{"id":"https://openalex.org/W7120344265","doi":"https://doi.org/10.7417/ct.2026.2052","title":"Time-Threshold Dose-Response Relationship Between Duration of Premature Rupture of Membranes and Maternal, Neonatal, and Laboratory Evidence of Infection: A Systematic Review and Meta-Analysis.","display_name":"Time-Threshold Dose-Response Relationship Between Duration of Premature Rupture of Membranes and Maternal, Neonatal, and Laboratory Evidence of Infection: A Systematic Review and Meta-Analysis.","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7120344265","doi":"https://doi.org/10.7417/ct.2026.2052","pmid":"https://pubmed.ncbi.nlm.nih.gov/42047155"},"language":"en","primary_location":{"id":"pmh:oai::article/1588","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1588","pdf_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1588/1057","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1588/1057","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134783905","display_name":"Iman Shawky Hassan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Iman Shawky Hassan","raw_affiliation_strings":["Complementary Medicine Department, National Research Centre, Dokki, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Complementary Medicine Department, National Research Centre, Dokki, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160523732","display_name":"Aziza Hussein Nassef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aziza Hussein Nassef","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100877812","display_name":"M. El\u2010Hadi Emam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mariam Salah Mohamed Emam","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043117204","display_name":"Mohammad AbdElhameed Alwaseef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohammad Abd Elhameed Alwaseef","raw_affiliation_strings":["Department of Clinical Pathology, Faculty of medicine, Al-Azhar university, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Faculty of medicine, Al-Azhar university, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134819299","display_name":"Kareem Salah Eldin Fekry Madbouly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800848923","display_name":"Jahra Hospital","ror":"https://ror.org/05kjeqc29","country_code":"KW","type":"healthcare","lineage":["https://openalex.org/I2800848923"]},{"id":"https://openalex.org/I4210129520","display_name":"Ministry of Health","ror":"https://ror.org/036njfn21","country_code":"KW","type":"government","lineage":["https://openalex.org/I4210129520"]},{"id":"https://openalex.org/I4210160667","display_name":"Ministry of Health and Population","ror":"https://ror.org/04f90ax67","country_code":"EG","type":"government","lineage":["https://openalex.org/I4210160667"]}],"countries":["EG","KW"],"is_corresponding":false,"raw_author_name":"Kareem Salah Eldin Fekry Madbouly","raw_affiliation_strings":["Paediatric& Neonatology consultant at Ain shams hospital, Ministry of Health, Egypt","Paediatric registrar at New Jahra Hospital, Jahra, Ministry of Health, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatric& Neonatology consultant at Ain shams hospital, Ministry of Health, Egypt","institution_ids":["https://openalex.org/I4210160667"]},{"raw_affiliation_string":"Paediatric registrar at New Jahra Hospital, Jahra, Ministry of Health, Kuwait","institution_ids":["https://openalex.org/I2800848923","https://openalex.org/I4210129520"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134756025","display_name":"Narmen Hamadelnil Ibrahim Eltrafi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narmen Hamadelnil Ibrahim Eltrafi","raw_affiliation_strings":["Department of Paediatrics, Mediclinic, Abu Dhabi, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Mediclinic, Abu Dhabi, United Arab Emirates","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116290156","display_name":"Naglaa Fathi Mohammed Agaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Naglaa Fathi Mohammed Agaba","raw_affiliation_strings":["Department of Paediatrics, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028979137","display_name":"Shaimaa Ali Barakat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shaimaa Ali Barakat","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157057348","display_name":"Asmaa R. Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Asmaa R Ali","raw_affiliation_strings":["Department of medical Microbiology and Immunology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of medical Microbiology and Immunology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134802168","display_name":"Amal Mahmoud Abd El Ghany Othman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amal Mahmoud Abd El Ghany Othman","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067088524","display_name":"Mai Nabil Ageez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mai Nabil Ageez","raw_affiliation_strings":["Department of Obstetrics and Gynecology, faculty of medicine, Tanta University, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, faculty of medicine, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157258418","display_name":"Abdulmabod Omar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abdulmabod Omar","raw_affiliation_strings":["Department of Clinical Pathology, Faculty of medicine, Al-Azhar university, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Faculty of medicine, Al-Azhar university, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134803610","display_name":"Rana Mahmoud Youssef Mohamed Breika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305919966","display_name":"York Hospital","ror":"https://ror.org/0003zy991","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1305919966","https://openalex.org/I4210113900"]},{"id":"https://openalex.org/I4210113900","display_name":"York Teaching Hospital NHS Foundation Trust","ror":"https://ror.org/027e4g787","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210113900"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rana Mahmoud Youssef Mohamed Breika","raw_affiliation_strings":["Department of Paediatrics, York teaching Hospital Foundation Trust, NHS, York, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, York teaching Hospital Foundation Trust, NHS, York, United Kingdom","institution_ids":["https://openalex.org/I1305919966","https://openalex.org/I4210113900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017070496","display_name":"Doaa Helmy Yousef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Doaa Helmy Abd Elkader Yousef","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134769933","display_name":"Rania Fakhry Abdulrazek Okasha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rania Fakhry Abdulrazek Okasha","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077614656","display_name":"Nawal Salama Gouda","orcid":"https://orcid.org/0000-0001-7178-7646","observed_orcids":["https://orcid.org/0000-0001-7178-7646"]},"institutions":[{"id":"https://openalex.org/I118590987","display_name":"Northern Border University","ror":"https://ror.org/03j9tzj20","country_code":"SA","type":"education","lineage":["https://openalex.org/I118590987"]},{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Nawal S Gouda","raw_affiliation_strings":["Microbiology Department, Faculty of Medicine, Northern Border University, KSA","Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology Department, Faculty of Medicine, Northern Border University, KSA","institution_ids":["https://openalex.org/I118590987"]},{"raw_affiliation_string":"Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Egypt","institution_ids":["https://openalex.org/I159247623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157251939","display_name":"Eman Hashish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84524832","display_name":"Alexandria University","ror":"https://ror.org/00mzz1w90","country_code":"EG","type":"education","lineage":["https://openalex.org/I84524832"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eman Hashish","raw_affiliation_strings":["Department of Hospital Administration, High Institute of Public Health, Alexandria, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Administration, High Institute of Public Health, Alexandria, Egypt","institution_ids":["https://openalex.org/I84524832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157039063","display_name":"Doaa Fouad Ali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Doaa Fouad Ali","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024552358","display_name":"Rehab Mohamed Ateya","orcid":"https://orcid.org/0009-0000-7886-0076","observed_orcids":["https://orcid.org/0009-0000-7886-0076","https://orcid.org/0000-0002-9777-3493"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hanan Shehata Mohamed","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024552358","display_name":"Rehab Mohamed Ateya","orcid":"https://orcid.org/0009-0000-7886-0076","observed_orcids":["https://orcid.org/0009-0000-7886-0076","https://orcid.org/0000-0002-9777-3493"]},"institutions":[{"id":"https://openalex.org/I192398990","display_name":"Zagazig University","ror":"https://ror.org/053g6we49","country_code":"EG","type":"education","lineage":["https://openalex.org/I192398990"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rehab Mohamed Ateya","raw_affiliation_strings":["Department of Clinical Pathology, Faculty of medicine, Zagazig university, Zagazig, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Faculty of medicine, Zagazig university, Zagazig, Egypt","institution_ids":["https://openalex.org/I192398990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075588071","display_name":"Haidy Mahmoud Nasr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Haidy Mahmoud Nasr","raw_affiliation_strings":["Department of Paediatrics, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055424537","display_name":"Hanan Abdelgawad Mohamed Hegazy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131959","display_name":"National Research Centre","ror":"https://ror.org/02n85j827","country_code":"EG","type":"facility","lineage":["https://openalex.org/I4210131959"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hanan A Hegazy","raw_affiliation_strings":["Environmental and Occupational Medicine Department, National Research Centre, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental and Occupational Medicine Department, National Research Centre, Giza, Egypt","institution_ids":["https://openalex.org/I4210131959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079630745","display_name":"Abd Elhalim Mohamed Abd Elhalim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184834183","display_name":"Al-Azhar University","ror":"https://ror.org/05fnp1145","country_code":"EG","type":"education","lineage":["https://openalex.org/I184834183"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Abd Elhalim Mohamed Abd Elhalim","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt","institution_ids":["https://openalex.org/I184834183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119796129","display_name":"Hala S M Abdelmotogaly","orcid":"https://orcid.org/0009-0006-5354-6308","observed_orcids":["https://orcid.org/0009-0006-5354-6308"]},"institutions":[{"id":"https://openalex.org/I4387155039","display_name":"New Valley University","ror":"https://ror.org/04349ry21","country_code":"EG","type":"education","lineage":["https://openalex.org/I4387155039"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Hala S M Abdelmotogaly","raw_affiliation_strings":["Department of Pediatrics, Faculty of Medicine, New Valley University, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Faculty of Medicine, New Valley University, Egypt","institution_ids":["https://openalex.org/I4387155039"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5116837350","display_name":"Ramy Saleh Abdelghany","orcid":"https://orcid.org/0000-0001-5335-2331","observed_orcids":["https://orcid.org/0000-0001-5335-2331"]},"institutions":[{"id":"https://openalex.org/I4210127717","display_name":"Armed Forces College of Medicine","ror":"https://ror.org/033ttrk34","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210127717"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ramy Saleh Abdelghany","raw_affiliation_strings":["Department of Pediatrics, Armed Forces College of Medicine, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Armed Forces College of Medicine, Cairo, Egypt","institution_ids":["https://openalex.org/I4210127717"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":15,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":20.25,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.96904025,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"177","issue":"3","first_page":"642","last_page":"651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12382","display_name":"History of Education Research in Brazil","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1202","display_name":"History"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12382","display_name":"History of Education Research in Brazil","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1202","display_name":"History"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13570","display_name":"Historical Education Studies Worldwide","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14480","display_name":"Historical Education and Society","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3304","display_name":"Education"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normal-schools","display_name":"normal schools","score":0.7239999771118164},{"id":"https://openalex.org/keywords/school-culture","display_name":"school culture","score":0.7749999761581421},{"id":"https://openalex.org/keywords/teacher-education","display_name":"teacher professional development","score":0.765999972820282},{"id":"https://openalex.org/keywords/history-of-education","display_name":"history of education","score":0.878000020980835},{"id":"https://openalex.org/keywords/normalism","display_name":"normalism","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.3921000063419342},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.28949999809265137},{"id":"https://openalex.org/C411171","wikidata":"https://www.wikidata.org/wiki/Q13222181","display_name":"Habitus","level":3,"score":0.287200003862381},{"id":"https://openalex.org/C2778355321","wikidata":"https://www.wikidata.org/wiki/Q17079427","display_name":"Identity (music)","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C2777855551","wikidata":"https://www.wikidata.org/wiki/Q12310021","display_name":"Subject (documents)","level":2,"score":0.2549999952316284},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.24899999797344208},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.2353000044822693},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.22669999301433563}],"mesh":[{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000071074","descriptor_name":"Neonatal Sepsis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002821","descriptor_name":"Chorioamnionitis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002821","descriptor_name":"Chorioamnionitis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005322","descriptor_name":"Premature Rupture of Fetal Membranes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011251","descriptor_name":"Pregnancy Complications, Infectious","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmh:oai::article/1588","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1588","pdf_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1588/1057","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:42047155","doi":"https://doi.org/10.7417/ct.2026.2052","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42047155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Clinica terapeutica","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai::article/1588","doi":null,"is_oa":true,"landing_page_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/view/1588","pdf_url":"http://www.clinicaterapeutica.it/ojs/index.php/1/article/download/1588/1057","source":{"id":"https://openalex.org/S7407065441","display_name":"La Clinica Terapeutica","issn_l":"1972-6007","issn":["1972-6007"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","ki-jl-1","medline","norway-1","poland-40"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1972-6007","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7120344265.pdf","grobid_xml":"https://content.openalex.org/works/W7120344265.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7157008954","https://openalex.org/W1527327447","https://openalex.org/W2206312773","https://openalex.org/W2082166839","https://openalex.org/W7160506555","https://openalex.org/W2511612688","https://openalex.org/W4312547052","https://openalex.org/W2987834139","https://openalex.org/W2387460463","https://openalex.org/W2041084276"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"identify":[2],"the":[3,8,17,84,94,99,109,123,146,221,251,259],"continuous":[4,52],"dose-response":[5],"relationship":[6],"between":[7],"duration":[9,49],"of":[10,13,19,47,73,77,96,101,122,151,158,169,193,223,253,262],"premature":[11],"rupture":[12],"membranes":[14],"(PROM)":[15],"and":[16,21,28,108,171,196],"probability":[18],"neonatal":[20],"maternal":[22,113],"infectious":[23],"morbidity.":[24],"Methods:":[25],"This":[26],"meta-analysis":[27],"systematic":[29],"review":[30],"synthesise":[31],"data":[32],"from":[33],"15":[34],"studies":[35],"worldwide":[36],"involving":[37],"more":[38],"than":[39,142],"70,000":[40],"mother-neonate":[41],"pairs.":[42],"A":[43],"two-step":[44],"random-effects":[45],"model":[46],"PROM":[48,200],"as":[50],"a":[51,69,127,205,229],"dose,":[53],"using":[54],"restricted":[55],"cubic":[56],"splines,":[57],"was":[58,106,115,145,165,184],"used":[59],"to":[60,225,239,242,258],"estimate":[61],"specific":[62],"risk":[63,157,202,261],"thresholds.":[64],"Results:":[65],"The":[66,75,120],"analysis":[67,121],"established":[68],"progressive,":[70],"non-linear":[71,245],"escalation":[72],"risk.":[74],"onset":[76],"statistical":[78],"risks":[79,252],"at":[80,132],"16":[81],"hours":[82,144,213,227],"is":[83,203,228],"early-onset":[85],"pneumonia":[86],"(Adjusted":[87],"OR":[88],"1.86,":[89],"95%":[90],"CI:":[91],"1.152.99).":[92],"At":[93],"age":[95,189],"18":[97,212],"hours,":[98,134],"incidence":[100],"culture-proven":[102,152],"sepsis":[103],"in":[104,167,172,191],"neonates":[105],"4.0%,":[107],"odds":[110],"ratio":[111],"for":[112],"fever":[114],"significantly":[116],"higher":[117],"(AOR":[118],"36.6).":[119],"ROC":[124],"curves":[125],"revealed":[126],"critical":[128],"mathematical":[129],"pivot":[130],"point":[131],"37":[133,224],"after":[135],"which":[136],"complications":[137],"escalate":[138],"exponentially.":[139],"Latency":[140],"greater":[141],"48":[143,226],"most":[147],"significant":[148],"independent":[149],"predictor":[150],"sepsis,":[153],"with":[154,209],"an":[155,216],"increased":[156],"8.2":[159],"(p":[160],"<":[161],"0.001).":[162],"Histologic":[163],"chorioamnionitis":[164],"detected":[166],"39%":[168],"mothers,":[170],"many":[173],"cases,":[174],"they":[175],"are":[176,255],"clinically":[177],"silent.":[178],"Considerable":[179],"heterogeneity":[180],"(I2":[181],">":[182],"60%)":[183],"mainly":[185],"caused":[186],"by":[187],"gestational":[188],"disparities":[190],"cohorts":[192],"extremely":[194],"preterm":[195],"term":[197],"babies.":[198],"Conclusion:":[199],"latency":[201],"not":[204],"threat":[206],"but":[207],"accelerates":[208],"time.":[210],"Although":[211],"will":[214],"be":[215,240],"acceptable":[217],"early":[218],"warning":[219],"level,":[220],"range":[222],"high-risk":[230],"period":[231],"that":[232],"needs":[233],"aggressive":[234],"treatment.":[235],"International":[236],"guidelines":[237],"need":[238],"reviewed":[241],"reflect":[243],"this":[244],"trend,":[246],"especially":[247],"regarding":[248],"pregnancy,":[249],"where":[250],"delivery":[254],"low":[256],"compared":[257],"rising":[260],"latency.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-01-10T00:00:00"}