{"id":"https://openalex.org/W7119783546","doi":"https://doi.org/10.1038/s42004-025-01885-5","title":"A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides","display_name":"A deep learning framework (CreoPep) for target-specific design and optimization of conotoxin peptides","publication_year":2026,"publication_date":"2026-01-09","ids":{"openalex":"https://openalex.org/W7119783546","doi":"https://doi.org/10.1038/s42004-025-01885-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/41513959"},"language":"en","primary_location":{"id":"doi:10.1038/s42004-025-01885-5","doi":"https://doi.org/10.1038/s42004-025-01885-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-025-01885-5","pdf_url":"https://www.nature.com/articles/s42004-025-01885-5_reference.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42004-025-01885-5_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121235869","display_name":"Cheng Ge","orcid":"https://orcid.org/0000-0003-4010-5686","observed_orcids":["https://orcid.org/0000-0003-4010-5686"]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Ge","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China"],"raw_orcid":"https://orcid.org/0000-0003-4010-5686","affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China","institution_ids":["https://openalex.org/I4210113896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023919017","display_name":"Han\u2010Shen Tae","orcid":"https://orcid.org/0000-0001-8961-7194","observed_orcids":["https://orcid.org/0000-0001-8961-7194"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Han-Shen Tae","raw_affiliation_strings":["Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122479655","display_name":"Lu Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Lu","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China","institution_ids":["https://openalex.org/I4210113896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122565802","display_name":"Zhenqiang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenqiang Zhang","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China","institution_ids":["https://openalex.org/I4210113896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122442600","display_name":"Zhijie Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhijie Huang","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China","institution_ids":["https://openalex.org/I4210113896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122492746","display_name":"Baixue An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baixue An","raw_affiliation_strings":["Ocean University of China, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yilin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Wang","raw_affiliation_strings":["Faculty of Information Science and Engineering, Ocean University of China, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Information Science and Engineering, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tao Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Jiang","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China","institution_ids":["https://openalex.org/I4210113896"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122477730","display_name":"Wenqing Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158954","display_name":"Shandong Academy of Pharmaceutical Sciences","ror":"https://ror.org/04q6c1q57","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210158954"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqing Cai","raw_affiliation_strings":["Shandong Academy of Pharmaceutical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Academy of Pharmaceutical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210158954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071710594","display_name":"Shan Chang","orcid":"https://orcid.org/0000-0001-7169-9398","observed_orcids":["https://orcid.org/0000-0001-7169-9398"]},"institutions":[{"id":"https://openalex.org/I4210144214","display_name":"Jiangsu University of Technology","ror":"https://ror.org/04jabhf80","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210144214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Chang","raw_affiliation_strings":["Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou, China","institution_ids":["https://openalex.org/I4210144214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025386235","display_name":"David J. Adams","orcid":"https://orcid.org/0000-0002-7030-2288","observed_orcids":["https://orcid.org/0000-0002-7030-2288"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David J. Adams","raw_affiliation_strings":["Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia"],"raw_orcid":"https://orcid.org/0000-0002-7030-2288","affiliations":[{"raw_affiliation_string":"Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086459069","display_name":"Rilei Yu","orcid":"https://orcid.org/0000-0001-6625-2014","observed_orcids":["https://orcid.org/0000-0001-6625-2014"]},"institutions":[{"id":"https://openalex.org/I4210113896","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210113896"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rilei Yu","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China. ryu@ouc.edu.cn","Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China. ryu@ouc.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-6625-2014","affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China. ryu@ouc.edu.cn","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, China. ryu@ouc.edu.cn","institution_ids":["https://openalex.org/I4210113896"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086459069"],"corresponding_institution_ids":["https://openalex.org/I4210113896","https://openalex.org/I59028903"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":3.5408,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.87659932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"9","issue":"1","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6050000190734863,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.25,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/conotoxins","display_name":"conotoxins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.7889999747276306},{"id":"https://openalex.org/keywords/generative-deep-learning","display_name":"generative deep learning","score":0.6959999799728394},{"id":"https://openalex.org/keywords/masked-language-modeling","display_name":"masked language modeling","score":0.921999990940094},{"id":"https://openalex.org/keywords/disulfide-rich-peptides","display_name":"disulfide-rich peptides","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6557999849319458},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.6229000091552734},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5967000126838684},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5960000157356262},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.574999988079071},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5210999846458435},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.4108999967575073},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C2777402240","wikidata":"https://www.wikidata.org/wiki/Q6783436","display_name":"Masking (illustration)","level":2,"score":0.3637000024318695},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3619999885559082},{"id":"https://openalex.org/C175234850","wikidata":"https://www.wikidata.org/wiki/Q417238","display_name":"Conotoxin","level":3,"score":0.3287999927997589},{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C77618280","wikidata":"https://www.wikidata.org/wiki/Q1155772","display_name":"Scheme (mathematics)","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25529998540878296},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s42004-025-01885-5","doi":"https://doi.org/10.1038/s42004-025-01885-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-025-01885-5","pdf_url":"https://www.nature.com/articles/s42004-025-01885-5_reference.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},{"id":"pmid:41513959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41513959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11702159","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12894894","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f5178803d30946a29a6e18a884138b02","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f5178803d30946a29a6e18a884138b02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Communications Chemistry, Vol 9, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12894894","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12894894/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Commun Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s42004-025-01885-5","doi":"https://doi.org/10.1038/s42004-025-01885-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-025-01885-5","pdf_url":"https://www.nature.com/articles/s42004-025-01885-5_reference.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.5836593508720398,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2064855699","display_name":null,"funder_award_id":"82122064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3753444709","display_name":null,"funder_award_id":"202441004","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G4762035495","display_name":null,"funder_award_id":"62373172","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5371506974","display_name":null,"funder_award_id":"82473832","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G632657752","display_name":null,"funder_award_id":"2022QNLM030003-4","funder_id":"https://openalex.org/F4320326721","funder_display_name":"Qingdao National Laboratory for Marine Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326721","display_name":"Qingdao National Laboratory for Marine Science and Technology","ror":"https://ror.org/026sv7t11"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119783546.pdf","grobid_xml":"https://content.openalex.org/works/W7119783546.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1975304761","https://openalex.org/W1991175900","https://openalex.org/W1992450378","https://openalex.org/W2001567877","https://openalex.org/W2037378018","https://openalex.org/W2052956415","https://openalex.org/W2092424786","https://openalex.org/W2115540209","https://openalex.org/W2127327997","https://openalex.org/W2134571618","https://openalex.org/W2143094533","https://openalex.org/W2160386479","https://openalex.org/W2163545771","https://openalex.org/W2746447661","https://openalex.org/W2751046065","https://openalex.org/W2786672974","https://openalex.org/W2799876761","https://openalex.org/W2911919235","https://openalex.org/W2920817727","https://openalex.org/W2981905730","https://openalex.org/W3127297964","https://openalex.org/W3139482760","https://openalex.org/W3177500196","https://openalex.org/W3177828909","https://openalex.org/W3178563513","https://openalex.org/W3186179742","https://openalex.org/W4212959738","https://openalex.org/W4283390570","https://openalex.org/W4286669150","https://openalex.org/W4293103647","https://openalex.org/W4296032638","https://openalex.org/W4315784590","https://openalex.org/W4323320132","https://openalex.org/W4327550249","https://openalex.org/W4383957026","https://openalex.org/W4387440676","https://openalex.org/W4387865628","https://openalex.org/W4389919417","https://openalex.org/W4396721167","https://openalex.org/W4399934548","https://openalex.org/W4400279796","https://openalex.org/W4401461669","https://openalex.org/W4406385633","https://openalex.org/W4407978845","https://openalex.org/W4408129349","https://openalex.org/W4408459591"],"related_works":[],"abstract_inverted_index":{"Conotoxins":[0,150],"are":[1,151],"small,":[2],"disulfide-rich":[3,152],"peptides":[4,137,154],"that":[5,79,107,185,195],"display":[6],"exceptional":[7],"affinity":[8,157],"and":[9,14,37,58,74,94,113,138,158,172,191,206,209],"selectivity":[10,159],"for":[11,20,131,142,160],"ion":[12,161],"channels":[13],"receptors,":[15],"making":[16],"them":[17],"valuable":[18],"templates":[19],"therapeutic":[21,153],"development.":[22],"However,":[23],"their":[24,164],"optimization":[25,165],"remains":[26],"challenging":[27],"due":[28],"to":[29,56,146],"the":[30,38,90,132,176],"limited":[31,169],"diversity":[32,171],"of":[33,41,92,135],"naturally":[34],"occurring":[35],"variants":[36,98,109],"labor-intensive":[39],"nature":[40],"conventional":[42],"engineering":[43],"strategies.":[44],"Here,":[45,175],"we":[46],"present":[47],"CreoPep,":[48,179],"a":[49,70,127,140,180,187],"deep":[50,181],"learning-based":[51,182],"generative":[52,183],"framework":[53,130,184],"specifically":[54],"developed":[55],"design":[57,134],"optimize":[59],"conotoxins":[60],"targeting":[61],"defined":[62],"receptors.":[63],"CreoPep":[64,125],"integrates":[65,186],"masked":[66],"language":[67],"modeling":[68],"with":[69,84,155,200],"progressive":[71,188],"masking":[72,189],"scheme":[73],"employs":[75],"an":[76,192],"augmentation":[77,193],"pipeline":[78,194],"combines":[80,196],"physics-based":[81,197],"energy":[82,198],"screening":[83,199],"temperature-controlled":[85,201],"multinomial":[86,202],"sampling.":[87],"This":[88],"enables":[89],"generation":[91],"structurally":[93],"functionally":[95],"diverse":[96,208],"peptide":[97,148],"while":[99],"retaining":[100],"essential":[101],"pharmacological":[102],"features.":[103],"Structural":[104],"analysis":[105],"shows":[106],"CreoPep-generated":[108],"adopt":[110],"both":[111],"conserved":[112],"previously":[114],"unobserved":[115],"binding":[116],"modes,":[117],"including":[118],"disulfide-deficient":[119],"forms.":[120],"Together,":[121],"these":[122],"findings":[123],"establish":[124],"as":[126],"powerful":[128],"computational-experimental":[129],"rational":[133],"conotoxin-based":[136],"provide":[139],"foundation":[141],"extending":[143],"similar":[144],"approaches":[145],"other":[147],"families.":[149],"high":[156],"channels,":[162],"yet":[163],"is":[166],"hindered":[167],"by":[168],"sequence":[170],"laborious":[173],"engineering.":[174],"authors":[177],"introduce":[178],"strategy":[190],"sampling,":[203],"rationally":[204],"designing":[205],"generating":[207],"potent":[210],"conotoxin":[211],"variants.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-10T00:00:00"}