{"id":"https://openalex.org/W7119210992","doi":"https://doi.org/10.21873/cdp.10504","title":"Methionine Restriction Must Be Continuously Maintained to Selectively Inhibit Cancer Cells Co-cultured With Normal Cells","display_name":"Methionine Restriction Must Be Continuously Maintained to Selectively Inhibit Cancer Cells Co-cultured With Normal Cells","publication_year":2026,"publication_date":"2026-01-03","ids":{"openalex":"https://openalex.org/W7119210992","doi":"https://doi.org/10.21873/cdp.10504","pmid":"https://pubmed.ncbi.nlm.nih.gov/41487927"},"language":"en","primary_location":{"id":"doi:10.21873/cdp.10504","doi":"https://doi.org/10.21873/cdp.10504","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cdp.10504","pdf_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/6/1/cdp-6-31.pdf","source":{"id":"https://openalex.org/S4210192968","display_name":"Cancer Diagnosis & Prognosis","issn_l":"2732-7787","issn":["2732-7787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagnosis & Prognosis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/6/1/cdp-6-31.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024868235","display_name":"Byung Mo Kang","orcid":"https://orcid.org/0000-0003-0900-094X","observed_orcids":["https://orcid.org/0000-0003-0900-094X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BYUNG MO KANG","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109489759","display_name":"Qinghong Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"QINGHONG HAN","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127201844","display_name":"SHUKUAN LI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHUKUAN LI","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121532644","display_name":"JIN SOO KIM","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JIN SOO KIM","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063794477","display_name":"KOHEI MIZUTA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KOHEI MIZUTA","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025471735","display_name":"Yohei Asano","orcid":"https://orcid.org/0000-0002-8777-6076","observed_orcids":["https://orcid.org/0000-0002-8777-6076"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YOHEI ASANO","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115725542","display_name":"YUTA MIYASHI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"YUTA MIYASHI","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087572625","display_name":"Michael Bouvet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MICHAEL BOUVET","raw_affiliation_strings":["Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT M. HOFFMAN","raw_affiliation_strings":["AntiCancer Inc., San Diego, CA, U.S.A","Department of Surgery, University of California, San Diego, CA, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AntiCancer Inc., San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I4210121314"]},{"raw_affiliation_string":"Department of Surgery, University of California, San Diego, CA, U.S.A","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.6537,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.80933361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"6","issue":"1","first_page":"31","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12996","display_name":"Cancer Research and Treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methionine-restriction","display_name":"methionine restriction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/recombinant-methioninase","display_name":"recombinant methioninase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7250000238418579},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/normal-fibroblasts","display_name":"normal fibroblasts","score":0.9070000052452087}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6614000201225281},{"id":"https://openalex.org/C2780912031","wikidata":"https://www.wikidata.org/wiki/Q180341","display_name":"Methionine","level":3,"score":0.6040999889373779},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.524399995803833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48170000314712524},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4375},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4293000102043152},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4244999885559082},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3662000000476837},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33809998631477356},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3203999996185303},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C151913843","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Dominance (genetics)","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.2646999955177307},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.25619998574256897}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21873/cdp.10504","doi":"https://doi.org/10.21873/cdp.10504","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cdp.10504","pdf_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/6/1/cdp-6-31.pdf","source":{"id":"https://openalex.org/S4210192968","display_name":"Cancer Diagnosis & Prognosis","issn_l":"2732-7787","issn":["2732-7787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagnosis & Prognosis","raw_type":"journal-article"},{"id":"pmid:41487927","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41487927","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer diagnosis & prognosis","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12758669","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12758669/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Diagn Progn","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21873/cdp.10504","doi":"https://doi.org/10.21873/cdp.10504","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cdp.10504","pdf_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/6/1/cdp-6-31.pdf","source":{"id":"https://openalex.org/S4210192968","display_name":"Cancer Diagnosis & Prognosis","issn_l":"2732-7787","issn":["2732-7787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagnosis & Prognosis","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7804200649261475,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119210992.pdf","grobid_xml":"https://content.openalex.org/works/W7119210992.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W1606880169","https://openalex.org/W2342714720"],"related_works":[],"abstract_inverted_index":{"Background/Aim:":[0],"Methionine":[1],"addiction":[2],"(Hoffman":[3],"effect)":[4],"is":[5,254],"a":[6],"fundamental":[7],"and":[8,35,63,70,78,132,163,173,188,194,208,241,262],"general":[9],"cancer":[10,53,184,260,268],"hallmark":[11],"targetable":[12],"by":[13,55,122,168,196,212,238,246],"methionine":[14,56,157,277],"restriction,":[15],"using":[16],"methionine-depleted":[17],"media":[18],"or":[19,21,108],"diet,":[20],"recombinant":[22],"methioninase":[23],"(rMETase).":[24],"Our":[25],"previous":[26],"studies":[27],"showed":[28,232],"differential":[29],"sensitivity":[30],"of":[31,52,61,74,114,161,227,234,259],"HCT-116":[32,62,75,104,162,183,204,236],"colon-cancer":[33,76],"cells":[34,54,65,77,185,205,217,237,245,261],"Hs27":[36,64,79,164,192,216,244],"normal":[37,80],"fibroblasts":[38,81,193],"to":[39,47,136,140,256,283],"rMETase":[40,67,101,253],"in":[41,58,84,87,118,148,265],"co-culture.":[42],"The":[43],"present":[44],"study":[45],"aimed":[46],"demonstrate":[48],"the":[49,59,103,138,145,179,191,200,221],"rescue":[50],"conditions":[51],"replenishment":[57,226],"co-cultures":[60,97,231],"after":[66,95,134],"treatment.":[68],"Materials":[69],"Methods:":[71],"Equal":[72],"numbers":[73],"were":[82,98,209],"co-cultured":[83],"6-well":[85],"plates":[86],"Dulbecco's":[88],"modified":[89],"Eagle's":[90],"medium":[91,147],"(DMEM).":[92],"Two":[93],"days":[94,126,175],"seeding,":[96],"treated":[99],"with":[100,153,252,267],"at":[102],"IC50":[105],"(0.46":[106],"U/ml)":[107],"left":[109],"untreated":[110,180],"as":[111],"controls.":[112],"Growth":[113],"each":[115],"cell":[116],"type":[117],"co-culture":[119,266],"was":[120,151,165],"evaluated":[121],"phase-contrast":[123,169],"microscopy":[124,170],"on":[125],"2,":[127],"4,":[128],"6,":[129,172],"8,":[130],"10,":[131],"12":[133],"treatment":[135,251],"assess":[137],"response":[139],"rMETase.":[141],"On":[142],"day":[143,197,213,239,247],"12,":[144,214],"existing":[146],"all":[149],"wells":[150],"replaced":[152],"fresh":[154],"DMEM":[155],"containing":[156],"(methionine":[158],"replenishment).":[159],"Regrowth":[160],"then":[166],"assessed":[167],"3,":[171],"9":[174],"later.":[176],"Results:":[177],"In":[178,199],"control":[181],"group,":[182,202],"rapidly":[186],"proliferated,":[187],"progressively":[189,206],"overtook":[190],"predominated":[195],"12.":[198],"rMETase-treated":[201,230],"viable":[203,219,235],"decreased":[207],"almost":[210],"undetectable":[211],"whereas":[215],"remained":[218],"throughout":[220],"observation":[222],"period.":[223],"After":[224],"day-12":[225],"methionine,":[228],"previously":[229],"reappearance":[233],"3":[240],"dominance":[242,264],"over":[243],"9.":[248],"Conclusion:":[249],"Continuous":[250],"necessary":[255],"maintain":[257],"inhibition":[258],"normal-cell":[263],"cells.":[269],"These":[270],"results":[271],"have":[272],"clinical":[273],"implications":[274],"indicating":[275],"that":[276],"restriction":[278],"must":[279],"be":[280],"continually":[281],"maintained":[282],"inhibit":[284],"cancer.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-08T00:00:00"}