{"id":"https://openalex.org/W7120421459","doi":null,"title":"Investigation of the development of innate immune tolerance and its role in neurodegeneration induced by \u03b2-amyloid peptide oligomers","display_name":"Investigation of the development of innate immune tolerance and its role in neurodegeneration induced by \u03b2-amyloid peptide oligomers","publication_year":2023,"publication_date":"2023-09-14","ids":{"openalex":"https://openalex.org/W7120421459"},"language":"pt","primary_location":{"id":"pmh:oai:arca.fiocruz.br:icict/73565","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/73565","pdf_url":"https://arca.fiocruz.br/bitstreams/25918425-bba2-4782-8b7f-b6ed5b59e20b/download","source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arca.fiocruz.br/bitstreams/25918425-bba2-4782-8b7f-b6ed5b59e20b/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116258817","display_name":"Rafaela Rodrigues Valerio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Valerio, Rafaela Rodrigues","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5116258817"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/innate-immune-tolerance","display_name":"innate immune tolerance","score":0.9309999942779541},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7789999842643738},{"id":"https://openalex.org/keywords/amyloid-beta-oligomers","display_name":"amyloid-beta oligomers","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.953000009059906},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9070000052452087},{"id":"https://openalex.org/keywords/trained-immunity","display_name":"trained immunity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6800000071525574},{"id":"https://openalex.org/keywords/microglial-morphology","display_name":"microglial morphology","score":0.6389999985694885},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6909999847412109},{"id":"https://openalex.org/keywords/memory-loss","display_name":"memory loss","score":0.38600000739097595},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.40799999237060547},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.683899998664856},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5422000288963318},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47029998898506165},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4156999886035919},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3930000066757202},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31709998846054077},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27090001106262207},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2632000148296356},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:arca.fiocruz.br:icict/73565","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/73565","pdf_url":"https://arca.fiocruz.br/bitstreams/25918425-bba2-4782-8b7f-b6ed5b59e20b/download","source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"}],"best_oa_location":{"id":"pmh:oai:arca.fiocruz.br:icict/73565","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/73565","pdf_url":"https://arca.fiocruz.br/bitstreams/25918425-bba2-4782-8b7f-b6ed5b59e20b/download","source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322749","display_name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","ror":"https://ror.org/03kk0s825"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7120421459.pdf","grobid_xml":"https://content.openalex.org/works/W7120421459.grobid-xml"},"referenced_works_count":305,"referenced_works":["https://openalex.org/W285963485","https://openalex.org/W297523562","https://openalex.org/W605176161","https://openalex.org/W1520284233","https://openalex.org/W1547269063","https://openalex.org/W1553210510","https://openalex.org/W1602771322","https://openalex.org/W1659055493","https://openalex.org/W1694984064","https://openalex.org/W1729010372","https://openalex.org/W1771440738","https://openalex.org/W1804731458","https://openalex.org/W1930672392","https://openalex.org/W1965942744","https://openalex.org/W1971748792","https://openalex.org/W1972179333","https://openalex.org/W1973276273","https://openalex.org/W1980825524","https://openalex.org/W1984008481","https://openalex.org/W1984228950","https://openalex.org/W1989369404","https://openalex.org/W1990752558","https://openalex.org/W1992680479","https://openalex.org/W1993197717","https://openalex.org/W1993589138","https://openalex.org/W1998440070","https://openalex.org/W1998514549","https://openalex.org/W2001645823","https://openalex.org/W2003827559","https://openalex.org/W2004492484","https://openalex.org/W2004852048","https://openalex.org/W2009034382","https://openalex.org/W2013333500","https://openalex.org/W2015186493","https://openalex.org/W2016087140","https://openalex.org/W2018708829","https://openalex.org/W2018710502","https://openalex.org/W2021133027","https://openalex.org/W2027020919","https://openalex.org/W2028003385","https://openalex.org/W2034126231","https://openalex.org/W2034632760","https://openalex.org/W2038197998","https://openalex.org/W2040423913","https://openalex.org/W2041308303","https://openalex.org/W2042233123","https://openalex.org/W2042751066","https://openalex.org/W2044013578","https://openalex.org/W2046952010","https://openalex.org/W2051532765","https://openalex.org/W2052275222","https://openalex.org/W2052476350","https://openalex.org/W2053665966","https://openalex.org/W2054252974","https://openalex.org/W2056313099","https://openalex.org/W2057842355","https://openalex.org/W2058845250","https://openalex.org/W2058873342","https://openalex.org/W2059403792","https://openalex.org/W2059696821","https://openalex.org/W2061313710","https://openalex.org/W2062084653","https://openalex.org/W2063231976","https://openalex.org/W2063995449","https://openalex.org/W2071610287","https://openalex.org/W2074472141","https://openalex.org/W2079054696","https://openalex.org/W2079158266","https://openalex.org/W2079749054","https://openalex.org/W2080274663","https://openalex.org/W2080946103","https://openalex.org/W2081530802","https://openalex.org/W2087011519","https://openalex.org/W2087243986","https://openalex.org/W2090465196","https://openalex.org/W2090804892","https://openalex.org/W2091497743","https://openalex.org/W2093618389","https://openalex.org/W2095369231","https://openalex.org/W2096401612","https://openalex.org/W2096782178","https://openalex.org/W2097335530","https://openalex.org/W2098999434","https://openalex.org/W2103090572","https://openalex.org/W2105921522","https://openalex.org/W2106682613","https://openalex.org/W2110841847","https://openalex.org/W2114636181","https://openalex.org/W2116797415","https://openalex.org/W2116876598","https://openalex.org/W2124343538","https://openalex.org/W2124490243","https://openalex.org/W2124836944","https://openalex.org/W2129737293","https://openalex.org/W2131705782","https://openalex.org/W2132259121","https://openalex.org/W2139778190","https://openalex.org/W2140876277","https://openalex.org/W2148898943","https://openalex.org/W2149500167","https://openalex.org/W2149671708","https://openalex.org/W2158173241","https://openalex.org/W2160779535","https://openalex.org/W2161130389","https://openalex.org/W2164710064","https://openalex.org/W2165021720","https://openalex.org/W2165763286","https://openalex.org/W2166264384","https://openalex.org/W2169152986","https://openalex.org/W2178843014","https://openalex.org/W2200279205","https://openalex.org/W2257129080","https://openalex.org/W2261085470","https://openalex.org/W2271127896","https://openalex.org/W2297172779","https://openalex.org/W2314634699","https://openalex.org/W2329735989","https://openalex.org/W2336656712","https://openalex.org/W2340464393","https://openalex.org/W2344638842","https://openalex.org/W2395179724","https://openalex.org/W2399044297","https://openalex.org/W2483619001","https://openalex.org/W2523652064","https://openalex.org/W2530446499","https://openalex.org/W2545733225","https://openalex.org/W2554131049","https://openalex.org/W2556702335","https://openalex.org/W2557169014","https://openalex.org/W2572710398","https://openalex.org/W2576056287","https://openalex.org/W2586324678","https://openalex.org/W2586662902","https://openalex.org/W2587609387","https://openalex.org/W2593488234","https://openalex.org/W2593993808","https://openalex.org/W2596326857","https://openalex.org/W2613019008","https://openalex.org/W2613048284","https://openalex.org/W2622807556","https://openalex.org/W2624934104","https://openalex.org/W2651656482","https://openalex.org/W2735217968","https://openalex.org/W2735344772","https://openalex.org/W2735527928","https://openalex.org/W2737075970","https://openalex.org/W2743513023","https://openalex.org/W2751182860","https://openalex.org/W2754890392","https://openalex.org/W2757456088","https://openalex.org/W2765164306","https://openalex.org/W2774947569","https://openalex.org/W2776223742","https://openalex.org/W2777711256","https://openalex.org/W2780667497","https://openalex.org/W2783037826","https://openalex.org/W2783642412","https://openalex.org/W2784120689","https://openalex.org/W2789865159","https://openalex.org/W2790470032","https://openalex.org/W2791894605","https://openalex.org/W2794844698","https://openalex.org/W2795344113","https://openalex.org/W2796983933","https://openalex.org/W2800782157","https://openalex.org/W2802276123","https://openalex.org/W2802616779","https://openalex.org/W2803198382","https://openalex.org/W2804509305","https://openalex.org/W2806300791","https://openalex.org/W2807227439","https://openalex.org/W2884603084","https://openalex.org/W2889599825","https://openalex.org/W2889787710","https://openalex.org/W2890627020","https://openalex.org/W2898194679","https://openalex.org/W2898375074","https://openalex.org/W2900726683","https://openalex.org/W2901020939","https://openalex.org/W2903016200","https://openalex.org/W2907135044","https://openalex.org/W2913751428","https://openalex.org/W2915713547","https://openalex.org/W2919063675","https://openalex.org/W2921781039","https://openalex.org/W2937149728","https://openalex.org/W2939604020","https://openalex.org/W2943524400","https://openalex.org/W2943823496","https://openalex.org/W2945677913","https://openalex.org/W2949239345","https://openalex.org/W2951400283","https://openalex.org/W2952294166","https://openalex.org/W2976163884","https://openalex.org/W2988557783","https://openalex.org/W2990624768","https://openalex.org/W2991550208","https://openalex.org/W2994063476","https://openalex.org/W2998293467","https://openalex.org/W3001051278","https://openalex.org/W3005382457","https://openalex.org/W3006557860","https://openalex.org/W3007853567","https://openalex.org/W3009920944","https://openalex.org/W3011252852","https://openalex.org/W3020417681","https://openalex.org/W3021156198","https://openalex.org/W3022707652","https://openalex.org/W3023098729","https://openalex.org/W3031604050","https://openalex.org/W3033107322","https://openalex.org/W3036525471","https://openalex.org/W3039325532","https://openalex.org/W3046275966","https://openalex.org/W3047418547","https://openalex.org/W3076640024","https://openalex.org/W3081530390","https://openalex.org/W3091570409","https://openalex.org/W3094572608","https://openalex.org/W3101181278","https://openalex.org/W3109024915","https://openalex.org/W3111509171","https://openalex.org/W3112309290","https://openalex.org/W3112419967","https://openalex.org/W3112948680","https://openalex.org/W3113709514","https://openalex.org/W3115243203","https://openalex.org/W3116215660","https://openalex.org/W3121751622","https://openalex.org/W3126081341","https://openalex.org/W3126766007","https://openalex.org/W3129189791","https://openalex.org/W3129406070","https://openalex.org/W3131890228","https://openalex.org/W3133050189","https://openalex.org/W3135705588","https://openalex.org/W3136174469","https://openalex.org/W3137875998","https://openalex.org/W3138980533","https://openalex.org/W3145503377","https://openalex.org/W3155386916","https://openalex.org/W3159116119","https://openalex.org/W3159530258","https://openalex.org/W3159907306","https://openalex.org/W3163439563","https://openalex.org/W3171637117","https://openalex.org/W3185881799","https://openalex.org/W3191428296","https://openalex.org/W3194685272","https://openalex.org/W3198052269","https://openalex.org/W3198065226","https://openalex.org/W3201798407","https://openalex.org/W3203622089","https://openalex.org/W3208406653","https://openalex.org/W3210575413","https://openalex.org/W3212138791","https://openalex.org/W4200545840","https://openalex.org/W4205261849","https://openalex.org/W4205689202","https://openalex.org/W4210368582","https://openalex.org/W4210531301","https://openalex.org/W4211072901","https://openalex.org/W4212876858","https://openalex.org/W4213258650","https://openalex.org/W4220721798","https://openalex.org/W4220819793","https://openalex.org/W4220825176","https://openalex.org/W4220956601","https://openalex.org/W4221128145","https://openalex.org/W4223591189","https://openalex.org/W4223644491","https://openalex.org/W4224278103","https://openalex.org/W4225377953","https://openalex.org/W4225681755","https://openalex.org/W4230693802","https://openalex.org/W4241651176","https://openalex.org/W4245386160","https://openalex.org/W4247759744","https://openalex.org/W4280541352","https://openalex.org/W4280613528","https://openalex.org/W4281762328","https://openalex.org/W4281871064","https://openalex.org/W4282931190","https://openalex.org/W4283805934","https://openalex.org/W4287448745","https://openalex.org/W4289517010","https://openalex.org/W4291000683","https://openalex.org/W4291916129","https://openalex.org/W4292320039","https://openalex.org/W4295086828","https://openalex.org/W4300981520","https://openalex.org/W4306393206","https://openalex.org/W4307425817","https://openalex.org/W4308150510","https://openalex.org/W4308510589","https://openalex.org/W4310461604","https://openalex.org/W4311242262","https://openalex.org/W4311585069","https://openalex.org/W4312085209","https://openalex.org/W4313442704","https://openalex.org/W4313830123","https://openalex.org/W4317401758","https://openalex.org/W4320731290","https://openalex.org/W4323042866","https://openalex.org/W4323542992"],"related_works":["https://openalex.org/W7117960986","https://openalex.org/W2789609881","https://openalex.org/W2534222271","https://openalex.org/W3022186276","https://openalex.org/W2765497529","https://openalex.org/W2043679754","https://openalex.org/W4281997512","https://openalex.org/W4313286531","https://openalex.org/W7165622570","https://openalex.org/W2321013019"],"abstract_inverted_index":{"A":[0,30,139],"doen\u00e7a":[1],"de":[2,16,21,24,32,46,114,131,135,154,182,184,250,281,285,339],"Alzheimer":[3],"(DA)":[4],"\u00e9":[5],"caracterizada":[6],"por":[7],"ser":[8],"uma":[9,129,155,214,228,271,321],"patologia":[10],"neurodegenerativa":[11],"associada":[12],"\u00e0":[13,346],"perda":[14],"progressiva":[15],"mem\u00f3ria,":[17],"que":[18,85,101,205,224,314],"afeta":[19],"mais":[20,296],"50":[22],"milh\u00f5es":[23],"pessoas":[25],"em":[26,34,320],"todo":[27],"o":[28,39,54,63,194,223,337],"mundo.":[29],"deteriora\u00e7\u00e3o":[31],"sinapses":[33],"regi\u00f5es":[35],"cerebrais":[36],"envolvidas":[37],"com":[38,148,210],"processamento":[40],"mnem\u00f4nico,":[41],"como":[42,108,168,288],"consequ\u00eancia":[43],"do":[44,49,103,208,327,348],"ac\u00famulo":[45],"olig\u00f4meros":[47],"sol\u00faveis":[48],"pept\u00eddeo":[50],"beta-amiloide":[51],"(A\u03b2Os),":[52],"constitui":[53],"evento":[55],"patog\u00eanico":[56],"central":[57,91],"na":[58,70,92,216,274,279,331],"fisiopatologia":[59],"da":[60,65,72,94,196,218,230,235,248,307,323],"DA.":[61,177],"Entretanto,":[62],"papel":[64,90],"inflama\u00e7\u00e3o":[66],"no":[67,172,305],"estabelecimento":[68,306],"e":[69,256,276,293,325],"progress\u00e3o":[71],"DA":[73,344],"tamb\u00e9m":[74,244],"tem":[75],"recebido":[76],"consider\u00e1vel":[77],"destaque":[78],"nas":[79],"\u00faltimas":[80],"d\u00e9cadas.":[81],"Diversas":[82],"evid\u00eancias":[83],"sugerem":[84,100,313],"a":[86,109,125,144,151,160,164,176,206,213,227,246,257,270,343],"neuroinflama\u00e7\u00e3o":[87,324],"desempenha":[88],"um":[89,145,165,283],"patog\u00eanese":[93],"doen\u00e7a.":[95],"Nesse":[96],"sentido,":[97],"estudos":[98,297],"recentes":[99],"c\u00e9lulas":[102],"sistema":[104,349],"imune":[105,137,141,198,309,350],"inato,":[106],"tais":[107],"microglia,":[110],"podem":[111],"exibir":[112],"efeitos":[113],"mem\u00f3ria":[115],"imunol\u00f3gica":[116,317],"ap\u00f3s":[117],"certos":[118],"est\u00edmulos,":[119],"acentuando":[120],"ou":[121,134],"suprimindo":[122],"respostas":[123,162],"inflamat\u00f3rias":[124,263],"est\u00edmulos":[126],"subsequentes,":[127],"caracterizando":[128],"resposta":[130,236,316],"imunidade":[132],"treinada":[133],"toler\u00e2ncia":[136,140,197,308],"inata.":[138],"ocorre":[142],"frente":[143,163],"pr\u00e9-condicionamento":[146],"imunol\u00f3gico,":[147],"exposi\u00e7\u00e3o":[149,240],"cr\u00f4nica":[150],"baixas":[152],"concentra\u00e7\u00f5es":[153],"determinada":[156],"subst\u00e2ncia":[157],"inflamat\u00f3ria,":[158],"levando":[159],"diferentes":[161],"est\u00edmulo":[166,209],"secund\u00e1rio,":[167],"os":[169,302],"A\u03b2Os":[170],"encontrados":[171],"tecido":[173],"cerebral":[174],"durante":[175],"Neste":[178],"trabalho,":[179],"culturas":[180],"organot\u00edpicas":[181],"hipocampo":[183],"ratos":[185],"foram":[186],"expostas":[187],"repetidamente":[188],"ao":[189,242],"lipopolissacar\u00eddeo":[190],"(LPS)":[191],"para":[192,300,336,342],"avaliar":[193],"desenvolvimento":[195,338],"inata":[199],"pela":[200,239],"microglia.":[201],"Nossos":[202],"resultados":[203],"mostram":[204],"repeti\u00e7\u00e3o":[207],"LPS":[211,243],"levou":[212,269],"redu\u00e7\u00e3o":[215,273,322],"ativa\u00e7\u00e3o":[217,247],"microglia":[219],"induzida":[220],"pelos":[221,265],"A\u03b2Os,":[222],"foi":[225],"associado":[226],"modula\u00e7\u00e3o":[229,347],"sua":[231],"morfologia.":[232],"Essa":[233],"mudan\u00e7a":[234],"microglial":[237],"causada":[238],"repetida":[241],"preveniu":[245],"via":[249],"sinaliza\u00e7\u00e3o":[251],"celular":[252],"mediada":[253],"pelo":[254],"NF\u03baB":[255],"eleva\u00e7\u00e3o":[258],"dos":[259],"n\u00edveis":[260],"das":[261,289],"citocinas":[262],"induzidas":[264],"A\u03b2Os.":[266],"Al\u00e9m":[267],"disso,":[268],"significativa":[272],"astrogliose":[275],"induziu":[277],"altera\u00e7\u00f5es":[278],"express\u00e3o":[280],"CD68,":[282],"marcador":[284],"fagocitose,":[286],"bem":[287],"prote\u00ednas":[290],"sin\u00e1pticas,":[291],"sinaptofisina":[292],"PSD95.":[294],"Embora":[295],"sejam":[298],"necess\u00e1rios":[299],"determinar":[301],"mecanismos":[303],"envolvidos":[304],"microglial,":[310],"nossos":[311],"achados":[312],"essa":[315],"pode":[318],"resultar":[319],"consequentemente":[326],"processo":[328],"neurodegenerativo":[329],"envolvido":[330],"DA,":[332],"abrindo":[333],"novos":[334],"caminhos":[335],"estrat\u00e9gias":[340],"terap\u00eauticas":[341],"voltadas":[345],"inato.":[351]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-01-10T00:00:00"}
