{"id":"https://openalex.org/W7119508593","doi":"https://doi.org/10.3389/fimmu.2025.1773432","title":"Editorial: Epigenetic regulation of T cell function in type 1 diabetes","display_name":"Editorial: Epigenetic regulation of T cell function in type 1 diabetes","publication_year":2026,"publication_date":"2026-01-09","ids":{"openalex":"https://openalex.org/W7119508593","doi":"https://doi.org/10.3389/fimmu.2025.1773432","pmid":"https://pubmed.ncbi.nlm.nih.gov/41583451"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1773432","doi":"https://doi.org/10.3389/fimmu.2025.1773432","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1773432","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1773432/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1773432/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110465551","display_name":"Ubaid Ullah","orcid":"https://orcid.org/0000-0002-2539-2296","observed_orcids":["https://orcid.org/0000-0002-2539-2296"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Ubaid Ullah Kalim","raw_affiliation_strings":["Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku,\u00a0Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku,\u00a0Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038004155","display_name":"Giuseppina Emanuela Grieco","orcid":"https://orcid.org/0000-0001-7325-6128","observed_orcids":["https://orcid.org/0000-0001-7325-6128"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppina Emanuela Grieco","raw_affiliation_strings":["Department of Medicine, Surgery and Neuroscience, University of Siena, Siena,\u00a0Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Surgery and Neuroscience, University of Siena, Siena,\u00a0Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110465551"],"corresponding_institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":"1773432","last_page":"1773432"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.26510000228881836,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7770000100135803},{"id":"https://openalex.org/keywords/induced-regulatory-t-cells","display_name":"induced regulatory T cells","score":0.878000020980835},{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.7319999933242798},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.843999981880188},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9340000152587891},{"id":"https://openalex.org/keywords/t-cell-plasticity","display_name":"T cell plasticity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/treg-stability","display_name":"Treg stability","score":0.4009999930858612},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.6420000195503235},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.7089999914169312},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7400000095367432},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.753000020980835},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.5260000228881836},{"id":"https://openalex.org/keywords/microbiome-metabolites","display_name":"microbiome metabolites","score":0.796999990940094},{"id":"https://openalex.org/keywords/non-coding-variants","display_name":"non-coding variants","score":0.640999972820282},{"id":"https://openalex.org/keywords/adoptive-treg-transfer","display_name":"adoptive Treg transfer","score":0.7639999985694885},{"id":"https://openalex.org/keywords/aplastic-anemia","display_name":"aplastic anemia","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8493000268936157},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.7253999710083008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5501999855041504},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5023999810218811},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.49950000643730164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49399998784065247},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49140000343322754},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.48570001125335693},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.4675999879837036},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.426800012588501},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.413100004196167},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.40560001134872437},{"id":"https://openalex.org/C63016187","wikidata":"https://www.wikidata.org/wiki/Q17162664","display_name":"Epigenetic regulation of neurogenesis","level":5,"score":0.3921000063419342},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.35519999265670776},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3521000146865845},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3467999994754791},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3402999937534332},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.3353999853134155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33239999413490295},{"id":"https://openalex.org/C74737994","wikidata":"https://www.wikidata.org/wiki/Q18031207","display_name":"RAR-related orphan receptor gamma","level":4,"score":0.3082999885082245},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.30799999833106995},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.3057999908924103},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.30239999294281006},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2025.1773432","doi":"https://doi.org/10.3389/fimmu.2025.1773432","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1773432","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1773432/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:41583451","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41583451","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:d2338c7220c34505a2478af5ae41996a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d2338c7220c34505a2478af5ae41996a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12828583","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12828583/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:utupub.fi:11111/59745","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/handle/11111/59745","pdf_url":null,"source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1773432","doi":"https://doi.org/10.3389/fimmu.2025.1773432","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1773432","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1773432/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119508593.pdf","grobid_xml":"https://content.openalex.org/works/W7119508593.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0,43,274,361,431,519],"original":[1],"research":[2,779],"article":[3],"by":[4,115,544,553],"Jadon":[5],"et":[6,198,359],"al.,":[7,199,360],"PRMT5":[8],"regulates":[9],"epigenetic":[10,23,129,154,201,220,291,323,349,370,390,542,610,631,644,675,756,784],"changes":[11],"in":[12,16,105,177,187,195,231,301,333,354,369,472,518,584,594,615,682,715,747,762],"suppressive":[13,29,53],"Th1-like":[14,54,100],"iTregs":[15,55,101],"response":[17],"to":[18,38,151,279,316,495,503,677,698,710,741,793],"IL-12":[19,47],"treatment,":[20],"examines":[21],"how":[22,219,235,243,259,294,700,755],"regulators":[24,386],"shape":[25,711],"the":[26,49,64,77,136,141,145,183,280,345,446,505,529,539,619,691,745,783],"plasticity":[27],"and":[28,56,90,122,160,225,238,249,255,258,288,339,365,407,413,418,425,445,486,501,516,528,531,556,570,579,598,630,663,671,706,764,789],"capacity":[30],"of":[31,51,98,109,119,143,169,185,203,209,218,347,363,372,387,404,411,420,448,467,483,507,511,533,541,612,652,658,693,754,786],"induced":[32],"regulatory":[33,60,93,166,318,450,704],"T":[34,116,172,192,204,227,269,373,388,457,525,549,659,679,712,759],"cells":[35,270,458,550,583,614],"(iTregs)":[36],"exposed":[37],"a":[39,81,106,215,649,655,766],"Th1-skewing":[40],"cytokine":[41],"environment.":[42],"authors":[44,275,432,620],"demonstrate":[45],"that":[46,57,127,311,321,434,452,463,563,684],"drives":[48],"differentiation":[50],"highly":[52,149],"this":[58,178,308,342,356,475,748,774],"enhanced":[59],"phenotype":[61],"depends":[62],"on":[63,182,381,546],"type":[65,210,534],"II":[66],"methyltransferase":[67],"PRMT5.":[68],"Using":[69],"ChIP-seq,":[70],"they":[71],"identify":[72],"PRMT5-mediated":[73],"symmetric":[74],"dimethylation":[75],"at":[76,247,262,325,438,730,781],"Sirt1":[78,85],"promoter":[79,237],"as":[80,157,384,416,480],"central":[82],"mechanism":[83],"repressing":[84],"expression,":[86],"thereby":[87],"stabilizing":[88],"Foxp3":[89],"promoting":[91],"durable":[92],"function.":[94,580],"Functionally,":[95],"adoptive":[96],"transfer":[97],"these":[99,636,718],"significantly":[102],"improves":[103],"survival":[104],"mouse":[107],"model":[108,138],"aplastic":[110],"anemia-an":[111],"autoimmune":[112,152,399,787],"disorder":[113],"characterized":[114],"cell-mediated":[117],"destruction":[118],"hematopoietic":[120],"stem":[121],"progenitor":[123],"cells-providing":[124],"compelling":[125],"evidence":[126,380,562],"targeted":[128,791],"remodeling":[130,261],"can":[131,297,455],"augment":[132],"Treg-based":[133],"immunotherapies.":[134],"Although":[135,608],"disease":[137,334,797],"lies":[139],"outside":[140],"context":[142],"T1D,":[144],"study":[146],"highlights":[147,395,477],"principles":[148],"relevant":[150],"diabetes:":[153],"enzymes":[155],"act":[156,437],"lineage-stabilizing":[158],"factors,":[159],"modulating":[161,727],"their":[162,453],"activity":[163],"may":[164,329,574,685,737],"reinforce":[165],"networks":[167],"capable":[168,510],"counterbalancing":[170],"pathogenic":[171,189,460],"cell":[173,193,205,228,389,526,577,628,660,680,713,760],"responses.Two":[174],"review":[175,309,394,476,560],"articles":[176],"Topic":[179,750],"focus":[180],"specifically":[181],"role":[184,362],"epigenetics":[186],"shaping":[188],"or":[190,327,604,687,733,795],"dysregulated":[191],"states":[194],"T1D.":[196,232,716],"Jabri":[197],"Linking":[200],"mechanisms":[202,757],"dysfunction":[206,714],"with":[207,602],"pathophysiology":[208],"1":[211,535],"diabetes":[212,536,788],"mellitus,":[213],"provide":[214,765],"comprehensive":[216],"overview":[217],"modifications":[221],"influence":[222],"both":[223,481],"CD4\u207a":[224],"CD8\u207a":[226,268],"subsets":[229],"implicated":[230],"They":[233],"summarize":[234],"FOXP3":[236],"TSDR":[239],"hypermethylation":[240],"destabilize":[241],"Tregs,":[242],"activating":[244],"histone":[245,443],"marks":[246],"IFNG":[248],"IL17A":[250],"enhancers":[251,326],"fuel":[252],"proinflammatory":[253],"Th1":[254],"Th17":[256],"responses,":[257],"chromatin":[260,423,441,707,728],"cytotoxic":[263],"effector":[264,606],"loci":[265],"primes":[266],"autoreactive":[267],"for":[271,351,376,492,768],"\u03b2-cell":[272],"destruction.":[273],"give":[276],"special":[277],"attention":[278],"interplay":[281],"between":[282,522,624],"environmental":[283,295,666],"factors-viral":[284],"infection,":[285],"dietary":[286],"components,":[287],"microbiome-derived":[289],"metabolites-and":[290],"dysregulation,":[292],"highlighting":[293],"exposures":[296],"accelerate":[298,504],"immune":[299,513,743],"activation":[300],"individuals":[302],"carrying":[303],"genetic":[304,469,484],"risk":[305,485,701],"alleles.":[306],"Importantly,":[307,581],"emphasizes":[310],"many":[312],"T1D-associated":[313,468],"variants":[314,470],"map":[315],"noncoding":[317],"elements,":[319,705],"suggesting":[320],"altered":[322,566,605],"responsiveness":[324],"promoters":[328],"underlie":[330],"individual":[331],"differences":[332],"trajectory.":[335],"By":[336],"integrating":[337],"mechanistic":[338],"translational":[340,770],"insights,":[341],"contribution":[343],"underscores":[344],"promise":[346],"targeting":[348,734],"pathways":[350,676],"precision":[352],"immunotherapy":[353],"T1D.Complementing":[355],"perspective,":[357],"Prasad":[358],"microRNAs":[364],"long":[366],"non-coding":[367,382,435,473,478,703,735],"RNAs":[368,383,436,479,736],"regulation":[371,419,543,645],"cells:":[374],"implications":[375],"autoimmunity":[377],",":[378,537],"synthesize":[379],"important":[385],"states.":[391],"Their":[392,490,559],"systematic":[393],"consistent":[396,601],"patterns":[397],"across":[398],"diseases,":[400],"including":[401],"T1D:":[402],"overexpression":[403],"miR-21,":[405],"miR-148a,":[406],"miR-155;":[408],"reduced":[409,587],"expression":[410],"miR-146a":[412],"lncRNAs":[414],"such":[415],"GAS5;":[417],"DNA":[421],"methyltransferases,":[422],"modifiers,":[424],"transcriptional":[426,599],"repressors":[427],"through":[428,674],"miRNA-lncRNA":[429],"networks.":[430],"emphasize":[433],"multiple":[439],"levels-controlling":[440],"accessibility,":[442],"modification,":[444],"stability":[447],"gene":[449],"circuits-and":[451],"dysregulation":[454],"drive":[456],"toward":[459],"phenotypes.":[461],"Given":[462],"more":[464],"than":[465],"90%":[466],"lie":[471],"regions,":[474],"interpreters":[482],"potential":[487],"therapeutic":[488,722],"targets.":[489],"call":[491],"single-cell":[493],"multiomics":[494],"capture":[496],"ncRNA-chromatin":[497],"interactions":[498],"is":[499,646,696],"timely":[500],"likely":[502],"development":[506],"RNA-based":[508],"therapeutics":[509],"restoring":[512,724],"tolerance.Finally,":[514],"Fraser":[515],"Stadnyk,":[517],"emerging":[520],"relationship":[521],"mucosal-associated":[523],"invariant":[524],"populations":[527],"onset":[530],"progression":[532],"expand":[538],"scope":[540],"focusing":[545],"MAIT":[547,576,582,613,627],"cells-innate-like":[548],"shaped":[551],"heavily":[552],"microbial":[554,568,625,669],"metabolites":[555],"developmental":[557],"programming.":[558],"synthesizes":[561],"gut":[564],"dysbiosis,":[565],"riboflavin-producing":[567],"communities,":[569],"impaired":[571],"mucosal":[572],"integrity":[573],"alter":[575],"maturation":[578],"T1D":[585,616,763],"show":[586],"circulating":[588],"frequencies":[589],"during":[590,633],"recent":[591],"onset,":[592],"accumulation":[593],"inflamed":[595],"pancreatic":[596],"tissue,":[597],"profiles":[600],"exhaustion":[603],"potential.":[607],"direct":[609],"studies":[611],"remain":[617],"limited,":[618],"highlight":[621,720],"strong":[622],"links":[623],"metabolites,":[626,670],"development,":[629],"imprinting":[632],"early":[634],"life.Across":[635],"four":[637],"articles,":[638],"several":[639],"unifying":[640],"concepts":[641],"emerge.":[642],"First,":[643],"not":[647],"merely":[648],"downstream":[650],"consequence":[651],"inflammation":[653],"but":[654],"primary":[656],"determinant":[657],"identity,":[661],"plasticity,":[662],"pathogenicity.":[664],"Second,":[665],"signals-including":[667],"cytokines,":[668],"metabolic":[672],"stress-act":[673],"modulate":[678],"responses":[681],"ways":[683],"promote":[686],"prevent":[688,794],"autoimmunity.":[689],"Third,":[690],"integration":[692],"multi-omic":[694],"approaches":[695],"beginning":[697],"reveal":[699],"variants,":[702],"landscapes":[708],"intersect":[709],"Finally,":[717],"insights":[719],"new":[721],"opportunities:":[723],"Treg":[725],"stability,":[726],"accessibility":[729],"inflammatory":[731],"loci,":[732],"offer":[738],"novel":[739],"strategies":[740],"re-establish":[742],"tolerance.Together,":[744],"contributions":[746],"Research":[749],"enrich":[751],"our":[752],"understanding":[753],"govern":[758],"function":[761],"foundation":[767],"future":[769],"advances.":[771],"We":[772],"hope":[773],"collection":[775],"stimulates":[776],"continued":[777],"interdisciplinary":[778],"aimed":[780],"decoding":[782],"architecture":[785],"developing":[790],"interventions":[792],"halt":[796],"progression.":[798]},"counts_by_year":[],"updated_date":"2026-10-07T09:51:55.459714","created_date":"2026-01-09T00:00:00"}
