{"id":"https://openalex.org/W7120375281","doi":null,"title":"The role of innate immunity in aging kidney","display_name":"The role of innate immunity in aging kidney","publication_year":2023,"publication_date":"2023-10-10","ids":{"openalex":"https://openalex.org/W7120375281"},"language":"pt","primary_location":{"id":"pmh:oai:teses.usp.br:tde-05022024-124436","doi":null,"is_oa":true,"landing_page_url":"https://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/publico/HelenaMendoncaTessaro.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/publico/HelenaMendoncaTessaro.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021101740","display_name":"Helena Mendon\u00e7a Tessaro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Tessaro, Helena Mendon\u00e7a","raw_affiliation_strings":["Faculdade de Medicina da Universidade de S\u00e3o Paulo para obten\u00e7\u00e3o do t\u00edtulo de Mestre em Ci\u00eancias Programa de Nefrologia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculdade de Medicina da Universidade de S\u00e3o Paulo para obten\u00e7\u00e3o do t\u00edtulo de Mestre em Ci\u00eancias Programa de Nefrologia","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021101740"],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.07069999724626541,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kidney-aging","display_name":"kidney aging","score":0.9039999842643738},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.718999981880188},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.722000002861023},{"id":"https://openalex.org/keywords/nf-kappab-inhibition","display_name":"NF-\u03baB inhibition","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9020000100135803},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7990000247955322},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8029999732971191},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.8209999799728394},{"id":"https://openalex.org/keywords/myofibroblasts","display_name":"myofibroblasts","score":0.8069999814033508},{"id":"https://openalex.org/keywords/glomerulosclerosis","display_name":"glomerulosclerosis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.9610000252723694},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.5460000038146973},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/aging-rats","display_name":"aging rats","score":0.3959999978542328},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.8848999738693237},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5906999707221985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5698000192642212},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.474700003862381},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.46619999408721924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43939998745918274},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.41290000081062317},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.37529999017715454},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36730000376701355},{"id":"https://openalex.org/C3018884230","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Renal tubule","level":3,"score":0.3197000026702881},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.31949999928474426},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.2955000102519989}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:teses.usp.br:tde-05022024-124436","doi":null,"is_oa":true,"landing_page_url":"https://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/publico/HelenaMendoncaTessaro.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/masterThesis"}],"best_oa_location":{"id":"pmh:oai:teses.usp.br:tde-05022024-124436","doi":null,"is_oa":true,"landing_page_url":"https://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/","pdf_url":"http://www.teses.usp.br/teses/disponiveis/5/5148/tde-05022024-124436/publico/HelenaMendoncaTessaro.pdf","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:USP","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7120375281.pdf","grobid_xml":"https://content.openalex.org/works/W7120375281.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404814291","https://openalex.org/W1979623335","https://openalex.org/W2369405850","https://openalex.org/W1817684258","https://openalex.org/W2300508172","https://openalex.org/W4412794227","https://openalex.org/W2123150238","https://openalex.org/W2149970971","https://openalex.org/W2047844752","https://openalex.org/W2020594138"],"abstract_inverted_index":{"A":[0,10],"patog\u00eanese":[1],"da":[2,30,123,130,173,181,232,238,249],"nefropatia":[3,57],"do":[4,19,58],"envelhecimento":[5],"ainda":[6],"n\u00e3o":[7,207],"foi":[8],"elucidada.":[9],"Angiotensina-II":[11],"(AngII)":[12],"intrarrenal":[13],"e":[14,22,41,47,91,97,126,138,144,167,195,200],"a":[15,37,56,149,160,189,212,214,217,253],"ativa\u00e7\u00e3o":[16,172,179,218],"das":[17],"vias":[18],"inflamassoma":[20],"NF-B":[21,51,240],"NLRP3":[23],"exercem":[24],"papel":[25],"patog\u00eanico":[26],"relevante":[27],"na":[28],"progress\u00e3o":[29],"doen\u00e7a":[31],"renal":[32,162,234,251],"cr\u00f4nica.":[33],"Procuramos":[34],"investigar":[35],"se":[36,155],"monoterapia":[38],"com":[39,45,71,186,252],"Losartan":[40,46,88,96,187],"o":[42,48,203,247],"tratamento":[43,185,222],"combinado":[44,223],"inibidor":[49],"de":[50,74,79,82,114,136,151,163,178,191,219],"pirrolidina":[52],"ditiocarbamato":[53],"(PDTC)":[54],"atenuariam":[55],"envelhecimento.":[59],"Ratos":[60],"Munich-Wistar":[61],"machos":[62],"foram":[63,104],"distribu\u00eddos":[64],"em":[65],"quatro":[66],"grupos:":[67],"12M":[68],"(n=10),":[69,77,85,93],"ratos":[70,78,86,94],"12":[72,110],"meses":[73,81,113],"idade;":[75,83],"15M":[76,118],"15":[80,112],"15MLos":[84],"recebendo":[87,95],"(50":[89],"mg/d)":[90],"15MLos+PDTC":[92],"PDTC":[98],"(15":[99],"mg/d).":[100],"Todos":[101],"os":[102],"tratamentos":[103],"administrados":[105],"por":[106,140],"via":[107,174,239],"oral":[108],"dos":[109],"aos":[111],"idade.":[115],"O":[116,184,221,230],"grupo":[117],"exibiu":[119],"uma":[120,243],"leve":[121],"diminui\u00e7\u00e3o":[122],"press\u00e3o":[124],"caudal":[125],"um":[127],"aumento":[128],"acentuado":[129],"albumin\u00faria,":[131,213],"glom\u00e9rulos":[132],"esclerosados,":[133],"deposi\u00e7\u00e3o":[134,190],"cortical":[135],"col\u00e1geno-1":[137,192],"infiltra\u00e7\u00e3o":[139],"miofibroblastos,":[141],"c\u00e9lulas":[142,196],"AngII-positivas":[143],"macr\u00f3fagos":[145,152],"M1":[146],"pr\u00f3-inflamat\u00f3rios,":[147],"enquanto":[148],"quantidade":[150],"M2":[153,204],"anti-inflamat\u00f3rios":[154],"mostrou":[156],"reduzida.":[157],"Al\u00e9m":[158],"disso,":[159],"abund\u00e2ncia":[161],"TLR4,":[164],"p65":[165],"nuclear":[166],"IL-6":[168],"estava":[169],"aumentada,":[170],"indicando":[171],"NF-B,":[175],"sem":[176],"evid\u00eancia":[177],"simult\u00e2nea":[180],"cascata":[182],"NLRP3.":[183],"diminuiu":[188],"cortical,":[193],"miofibroblastos":[194],"positivas":[197],"para":[198,245],"AngII":[199,233],"restaurou":[201],"parcialmente":[202],"renal,":[205],"mas":[206],"teve":[208],"efeito":[209],"significativo":[210],"sobre":[211],"glomeruloesclerose":[215],"ou":[216],"NF-B.":[220],"Losartan+PDTC":[224],"preveniu":[225],"todas":[226],"as":[227],"anormalidades":[228],"observadas.":[229],"bloqueio":[231],"associado":[235],"\u00e0":[236],"inibi\u00e7\u00e3o":[237],"pode":[241],"ser":[242],"alternativa":[244],"limitar":[246],"decl\u00ednio":[248],"fun\u00e7\u00e3o":[250],"idade":[254]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2026-01-10T00:00:00"}