{"id":"https://openalex.org/W7119979216","doi":"https://doi.org/10.1016/j.nbd.2026.107267","title":"A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid \u03b2-peptide","display_name":"A C. elegans model of familial Alzheimer's disease shows age-dependent synaptic degeneration independent of amyloid \u03b2-peptide","publication_year":2026,"publication_date":"2026-01-10","ids":{"openalex":"https://openalex.org/W7119979216","doi":"https://doi.org/10.1016/j.nbd.2026.107267","pmid":"https://pubmed.ncbi.nlm.nih.gov/40791515","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12338675"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbd.2026.107267","doi":"https://doi.org/10.1016/j.nbd.2026.107267","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107267","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.nbd.2026.107267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066788719","display_name":"Vaishnavi Divya Nagarajan","orcid":"https://orcid.org/0000-0002-0368-129X","observed_orcids":["https://orcid.org/0000-0002-0368-129X"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaishnavi Nagarajan","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119014932","display_name":"Caitlin L. Libowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin L. Libowitz","raw_affiliation_strings":["Graduate Program in Neurosciences, Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS 66045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Neurosciences, Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS 66045, USA","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066912849","display_name":"Brian D. Ackley","orcid":"https://orcid.org/0000-0002-1257-2407","observed_orcids":["https://orcid.org/0000-0002-1257-2407"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian D. Ackley","raw_affiliation_strings":["Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. Electronic address: bdackley@ku.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, University of Kansas, Lawrence, KS 66045, USA. Electronic address: bdackley@ku.edu","institution_ids":["https://openalex.org/I146416000"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103148406","display_name":"Michael S. Wolfe","orcid":"https://orcid.org/0000-0002-2923-3436","observed_orcids":["https://orcid.org/0000-0002-2923-3436"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Wolfe","raw_affiliation_strings":["Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA. Electronic address: mswolfe@ku.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA. Electronic address: mswolfe@ku.edu","institution_ids":["https://openalex.org/I146416000"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066912849","https://openalex.org/A5103148406"],"corresponding_institution_ids":["https://openalex.org/I146416000"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":{"value":4180,"currency":"USD","value_usd":4180},"fwci":7.5043,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.95045,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"219","issue":null,"first_page":"107267","last_page":"107267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/familial-alzheimer-s-disease","display_name":"familial Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.777999997138977},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8169999718666077},{"id":"https://openalex.org/keywords/c99","display_name":"C99","score":0.6899999976158142},{"id":"https://openalex.org/keywords/synaptic-degeneration","display_name":"synaptic degeneration","score":0.8669999837875366},{"id":"https://openalex.org/keywords/enzyme-substrate-complex","display_name":"enzyme-substrate complex","score":0.8489999771118164},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.5699999928474426},{"id":"https://openalex.org/keywords/intramembrane-proteolysis","display_name":"intramembrane proteolysis","score":0.7960000038146973},{"id":"https://openalex.org/keywords/age-related-neurodegeneration","display_name":"age-related neurodegeneration","score":0.8090000152587891},{"id":"https://openalex.org/keywords/caenorhabditis-elegans-model","display_name":"Caenorhabditis elegans model","score":0.8600000143051147},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7976999878883362},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5665000081062317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5257999897003174},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5181000232696533},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5023999810218811},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.4943000078201294},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.46299999952316284},{"id":"https://openalex.org/C2781452922","wikidata":"https://www.wikidata.org/wiki/Q2892805","display_name":"Proteostasis","level":2,"score":0.45910000801086426},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.44909998774528503},{"id":"https://openalex.org/C36103677","wikidata":"https://www.wikidata.org/wiki/Q4749551","display_name":"Amyloid precursor protein secretase","level":5,"score":0.41019999980926514},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4074000120162964},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.3986000120639801},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34540000557899475},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.3449000120162964},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3382999897003174},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C177907266","wikidata":"https://www.wikidata.org/wiki/Q17155455","display_name":"P3 peptide","level":5,"score":0.28929999470710754},{"id":"https://openalex.org/C180081513","wikidata":"https://www.wikidata.org/wiki/Q4914721","display_name":"Biochemistry of Alzheimer's disease","level":5,"score":0.2824000120162964},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.2766999900341034},{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.2759000062942505},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2639000117778778},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.nbd.2026.107267","doi":"https://doi.org/10.1016/j.nbd.2026.107267","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107267","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"doi:10.1101/2025.07.16.665161","doi":"https://doi.org/10.1101/2025.07.16.665161","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.16.665161","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/20/2025.07.16.665161.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40791515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40791515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41525885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41525885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12338675","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12338675","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:41a111b0d6084c1c836a2ad7a47fb804","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/41a111b0d6084c1c836a2ad7a47fb804","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 219, Iss , Pp 107267- (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13151068","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13151068/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiol Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.nbd.2026.107267","doi":"https://doi.org/10.1016/j.nbd.2026.107267","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107267","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2610077870","display_name":"Structure and Function of Gamma-Secretase in Familial Alzheimer's Disease","funder_award_id":"R01AG066986","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3881021852","display_name":null,"funder_award_id":"AG79569","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8969343261","display_name":null,"funder_award_id":"AG66986","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000864426","display_name":"Leveraging Heterogeneity in Autosomal Dominant AD to Elucidate Pathophysiology and Improve AD Biomarkers","funder_award_id":"R01AG079569","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000877962","display_name":"University of Kansas Alzheimer's Disease Research Center (KU ADRC)","funder_award_id":"P30AG072973","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310131","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119979216.pdf","grobid_xml":"https://content.openalex.org/works/W7119979216.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1504590764","https://openalex.org/W1560202903","https://openalex.org/W1639521477","https://openalex.org/W1669755322","https://openalex.org/W1944127002","https://openalex.org/W1964117773","https://openalex.org/W1967027232","https://openalex.org/W1972706019","https://openalex.org/W1975595547","https://openalex.org/W1984087572","https://openalex.org/W1985861361","https://openalex.org/W2015161609","https://openalex.org/W2019007505","https://openalex.org/W2046209489","https://openalex.org/W2051573801","https://openalex.org/W2051629075","https://openalex.org/W2058723245","https://openalex.org/W2082723673","https://openalex.org/W2087895896","https://openalex.org/W2088989293","https://openalex.org/W2096012124","https://openalex.org/W2098503611","https://openalex.org/W2116964904","https://openalex.org/W2128084592","https://openalex.org/W2147083367","https://openalex.org/W2156326104","https://openalex.org/W2156542857","https://openalex.org/W2159565935","https://openalex.org/W2162588539","https://openalex.org/W2171288353","https://openalex.org/W2266892604","https://openalex.org/W2285119592","https://openalex.org/W2344407798","https://openalex.org/W2512798183","https://openalex.org/W2536701740","https://openalex.org/W2881473390","https://openalex.org/W2884933563","https://openalex.org/W2906336433","https://openalex.org/W2949872535","https://openalex.org/W2967807085","https://openalex.org/W3034425852","https://openalex.org/W3037926339","https://openalex.org/W3086885596","https://openalex.org/W3112560954","https://openalex.org/W3112777140","https://openalex.org/W3112948680","https://openalex.org/W3119714211","https://openalex.org/W3135391394","https://openalex.org/W3190549844","https://openalex.org/W3216557857","https://openalex.org/W4205826922","https://openalex.org/W4210279925","https://openalex.org/W4231640017","https://openalex.org/W4233829850","https://openalex.org/W4252175039","https://openalex.org/W4280526065","https://openalex.org/W4321763836","https://openalex.org/W4322742551","https://openalex.org/W4324150557","https://openalex.org/W4385283633","https://openalex.org/W4385563366","https://openalex.org/W4391800171","https://openalex.org/W4394808067","https://openalex.org/W4401540448","https://openalex.org/W4403680990","https://openalex.org/W4407369314","https://openalex.org/W4407582534","https://openalex.org/W4407941091","https://openalex.org/W4408840179","https://openalex.org/W4408869794","https://openalex.org/W4410512870","https://openalex.org/W4411254223","https://openalex.org/W4411951393"],"related_works":["https://openalex.org/W4386579685","https://openalex.org/W4391800171","https://openalex.org/W4404749154","https://openalex.org/W3119714211","https://openalex.org/W1878009217","https://openalex.org/W2029506291","https://openalex.org/W1928655587","https://openalex.org/W4411951393","https://openalex.org/W1999144284","https://openalex.org/W4407941091"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1],"membrane-embedded":[2],"\u03b3-secretase":[3,91,183,206,238],"complex":[4,155],"is":[5,47,251,291,312],"involved":[6],"in":[7,37,53,59,77,100,118,127,164,196,209,241,255,304,310,360],"the":[8,30,38,48,78,210,234,256,292,315,324,328,341],"intramembrane":[9,121],"cleavage":[10],"of":[11,16,40,51,65,82,90,98,123,134,169,173,181,212,220,236,270,278,295,307,319,355],"\u223c":[12],"150":[13],"substrates.":[14],"Cleavage":[15],"amyloid":[17,26,262],"precursor":[18],"protein":[19],"(APP)-derived":[20],"substrate":[21,113,176,184,239,259,271],"C99":[22,83,112,124,136,170],"generates":[23],"38-43-residue":[24],"secreted":[25],"\u03b2-peptides":[27,263],"(A\u03b2),":[28],"with":[29,171,358],"aggregation-prone":[31,281],"42-residue":[32],"form":[33],"(A\u03b242)":[34],"particularly":[35],"implicated":[36],"pathogenesis":[39],"Alzheimer\u2019s":[41,248],"Disease":[42],"(AD).":[43],"However,":[44],"whether":[45,289],"A\u03b242":[46,158],"primary":[49,293],"driver":[50,294],"neurodegeneration":[52,99],"AD":[54,69,296],"remains":[55,297],"unclear.":[56],"Dominant":[57],"mutations":[58,150,254,266],"APP":[60],"or":[61,74,110,137,159,258,348],"presenilin\u2014the":[62],"catalytic":[63],"component":[64],"\u03b3-secretase\u2014cause":[66],"early-onset":[67],"familial":[68,247],"(FAD)":[70,250],"and":[71,114,215,274],"reduce":[72],"one":[73],"more":[75],"steps":[76],"multi-step":[79],"processive":[80],"proteolysis":[81],"to":[84,125,140,188,232,272,280,314],"A\u03b2":[85,126,160,213,273,279,290,320,325,347],"peptides,":[86],"apparently":[87],"through":[88],"stabilization":[89],"enzyme-substrate":[92],"(E-S)":[93],"complexes.":[94],"To":[95],"investigate":[96],"mechanisms":[97],"FAD,":[101],"we":[102,337],"developed":[103],"new":[104,224],"C.":[105,225,330],"elegans":[106,226,331],"models":[107],"co-expressing":[108],"wild-type":[109],"FAD-mutant":[111],"presenilin-1":[115],"(PSEN1)":[116],"variants":[117,172],"neurons,":[119],"allowing":[120],"processing":[122,180,240,269],"vivo.":[128],"We":[129],"demonstrate":[130],"that":[131,151,178,260,283,340],"while":[132],"FAD-mutation":[133],"either":[135],"PSEN1":[138,146],"leads":[139],"age-dependent":[141],"synaptic":[142,165,189,198],"loss,":[143],"proteolytically":[144],"inactive":[145],"did":[147],"not.":[148],"Designed":[149],"allow":[152],"stable":[153],"E-S":[154,207],"formation":[156],"without":[157],"production":[161,214,277],"likewise":[162],"result":[163],"degeneration.":[166,190],"Moreover,":[167],"replacement":[168],"a":[174,194,229,302,333],"Notch1-based":[175],"revealed":[177],"disrupted":[179],"another":[182],"can":[185,200,275,352],"similarly":[186],"lead":[187],"These":[191,265],"results":[192],"support":[193],"model":[195,303,335,363],"which":[197,305],"loss":[199,219,306,354],"be":[201],"triggered":[202],"by":[203,217,253],"toxic,":[204],"stalled":[205,316,342],"complexes":[208],"absence":[211],"not":[216],"simple":[218,362],"proteolytic":[221],"function.":[222],"This":[223],"system":[227],"provides":[228],"powerful":[230],"platform":[231],"study":[233],"role":[235],"dysfunctional":[237],"FAD":[242,311],"pathogenesis.":[243],"SIGNIFICANCE":[244],"Dominantly":[245],"inherited":[246],"disease":[249],"caused":[252],"enzyme":[257,268,350],"produces":[261],"(A\u03b2).":[264],"alter":[267],"skew":[276],"forms":[282],"deposit":[284],"as":[285,332],"pathological":[286],"plaques.":[287],"Nevertheless,":[288],"unresolved.":[298],"Recent":[299],"evidence":[300],"supports":[301],"neuronal":[308,356],"connections":[309,357],"due":[313],"enzymatic":[317],"process":[318,343],"production,":[321],"rather":[322,345],"than":[323,346],"products.":[326],"Using":[327],"roundworm":[329],"genetic":[334],"system,":[336],"show":[338],"here":[339],"itself,":[344],"reduced":[349],"activity,":[351],"trigger":[353],"age":[359],"this":[361],"animal.":[364]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-10T00:00:00"}
