{"id":"https://openalex.org/W7119829953","doi":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","title":"Blood biomarkers of frailty and cognition: A scoping review","display_name":"Blood biomarkers of frailty and cognition: A scoping review","publication_year":2026,"publication_date":"2026-01-09","ids":{"openalex":"https://openalex.org/W7119829953","doi":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","pmid":"https://pubmed.ncbi.nlm.nih.gov/41544446"},"language":"en","primary_location":{"id":"doi:10.1016/j.neurobiolaging.2026.01.003","doi":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146784649","display_name":"Maddison L. Hodgins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maddison L. Hodgins","raw_affiliation_strings":["Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: maddison.hodgins@dal.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: maddison.hodgins@dal.ca","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081334479","display_name":"Selena P. Maxwell","orcid":"https://orcid.org/0000-0001-9969-648X","observed_orcids":["https://orcid.org/0000-0001-9969-648X"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Selena P. Maxwell","raw_affiliation_strings":["Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: selena.maxwell@dal.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: selena.maxwell@dal.ca","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044537891","display_name":"Susan E. Howlett","orcid":"https://orcid.org/0000-0001-5351-6308","observed_orcids":["https://orcid.org/0000-0001-5351-6308"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Susan E. Howlett","raw_affiliation_strings":["Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada; Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: susan.howlett@dal.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada; Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: susan.howlett@dal.ca","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006205778","display_name":"Kenneth J. Rockwood","orcid":"https://orcid.org/0000-0002-6674-995X","observed_orcids":["https://orcid.org/0000-0002-6674-995X"]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Kenneth Rockwood","raw_affiliation_strings":["Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: Kenneth.Rockwood@dal.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada. Electronic address: Kenneth.Rockwood@dal.ca","institution_ids":["https://openalex.org/I129902397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006205778"],"corresponding_institution_ids":["https://openalex.org/I129902397"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":34.2984,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.99813567,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"161","issue":null,"first_page":"14","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.3253999948501587,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8640000224113464},{"id":"https://openalex.org/keywords/blood-biomarkers","display_name":"blood biomarkers","score":0.8379999995231628},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.828000009059906},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9670000076293945},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":1.0},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":1.0},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/nutrient-sensing","display_name":"nutrient sensing","score":0.9070000052452087},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7368000149726868},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6435999870300293},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6384999752044678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6362000107765198},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5911999940872192},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5817000269889832},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.47099998593330383},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.46810001134872437},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.4429999887943268},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.40880000591278076},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3434999883174896},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2946999967098236},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.29249998927116394},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.2743000090122223},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000072197","descriptor_name":"ADAM10 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000073496","descriptor_name":"Frailty","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074702","descriptor_name":"Proteostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016330","descriptor_name":"Frail Elderly","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neurobiolaging.2026.01.003","doi":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},{"id":"pmid:41544446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41544446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.neurobiolaging.2026.01.003","doi":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neurobiolaging.2026.01.003","pdf_url":null,"source":{"id":"https://openalex.org/S284573","display_name":"Neurobiology of Aging","issn_l":"0197-4580","issn":["0197-4580","1558-1497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Reduced inequalities","score":0.4681701362133026,"id":"https://metadata.un.org/sdg/10"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[{"id":"https://openalex.org/G208905592","display_name":"Phase Two of the Canadian Consortium on Neurodegeneration in Aging","funder_award_id":"163902_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6293678399","display_name":"Clinicopathological correlates of executive dysfunction","funder_award_id":"187960_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320315912","display_name":"Consortium canadien en neurod\u00e9g\u00e9n\u00e9rescence associ\u00e9e au vieillissement","ror":"https://ror.org/029c4ct76"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W57510132","https://openalex.org/W1557365633","https://openalex.org/W1847168837","https://openalex.org/W1861440079","https://openalex.org/W1912772214","https://openalex.org/W1934883852","https://openalex.org/W1972477405","https://openalex.org/W1980827933","https://openalex.org/W1993662614","https://openalex.org/W1994221276","https://openalex.org/W1995898214","https://openalex.org/W2010545568","https://openalex.org/W2010681077","https://openalex.org/W2022324453","https://openalex.org/W2024501220","https://openalex.org/W2029884260","https://openalex.org/W2062601898","https://openalex.org/W2072371192","https://openalex.org/W2082402714","https://openalex.org/W2087595637","https://openalex.org/W2091173932","https://openalex.org/W2098930053","https://openalex.org/W2099061000","https://openalex.org/W2122215582","https://openalex.org/W2123283886","https://openalex.org/W2126525177","https://openalex.org/W2128289558","https://openalex.org/W2136250824","https://openalex.org/W2136909785","https://openalex.org/W2139520621","https://openalex.org/W2143261494","https://openalex.org/W2147890097","https://openalex.org/W2152601025","https://openalex.org/W2153182649","https://openalex.org/W2158766477","https://openalex.org/W2159914115","https://openalex.org/W2164059021","https://openalex.org/W2164785427","https://openalex.org/W2165758561","https://openalex.org/W2166350749","https://openalex.org/W2215566856","https://openalex.org/W2234296837","https://openalex.org/W2287100306","https://openalex.org/W2312760741","https://openalex.org/W2410374774","https://openalex.org/W2536610984","https://openalex.org/W2606929500","https://openalex.org/W2623732540","https://openalex.org/W2735761770","https://openalex.org/W2752701793","https://openalex.org/W2758168537","https://openalex.org/W2780992699","https://openalex.org/W2791806066","https://openalex.org/W2867079663","https://openalex.org/W2882980488","https://openalex.org/W2891378911","https://openalex.org/W2897167390","https://openalex.org/W2909144970","https://openalex.org/W2913735267","https://openalex.org/W2921161310","https://openalex.org/W2928638573","https://openalex.org/W2939373830","https://openalex.org/W2939945403","https://openalex.org/W2961833193","https://openalex.org/W2969954667","https://openalex.org/W3012912505","https://openalex.org/W3034872748","https://openalex.org/W3090147671","https://openalex.org/W3090740667","https://openalex.org/W3099887452","https://openalex.org/W3106380749","https://openalex.org/W3107254828","https://openalex.org/W3119134848","https://openalex.org/W3129442345","https://openalex.org/W3135056748","https://openalex.org/W3135310484","https://openalex.org/W3161768530","https://openalex.org/W3165252591","https://openalex.org/W3186980837","https://openalex.org/W3191156627","https://openalex.org/W3216199250","https://openalex.org/W4200117820","https://openalex.org/W4200413972","https://openalex.org/W4200519882","https://openalex.org/W4200581018","https://openalex.org/W4210694182","https://openalex.org/W4220686936","https://openalex.org/W4220702740","https://openalex.org/W4229369364","https://openalex.org/W4247665917","https://openalex.org/W4282587572","https://openalex.org/W4286268338","https://openalex.org/W4296817559","https://openalex.org/W4297219834","https://openalex.org/W4307342071","https://openalex.org/W4308102944","https://openalex.org/W4309514412","https://openalex.org/W4309848249","https://openalex.org/W4311237378","https://openalex.org/W4312088129","https://openalex.org/W4313434430","https://openalex.org/W4313531093","https://openalex.org/W4318479276","https://openalex.org/W4376875562","https://openalex.org/W4377564460","https://openalex.org/W4384828049","https://openalex.org/W4385827458","https://openalex.org/W4390638676","https://openalex.org/W4390788175","https://openalex.org/W4391815419","https://openalex.org/W4392672292","https://openalex.org/W4394866066","https://openalex.org/W4395109663","https://openalex.org/W4396967788","https://openalex.org/W4399732783","https://openalex.org/W4401164724","https://openalex.org/W4401382411","https://openalex.org/W4402497563","https://openalex.org/W4402923544","https://openalex.org/W4404171657","https://openalex.org/W4404252863","https://openalex.org/W4406045743","https://openalex.org/W4406999212","https://openalex.org/W4407317431","https://openalex.org/W4410571145","https://openalex.org/W4412929242","https://openalex.org/W4415816079","https://openalex.org/W4416445386"],"related_works":[],"abstract_inverted_index":{"Frailty":[0],"increasingly":[1],"is":[2],"recognized":[3],"as":[4],"a":[5,41,185],"factor":[6],"that":[7,75],"modifies":[8],"the":[9,22,47,68,78,82,89,93,156,171],"relationship":[10,23],"between":[11,24,49],"disease":[12],"biomarkers,":[13,51],"including":[14,132],"neuropathology,":[15],"and":[16,26,53,100,111,116,122,152,161,181,201,210,224,237],"dementia":[17,27],"expression.":[18],"The":[19],"mechanisms":[20],"underlying":[21],"frailty":[25,71,121,151,182,200,236],"remain":[28],"unclear,":[29],"but":[30],"blood":[31,50,65,197,249],"biomarkers":[32,66,96,126,144,165,198,219,250],"can":[33],"offer":[34],"insight":[35],"into":[36],"these":[37,164],"mechanisms.":[38],"We":[39,192],"completed":[40],"scoping":[42],"review":[43],"of":[44,70,92,150,159,173,188],"research":[45,63,177],"examining":[46,64],"associations":[48],"frailty,":[52],"cognition.":[54,123],"Three":[55],"online":[56],"databases":[57],"were":[58,114,220,242],"searched":[59],"to":[60,129],"identify":[61],"original":[62],"in":[67,81,88,178,199,214,222,245,248],"context":[69],"and/or":[72,139],"cognitive":[73,153,179,202],"decline":[74,180,203],"accounted":[76],"for":[77,234],"other":[79],"condition":[80],"analysis":[83],"through":[84],"stratification":[85],"or":[86],"inclusion":[87],"model.":[90],"Five":[91],"76":[94],"unique":[95],"identified":[97],"\u2014A":[98],"disintegrin":[99],"Metalloproteinase":[101],"10":[102],"(ADAM10),":[103],"fibrinogen,":[104,208],"interleukin":[105],"(IL)-6,":[106],"neurofilament":[107],"light":[108],"chain":[109],"(NfL)":[110],"vitamin":[112,206],"D\u2014":[113],"significantly":[115],"independently":[117],"associated":[118],"with":[119],"both":[120,215,235],"All":[124],"five":[125],"could":[127,145],"contribute":[128],"aging":[130],"mechanisms,":[131],"disrupted":[133],"proteostasis,":[134],"chronic":[135],"inflammation,":[136],"dysregulated":[137],"metabolism":[138],"deregulated":[140],"nutrient":[141,225],"sensing.":[142],"These":[143],"thus":[146],"be":[147],"common":[148],"pathways":[149],"decline.":[154],"Despite":[155],"Alzheimer-defining":[157],"roles":[158],"\u03b2-amyloid":[160],"phosphorylated":[162],"tau,":[163],"typically":[166],"are":[167,212],"reported":[168],"without":[169],"considering":[170],"degree":[172],"frailty.":[174],"Future":[175],"biomarker":[176],"should":[183],"seek":[184],"clearer":[186],"understanding":[187],"their":[189],"relationship.":[190],"\u2022":[191,204,217,227,239],"reviewed":[193],"33":[194],"articles":[195],"exploring":[196],"ADAM10,":[205],"D,":[207],"IL-6,":[209],"NfL":[211],"altered":[213],"processes":[216],"Most":[218,228,240],"involved":[221],"inflammation":[223],"sensing":[226],"studies":[229,241],"did":[230],"not":[231,243],"report":[232],"coefficients/estimates":[233],"cognition":[238],"interested":[244],"sex":[246],"differences":[247]},"counts_by_year":[{"year":2026,"cited_by_count":9}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-10T00:00:00"}
