{"id":"https://openalex.org/W7119484233","doi":"https://doi.org/10.1126/science.adv7953","title":"Computational design of conformation-biasing mutations to alter protein functions","display_name":"Computational design of conformation-biasing mutations to alter protein functions","publication_year":2026,"publication_date":"2026-01-08","ids":{"openalex":"https://openalex.org/W7119484233","doi":"https://doi.org/10.1126/science.adv7953","pmid":"https://pubmed.ncbi.nlm.nih.gov/40501788"},"language":"en","primary_location":{"id":"doi:10.1126/science.adv7953","doi":"https://doi.org/10.1126/science.adv7953","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.adv7953","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/03/2025.05.03.652001.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091454103","display_name":"Peter E. Cavanagh","orcid":"https://orcid.org/0000-0003-3146-664X","observed_orcids":["https://orcid.org/0000-0003-3146-664X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter E. Cavanagh","raw_affiliation_strings":["Department of Biochemistry, Stanford University"],"raw_orcid":"https://orcid.org/0000-0003-3146-664X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087026664","display_name":"Andrew G. Xue","orcid":"https://orcid.org/0000-0002-8575-8376","observed_orcids":["https://orcid.org/0000-0002-8575-8376"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew G. Xue","raw_affiliation_strings":["Biophysics Program, Stanford University"],"raw_orcid":"https://orcid.org/0000-0002-8575-8376","affiliations":[{"raw_affiliation_string":"Biophysics Program, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036687007","display_name":"Shizhong A. Dai","orcid":"https://orcid.org/0000-0001-9679-2353","observed_orcids":["https://orcid.org/0000-0001-9679-2353"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shizhong Dai","raw_affiliation_strings":["Department of Genetics, Stanford University"],"raw_orcid":"https://orcid.org/0000-0001-9679-2353","affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117425382","display_name":"Albert Qiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Qiang","raw_affiliation_strings":["Department of Genetics, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009946597","display_name":"Tsutomu Matsui","orcid":"https://orcid.org/0000-0001-7101-5259","observed_orcids":["https://orcid.org/0000-0001-7101-5259"]},"institutions":[{"id":"https://openalex.org/I2801935854","display_name":"SLAC National Accelerator Laboratory","ror":"https://ror.org/05gzmn429","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4210120900","display_name":"Stanford Synchrotron Radiation Lightsource","ror":"https://ror.org/02vzbm991","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I2801935854","https://openalex.org/I39565521","https://openalex.org/I4210120900","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tsutomu Matsui","raw_affiliation_strings":["Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University","institution_ids":["https://openalex.org/I2801935854","https://openalex.org/I4210120900","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048170851","display_name":"Alice Y. Ting","orcid":"https://orcid.org/0000-0002-8277-5226","observed_orcids":["https://orcid.org/0000-0002-8277-5226"]},"institutions":[{"id":"https://openalex.org/I4210100286","display_name":"Chan Zuckerberg Biohub San Francisco","ror":"https://ror.org/00knt4f32","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210100286","https://openalex.org/I4210121800","https://openalex.org/I95457486","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alice Y. Ting","raw_affiliation_strings":["Chan Zuckerberg Biohub \u2013 San Francisco","Department of Genetics, Stanford University","Departments of Biology, and by courtesy, Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub \u2013 San Francisco","institution_ids":["https://openalex.org/I4210100286"]},{"raw_affiliation_string":"Department of Genetics, Stanford University","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Departments of Biology, and by courtesy, Chemistry","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5048170851"],"corresponding_institution_ids":["https://openalex.org/I4210100286","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":48.293,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.99940029,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"391","issue":"6790","first_page":"eadv7953","last_page":"eadv7953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-conformational-states","display_name":"protein conformational states","score":0.6729999780654907},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.8759999871253967},{"id":"https://openalex.org/keywords/sars-cov-2-spike-protein","display_name":"SARS-CoV-2 spike protein","score":1.0},{"id":"https://openalex.org/keywords/beta2-adrenergic-receptor","display_name":"beta2-adrenergic receptor","score":0.9409999847412109},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enzyme-promiscuity","display_name":"enzyme promiscuity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/site-specific-protein-labeling","display_name":"site-specific protein labeling","score":0.6259999871253967},{"id":"https://openalex.org/keywords/fluorescent-labeling","display_name":"fluorescent labeling","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6245999932289124},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4860999882221222},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.46149998903274536},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.46000000834465027},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.45089998841285706},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.4487999975681305},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4147000014781952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3950999975204468},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.3711000084877014},{"id":"https://openalex.org/C2777936996","wikidata":"https://www.wikidata.org/wiki/Q17148461","display_name":"Conformational ensembles","level":3,"score":0.3643999993801117},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3472999930381775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33880001306533813},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.3325999975204468},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.3292999863624573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32420000433921814},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.31769999861717224},{"id":"https://openalex.org/C2780430158","wikidata":"https://www.wikidata.org/wiki/Q7685902","display_name":"Target protein","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C19472624","wikidata":"https://www.wikidata.org/wiki/Q583851","display_name":"Native state","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.2718000113964081},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C207467116","wikidata":"https://www.wikidata.org/wiki/Q4385666","display_name":"Inverse","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.2554999887943268}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1126/science.adv7953","doi":"https://doi.org/10.1126/science.adv7953","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.adv7953","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"doi:10.1101/2025.05.03.652001","doi":"https://doi.org/10.1101/2025.05.03.652001","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.03.652001","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/03/2025.05.03.652001.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40501788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40501788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:41505504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41505504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12157495","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12157495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:zenodo.org:17364476","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.03.652001","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/other"}],"best_oa_location":{"id":"doi:10.1101/2025.05.03.652001","doi":"https://doi.org/10.1101/2025.05.03.652001","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.05.03.652001","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/05/03/2025.05.03.652001.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1904012195","display_name":null,"funder_award_id":"1K99CA297018-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G303061748","display_name":null,"funder_award_id":"DE\u2013AC02\u201376SF00515","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G4873878738","display_name":"PILATUS3 X 1M X-ray detector","funder_award_id":"1s10od021512-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000865433","display_name":"RIGERR: Resources for Investigating Genetic and Epigenetic Regulation of Renal Disease","funder_award_id":"RC2DK129964","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000873479","display_name":"A Synchrotron Radiation Structural Biology Resource","funder_award_id":"P30GM133894","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320310040","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333615","display_name":"Wu Tsai Neurosciences Institute, Stanford University","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119484233.pdf","grobid_xml":"https://content.openalex.org/works/W7119484233.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W79141321","https://openalex.org/W1964396270","https://openalex.org/W1966065301","https://openalex.org/W1969231606","https://openalex.org/W1976231288","https://openalex.org/W1977038370","https://openalex.org/W1981748166","https://openalex.org/W1982126789","https://openalex.org/W1988464139","https://openalex.org/W1994943005","https://openalex.org/W2014038272","https://openalex.org/W2023626818","https://openalex.org/W2028017072","https://openalex.org/W2037511678","https://openalex.org/W2048633418","https://openalex.org/W2051192457","https://openalex.org/W2054979333","https://openalex.org/W2082618271","https://openalex.org/W2090406639","https://openalex.org/W2090682502","https://openalex.org/W2104477830","https://openalex.org/W2135415653","https://openalex.org/W2143697213","https://openalex.org/W2156480395","https://openalex.org/W2161151688","https://openalex.org/W2167197258","https://openalex.org/W2167857702","https://openalex.org/W2169284795","https://openalex.org/W2337732629","https://openalex.org/W2551865651","https://openalex.org/W2735652142","https://openalex.org/W2787248717","https://openalex.org/W2888618670","https://openalex.org/W2932287678","https://openalex.org/W2975366048","https://openalex.org/W2998581726","https://openalex.org/W3005012312","https://openalex.org/W3037107407","https://openalex.org/W3080644118","https://openalex.org/W3094232626","https://openalex.org/W3119285888","https://openalex.org/W3131852822","https://openalex.org/W3134186384","https://openalex.org/W3177828909","https://openalex.org/W4223581484","https://openalex.org/W4226443232","https://openalex.org/W4250634823","https://openalex.org/W4254788191","https://openalex.org/W4281873659","https://openalex.org/W4282935478","https://openalex.org/W4283026725","https://openalex.org/W4296032638","https://openalex.org/W4309306331","https://openalex.org/W4316500219","https://openalex.org/W4327566741","https://openalex.org/W4366823175","https://openalex.org/W4383957026","https://openalex.org/W4385298573","https://openalex.org/W4385930396","https://openalex.org/W4388627063","https://openalex.org/W4389794855","https://openalex.org/W4389916165","https://openalex.org/W4390778100","https://openalex.org/W4391242640","https://openalex.org/W4391308485","https://openalex.org/W4391747328","https://openalex.org/W4391807399","https://openalex.org/W4393114248","https://openalex.org/W4394844185","https://openalex.org/W4396610855","https://openalex.org/W4399717655","https://openalex.org/W4400313991","https://openalex.org/W4401574080","https://openalex.org/W4403607174","https://openalex.org/W4403650746","https://openalex.org/W4408666727","https://openalex.org/W4410706171","https://openalex.org/W4412165572","https://openalex.org/W6606553652","https://openalex.org/W7119484233"],"related_works":[],"abstract_inverted_index":{"Most":[0],"natural":[1],"proteins":[2],"alternate":[3],"between":[4],"distinct":[5],"conformational":[6,16,52,116,175],"states,":[7],"each":[8],"associated":[9],"with":[10,77,148,177],"specific":[11,136],"functions.":[12],"Intentional":[13],"manipulation":[14],"of":[15,67,106,118,142,158],"equilibria":[17],"could":[18],"lead":[19],"to":[20,46,91],"improved":[21,78],"or":[22,85],"altered":[23],"protein":[24,107,146,174],"properties.":[25],"Here":[26],"we":[27],"develop":[28],"Conformational":[29],"Biasing":[30],"(CB),":[31],"a":[32,95,111],"rapid":[33],"and":[34,74,156,172,183],"streamlined":[35],"computational":[36],"method":[37],"that":[38,99,164],"utilizes":[39],"contrastive":[40],"scoring":[41],"by":[42],"inverse":[43],"folding":[44],"models":[45],"predict":[47],"variants":[48,66,132],"biased":[49,121],"towards":[50],"desired":[51],"states.":[53],"We":[54],"validated":[55],"CB":[56,90,159],"across":[57],"seven":[58],"diverse":[59],"deep":[60],"mutational":[61],"scanning":[62],"datasets,":[63],"successfully":[64],"predicting":[65],"K-Ras,":[68],"SARS-CoV-2":[69],"spike,":[70],"\u03b22":[71],"adrenergic":[72],"receptor,":[73],"Src":[75],"kinase":[76],"conformation-specific":[79],"functions":[80],"including":[81],"enhanced":[82],"effector":[83],"binding":[84],"enzymatic":[86],"activity.":[87],"Furthermore,":[88],"applying":[89],"lipoic":[92],"acid":[93],"ligase,":[94],"conformation-switching":[96],"bacterial":[97],"enzyme":[98],"has":[100],"been":[101],"used":[102],"for":[103,115,144,170,179],"the":[104,123,140],"development":[105],"labeling":[108,147],"technologies,":[109],"revealed":[110],"previously":[112],"unknown":[113],"mechanism":[114],"gating":[117],"sequence-specificity.":[119],"Variants":[120],"toward":[122],"\"open\"":[124],"conformation":[125],"were":[126,133],"highly":[127],"promiscuous,":[128],"while":[129],"\"closed\"":[130],"conformation-biased":[131],"even":[134],"more":[135],"than":[137],"wild-type,":[138],"enhancing":[139],"utility":[141],"LplA":[143],"site-specific":[145],"fluorophores":[149],"in":[150],"living":[151],"cells.":[152],"The":[153],"speed,":[154],"simplicity,":[155],"versatility":[157],"(available":[160],"at:":[161],"https://github.com/alicetinglab/ConformationalBiasing/)":[162],"suggest":[163],"it":[165],"may":[166],"be":[167],"broadly":[168],"applicable":[169],"understanding":[171],"engineering":[173],"dynamics,":[176],"implications":[178],"basic":[180],"research,":[181],"biotechnology,":[182],"medicine.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":26},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-01-09T00:00:00"}
