{"id":"https://openalex.org/W7119615905","doi":"https://doi.org/10.1590/0074-02760250109","title":"Extracellular vesicles isolated from the plasma of COVID-19 and sepsis patients: characterisation and association with clinical outcomes","display_name":"Extracellular vesicles isolated from the plasma of COVID-19 and sepsis patients: characterisation and association with clinical outcomes","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7119615905","doi":"https://doi.org/10.1590/0074-02760250109","pmid":"https://pubmed.ncbi.nlm.nih.gov/41779553"},"language":"en","primary_location":{"id":"doi:10.1590/0074-02760250109","doi":"https://doi.org/10.1590/0074-02760250109","is_oa":true,"landing_page_url":"https://doi.org/10.1590/0074-02760250109","pdf_url":null,"source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1590/0074-02760250109","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002964132","display_name":"Jaques Franco Novaes de Carvalho","orcid":"https://orcid.org/0000-0002-4937-7648","observed_orcids":["https://orcid.org/0000-0002-4937-7648"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jaques Franco Novaes de Carvalho","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014006142","display_name":"Paula Meneghetti","orcid":"https://orcid.org/0000-0001-9885-3818","observed_orcids":["https://orcid.org/0000-0001-9885-3818"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paula Meneghetti","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122560799","display_name":"Gabriela Rodrigues [UNIFESP] Barbosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriela Rodrigues Barbosa","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033252337","display_name":"Marina Malheiros Ara\u00fajo Silvestrini","orcid":"https://orcid.org/0000-0001-7641-3360","observed_orcids":["https://orcid.org/0000-0001-7641-3360"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marina Malheiros Ara\u00fajo Silvestrini","raw_affiliation_strings":["Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089530606","display_name":"Sidn\u00e9ia Sousa Santos","orcid":"https://orcid.org/0000-0002-6807-9881","observed_orcids":["https://orcid.org/0000-0002-6807-9881"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sidneia Sousa Santos","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122445379","display_name":"Flavio Geraldo Rezende de [UNIFESP] Freitas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141479","display_name":"Hospital Sepaco","ror":"https://ror.org/04exbp452","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210141479"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1vio Geraldo Freitas","raw_affiliation_strings":["Hospital Sepaco,  Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Sepaco,  Brasil","institution_ids":["https://openalex.org/I4210141479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106679045","display_name":"Daniela Boschetti","orcid":"https://orcid.org/0000-0002-4702-6318","observed_orcids":["https://orcid.org/0000-0002-4702-6318"]},"institutions":[{"id":"https://openalex.org/I4210141479","display_name":"Hospital Sepaco","ror":"https://ror.org/04exbp452","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210141479"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Daniela Boschetti","raw_affiliation_strings":["Hospital Sepaco,  Brasil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Sepaco,  Brasil","institution_ids":["https://openalex.org/I4210141479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079505771","display_name":"Nancy Bellei","orcid":"https://orcid.org/0000-0001-6080-5693","observed_orcids":["https://orcid.org/0000-0001-6080-5693"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nancy Cristina Junqueira Bellei","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122420038","display_name":"Andrea Simone Silva Ferreira Carvalho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9a Teixeira-Carvalho","raw_affiliation_strings":["Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030989702","display_name":"Ana Cl\u00e1udia Torrecilhas","orcid":"https://orcid.org/0000-0001-5724-2199","observed_orcids":["https://orcid.org/0000-0001-5724-2199"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Claudia Torrecilhas","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":"https://orcid.org/0000-0001-5724-2199","affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079261852","display_name":"Reinaldo Salom\u00e3o","orcid":"https://orcid.org/0000-0003-1149-4598","observed_orcids":["https://orcid.org/0000-0003-1149-4598"]},"institutions":[{"id":"https://openalex.org/I88273585","display_name":"Universidade Federal de S\u00e3o Paulo","ror":"https://ror.org/02k5swt12","country_code":"BR","type":"education","lineage":["https://openalex.org/I88273585"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Reinaldo Salomao","raw_affiliation_strings":["Universidade Federal de S\u00e3o Paulo,  Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1149-4598","affiliations":[{"raw_affiliation_string":"Universidade Federal de S\u00e3o Paulo,  Brazil","institution_ids":["https://openalex.org/I88273585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.02020673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"121","issue":null,"first_page":"e250109","last_page":"e250109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":1.0},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9589999914169312},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.968999981880188},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plasma-microparticles","display_name":"plasma microparticles","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cd81","display_name":"CD81","score":0.8610000014305115},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7260000109672546},{"id":"https://openalex.org/keywords/platelets","display_name":"platelets","score":0.9750000238418579},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.5649999976158142},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.6039999723434448},{"id":"https://openalex.org/keywords/gamma-variant","display_name":"Gamma variant","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2778120352","wikidata":"https://www.wikidata.org/wiki/Q3870163","display_name":"Nanoparticle tracking analysis","level":5,"score":0.7529000043869019},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7127000093460083},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7017999887466431},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6998999714851379},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.6629999876022339},{"id":"https://openalex.org/C2776385711","wikidata":"https://www.wikidata.org/wiki/Q4035583","display_name":"CD63","level":5,"score":0.6129999756813049},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5022000074386597},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.484499990940094},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.4462999999523163},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.43849998712539673},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.4359000027179718},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.40630000829696655},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.40209999680519104},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.3889000117778778},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3671000003814697},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.3630000054836273},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.35580000281333923},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3230000138282776},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C2909763251","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicle","level":5,"score":0.31349998712539673},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3050999939441681},{"id":"https://openalex.org/C2776507628","wikidata":"https://www.wikidata.org/wiki/Q21131199","display_name":"CD81","level":4,"score":0.29910001158714294},{"id":"https://openalex.org/C2778914503","wikidata":"https://www.wikidata.org/wiki/Q7202244","display_name":"Platelet-poor plasma","level":4,"score":0.288100004196167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28349998593330383},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C2779379848","wikidata":"https://www.wikidata.org/wiki/Q917069","display_name":"Rhabdomyolysis","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1590/0074-02760250109","doi":"https://doi.org/10.1590/0074-02760250109","is_oa":true,"landing_page_url":"https://doi.org/10.1590/0074-02760250109","pdf_url":null,"source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},{"id":"pmid:41779553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41779553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Memorias do Instituto Oswaldo Cruz","raw_type":"Journal Article"},{"id":"pmh:oai:arca.fiocruz.br:icict/73832","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/73832","pdf_url":"https://arca.fiocruz.br/bitstreams/47a202d0-78ad-4220-8c1c-dcf73ac7bfd2/download","source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12952797","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12952797/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12952797/pdf/1678-8060-mioc-121-e250109.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mem Inst Oswaldo Cruz","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1590/0074-02760250109","doi":"https://doi.org/10.1590/0074-02760250109","is_oa":true,"landing_page_url":"https://doi.org/10.1590/0074-02760250109","pdf_url":null,"source":{"id":"https://openalex.org/S165991124","display_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","issn_l":"0074-0276","issn":["0074-0276","1678-8060"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","medline","norway-1","poland-70","russia-white-list-1","scielo"],"host_organization":"https://openalex.org/P4310312016","host_organization_name":"Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade","host_organization_lineage":["https://openalex.org/P4310312016"],"host_organization_lineage_names":["Instituto Oswaldo Cruz, Minist\u00e9rio da Sa\u00fade"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mem\u00f3rias do Instituto Oswaldo Cruz","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.43047770857810974,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1579666707","display_name":"Prospective cohort study to assess clinical, virological and host response aspects in patients with COVID-19","funder_award_id":"20/05110-2","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G4725574172","display_name":"Sepsis: mechanisms, therapeutic targets and epidemiology","funder_award_id":"17/21052-0","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"},{"id":"https://openalex.org/G6019508174","display_name":"Mechanisms of trypanosomatid adaptation to hosts through the control of transcription, protein synthesis and secretion of extracellular vesicles","funder_award_id":"20/07870-4","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321992","display_name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o","ror":"https://ror.org/050zdnc69"},{"id":"https://openalex.org/F4320327334","display_name":"Centro Nacional de Pesquisa em Energia e Materiais","ror":"https://ror.org/05m235j20"},{"id":"https://openalex.org/F4320335751","display_name":"Laborat\u00f3rio Nacional de Nanotecnologia","ror":"https://ror.org/03e51yr27"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Extracellular":[1],"vesicles":[2],"(EVs)":[3],"are":[4],"involved":[5],"in":[6,32,131,140,167],"the":[7,21,52,138,149],"pathogenesis":[8],"of":[9,129,135,144,165,178,199,210],"severe":[10],"acute":[11],"respiratory":[12],"syndrome":[13],"Coronavirus":[14,38],"2":[15],"(SARS-CoV-2)":[16],"infection.":[17],"OBJECTIVES:":[18],"We":[19],"analysed":[20],"concentration,":[22],"size,":[23],"cellular":[24],"origin,":[25],"and":[26,42,62,75,89,99,112,121,158,160],"capacity":[27],"for":[28,86,92,106],"carrying":[29],"viral":[30,191],"components":[31],"plasma":[33],"samples":[34,46],"from":[35,47,155,204],"patients":[36,49,206],"with":[37,57,97,148,174],"disease":[39],"2019":[40],"(COVID-19)":[41],"sepsis.":[43],"METHODS:":[44],"Plasma":[45],"COVID-19":[48],"admitted":[50],"to":[51,117],"intensive":[53],"care":[54],"unit":[55],"(ICU)":[56],"sepsis":[58],"(N":[59,65],"=":[60,66],"42)":[61],"healthy":[63],"individuals":[64,168],"19)":[67],"were":[68,71,95,104,146],"analysed.":[69],"EVs":[70,94,136,152,173,188,203],"characterised":[72],"by":[73],"size":[74,120,177],"concentration":[76,128],"using":[77],"nanoparticle":[78],"tracking":[79],"analysis":[80,134],"(NTA),":[81],"polymerase":[82],"chain":[83],"reaction":[84],"(RT-qPCR)":[85],"SARS-CoV-2":[87],"components,":[88,192],"flow":[90],"cytometry":[91],"immunophenotyping.":[93],"marked":[96],"phosphatidylserine":[98],"tetraspanins.":[100],"Cellular":[101],"origin":[102],"markers":[103],"used":[105,116],"neutrophils,":[107],"endothelial":[108],"cells,":[109],"T":[110,156],"lymphocytes":[111],"platelets.":[113],"Cryo-EM":[114,171],"was":[115],"assess":[118],"EV":[119],"integrity.":[122],"FINDINGS:":[123],"NTA":[124],"showed":[125],"an":[126,162,175],"increased":[127,163],"microparticles":[130],"patients.":[132],"RT-qPCR":[133],"detected":[137],"virus":[139],"14":[141],"samples,":[142],"two":[143],"which":[145],"consistent":[147],"Gamma":[150],"variant.":[151],"predominantly":[153],"derived":[154],"cells":[157],"platelets":[159],"demonstrated":[161,207],"expression":[164],"CD81":[166,211],"who":[169],"died.":[170],"revealed":[172],"average":[176],"200":[179],"nm.":[180],"MAIN":[181],"CONCLUSIONS:":[182],"Our":[183],"findings":[184],"suggest":[185],"that":[186],"patients'":[187],"likely":[189],"harboured":[190],"suggesting":[193],"their":[194],"potential":[195],"role":[196],"as":[197],"carriers":[198],"SARS-CoV-2.":[200],"In":[201],"addition,":[202],"deceased":[205],"elevated":[208],"levels":[209],"expression.":[212]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-01-10T00:00:00"}