{"id":"https://openalex.org/W7120100797","doi":"https://doi.org/10.1038/s41467-025-68188-0","title":"Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis","display_name":"Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis","publication_year":2026,"publication_date":"2026-01-09","ids":{"openalex":"https://openalex.org/W7120100797","doi":"https://doi.org/10.1038/s41467-025-68188-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41513654"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-025-68188-0","doi":"https://doi.org/10.1038/s41467-025-68188-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-68188-0","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41467-025-68188-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059678438","display_name":"Wenhui Wu","orcid":"https://orcid.org/0000-0002-0336-6011","observed_orcids":["https://orcid.org/0000-0002-0336-6011"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Hui Wu","raw_affiliation_strings":["School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-0336-6011","affiliations":[{"raw_affiliation_string":"School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113335702","display_name":"Li-Zeng Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Zeng Zhu","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122446828","display_name":"Kang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Liu","raw_affiliation_strings":["Department of Nephrology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110809781","display_name":"Liyun Cao","orcid":"https://orcid.org/0000-0001-8539-3453","observed_orcids":["https://orcid.org/0000-0001-8539-3453"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Cao","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100658346","display_name":"Yu Fan","orcid":"https://orcid.org/0000-0003-4095-8427","observed_orcids":["https://orcid.org/0000-0003-4095-8427"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan-Ming Fan","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122580203","display_name":"Ping Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Zhou","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146677923","display_name":"Yue Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081791924","display_name":"Gaoxiang Ma","orcid":"https://orcid.org/0000-0002-1774-6445","observed_orcids":["https://orcid.org/0000-0002-1774-6445"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaoxiang Ma","raw_affiliation_strings":["Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, Nanjing, China","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-1774-6445","affiliations":[{"raw_affiliation_string":"Pukou Hospital of Chinese Medicine affiliated to China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424762","display_name":"Jinfeng Liu","orcid":"https://orcid.org/0000-0002-0614-5097","observed_orcids":["https://orcid.org/0000-0002-0614-5097","https://orcid.org/0000-0002-5542-827X"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Feng Liu","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0002-0614-5097","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122503600","display_name":"Bao-Lin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]},{"id":"https://openalex.org/I4391767909","display_name":"State Key Laboratory of Natural Medicine","ror":"https://ror.org/01as92r37","country_code":null,"type":"facility","lineage":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bao-Lin Liu","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I4391767909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025530383","display_name":"Lian\u2010Wen Qi","orcid":"https://orcid.org/0000-0003-0728-4475","observed_orcids":["https://orcid.org/0000-0003-0728-4475"]},"institutions":[{"id":"https://openalex.org/I103890011","display_name":"Shenyang Pharmaceutical University","ror":"https://ror.org/03dnytd23","country_code":"CN","type":"education","lineage":["https://openalex.org/I103890011"]},{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lian-Wen Qi","raw_affiliation_strings":["School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. qilw@cpu.edu.cn","State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. qilw@cpu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-0728-4475","affiliations":[{"raw_affiliation_string":"School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China. qilw@cpu.edu.cn","institution_ids":["https://openalex.org/I103890011"]},{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. qilw@cpu.edu.cn","institution_ids":["https://openalex.org/I161716053"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100426183","display_name":"Qun Liu","orcid":"https://orcid.org/0000-0003-0991-8144","observed_orcids":["https://orcid.org/0000-0003-0991-8144"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qun Liu","raw_affiliation_strings":["State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. liuquncpu@126.com"],"raw_orcid":"https://orcid.org/0000-0003-0991-8144","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, China. liuquncpu@126.com","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5025530383","https://openalex.org/A5100426183"],"corresponding_institution_ids":["https://openalex.org/I103890011","https://openalex.org/I161716053"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":28.4309,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.99612846,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"17","issue":"1","first_page":"1453","last_page":"1453"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.08649999648332596,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgl1","display_name":"FGL1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hepatokines","display_name":"hepatokines","score":0.8259999752044678},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alk5","display_name":"ALK5","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7200000286102295},{"id":"https://openalex.org/keywords/polyubiquitination","display_name":"polyubiquitination","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6039999723434448},{"id":"https://openalex.org/keywords/p-hydroxybenzaldehyde","display_name":"p-hydroxybenzaldehyde","score":0.8610000014305115},{"id":"https://openalex.org/keywords/ureteral-obstruction","display_name":"ureteral obstruction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/adenine-induced-nephropathy","display_name":"adenine-induced nephropathy","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.8996000289916992},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.8255000114440918},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6940000057220459},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6383000016212463},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5527999997138977},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.48100000619888306},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46810001134872437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4422999918460846},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38830000162124634},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34860000014305115},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3416000008583069},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3337000012397766},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.3208000063896179},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29980000853538513},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.2978000044822693},{"id":"https://openalex.org/C2994217296","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Liver fibrosis","level":3,"score":0.2921999990940094},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.287200003862381},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.27239999175071716},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2533000111579895}],"mesh":[{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000077293","descriptor_name":"Receptor, Transforming Growth Factor-beta Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-025-68188-0","doi":"https://doi.org/10.1038/s41467-025-68188-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-68188-0","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:41513654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41513654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11694558","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12886963","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:69aca9e784a04bffa0f4ba6ae5e56d21","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/69aca9e784a04bffa0f4ba6ae5e56d21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12886963","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12886963/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-025-68188-0","doi":"https://doi.org/10.1038/s41467-025-68188-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-68188-0","pdf_url":null,"source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8242247104644775,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1636167907","display_name":null,"funder_award_id":"82374103","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5729384055","display_name":null,"funder_award_id":"82174036","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7802476709","display_name":null,"funder_award_id":"82330123","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1631449371","https://openalex.org/W1972399884","https://openalex.org/W1979395812","https://openalex.org/W2013584300","https://openalex.org/W2033200911","https://openalex.org/W2033457930","https://openalex.org/W2065633653","https://openalex.org/W2088940658","https://openalex.org/W2117457995","https://openalex.org/W2154568166","https://openalex.org/W2175518135","https://openalex.org/W2342679639","https://openalex.org/W2798055176","https://openalex.org/W2896518632","https://openalex.org/W2906369032","https://openalex.org/W2942227779","https://openalex.org/W2942588693","https://openalex.org/W2973071766","https://openalex.org/W2980529195","https://openalex.org/W2997954936","https://openalex.org/W3010857647","https://openalex.org/W3027158038","https://openalex.org/W3086210886","https://openalex.org/W3088173406","https://openalex.org/W3112435365","https://openalex.org/W3201766594","https://openalex.org/W3210858080","https://openalex.org/W3215665003","https://openalex.org/W4212835316","https://openalex.org/W4296793527","https://openalex.org/W4300772763","https://openalex.org/W4303614593","https://openalex.org/W4319461991","https://openalex.org/W4367320514","https://openalex.org/W4376608659","https://openalex.org/W4384120022","https://openalex.org/W4391068043","https://openalex.org/W4394740672","https://openalex.org/W4399345729","https://openalex.org/W4401362468","https://openalex.org/W4403921869","https://openalex.org/W4404195135","https://openalex.org/W4404347370","https://openalex.org/W4410316023"],"related_works":[],"abstract_inverted_index":{"The":[0],"concept":[1],"of":[2,15,66,158],"organ-organ":[3,168],"communication":[4,39],"in":[5,40,52,61,78,111,170],"systemic":[6],"diseases":[7],"has":[8],"gained":[9],"significant":[10],"traction.":[11],"Despite":[12],"accumulating":[13],"evidence":[14],"liver-kidney":[16,38,160],"crosstalk,":[17],"the":[18,53],"underlying":[19],"regulatory":[20],"mechanisms":[21],"remain":[22],"poorly":[23],"understood.":[24],"Here,":[25],"we":[26],"identify":[27],"hepatokine":[28],"fibrinogen-like":[29],"protein":[30],"1":[31],"(FGL1)":[32],"as":[33,154],"a":[34,155],"pivotal":[35],"mediator":[36,157],"driving":[37],"renal":[41,69,90,146,171],"fibrosis.":[42,91,172],"Integrative":[43],"RNA":[44],"sequencing":[45],"and":[46,74,82,99,121,128,162],"clinical":[47],"analyses":[48,107],"revealed":[49],"FGL1":[50,67,87,93,115,153],"upregulation":[51],"liver":[54],"post-renal":[55],"injury,":[56],"with":[57,103],"subsequent":[58],"selective":[59],"accumulation":[60],"fibrotic":[62],"kidneys.":[63],"Hepatocyte-specific":[64],"knockout":[65],"improved":[68],"morphology,":[70],"attenuated":[71],"collagen":[72],"deposition,":[73],"inhibited":[75],"fibrosis":[76,147],"markers":[77],"unilateral":[79],"ureteral":[80],"obstruction":[81],"adenine-induced":[83],"mouse":[84],"models.":[85],"Conversely,":[86],"overexpression":[88],"exacerbated":[89],"Mechanistically,":[92],"binds":[94],"to":[95,166],"TGF-\u03b2":[96],"receptor":[97],"ALK5":[98],"blocks":[100],"its":[101],"interaction":[102],"K48-linked":[104],"polyubiquitin.":[105],"Structural":[106],"identified":[108],"critical":[109],"residues":[110],"FGL1-ALK5":[112],"interaction.":[113],"Hepatic":[114],"is":[116],"transcriptionally":[117],"regulated":[118],"by":[119,123,132],"STAT3,":[120],"activated":[122],"inflammatory":[124],"cytokines":[125],"(IL-6,":[126],"IL-1\u03b2":[127],"TNF-\u03b1).":[129],"Pharmacological":[130],"inhibition":[131],"p-hydroxybenzaldehyde":[133],"(screened":[134],"out":[135],"from":[136],"4080":[137],"compounds)":[138],"or":[139],"an":[140],"anti-FGL1":[141],"monoclonal":[142],"antibody":[143],"significantly":[144],"reduced":[145],"without":[148],"hepatotoxicity.":[149],"These":[150],"findings":[151],"establish":[152],"key":[156],"pathogenic":[159],"crosstalk":[161],"highlights":[163],"therapeutic":[164],"strategies":[165],"targeting":[167],"networks":[169]},"counts_by_year":[{"year":2026,"cited_by_count":6}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-10T00:00:00"}