{"id":"https://openalex.org/W7119085886","doi":"https://doi.org/10.1126/sciadv.aea0567","title":"Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance","display_name":"Allospecific splenic Tr1 cells drive effector T cell exhaustion through up-regulated Areg-EGFR signaling to promote transplant tolerance","publication_year":2026,"publication_date":"2026-01-07","ids":{"openalex":"https://openalex.org/W7119085886","doi":"https://doi.org/10.1126/sciadv.aea0567","pmid":"https://pubmed.ncbi.nlm.nih.gov/41499508"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aea0567","doi":"https://doi.org/10.1126/sciadv.aea0567","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aea0567","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aea0567?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aea0567?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038546152","display_name":"Amar Ranjan Singh","orcid":"https://orcid.org/0000-0002-4721-1513","observed_orcids":["https://orcid.org/0000-0002-4721-1513"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Amar Singh","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-4721-1513","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028458306","display_name":"Adam Herman","orcid":"https://orcid.org/0000-0001-7463-9462","observed_orcids":["https://orcid.org/0000-0001-7463-9462"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4400573273","display_name":"Minnesota Supercomputing Institute","ror":"https://ror.org/038kp1442","country_code":"US","type":"facility","lineage":["https://openalex.org/I4400573273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Herman","raw_affiliation_strings":["Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0001-7463-9462","affiliations":[{"raw_affiliation_string":"Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4400573273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101894775","display_name":"Devanjan Dey","orcid":"https://orcid.org/0000-0001-9502-1186","observed_orcids":["https://orcid.org/0000-0001-9502-1186"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devanjan Dey","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106637834","display_name":"Samuel Menge","orcid":"https://orcid.org/0009-0000-2641-1957","observed_orcids":["https://orcid.org/0009-0000-2641-1957"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Menge","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0009-0000-2641-1957","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101891741","display_name":"Shilpi Singh","orcid":"https://orcid.org/0000-0002-9938-7043","observed_orcids":["https://orcid.org/0000-0002-9938-7043"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilpi Singh","raw_affiliation_strings":["Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-9938-7043","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043675231","display_name":"Anna Tran","orcid":"https://orcid.org/0000-0001-7165-2063","observed_orcids":["https://orcid.org/0000-0001-7165-2063"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Tran","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007602719","display_name":"Anders W. Matson","orcid":"https://orcid.org/0000-0001-8470-5822","observed_orcids":["https://orcid.org/0000-0001-8470-5822"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders Matson","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0001-8470-5822","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ahmed Mourad","orcid":"https://orcid.org/0009-0000-6685-5659","observed_orcids":["https://orcid.org/0009-0000-6685-5659"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Mourad","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0009-0000-6685-5659","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063554250","display_name":"Parthasarathy Rangarajan","orcid":"https://orcid.org/0009-0003-5955-397X","observed_orcids":["https://orcid.org/0009-0003-5955-397X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parthasarathy Rangarajan","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0009-0003-5955-397X","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093113467","display_name":"Ravi Masuria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Masuria","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032204467","display_name":"Naoya Sato","orcid":"https://orcid.org/0000-0003-4572-7855","observed_orcids":["https://orcid.org/0000-0003-4572-7855","https://orcid.org/0009-0003-0273-4577"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naoya Sato","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0003-4572-7855","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sarah Vadnais","orcid":"https://orcid.org/0009-0005-8111-3000","observed_orcids":["https://orcid.org/0009-0005-8111-3000"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Vadnais","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0009-0005-8111-3000","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042635708","display_name":"Joseph Sushil Rao","orcid":"https://orcid.org/0000-0002-0197-6107","observed_orcids":["https://orcid.org/0000-0002-0197-6107"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Sushil Rao","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-0197-6107","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035559971","display_name":"Gatikrushna Singh","orcid":"https://orcid.org/0000-0002-9870-5556","observed_orcids":["https://orcid.org/0000-0002-9870-5556"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gatikrushna Singh","raw_affiliation_strings":["Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-9870-5556","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081953570","display_name":"Melanie L. Graham","orcid":"https://orcid.org/0000-0002-2475-6975","observed_orcids":["https://orcid.org/0000-0002-2475-6975"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie L. Graham","raw_affiliation_strings":["Preclinical Research Center, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-2475-6975","affiliations":[{"raw_affiliation_string":"Preclinical Research Center, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065374768","display_name":"Sabarinathan Ramachandran","orcid":"https://orcid.org/0000-0003-2239-8083","observed_orcids":["https://orcid.org/0000-0003-2239-8083"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sabarinathan Ramachandran","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0003-2239-8083","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039801066","display_name":"Bernhard J. Hering","orcid":"https://orcid.org/0000-0002-5962-7284","observed_orcids":["https://orcid.org/0000-0002-5962-7284"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bernhard J. Hering","raw_affiliation_strings":["Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0002-5962-7284","affiliations":[{"raw_affiliation_string":"Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038546152","https://openalex.org/A5039801066","https://openalex.org/A5065374768"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":4.5287,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.91634721,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"2","first_page":"eaea0567","last_page":"eaea0567"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transplantation-tolerance","display_name":"transplantation tolerance","score":0.9539999961853027},{"id":"https://openalex.org/keywords/allospecific-t-cells","display_name":"allospecific T cells","score":0.7350000143051147},{"id":"https://openalex.org/keywords/tr1-cells","display_name":"Tr1 cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.7509999871253967},{"id":"https://openalex.org/keywords/allogeneic-islets","display_name":"allogeneic islets","score":0.7049999833106995},{"id":"https://openalex.org/keywords/nr4a1","display_name":"Nur77","score":0.703000009059906},{"id":"https://openalex.org/keywords/tox","display_name":"TOX","score":0.7089999914169312},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.5199999809265137},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.9829999804496765},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6940000057220459},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.7419999837875366},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7103000283241272},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6107000112533569},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.567300021648407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.541100025177002},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47999998927116394},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4334999918937683},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.37450000643730164},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.3650999963283539},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.3634999990463257},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.3483999967575073},{"id":"https://openalex.org/C2777016536","wikidata":"https://www.wikidata.org/wiki/Q7168713","display_name":"Peripheral tolerance","level":4,"score":0.3418999910354614},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C2777868816","wikidata":"https://www.wikidata.org/wiki/Q5134952","display_name":"Clonal deletion","level":5,"score":0.31139999628067017},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.30390000343322754},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C2778015335","wikidata":"https://www.wikidata.org/wiki/Q17051163","display_name":"Mass cytometry","level":4,"score":0.2930000126361847},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27649998664855957},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.27459999918937683},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C2777367678","wikidata":"https://www.wikidata.org/wiki/Q2304808","display_name":"Memory T cell","level":4,"score":0.2526000142097473},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000094383","descriptor_name":"T-Cell Exhaustion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D023001","descriptor_name":"Transplantation Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1126/sciadv.aea0567","doi":"https://doi.org/10.1126/sciadv.aea0567","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aea0567","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aea0567?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmid:41499508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41499508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12778058","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12778058/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Adv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aea0567","doi":"https://doi.org/10.1126/sciadv.aea0567","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aea0567","pdf_url":"https://www.science.org/doi/pdf/10.1126/sciadv.aea0567?download=true","source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1919376332","display_name":null,"funder_award_id":"U19 AI174966","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2233621646","display_name":"Deep Immune Profiling of Nonchimeric Tolerance of Transplants in Nonhuman Primates","funder_award_id":"R21AI166163","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7463591348","display_name":"CTSA Postdoctoral T32 at University of Minnesota","funder_award_id":"1t32tr004376-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G816098755","display_name":null,"funder_award_id":"U01-AI102463","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000868899","display_name":"University of Minnesota Clinical and Translational Science Institute (UMN CTSI)","funder_award_id":"5um1tr004405-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000893885","display_name":"The role of the spleen in maintaining immune tolerance to transplanted islets","funder_award_id":"R21AI190721","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320316940","display_name":"University of Minnesota Foundation","ror":null},{"id":"https://openalex.org/F4320319991","display_name":"Diabetes Research and Wellness Foundation","ror":"https://ror.org/02bz4qp22"},{"id":"https://openalex.org/F4320324177","display_name":"Otsuka Pharmaceutical","ror":"https://ror.org/013k5y296"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119085886.pdf","grobid_xml":"https://content.openalex.org/works/W7119085886.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1573103899","https://openalex.org/W1596806896","https://openalex.org/W1896583420","https://openalex.org/W1910012553","https://openalex.org/W1976696463","https://openalex.org/W1985413676","https://openalex.org/W1989473696","https://openalex.org/W1994638587","https://openalex.org/W1996242699","https://openalex.org/W2001739973","https://openalex.org/W2004188003","https://openalex.org/W2008264147","https://openalex.org/W2038694264","https://openalex.org/W2045847416","https://openalex.org/W2046801873","https://openalex.org/W2067582927","https://openalex.org/W2074189021","https://openalex.org/W2076327296","https://openalex.org/W2081551852","https://openalex.org/W2088270805","https://openalex.org/W2094288996","https://openalex.org/W2095474336","https://openalex.org/W2101957891","https://openalex.org/W2111329034","https://openalex.org/W2118808528","https://openalex.org/W2121602730","https://openalex.org/W2122400330","https://openalex.org/W2162538143","https://openalex.org/W2194972574","https://openalex.org/W2210124838","https://openalex.org/W2476937757","https://openalex.org/W2515876677","https://openalex.org/W2604240183","https://openalex.org/W2765728936","https://openalex.org/W2782893319","https://openalex.org/W2790052322","https://openalex.org/W2804786344","https://openalex.org/W2904344461","https://openalex.org/W2905181502","https://openalex.org/W2905370254","https://openalex.org/W2912648593","https://openalex.org/W2916567659","https://openalex.org/W2917547201","https://openalex.org/W2927507212","https://openalex.org/W2928871599","https://openalex.org/W2929109925","https://openalex.org/W2950413690","https://openalex.org/W2951520325","https://openalex.org/W2951799803","https://openalex.org/W2952815301","https://openalex.org/W2966520119","https://openalex.org/W2979874482","https://openalex.org/W2993390900","https://openalex.org/W2993840944","https://openalex.org/W3010719938","https://openalex.org/W3013205114","https://openalex.org/W3022994813","https://openalex.org/W3132661792","https://openalex.org/W3157888956","https://openalex.org/W3168022908","https://openalex.org/W3188707113","https://openalex.org/W4206027424","https://openalex.org/W4220652655","https://openalex.org/W4224223707","https://openalex.org/W4285039647","https://openalex.org/W4310054428","https://openalex.org/W4312100125","https://openalex.org/W4313427306","https://openalex.org/W4361007123","https://openalex.org/W4376256338","https://openalex.org/W4386112164","https://openalex.org/W4388977891","https://openalex.org/W4391811190","https://openalex.org/W4393398071","https://openalex.org/W4401077890","https://openalex.org/W4403784250","https://openalex.org/W4409781969"],"related_works":[],"abstract_inverted_index":{"Inducing":[0],"stable":[1],"tolerance":[2,13],"to":[3,14,24,128,148],"transplants":[4],"remains":[5],"a":[6,142,160],"challenge":[7],"in":[8,17,27,49,164],"immunology.":[9],"Previously,":[10],"we":[11],"induced":[12],"allogeneic":[15],"islets":[16],"nonhuman":[18],"primates":[19],"by":[20],"preemptive":[21],"alloantigen":[22],"delivery":[23],"antigen-presenting":[25],"cells":[26,66,80,108,113,124,140],"situ.":[28],"Here,":[29],"mass":[30],"cytometry":[31],"phenotyping":[32],"with":[33,110],"incorporated":[34],"donor-derived":[35],"MHC-I":[36],"peptide\u2013loaded":[37],"MHC-II":[38],"tetramers":[39],"revealed":[40],"accumulation":[41],"of":[42,52,136],"allospecific":[43,70,111],"CD4":[44,137],"+":[45,56,85,89,91,93,138,152,155],"T":[46,64,79,107,139],"cell":[47,157],"clusters":[48],"the":[50,68,115,130,149],"spleen":[51],"tolerant":[53],"recipients.":[54],"Areg":[55,84,151],"Tr1":[57,86,112,123,153],"regulatory":[58],"and":[59,87,104,133],"terminally":[60],"exhausted":[61,103],"EGFR":[62,88],"hi":[63],"(Tex)":[65],"represented":[67],"predominant":[69],"subsets.":[71,97],"Trajectory":[72],"analysis":[73],"showed":[74,101],"that":[75,102,122],"antigen-experienced":[76],"effector":[77,105],"memory":[78,106],"differentiated":[81],"into":[82],"suppressive":[83],"TOX":[90],"Nur77":[92],"TCF-1":[94],"\u2212":[95],"Tex":[96],"Cell-cell":[98],"communication":[99],"mapping":[100],"engaged":[109],"via":[114],"Areg-EGFR":[116,126],"axis.":[117],"Gene":[118],"silencing":[119],"studies":[120],"confirmed":[121],"use":[125],"signaling":[127],"drive":[129],"metabolic":[131],"suppression":[132],"epigenetic":[134],"reprogramming":[135],"through":[141],"Nur77-dependent":[143],"pathway.":[144],"These":[145],"findings":[146],"point":[147],"splenic":[150],"cell-EGFR":[154],"Teff":[156],"axis":[158],"as":[159],"critical":[161],"immunoregulatory":[162],"pathway":[163],"peripheral":[165],"transplant":[166],"tolerance.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-01-08T00:00:00"}
