,70,98,254,415,526,541,548,564,570],"prolifera\u00e7\u00e3o":[41,80,191,307,571,580],"diferencia\u00e7\u00e3o":[43,355,378,473,573],"destas":[44],"c\u00e9lulas":[45,78,110,208,232,284,305,334,433,455,492,520,582],"miog\u00eanicas":[46],"especial":[48],"\u00eanfase":[49],"na":[50,360,371,396,408,428],"resolvina":[51],"E1":[52],"(RvE1).":[53],"M\u00e9todos:":[54],"C\u00e9lulas":[55,471],"miobl\u00e1sticas":[57],"camundongo":[59],"foram":[60,111,164],"cultivadas":[61,209,474],"NOP":[63,251,314,344,367,459,476,524,539],"(25":[64],"\u00b5M":[65],"EPA)":[67],"por":[68,184,200,247],"3":[69],"5":[71],"dias":[72,249],"protocolo":[74],"cultivo":[76],"das":[77,581],"ou":[81,123,140,392,504],"diferencia\u00e7\u00e3o,":[82],"respectivamente.":[83,332],"A":[84,514,533,554],"an\u00e1lise":[85,515],"EPA":[91,221,268,544,605],"DHA":[93,223,270,607],"foi":[94,192],"realizada":[95],"cromatografia":[97],"g\u00e1s":[99],"acoplada":[100],"\u00e0":[101,421],"espectrometria":[102],"massas":[104],"(CG/MS).":[105],"De":[106,242],"outra":[107],"parte,":[108],"as":[109,166,207,304,353,454],"previamente":[112],"incubadas":[113,285,308,337,380,434,494],"inibidor":[115,137,144,439],"receptor":[117,132,441,561,588],"BLT1":[119,350,442,558,589],"(LY293111-":[120],"0,25":[121],"\uf06dM)":[122],"os":[125],"inibidores":[126],"da":[127,168,385,398,447,481,510,517,579],"via":[128,587],"sinaliza\u00e7\u00e3o":[130],"CMKLR1/ChemR23":[133,180,562],"(rapamicina,":[134],"0,08":[135],"\u00b5M-":[136],"mTOR,":[139],"wortmanina,":[141],"500":[142],"nM,":[143],"PI3K)":[146],"seguida":[147],"pela":[148,585,593],"fosfolipase":[149],"A2":[150],"(FLA2)":[151],"isolada":[152],"veneno":[154],"Crotalus":[156],"durissus":[157],"terrificus":[158],"(0,16":[159],"\uf06dM).":[160],"Ap\u00f3s":[161],"24":[162],"h,":[163],"realizadas":[165],"an\u00e1lises":[167],"express\u00e3o":[169,324,361,372,386,448,466,482,511],"proteica":[170,325,467],"BLT1,":[172],"COX-2,":[173],"CYP450,":[174],"MyoD":[175,452,484],"Myf-5":[177],"(prolifera\u00e7\u00e3o)":[178],"Myf-6":[182],"(diferencia\u00e7\u00e3o)":[183],"western":[185],"blotting.":[186],"Ainda":[187],"analisado":[193],"pelo":[194],"padr\u00e3o":[195],"BrDU,":[199],"espectrofotometria.":[201],"Resultados:":[202],"Os":[203],"resultados":[204],"mostraram":[205],"que":[206],"NOP,":[211,395],"meio":[213,287],"proliferativo,":[214],"apresentaram":[215,262,315,345,356,369,383,400,444,461,506],"aumento":[216,316,346,401,578],"(p>0,05)":[217],"no":[218,265],"teor":[219,266],"(118,41\u00b113,51":[224],"5,43\u00b10,64":[226],"\u00b5g/mg,":[227],"respectivamente),":[228,280],"quando":[229,281,493],"comparadas":[230,282],"\u00e0s":[231,283],"controle":[233],"(18,":[234],"91\u00b12.24":[235],"0,74\u00b10,10":[237],"\u00b5g/mg":[238,277,299],"prote\u00edna,":[240,279,301],"respectivamente).":[241,302],"forma":[243,486],"semelhante,":[244],"incubados":[246],"6":[248],"at\u00e9":[252],"atingir":[253],"conflu\u00eancia":[255],"100%":[257],"(protocolo":[258],"experimental":[259],"diferencia\u00e7\u00e3o)":[261],"eleva\u00e7\u00e3o":[263,507],"(p<0,05)":[264],"(139,41":[271],"\u00b124,0":[272],"70,63":[274],"\u00b1":[275,293,297],"11,43":[276],"apenas":[290],"(controle)":[291],"(45,96":[292],"1,44":[294],"16,23":[296],"1,07":[298],"Apenas":[303,375],"FLA2":[310,339,382,436,478,496,586],"suplementadas":[312,342,365,603],"25%":[318],"30%,":[320],"nos":[321,347,463],"n\u00edveis":[322,348,464],"COX-2":[327],"CYP450":[329],"4A":[330],"(p<0,05),":[331],"As":[333,432],"prolifera\u00e7\u00e3o,":[336],"n\u00e3o":[341,368,393,460,501],"(35%),":[351],"enquanto":[352,453],"diminui\u00e7\u00e3o":[357,422,480],"60%":[359],"deste":[362],"receptor.":[363],"Quando":[364],"altera\u00e7\u00e3o":[370,462],"BLT1.":[374],"redu\u00e7\u00e3o":[384,445],"CMKLR1":[388],"(35%).":[389],"Mioblastos":[390,602],"suplementados":[391],"presen\u00e7a":[397,555],"FLA2,":[399],"significativo":[402],"90":[404],"25%,":[406],"respectivamente,":[407],"BrdU.":[411,431],"Por":[412],"outro":[413],"lado,":[414],"associa\u00e7\u00e3o":[416],"Ly293111,":[419,505],"levou":[420],"significativa":[423,446,487,508],"26":[425],"43%,":[427],"(Ly293111)":[443],"Myf5":[450,599],"prolfiera\u00e7\u00e3o":[457],"destes":[468],"fatores":[469,598],"miog\u00eanicos.":[470],"apresentam":[479,608],"(15%).":[488],"No":[489],"entanto,":[490],"estas":[491],"associada":[497],"ao":[498],"rapamicina,":[499],"mas":[500,595],"wortmanina":[503],"(65%)":[509],"MyoD.":[513],"morfol\u00f3gica":[516],"miofibras":[518],"pr\u00e9-suplementadas":[522],"indicou":[525],"forma\u00e7\u00e3o":[527,610],"fibras":[529],"mais":[530,609],"espessas.":[531],"Conclus\u00f5es:":[532],"suplementa\u00e7\u00e3o":[534],"aumenta":[540],"DHA,":[546],"favorecendo":[547],"produ\u00e7\u00e3o":[549],"mediadores":[551],"lip\u00eddicos":[552],"pr\u00f3-resolutivos.":[553],"receptores":[557],"evidencia":[563],"atividade":[565],"modulat\u00f3ria":[566],"RVE1":[568],"C2C12;":[576],"induzida":[584],"pode":[590],"ser":[591],"mediada":[592],"RVE1,":[594],"independente":[596],"MyoD;":[601],"miotubos":[612],"espessos.":[613]},"counts_by_year":[],"updated_date":"2026-07-02T06:18:51.028212","created_date":"2026-01-10T00:00:00"}