{"id":"https://openalex.org/W7119254526","doi":null,"title":"Papel da liraglutida sobre a fun\u00e7\u00e3o quimiorreflexa e estresse oxidativo de ratas hipertensas ovariectomizadas","display_name":"Papel da liraglutida sobre a fun\u00e7\u00e3o quimiorreflexa e estresse oxidativo de ratas hipertensas ovariectomizadas","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W7119254526"},"language":"pt","primary_location":{"id":"pmh:oai:repositorio.ufes.br:10/12352","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufes.br/handle/10/12352","pdf_url":null,"source":{"id":"https://openalex.org/S4377196748","display_name":"riUfes (Universidade Federal do Esp\u00edrito Santo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51235708","host_organization_name":"Universidade Federal do Esp\u00edrito Santo","host_organization_lineage":["https://openalex.org/I51235708"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.ufes.br/handle/10/12352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043069574","display_name":"Thatiany Jardim Batista","orcid":"https://orcid.org/0000-0002-2029-2253","observed_orcids":["https://orcid.org/0000-0002-2029-2253"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Batista, Thatiany Jardim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043069574"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.23649999499320984,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.23649999499320984,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.20419999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.1492999941110611,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liraglutide","display_name":"liraglutide","score":1.0},{"id":"https://openalex.org/keywords/chemoreflex","display_name":"chemoreflex","score":0.8420000076293945},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7730000019073486},{"id":"https://openalex.org/keywords/spontaneously-hypertensive-rats","display_name":"spontaneously hypertensive rats","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bradycardia","display_name":"bradycardia","score":0.8050000071525574},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.9900000095367432},{"id":"https://openalex.org/keywords/advanced-oxidation-protein-products","display_name":"advanced oxidation protein products","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nitrate-nitrite","display_name":"nitrite/nitrate","score":0.8169999718666077},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.7919999957084656},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.8960000276565552},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.4180000126361847},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.7609999775886536},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.6899999976158142},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7954999804496765},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7670999765396118},{"id":"https://openalex.org/C2777495988","wikidata":"https://www.wikidata.org/wiki/Q217111","display_name":"Bradycardia","level":4,"score":0.5755000114440918},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5745000243186951},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4918000102043152},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4097000062465668},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.39910000562667847},{"id":"https://openalex.org/C103038586","wikidata":"https://www.wikidata.org/wiki/Q1152037","display_name":"Aerobic exercise","level":2,"score":0.36899998784065247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35019999742507935},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.3449999988079071},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.34439998865127563},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.3273000121116638},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.29030001163482666},{"id":"https://openalex.org/C117437137","wikidata":"https://www.wikidata.org/wiki/Q5038720","display_name":"Cardiorespiratory fitness","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.28690001368522644},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C174940676","wikidata":"https://www.wikidata.org/wiki/Q495626","display_name":"Constriction","level":2,"score":0.2818000018596649},{"id":"https://openalex.org/C196310339","wikidata":"https://www.wikidata.org/wiki/Q60354","display_name":"VO2 max","level":4,"score":0.262800008058548},{"id":"https://openalex.org/C2779723990","wikidata":"https://www.wikidata.org/wiki/Q707174","display_name":"Femoral artery","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C17291353","wikidata":"https://www.wikidata.org/wiki/Q6807308","display_name":"Medulla","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:repositorio.ufes.br:10/12352","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufes.br/handle/10/12352","pdf_url":null,"source":{"id":"https://openalex.org/S4377196748","display_name":"riUfes (Universidade Federal do Esp\u00edrito Santo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51235708","host_organization_name":"Universidade Federal do Esp\u00edrito Santo","host_organization_lineage":["https://openalex.org/I51235708"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:repositorio.ufes.br:10/12352","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufes.br/handle/10/12352","pdf_url":null,"source":{"id":"https://openalex.org/S4377196748","display_name":"riUfes (Universidade Federal do Esp\u00edrito Santo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I51235708","host_organization_name":"Universidade Federal do Esp\u00edrito Santo","host_organization_lineage":["https://openalex.org/I51235708"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409490635","https://openalex.org/W2578754927","https://openalex.org/W1977171241","https://openalex.org/W7045693930","https://openalex.org/W2624900654","https://openalex.org/W7202426062","https://openalex.org/W7017397671","https://openalex.org/W2105659988","https://openalex.org/W2726698423","https://openalex.org/W2324197323"],"abstract_inverted_index":{"Methodology:":[0],"SHR":[1],"females":[2],"at":[3],"8":[4],"weeks":[5],"of":[6,105,110,115,119,145,150,192,234,271,288,318,341],"age":[7],"were":[8,39,88,95],"OVX":[9,164,174,187,199,206,219,226,230,268],"or":[10,28],"SHAM":[11],"operated":[12],"and":[13,37,53,70,79,90,93,117,123,138,148,202,222,241,273,308,323,337],"treated":[14],"for":[15],"30":[16],"days":[17],"s.c.":[18],"with":[19,312],"liraglutide":[20,301],"0.6mg/kg":[21],"twice":[22],"daily":[23],"(OVX":[24,30,170,197,217,224,236,244,258],"Lira;":[25],"Sham":[26,32,183,238,246],"Lira)":[27],"saline":[29],"Sal;":[31],"Sal).":[33],"The":[34,86,155,163],"femoral":[35],"artery":[36],"vein":[38],"catheterized":[40],"under":[41],"anesthesia":[42],"to":[43,77,97,254,331],"evaluate":[44],"the":[45,83,91,146,232,265,281,286,334,339],"chemoreflex":[46,168],"(MAP":[47],"(\u0394mmHg),":[48],"HR":[49,62,78],"(\u0394bpm),":[50],"fR":[51,64],"(cpm));":[52],"obtain":[54],"baseline":[55],"cardiorespiratory":[56],"parameters:":[57],"SBP,":[58],"MAP,":[59],"DBP":[60],"(mmHg),":[61],"(bpm),":[63],"(cpm),":[65],"VT":[66],"(tidal":[67],"volume,":[68],"mL/Kg-1)":[69],"VE":[71],"(minute":[72],"ventilation,":[73],"mL.Kg-1.min-1),":[74],"in":[75,82,194,214,264,280,316],"addition":[76],"SBP":[80],"variability":[81,181],"time":[84],"domain.":[85],"animals":[87],"euthanized":[89],"heart":[92,179],"brainstem":[94,203,223],"used":[96],"determination":[98],"advanced":[99],"oxidation":[100],"protein":[101],"products":[102],"(AOPP)":[103],"(\u03bcmol/mg":[104,109],"protein),":[106,111],"lipid":[107,242],"peroxidation":[108,243],"nitrite/nitrate":[112],"levels":[113,270],"(nmol/mg":[114],"protein)":[116],"expression":[118,191,233],"NADPH":[120],"oxidase":[121],"(NOX2)":[122],"catalase":[124],"(CAT)":[125],"proteins":[126],"(protein/GAPDH)":[127],"by":[128,135,159],"Western":[129],"Blot":[130],"(WB).":[131],"Data":[132],"was":[133,157,252],"analyzed":[134],"Twoway":[136],"ANOVA":[137],"expressed":[139],"as":[140,153,209,211],"mean":[141,147],"\u00b1":[142],"error":[143],"standard":[144],"level":[149],"significance":[151],"set":[152],"p<0.05.":[154],"project":[156],"approved":[158],"CEUA-UFES":[160],"n\u00ba11/2019.":[161],"Results:":[162],"Lira":[165,251],"showed":[166],"greater":[167,178],"bradycardia":[169],"Sal=":[171,247],"-":[172,275,278],"102\u00b114;":[173],"Lira=":[175],"-177\u00b17;":[176],"n=11),":[177,189],"rate":[180],"(RMSSD:":[182],"Sal=4.3\u00b10.3,":[184],"n=":[185],"10;":[186],"Lira=6.6\u00b10.8;":[188],"higher":[190],"CAT":[193],"cardiac":[195,215,304],"tissue":[196,216],"Sal=0.4\u00b10.02;":[198],"Lira=0.7\u00b10.09;":[200],"n=5)":[201,221,240,249,263],"(Sham":[204],"Lira=0.4\u00b10.01;":[205],"Lira=0.5\u00b10.04;":[207],"n=5),":[208],"well":[210],"lower":[212],"AOPP":[213],"Sal=0.039\u00b10.002;":[218],"Lira=0.032\u00b10.001;":[220],"Sal=23\u00b10.7;":[225],"Lira=18\u00b10.8;":[227],"n=5).":[228],"Furthermore,":[229],"increased":[231,285],"NOX2":[235],"Sal=1.96\u00b10.3;":[237],"Sal=0.95\u00b10.2;":[239],"Sal=0.0013;":[245],"0.0009;":[248],"while":[250],"able":[253],"prevent":[255],"these":[256,289],"changes":[257],"Lira:":[259],"NOX2=1.25\u00b10.3,":[260],"n=5;":[261],"MDA=0.0012,":[262],"heart.":[266],"Finally,":[267],"reduced":[269],"NOx":[272],"NO3":[274,277],"(NOx=10.3\u00b10.3;":[276],"=7.1\u00b10.1)":[279],"brainstem,":[282],"but":[283],"lira":[284],"bioavailability":[287],"metabolites":[290],"NO":[291],"(NOx":[292],"=12.4\u00b10.6;":[293],"NO3-":[294],"=8.7\u00b10.5).":[295],"Conclusion:":[296],"These":[297],"results":[298],"indicate":[299],"that":[300],"can":[302],"protect":[303],"function":[305],"through":[306],"peripheral":[307],"central":[309],"mechanisms":[310],"associated":[311],"improving":[313],"redox":[314],"balance":[315],"situations":[317],"hypertension,":[319],"ovarian":[320],"hormone":[321],"deficiency":[322],"nondiabetic":[324],"conditions.":[325],"However,":[326],"more":[327],"studies":[328],"are":[329],"needed":[330],"better":[332],"understand":[333],"biological":[335],"benefits":[336],"unravel":[338],"mechanism":[340],"this":[342],"important":[343],"protective":[344],"effect.":[345]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-01-08T00:00:00"}