{"id":"https://openalex.org/W7119898331","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.12.060","title":"Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer","display_name":"Dihydroartemisinin targets GPX4 to induce autophagy-dependent ferroptosis and reduce radioresistance in triple-negative breast cancer","publication_year":2026,"publication_date":"2026-01-09","ids":{"openalex":"https://openalex.org/W7119898331","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.12.060","pmid":"https://pubmed.ncbi.nlm.nih.gov/41520847"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2025.12.060","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.12.060","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.12.060","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122497223","display_name":"Youyi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youyi Wu","raw_affiliation_strings":["Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Radiology of Jiangbei Campus, The First Affiliated Hospital of Army Medical University, Chongqing, 400020, China. Electronic address: yywu@stu.cqmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China; Department of Radiology of Jiangbei Campus, The First Affiliated Hospital of Army Medical University, Chongqing, 400020, China. Electronic address: yywu@stu.cqmu.edu.cn","institution_ids":["https://openalex.org/I151075929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122434013","display_name":"Dan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dan Chen","raw_affiliation_strings":["Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: chendan991228@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: chendan991228@163.com","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122608153","display_name":"Xiaohu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohu Wang","raw_affiliation_strings":["Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: wangmcqmu@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: wangmcqmu@163.com","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021313551","display_name":"Mengyao Song","orcid":"https://orcid.org/0009-0001-0630-8554","observed_orcids":["https://orcid.org/0009-0001-0630-8554"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengyao Song","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China. Electronic address: mengyao_s@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China. Electronic address: mengyao_s@163.com","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146688568","display_name":"Jingyi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Wu","raw_affiliation_strings":["Department of Thoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 18353131803@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 18353131803@163.com","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100569215","display_name":"Shunlong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shunlong Wu","raw_affiliation_strings":["Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 203058@hospital.cqmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 203058@hospital.cqmu.edu.cn","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104077467","display_name":"Kui Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kui Liao","raw_affiliation_strings":["Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 202169@hospital.cqmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Laboratory of Immunity, Inflammation & Cancer, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: 202169@hospital.cqmu.edu.cn","institution_ids":["https://openalex.org/I4210129459"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5104077467"],"corresponding_institution_ids":["https://openalex.org/I4210129459"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":42.2835,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.99813075,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"246","issue":null,"first_page":"35","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dihydroartemisinin","display_name":"dihydroartemisinin","score":1.0},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.8209999799728394},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":1.0},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.859000027179718},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.9089999794960022},{"id":"https://openalex.org/keywords/herbal-compounds","display_name":"herbal compounds","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.84579998254776},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7106999754905701},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6585000157356262},{"id":"https://openalex.org/C158086472","wikidata":"https://www.wikidata.org/wiki/Q21103287","display_name":"GPX4","level":5,"score":0.6187999844551086},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.5841000080108643},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5558000206947327},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5368000268936157},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4975999891757965},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4973999857902527},{"id":"https://openalex.org/C2781160685","wikidata":"https://www.wikidata.org/wiki/Q5276420","display_name":"Dihydroartemisinin","level":5,"score":0.4887000024318695},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.44749999046325684},{"id":"https://openalex.org/C2777122948","wikidata":"https://www.wikidata.org/wiki/Q3631793","display_name":"BECN1","level":4,"score":0.4472000002861023},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4449999928474426},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.4226999878883362},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3977999985218048},{"id":"https://openalex.org/C2776428644","wikidata":"https://www.wikidata.org/wiki/Q2126468","display_name":"Radiosensitizer","level":3,"score":0.3935999870300293},{"id":"https://openalex.org/C2776104650","wikidata":"https://www.wikidata.org/wiki/Q2113512","display_name":"Proteotoxicity","level":3,"score":0.3889999985694885},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.33970001339912415},{"id":"https://openalex.org/C2778050619","wikidata":"https://www.wikidata.org/wiki/Q6058567","display_name":"Intravasation","level":4,"score":0.32580000162124634},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2766999900341034},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.25450000166893005},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2508000135421753}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000080662","descriptor_name":"Phospholipid Hydroperoxide Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D064726","descriptor_name":"Triple Negative Breast Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2025.12.060","doi":"https://doi.org/10.1016/j.freeradbiomed.2025.12.060","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2025.12.060","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:41520847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41520847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2863138825","display_name":null,"funder_award_id":"CSTB2023NSCQ-MSX1037","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1965003536","https://openalex.org/W2096592126","https://openalex.org/W2515795587","https://openalex.org/W2553948338","https://openalex.org/W2912993657","https://openalex.org/W2967901922","https://openalex.org/W2996356562","https://openalex.org/W3033869790","https://openalex.org/W3154081832","https://openalex.org/W3159438706","https://openalex.org/W3200634825","https://openalex.org/W4210941435","https://openalex.org/W4225352727","https://openalex.org/W4292407583","https://openalex.org/W4302766709","https://openalex.org/W4317234129","https://openalex.org/W4324010199","https://openalex.org/W4377563974","https://openalex.org/W4378980763","https://openalex.org/W4380884711","https://openalex.org/W4382068653","https://openalex.org/W4385755952","https://openalex.org/W4386407597","https://openalex.org/W4386813133","https://openalex.org/W4387873756","https://openalex.org/W4393160259","https://openalex.org/W4393855312","https://openalex.org/W4399739178","https://openalex.org/W4401895991","https://openalex.org/W4404893983","https://openalex.org/W4406979600"],"related_works":["https://openalex.org/W4401895991","https://openalex.org/W4388706190","https://openalex.org/W4405777268","https://openalex.org/W7171965139","https://openalex.org/W4288081264","https://openalex.org/W4410012204","https://openalex.org/W7131681767","https://openalex.org/W4236630094","https://openalex.org/W4205262178","https://openalex.org/W4393021085"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-01-10T00:00:00"}