{"id":"https://openalex.org/W7119476201","doi":"https://doi.org/10.1158/2326-6066.31028321","title":"Figure S5 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma","display_name":"Figure S5 from RAS(ON) Multiselective Inhibition Drives Antitumor Immunity in Preclinical Models of NRAS-Mutant Melanoma","publication_year":2026,"publication_date":"2026-01-08","ids":{"openalex":"https://openalex.org/W7119476201","doi":"https://doi.org/10.1158/2326-6066.31028321"},"language":null,"primary_location":{"id":"doi:10.1158/2326-6066.31028321","doi":"https://doi.org/10.1158/2326-6066.31028321","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.31028321","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2326-6066.31028321","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068864750","display_name":"Larissa Anast\u00e1cio da Costa Carvalho","orcid":"https://orcid.org/0000-0001-5720-5910","observed_orcids":["https://orcid.org/0000-0001-5720-5910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larissa Anastacio Da Costa Carvalho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5720-5910","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046001195","display_name":"Nataliya Tovbis Shifrin","orcid":"https://orcid.org/0000-0002-4312-0606","observed_orcids":["https://orcid.org/0000-0002-4312-0606"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nataliya Tovbis Shifrin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4312-0606","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104037310","display_name":"Manali S. Phadke","orcid":"https://orcid.org/0009-0009-4047-9304","observed_orcids":["https://orcid.org/0009-0009-4047-9304"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manali S. Phadke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4047-9304","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013287959","display_name":"Michael F. Emmons","orcid":"https://orcid.org/0000-0002-0008-8335","observed_orcids":["https://orcid.org/0000-0002-0008-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. Emmons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0008-8335","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025699271","display_name":"Ximo Pechuan-Jorge","orcid":"https://orcid.org/0000-0001-8938-7931","observed_orcids":["https://orcid.org/0000-0001-8938-7931"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ximo Pechuan-Jorge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8938-7931","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074561290","display_name":"Felix Mbuga","orcid":"https://orcid.org/0009-0002-0542-9669","observed_orcids":["https://orcid.org/0009-0002-0542-9669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felix Mbuga","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0542-9669","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082157049","display_name":"Oscar E. Ospina","orcid":"https://orcid.org/0000-0001-5986-4207","observed_orcids":["https://orcid.org/0000-0001-5986-4207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oscar E. Ospina","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5986-4207","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122321580","display_name":"Christopher Chow","orcid":"https://orcid.org/0009-0001-9117-6057","observed_orcids":["https://orcid.org/0009-0001-9117-6057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher Chow","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-9117-6057","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042876583","display_name":"Lillian Seu","orcid":"https://orcid.org/0000-0002-8456-019X","observed_orcids":["https://orcid.org/0000-0002-8456-019X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lillian Seu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8456-019X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081500438","display_name":"Olivia L. Rose","orcid":"https://orcid.org/0000-0002-7945-4691","observed_orcids":["https://orcid.org/0000-0002-7945-4691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivia L. Rose","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7945-4691","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040118284","display_name":"Aparna Madhukeshwar Hegde","orcid":"https://orcid.org/0000-0001-6616-4882","observed_orcids":["https://orcid.org/0000-0001-6616-4882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aparna Hegde","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6616-4882","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058902095","display_name":"Nikhil I. Khushalani","orcid":"https://orcid.org/0000-0002-3636-4143","observed_orcids":["https://orcid.org/0000-0002-3636-4143"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikhil I. Khushalani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3636-4143","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023590155","display_name":"Elsa Quintana","orcid":"https://orcid.org/0000-0002-4123-1695","observed_orcids":["https://orcid.org/0000-0002-4123-1695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elsa Quintana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4123-1695","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059758317","display_name":"Keiran S.M. Smalley","orcid":"https://orcid.org/0000-0003-1089-9307","observed_orcids":["https://orcid.org/0000-0003-1089-9307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiran S.M. Smalley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1089-9307","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rmc-7977","display_name":"RMC-7977","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nras-mutant-melanoma","display_name":"NRAS-mutant melanoma","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anti-pd-1-combination-therapy","display_name":"anti-PD-1 combination therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cd4-foxp3-t-cells","display_name":"CD4+ Foxp3+ T cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8550000190734863},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.82669997215271},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6294999718666077},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5090000033378601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4927999973297119},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48019999265670776},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43209999799728394},{"id":"https://openalex.org/C2777928079","wikidata":"https://www.wikidata.org/wiki/Q2677027","display_name":"Rat\u00f3n","level":2,"score":0.413100004196167},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3725000023841858},{"id":"https://openalex.org/C2780339063","wikidata":"https://www.wikidata.org/wiki/Q5201367","display_name":"Cytometry","level":3,"score":0.3434000015258789},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.326200008392334},{"id":"https://openalex.org/C3017712846","wikidata":"https://www.wikidata.org/wiki/Q4891747","display_name":"Tumor immunology","level":4,"score":0.3142000138759613},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.310699999332428},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C3019361144","wikidata":"https://www.wikidata.org/wiki/Q367359","display_name":"Negative control","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C109335069","wikidata":"https://www.wikidata.org/wiki/Q5421165","display_name":"Experimental pathology","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C3020391436","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte subsets","level":4,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2326-6066.31028321","doi":"https://doi.org/10.1158/2326-6066.31028321","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.31028321","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2326-6066.31028321","doi":"https://doi.org/10.1158/2326-6066.31028321","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2326-6066.31028321","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Supplemental":[0],"Figure":[1],"5:":[2],"The":[3],"RMC-7977":[4,25,29,62,66,124,129,135,145,158,161],"+":[5,28,65,136,157],"Anti-PD1":[6,27,64,113,118,137,147,154,156],"combination":[7,143],"increases":[8],"durable":[9],"anti-tumor":[10],"responses.":[11],"(A)":[12],"Flow":[13,48],"cytometry":[14,49],"analysis":[15,50],"of":[16,31,44,51,68,82,91,144],"Foxp3+":[17],"CD4+":[18,45],"T":[19,74],"cells":[20,75],"(Tregs)":[21],"in":[22,59],"control,":[23,60],"anti-PD1,":[24,61],"and":[26,57,63,88,109,134,146,160],"groups":[30,67],"the":[32,41,69,79,92],"syngeneic":[33,70,93],"OSUMMER.13":[34,71],"mouse":[35,72,95],"model.":[36,73,96],"Tregs":[37],"were":[38,76],"normalized":[39,77],"to":[40,78,165],"total":[42,80],"number":[43,81],"cells.":[46,84],"(B)":[47],"exhaustion":[52],"markers":[53],"(PD-1,":[54],"TIM-3,":[55],"LAG-3":[56],"CTLA-4)":[58],"live":[83],"(C-D)":[85],"Tumor":[86],"growth":[87],"survival":[89],"curve":[90],"SW1":[94],"Control":[97,152],"group":[98,114,125,138],"was":[99,115,126,139],"treated":[100,116,127,140],"with":[101,117,128,141],"IgG":[102],"control":[103],"(2\u00b5g/\u00b5L,":[104,119],"I.P.,":[105,120],"every":[106,121],"5":[107,122],"days)":[108],"vehicle":[110],"(P.O.,":[111],"q.d.),":[112,133],"days),":[123],"(25":[130],"mg/kg,":[131],"P.O.,":[132],"a":[142],"as":[148],"indicated":[149],"until":[150],"endpoint.":[151],"n=10M,":[153,155],"n=10M":[159],"n=10M.":[162],"Plots":[163],"correspond":[164],"individual":[166],"mouse.":[167]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-01-09T00:00:00"}