{"id":"https://openalex.org/W7120175790","doi":"https://doi.org/10.1021/acsptsci.5c00646","title":"Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics","display_name":"Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics","publication_year":2026,"publication_date":"2026-01-09","ids":{"openalex":"https://openalex.org/W7120175790","doi":"https://doi.org/10.1021/acsptsci.5c00646","pmid":"https://pubmed.ncbi.nlm.nih.gov/41710756","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12910498"},"language":"en","primary_location":{"id":"doi:10.1021/acsptsci.5c00646","doi":"https://doi.org/10.1021/acsptsci.5c00646","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsptsci.5c00646","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00646?ref=article_openPDF","source":{"id":"https://openalex.org/S4210207642","display_name":"ACS Pharmacology & Translational Science","issn_l":"2575-9108","issn":["2575-9108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Pharmacology & Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00646?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075044737","display_name":"Mohammad Alkhatib","orcid":"https://orcid.org/0009-0003-1763-5475","observed_orcids":["https://orcid.org/0009-0003-1763-5475"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Alkhatib","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043626652","display_name":"Franziska M. Jakobs","orcid":"https://orcid.org/0000-0003-2861-8868","observed_orcids":["https://orcid.org/0000-0003-2861-8868"]},"institutions":[{"id":"https://openalex.org/I101240087","display_name":"High Point University","ror":"https://ror.org/029qx3s09","country_code":"US","type":"education","lineage":["https://openalex.org/I101240087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franziska M. Jakobs","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States"],"raw_orcid":"https://orcid.org/0000-0003-2861-8868","affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States","institution_ids":["https://openalex.org/I101240087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104299072","display_name":"John N. Hanson","orcid":"https://orcid.org/0009-0006-5238-6963","observed_orcids":["https://orcid.org/0009-0006-5238-6963"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John N. Hanson","raw_affiliation_strings":["Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048984594","display_name":"Ashley N. Nilson","orcid":"https://orcid.org/0000-0003-3830-1581","observed_orcids":["https://orcid.org/0000-0003-3830-1581"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley N. Nilson","raw_affiliation_strings":["Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028024335","display_name":"Amy E. Moritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy E. Moritz","raw_affiliation_strings":["Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345575","display_name":"Tian Li","orcid":"https://orcid.org/0000-0002-6943-4128","observed_orcids":["https://orcid.org/0000-0002-6943-4128"]},"institutions":[{"id":"https://openalex.org/I101240087","display_name":"High Point University","ror":"https://ror.org/029qx3s09","country_code":"US","type":"education","lineage":["https://openalex.org/I101240087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Li","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States","institution_ids":["https://openalex.org/I101240087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115539233","display_name":"Afua B. Faibille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101240087","display_name":"High Point University","ror":"https://ror.org/029qx3s09","country_code":"US","type":"education","lineage":["https://openalex.org/I101240087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Afua B. Faibille","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States","institution_ids":["https://openalex.org/I101240087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115539234","display_name":"Lindsay A. Bourn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101240087","display_name":"High Point University","ror":"https://ror.org/029qx3s09","country_code":"US","type":"education","lineage":["https://openalex.org/I101240087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay A. Bourn","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States","institution_ids":["https://openalex.org/I101240087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036698282","display_name":"Peter Ramdhan","orcid":"https://orcid.org/0000-0002-2027-1591","observed_orcids":["https://orcid.org/0000-0002-2027-1591"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter A. Ramdhan","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, Florida 32610, United States"],"raw_orcid":"https://orcid.org/0000-0002-2027-1591","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, Florida 32610, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058931925","display_name":"Joseph Ricchezza","orcid":"https://orcid.org/0009-0002-2795-8406","observed_orcids":["https://orcid.org/0009-0002-2795-8406"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Ricchezza","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":"https://orcid.org/0009-0002-2795-8406","affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109715400","display_name":"Shannon Jordan","orcid":"https://orcid.org/0009-0006-2581-1741","observed_orcids":["https://orcid.org/0009-0006-2581-1741"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon Jordan","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":"https://orcid.org/0009-0006-2581-1741","affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055669047","display_name":"Diandra Panasis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diandra Panasis","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110371213","display_name":"N. V. NGUYEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman Nguyen","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091972535","display_name":"Nitish Kasarla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitish Kasarla","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121970054","display_name":"Bryant Wang","orcid":"https://orcid.org/0009-0003-4695-8660","observed_orcids":["https://orcid.org/0009-0003-4695-8660"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryant Wang","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104299075","display_name":"Sergio Sola Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Sola Garcia","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038456881","display_name":"Julianna Saez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julianna Saez","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092545418","display_name":"James Paule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Paule","raw_affiliation_strings":["Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122703177","display_name":"Chae Bin Lee","orcid":"https://orcid.org/0000-0003-4551-9191","observed_orcids":["https://orcid.org/0000-0003-4551-9191"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chae Bin Lee","raw_affiliation_strings":["Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States"],"raw_orcid":"https://orcid.org/0000-0003-4551-9191","affiliations":[{"raw_affiliation_string":"Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090359406","display_name":"Rana Rais","orcid":"https://orcid.org/0000-0003-4059-2453","observed_orcids":["https://orcid.org/0000-0003-4059-2453"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rana Rais","raw_affiliation_strings":["Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States"],"raw_orcid":"https://orcid.org/0000-0003-4059-2453","affiliations":[{"raw_affiliation_string":"Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023686004","display_name":"Barbara Stauch Slusher","orcid":"https://orcid.org/0000-0001-9814-4157","observed_orcids":["https://orcid.org/0000-0001-9814-4157"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara S. Slusher","raw_affiliation_strings":["Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States"],"raw_orcid":"https://orcid.org/0000-0001-9814-4157","affiliations":[{"raw_affiliation_string":"Department of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076880355","display_name":"David R. Sibley","orcid":"https://orcid.org/0000-0002-0624-962X","observed_orcids":["https://orcid.org/0000-0002-0624-962X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Sibley","raw_affiliation_strings":["Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","National Institutes of Health"],"raw_orcid":"https://orcid.org/0000-0002-0624-962X","affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program","institution_ids":["https://openalex.org/I4210110767"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128286508","display_name":"Chenglong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenglong Li","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, Florida 32610, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, Florida 32610, United States","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067184628","display_name":"Thomas M. Keck","orcid":"https://orcid.org/0000-0003-1845-9373","observed_orcids":["https://orcid.org/0000-0003-1845-9373"]},"institutions":[{"id":"https://openalex.org/I44265643","display_name":"Rowan University","ror":"https://ror.org/049v69k10","country_code":"US","type":"education","lineage":["https://openalex.org/I44265643"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas M. Keck","raw_affiliation_strings":["Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States"],"raw_orcid":"https://orcid.org/0000-0003-1845-9373","affiliations":[{"raw_affiliation_string":"Department of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States","institution_ids":["https://openalex.org/I44265643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012510426","display_name":"Comfort A. Boateng","orcid":"https://orcid.org/0000-0003-1907-431X","observed_orcids":["https://orcid.org/0000-0003-1907-431X"]},"institutions":[{"id":"https://openalex.org/I101240087","display_name":"High Point University","ror":"https://ror.org/029qx3s09","country_code":"US","type":"education","lineage":["https://openalex.org/I101240087"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Comfort A. Boateng","raw_affiliation_strings":["Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States"],"raw_orcid":"https://orcid.org/0000-0003-1907-431X","affiliations":[{"raw_affiliation_string":"Department of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States","institution_ids":["https://openalex.org/I101240087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5012510426","https://openalex.org/A5067184628"],"corresponding_institution_ids":["https://openalex.org/I101240087","https://openalex.org/I44265643"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":6.1432,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.9520387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"9","issue":"2","first_page":"385","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.5800999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.1695999950170517,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.10869999974966049,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-d4-receptor","display_name":"dopamine D4 receptor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/1-2-3-triazoles","display_name":"1,2,3-triazoles","score":0.8569999933242798},{"id":"https://openalex.org/keywords/bioisosteric-replacement","display_name":"bioisosteric replacement","score":0.8190000057220459},{"id":"https://openalex.org/keywords/amide-hydrolysis","display_name":"amide hydrolysis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.5370000004768372},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.6859999895095825},{"id":"https://openalex.org/keywords/partial-agonists","display_name":"partial agonists","score":0.5979999899864197},{"id":"https://openalex.org/keywords/antagonists","display_name":"antagonists","score":0.621999979019165},{"id":"https://openalex.org/keywords/brain-exposure","display_name":"brain exposure","score":0.5789999961853027},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6069999933242798},{"id":"https://openalex.org/keywords/beta-arrestin-recruitment","display_name":"\u03b2-arrestin recruitment","score":0.8360000252723694},{"id":"https://openalex.org/keywords/receptor-ligands","display_name":"receptor ligands","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7555000185966492},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.7402999997138977},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.7057999968528748},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6212999820709229},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6154999732971191},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5867000222206116},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5623999834060669},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4846000075340271},{"id":"https://openalex.org/C2777066959","wikidata":"https://www.wikidata.org/wiki/Q869711","display_name":"Cricetulus","level":4,"score":0.4779999852180481},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.4666999876499176},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.4438000023365021},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.44020000100135803},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42809998989105225},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.4180000126361847},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.3619000017642975},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3564000129699707},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.35109999775886536},{"id":"https://openalex.org/C38533456","wikidata":"https://www.wikidata.org/wiki/Q1671589","display_name":"Intrinsic activity","level":4,"score":0.34769999980926514},{"id":"https://openalex.org/C2778327999","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Carboxamide","level":2,"score":0.3314000070095062},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3246000111103058},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.321399986743927},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31700000166893005},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.3091999888420105},{"id":"https://openalex.org/C2991874392","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Metabolic stability","level":3,"score":0.30219998955726624},{"id":"https://openalex.org/C120750228","wikidata":"https://www.wikidata.org/wiki/Q2035393","display_name":"Dopamine receptor D1","level":4,"score":0.2842000126838684},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.2827000021934509},{"id":"https://openalex.org/C31684184","wikidata":"https://www.wikidata.org/wiki/Q33293","display_name":"Peptide bond","level":3,"score":0.2786000072956085},{"id":"https://openalex.org/C2777907353","wikidata":"https://www.wikidata.org/wiki/Q903341","display_name":"Triazole","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C199596767","wikidata":"https://www.wikidata.org/wiki/Q21110872","display_name":"Dopamine receptor D3","level":4,"score":0.26109999418258667},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.2572999894618988},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1021/acsptsci.5c00646","doi":"https://doi.org/10.1021/acsptsci.5c00646","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsptsci.5c00646","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00646?ref=article_openPDF","source":{"id":"https://openalex.org/S4210207642","display_name":"ACS Pharmacology & Translational Science","issn_l":"2575-9108","issn":["2575-9108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Pharmacology & Translational Science","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2024-0z6jk","doi":"https://doi.org/10.26434/chemrxiv-2024-0z6jk","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2024-0z6jk","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/675765dc7be152b1d0728dd0/original/bioisosteric-replacement-of-amides-with-1-2-3-triazoles-improves-dopamine-d4-receptor-ligand-pharmacokinetics.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.26434/chemrxiv-2024-0z6jk-v2","doi":"https://doi.org/10.26434/chemrxiv-2024-0z6jk-v2","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2024-0z6jk-v2","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/68bf200f728bf9025e1662f4/original/bioisosteric-replacement-of-amides-with-1-2-3-triazoles-improves-dopamine-d4-receptor-ligand-pharmacokinetics.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12910498","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41710756/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12910498/pdf/nihms-2146938.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Pharmacol Transl Sci","raw_type":"Text"},{"id":"pmid:41710756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41710756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS pharmacology & translational science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsptsci.5c00646","doi":"https://doi.org/10.1021/acsptsci.5c00646","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsptsci.5c00646","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.5c00646?ref=article_openPDF","source":{"id":"https://openalex.org/S4210207642","display_name":"ACS Pharmacology & Translational Science","issn_l":"2575-9108","issn":["2575-9108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Pharmacology & Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G102925328","display_name":null,"funder_award_id":"08028","funder_id":"https://openalex.org/F4320316439","funder_display_name":"Rowan University"},{"id":"https://openalex.org/G1232909846","display_name":null,"funder_award_id":"1919685","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G2476831334","display_name":null,"funder_award_id":"HHSN-271-2018-00023-C","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3019568981","display_name":"MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Support Undergraduate Research at High Point University","funder_award_id":"1919685","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G407328629","display_name":"Low-Efficacy Dopamine D4 Receptor Partial Agonists for Cocaine Addiction","funder_award_id":"R21DA050896","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G4364667842","display_name":null,"funder_award_id":"20892","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4950536974","display_name":null,"funder_award_id":"-0001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7009490193","display_name":null,"funder_award_id":"HHSN-271-2018-00023-C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000859986","display_name":"Molecular And Pharmacological Studies Of Dopamine Receptors","funder_award_id":"ZIANS002263","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000870450","display_name":"U-Rise at Rowan University","funder_award_id":"T34GM136492","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000894981","display_name":"Development of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype Variants","funder_award_id":"DP1DA058385","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320313822","display_name":"High Point University","ror":"https://ror.org/029qx3s09"},{"id":"https://openalex.org/F4320316439","display_name":"Rowan University","ror":"https://ror.org/049v69k10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332600","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7120175790.pdf","grobid_xml":"https://content.openalex.org/works/W7120175790.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W2730235","https://openalex.org/W860101668","https://openalex.org/W1966779141","https://openalex.org/W1972261780","https://openalex.org/W1973825719","https://openalex.org/W1978189250","https://openalex.org/W1984191254","https://openalex.org/W1985588649","https://openalex.org/W1994941561","https://openalex.org/W1998670974","https://openalex.org/W2002325400","https://openalex.org/W2015688756","https://openalex.org/W2016575780","https://openalex.org/W2016943172","https://openalex.org/W2035266068","https://openalex.org/W2048280135","https://openalex.org/W2054560340","https://openalex.org/W2066158398","https://openalex.org/W2066690664","https://openalex.org/W2068057675","https://openalex.org/W2072679875","https://openalex.org/W2074631079","https://openalex.org/W2080094366","https://openalex.org/W2088172202","https://openalex.org/W2097744565","https://openalex.org/W2105435611","https://openalex.org/W2110112655","https://openalex.org/W2117458899","https://openalex.org/W2118200565","https://openalex.org/W2118233996","https://openalex.org/W2138569000","https://openalex.org/W2146709629","https://openalex.org/W2147751152","https://openalex.org/W2147993766","https://openalex.org/W2169678694","https://openalex.org/W2300160852","https://openalex.org/W2395815812","https://openalex.org/W2398465145","https://openalex.org/W2404186171","https://openalex.org/W2461901476","https://openalex.org/W2509149624","https://openalex.org/W2540491215","https://openalex.org/W2592194193","https://openalex.org/W2610001318","https://openalex.org/W2613490892","https://openalex.org/W2766694609","https://openalex.org/W2795345791","https://openalex.org/W2806985340","https://openalex.org/W2914015796","https://openalex.org/W2921738541","https://openalex.org/W2945218994","https://openalex.org/W2950671078","https://openalex.org/W2989052455","https://openalex.org/W2997234536","https://openalex.org/W3005043246","https://openalex.org/W3022933714","https://openalex.org/W3113827086","https://openalex.org/W3145662144","https://openalex.org/W3162951634","https://openalex.org/W3199531963","https://openalex.org/W4210272186","https://openalex.org/W4221096499","https://openalex.org/W4295423299","https://openalex.org/W4298144298","https://openalex.org/W4362677501","https://openalex.org/W4386272479","https://openalex.org/W4408966851","https://openalex.org/W4410519470","https://openalex.org/W4410841818"],"related_works":["https://openalex.org/W4396850021","https://openalex.org/W4408935730","https://openalex.org/W7066487800","https://openalex.org/W4377020756","https://openalex.org/W2048280135","https://openalex.org/W2949819865","https://openalex.org/W2111763371","https://openalex.org/W7204564655","https://openalex.org/W7034228069","https://openalex.org/W1993934642"],"abstract_inverted_index":{"Dopamine":[0],"D4":[1],"receptor":[2],"(D4R)":[3],"signaling":[4,136],"affects":[5],"decision-making,":[6],"memory":[7],"formation,":[8],"cognition,":[9],"and":[10,54,64,100,111],"attention.":[11],"Previously":[12],"developed":[13],"D4R-selective":[14],"ligands":[15],"were":[16,32],"metabolically":[17,96],"unstable":[18],"in":[19,98,114,137],"vivo":[20],"due":[21],"to":[22,68,132],"amide":[23,85],"bond":[24],"linker":[25],"hydrolysis.":[26],"In":[27,87],"this":[28],"study,":[29],"analog":[30],"compounds":[31,81],"synthesized":[33],"using":[34],"click":[35],"chemistry,":[36],"bioisosterically":[37],"replacing":[38],"amides":[39],"with":[40,104],"a":[41,91,105],"1,2,3-triazole":[42],"linker.":[43],"Herein,":[44],"we":[45,73],"report":[46],"1,2,3-":[47],"triazole":[48,80],"analogs":[49,127],"maintained":[50],"high":[51],"D4R":[52,93,135],"affinity":[53],"subtype":[55],"selectivity":[56],"while":[57],"retaining":[58],"their":[59],"functional":[60],"activity.":[61],"Using":[62],"rat":[63,99],"human":[65,101],"liver":[66,102],"microsomes":[67],"evaluate":[69],"phase":[70],"I":[71],"metabolism,":[72],"determined":[74],"that":[75,119],"the":[76],"metabolic":[77],"stability":[78],"of":[79],"was":[82],"improved":[83,129],"over":[84],"analogs.":[86],"particular,":[88],"18":[89],"is":[90,120],"potent":[92],"partial":[94],"agonist,":[95],"stable":[97],"microsomes,":[103],"half-life":[106],"(t1/2":[107],"\u2248":[108],"1":[109],"hour)":[110],"brain":[112],"penetration":[113],"rats":[115],"(AUCbrain/plasma":[116],">":[117],"2.70)":[118],"suitable":[121],"for":[122],"behavioral":[123],"studies.":[124],"These":[125],"new":[126],"represent":[128],"molecular":[130],"tools":[131],"further":[133],"explore":[134],"rodent":[138],"models.":[139]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-01-10T00:00:00"}