{"id":"https://openalex.org/W7119203440","doi":"https://doi.org/10.56557/jirmeps/2026/v21i110095","title":"Next-Generation Cancer Models: Integrating 3D Bioprinting and Organ-on-Chip Systems for Precision Oncology","display_name":"Next-Generation Cancer Models: Integrating 3D Bioprinting and Organ-on-Chip Systems for Precision Oncology","publication_year":2026,"publication_date":"2026-01-03","ids":{"openalex":"https://openalex.org/W7119203440","doi":"https://doi.org/10.56557/jirmeps/2026/v21i110095"},"language":"en","primary_location":{"id":"doi:10.56557/jirmeps/2026/v21i110095","doi":"https://doi.org/10.56557/jirmeps/2026/v21i110095","is_oa":true,"landing_page_url":"https://doi.org/10.56557/jirmeps/2026/v21i110095","pdf_url":null,"source":{"id":"https://openalex.org/S4393918613","display_name":"Journal of international research in medical and pharmaceutical sciences","issn_l":"2395-4477","issn":["2395-4477","2395-4485"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Research in Medical and Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.56557/jirmeps/2026/v21i110095","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122062976","display_name":"DhruvaKumar Chatarajupalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DhruvaKumar Chatarajupalli","raw_affiliation_strings":["Health data science, Saint Louis University, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health data science, Saint Louis University, Missouri, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122090664","display_name":"Yaswanth Reddy Gogireddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaswanth Reddy Gogireddy","raw_affiliation_strings":["Health data science, Saint Louis University, Missouri, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health data science, Saint Louis University, Missouri, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5092459040","display_name":"Seetharam GUDE","orcid":"https://orcid.org/0009-0004-7258-3011","observed_orcids":["https://orcid.org/0009-0004-7258-3011"]},"institutions":[{"id":"https://openalex.org/I4210110833","display_name":"Aurobindo Pharma (India)","ror":"https://ror.org/01wzc4m50","country_code":"IN","type":"company","lineage":["https://openalex.org/I4210110833"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Seetharam Gude","raw_affiliation_strings":["Research and Development, Aurobindo Pharma Limited, Hyderabad, India"],"raw_orcid":"https://orcid.org/0009-0004-7258-3011","affiliations":[{"raw_affiliation_string":"Research and Development, Aurobindo Pharma Limited, Hyderabad, India","institution_ids":["https://openalex.org/I4210110833"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5092459040"],"corresponding_institution_ids":["https://openalex.org/I4210110833"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"1","first_page":"26","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-bioprinting","display_name":"3D bioprinting","score":0.9229999780654907},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9190000295639038},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bioinks","display_name":"bioinks","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tumor-spheroids","display_name":"tumor spheroids","score":0.6880000233650208},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.8270000219345093},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.6700000166893005},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.781000018119812},{"id":"https://openalex.org/keywords/extracellular-matrix-mimics","display_name":"extracellular matrix mimics","score":0.7570000290870667},{"id":"https://openalex.org/keywords/patient-derived-models","display_name":"patient-derived models","score":0.7580000162124634},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.5950000286102295},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.6700000166893005},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.8889999985694885},{"id":"https://openalex.org/keywords/drug-response-monitoring","display_name":"drug response monitoring","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2779718196","wikidata":"https://www.wikidata.org/wiki/Q17018741","display_name":"3D bioprinting","level":3,"score":0.6119999885559082},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5213000178337097},{"id":"https://openalex.org/C2780609957","wikidata":"https://www.wikidata.org/wiki/Q108887885","display_name":"Biofabrication","level":3,"score":0.4018999934196472},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3555999994277954},{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.33959999680519104},{"id":"https://openalex.org/C3018809729","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Nonhuman primate","level":2,"score":0.32839998602867126},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.32260000705718994},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.31630000472068787},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.3091000020503998},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3052000105381012},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3001999855041504},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.2865000069141388},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C165932988","wikidata":"https://www.wikidata.org/wiki/Q7101746","display_name":"Organ-on-a-chip","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.26019999384880066},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.25279998779296875},{"id":"https://openalex.org/C2994543053","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical testing","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.56557/jirmeps/2026/v21i110095","doi":"https://doi.org/10.56557/jirmeps/2026/v21i110095","is_oa":true,"landing_page_url":"https://doi.org/10.56557/jirmeps/2026/v21i110095","pdf_url":null,"source":{"id":"https://openalex.org/S4393918613","display_name":"Journal of international research in medical and pharmaceutical sciences","issn_l":"2395-4477","issn":["2395-4477","2395-4485"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Research in Medical and Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:ikprress.org:article/10095","doi":null,"is_oa":true,"landing_page_url":"https://ikprress.org/index.php/JIRMEPS/article/view/10095","pdf_url":null,"source":{"id":"https://openalex.org/S4393918613","display_name":"Journal of international research in medical and pharmaceutical sciences","issn_l":"2395-4477","issn":["2395-4477","2395-4485"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2395-4485","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05446355v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05446355","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of International Research in Medical and Pharmaceutical Sciences, 2026, 21 (1), pp.26 - 45","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.56557/jirmeps/2026/v21i110095","doi":"https://doi.org/10.56557/jirmeps/2026/v21i110095","is_oa":true,"landing_page_url":"https://doi.org/10.56557/jirmeps/2026/v21i110095","pdf_url":null,"source":{"id":"https://openalex.org/S4393918613","display_name":"Journal of international research in medical and pharmaceutical sciences","issn_l":"2395-4477","issn":["2395-4477","2395-4485"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of International Research in Medical and Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3199795185","https://openalex.org/W7162213639","https://openalex.org/W7164992973","https://openalex.org/W4293859568","https://openalex.org/W7213515417","https://openalex.org/W2460755825","https://openalex.org/W4297834461","https://openalex.org/W4283793467","https://openalex.org/W4414403771","https://openalex.org/W4389508537"],"abstract_inverted_index":{"Aims:":[0],"This":[1],"review":[2,54],"aims":[3],"to":[4,27,90,243],"provide":[5],"a":[6,205],"comprehensive":[7],"overview":[8],"of":[9,46,78,112,132],"recent":[10],"advancements":[11],"in":[12,163,197,208,217,227,236],"3D":[13,63],"bioprinting":[14,64,168],"integrated":[15],"with":[16,127,195],"organ-on-a-chip":[17],"technologies":[18],"for":[19,117,254],"developing":[20],"next-generation":[21,249],"cancer-on-a-chip":[22,86,202],"systems.":[23],"The":[24],"objective":[25],"is":[26],"highlight":[28],"how":[29],"these":[30],"hybrid":[31],"platforms":[32,203,250],"replicate":[33],"the":[34,43,110,130,213],"tumor":[35,134,209],"microenvironment":[36],"(TME),":[37],"enhance":[38],"physiological":[39],"relevance,":[40],"and":[41,69,72,84,109,114,144,159,166,174,179,190,220,230,239,258],"improve":[42],"predictive":[44],"power":[45],"preclinical":[47],"cancer":[48],"research.":[49],"Methodology:":[50],"A":[51],"thorough":[52],"literature":[53],"was":[55,88,97],"conducted":[56],"focusing":[57],"on":[58,99],"key":[59],"technological":[60],"domains":[61],"including":[62,155],"strategies,":[65],"microfluidic":[66],"design,":[67],"biomaterial":[68],"bioink":[70,101],"innovations,":[71],"tumor\u2013stroma":[73],"co-culture":[74],"methods.":[75],"Comparative":[76],"analysis":[77],"traditional":[79,216],"2D":[80],"cultures,":[81],"spheroids,":[82],"organoids,":[83],"advanced":[85],"constructs":[87,135],"performed":[89],"assess":[91],"their":[92,245],"biological":[93],"relevance.":[94],"Special":[95],"emphasis":[96],"placed":[98],"evaluating":[100],"selection,":[102],"vascularization":[103],"approaches,":[104],"ECM-mimetic":[105],"materials,":[106],"patient-derived":[107,164],"models,":[108],"integration":[111],"biosensing":[113],"artificial":[115],"intelligence":[116],"real-time":[118],"monitoring.":[119],"Results:":[120],"Findings":[121],"show":[122],"that":[123],"integrating":[124],"additive":[125],"manufacturing":[126],"microfluidics":[128],"enables":[129],"fabrication":[131],"physiomimetic":[133],"featuring":[136],"spatially":[137],"organized":[138],"cell":[139],"populations,":[140],"perfusable":[141],"vascular":[142],"networks,":[143],"controllable":[145],"biochemical":[146],"gradients.":[147],"These":[148,248],"systems":[149,241],"successfully":[150],"recapitulate":[151],"critical":[152],"TME":[153],"characteristics,":[154],"hypoxia,":[156],"cellular":[157],"heterogeneity,":[158],"stromal":[160],"interactions.":[161],"Innovations":[162],"bioinks":[165],"multi-nozzle":[167],"have":[169],"enhanced":[170],"architectural":[171],"complexity,":[172],"personalization,":[173],"scalability.":[175],"Additionally,":[176],"incorporating":[177],"biosensors":[178],"AI-driven":[180],"analytics":[181],"strengthens":[182],"drug-response":[183],"monitoring,":[184],"enabling":[185],"more":[186],"accurate":[187],"mechanistic":[188],"studies":[189],"high-throughput":[191],"drug":[192,256],"screening":[193],"compared":[194],"conventional":[196],"vitro":[198,218],"models.":[199,222],"Conclusion:":[200],"3D-bioprinted":[201],"represent":[204],"transformative":[206],"paradigm":[207],"modeling":[210],"by":[211],"bridging":[212],"gap":[214],"between":[215],"assays":[219],"animal":[221],"Despite":[223],"existing":[224],"challenges":[225],"particularly":[226],"vascularization,":[228],"standardization,":[229],"maintaining":[231],"long-term":[232],"viability":[233],"ongoing":[234],"advances":[235],"biomaterials,":[237],"automation,":[238],"immunocompetent":[240],"continue":[242],"elevate":[244],"translational":[246],"potential.":[247],"hold":[251],"significant":[252],"promise":[253],"accelerating":[255],"discovery":[257],"supporting":[259],"precision":[260],"oncology.":[261]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-01-08T00:00:00"}