{"id":"https://openalex.org/W7119081900","doi":"https://doi.org/10.64898/2026.01.05.697733","title":"Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP","display_name":"Hyperactive BMP and Mechanosignaling Remodel Chromatin to Drive Aberrant Osteogenesis in FOP","publication_year":2026,"publication_date":"2026-01-05","ids":{"openalex":"https://openalex.org/W7119081900","doi":"https://doi.org/10.64898/2026.01.05.697733","pmid":"https://pubmed.ncbi.nlm.nih.gov/41542484"},"language":"en","primary_location":{"id":"doi:10.64898/2026.01.05.697733","doi":"https://doi.org/10.64898/2026.01.05.697733","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.01.05.697733","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12803056/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070970589","display_name":"Ellen Y. Zhang","orcid":"https://orcid.org/0009-0008-5089-6796","observed_orcids":["https://orcid.org/0009-0008-5089-6796"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Y. Zhang","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016231566","display_name":"Douglas W. Roberts","orcid":"https://orcid.org/0000-0001-7751-7268","observed_orcids":["https://orcid.org/0000-0001-7751-7268"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas W. Roberts","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","The Center for Research in FOP and Related Disorders, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":"https://orcid.org/0000-0001-7751-7268","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"The Center for Research in FOP and Related Disorders, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122237361","display_name":"Sang Hyun Lee","orcid":"https://orcid.org/0009-0009-3323-7905","observed_orcids":["https://orcid.org/0009-0009-3323-7905"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang Hyun Lee","raw_affiliation_strings":["Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, KOR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, KOR","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093098883","display_name":"Bat\u2010Ider Tumenbayar","orcid":"https://orcid.org/0009-0008-7207-8233","observed_orcids":["https://orcid.org/0009-0008-7207-8233","https://orcid.org/0009-0003-3236-057X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bat-Ider Tumenbayar","raw_affiliation_strings":["Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122053435","display_name":"Jaeun Jung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaeun Jung","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013045598","display_name":"Loreilys Mejias Rivera","orcid":"https://orcid.org/0000-0003-4576-9051","observed_orcids":["https://orcid.org/0000-0003-4576-9051"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loreilys Mej\u00edas Rivera","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121167167","display_name":"Inkyung Jung","orcid":"https://orcid.org/0000-0002-5885-2754","observed_orcids":["https://orcid.org/0000-0002-5885-2754"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Inkyung Jung","raw_affiliation_strings":["Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, KOR"],"raw_orcid":"https://orcid.org/0000-0002-5885-2754","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, KOR","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111095675","display_name":"Robert L. Mauck","orcid":"https://orcid.org/0000-0002-9537-603X","observed_orcids":["https://orcid.org/0000-0002-9537-603X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Mauck","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019206850","display_name":"Eileen Malko Shore","orcid":"https://orcid.org/0000-0003-2609-6971","observed_orcids":["https://orcid.org/0000-0003-2609-6971"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eileen M. Shore","raw_affiliation_strings":["Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","The Center for Research in FOP and Related Disorders, University of Pennsylvania, Philadelphia, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"The Center for Research in FOP and Related Disorders, University of Pennsylvania, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017867104","display_name":"Su\u2010Jin Heo","orcid":"https://orcid.org/0000-0003-2771-5076","observed_orcids":["https://orcid.org/0000-0003-2771-5076"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]},{"id":"https://openalex.org/I4210134882","display_name":"Kyung Hee University Dental Hospital","ror":"https://ror.org/02ss0kx69","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I35928602","https://openalex.org/I4210112503","https://openalex.org/I4210134882","https://openalex.org/I4405258385"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Su Chin Heo","raw_affiliation_strings":["Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","Department of Dentistry, College of Dentistry, Kyung Hee University, Seoul, KOR","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA"],"raw_orcid":"https://orcid.org/0000-0003-2771-5076","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Dentistry, College of Dentistry, Kyung Hee University, Seoul, KOR","institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4210134882"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017867104"],"corresponding_institution_ids":["https://openalex.org/I35928602","https://openalex.org/I4210134882","https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12960","display_name":"Heterotopic Ossification and Related Conditions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrodysplasia-ossificans-progressiva","display_name":"fibrodysplasia ossificans progressiva","score":0.9980000257492065},{"id":"https://openalex.org/keywords/acvr1-r206h-mutation","display_name":"ACVR1 R206H mutation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/heterotopic-ossification","display_name":"heterotopic ossification","score":0.9509999752044678},{"id":"https://openalex.org/keywords/bmp-smad-signaling","display_name":"BMP/Smad signaling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8230000138282776},{"id":"https://openalex.org/keywords/chromatin-decondensation","display_name":"chromatin decondensation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rho-rock-signaling-pathway","display_name":"Rho/ROCK signaling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.4350000023841858},{"id":"https://openalex.org/keywords/extracellular-matrix-organization","display_name":"extracellular matrix organization","score":0.5540000200271606},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C2777995074","wikidata":"https://www.wikidata.org/wiki/Q1410831","display_name":"Fibrodysplasia ossificans progressiva","level":3,"score":0.8974999785423279},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.8137999773025513},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.552299976348877},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5450000166893005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5199000239372253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5181000232696533},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4228000044822693},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39320001006126404},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.3707999885082245},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.31130000948905945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.29440000653266907},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2928999960422516},{"id":"https://openalex.org/C2778908642","wikidata":"https://www.wikidata.org/wiki/Q200779","display_name":"Genetic disorder","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2646999955177307},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.2533999979496002},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2531000077724457},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25200000405311584},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2515000104904175},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.25049999356269836}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.01.05.697733","doi":"https://doi.org/10.64898/2026.01.05.697733","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.01.05.697733","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41542484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41542484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12803056","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12803056/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:12803056","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12803056/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1528120845","https://openalex.org/W1908563203","https://openalex.org/W1964464117","https://openalex.org/W2003070261","https://openalex.org/W2014677321","https://openalex.org/W2022904912","https://openalex.org/W2028861424","https://openalex.org/W2035618305","https://openalex.org/W2041728210","https://openalex.org/W2066050937","https://openalex.org/W2080479776","https://openalex.org/W2080929272","https://openalex.org/W2098200075","https://openalex.org/W2100010244","https://openalex.org/W2101205238","https://openalex.org/W2102619694","https://openalex.org/W2108234281","https://openalex.org/W2131271579","https://openalex.org/W2138207763","https://openalex.org/W2154767933","https://openalex.org/W2169456326","https://openalex.org/W2169474931","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2463708289","https://openalex.org/W2748881498","https://openalex.org/W2786308339","https://openalex.org/W2805052976","https://openalex.org/W2899483759","https://openalex.org/W2923240451","https://openalex.org/W2945722290","https://openalex.org/W2960456118","https://openalex.org/W3022578129","https://openalex.org/W3035887726","https://openalex.org/W3084362394","https://openalex.org/W3126031876","https://openalex.org/W3198098339","https://openalex.org/W4296875666","https://openalex.org/W4365135307","https://openalex.org/W4377288200","https://openalex.org/W4381051406","https://openalex.org/W4391168196","https://openalex.org/W4393408937","https://openalex.org/W4411672039","https://openalex.org/W4412895647","https://openalex.org/W6925356896"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Fibrodysplasia":[1,232],"ossificans":[2,233],"progressiva":[3,234],"(FOP)":[4,235],"is":[5,236,260],"a":[6,12,33,186,207,237,243,256],"rare":[7,238],"genetic":[8,239],"disorder":[9,208,240],"in":[10,131,155,175,241,245],"which":[11,242],"recurrent":[13],"ACVR1":[14],"(R206H)":[15],"mutation":[16,31,244,254,269],"drives":[17,247],"progressive":[18,248],"heterotopic":[19,249],"ossification":[20],"(HO).":[21],"While":[22],"aberrant":[23,199],"BMP":[24,129],"hypersensitivity":[25],"has":[26],"been":[27],"studied,":[28],"how":[29,59,252],"this":[30,253],"enforces":[32,185,255],"persistent":[34,257],"pro-osteogenic":[35,187,258],"state":[36,259],"remains":[37],"unclear.":[38,261],"Here,":[39,262],"we":[40,263],"combined":[41],"super-resolution":[42],"stochastic":[43],"optical":[44],"reconstruction":[45],"microscopy":[46],"(STORM),":[47],"transposase-accessible":[48],"chromatin":[49,63,77,146,161,188,213,271,291],"with":[50,117,297],"sequencing":[51,55],"(ATAC-Seq),":[52],"and":[53,78,83,90,96,112,120,150,193,215,225,273,278,295,309],"RNA":[54],"(RNA-Seq)":[56],"to":[57,64,128,136,172,198,220,304],"investigate":[58],"Acvr1":[60,132,183,267],"R206H":[61,184,268],"remodels":[62,270],"promote":[65],"osteogenic":[66,84],"transcriptional":[67,100],"programs.":[68],"Mutant":[69],"mouse":[70],"embryonic":[71],"fibroblasts":[72],"(MEFs)":[73],"exhibited":[74],"globally":[75],"decondensed":[76],"increased":[79],"accessibility":[80,274],"at":[81],"developmental":[82],"loci":[85],"enriched":[86],"for":[87,103],"HOX,":[88],"TEAD,":[89],"RUNX":[91],"motifs.":[92],"Integration":[93],"of":[94,153,165,209],"ATAC-Seq":[95],"RNA-Seq":[97],"data":[98],"identified":[99],"networks":[101,284],"primed":[102],"osteochondrogenic":[104,287],"gene":[105,288],"expression,":[106],"including":[107],"ossification,":[108],"extracellular":[109],"matrix":[110],"organization,":[111],"cell":[113,223,307],"adhesion":[114],"pathways,":[115],"consistent":[116],"enhanced":[118],"BMP\u2013SMAD":[119,168,192,277],"mechanotransduction":[121],"activity.":[122],"Time-course":[123],"experiments":[124],"revealed":[125],"heightened":[126],"responses":[127],"ligands":[130],"R206H/+":[133],"MEFs":[134],"compared":[135],"wild-type,":[137],"highlighting":[138],"ligand":[139],"hypersensitivity.":[140],"Importantly,":[141],"pharmacological":[142],"modulation":[143],"showed":[144],"that":[145,182,265,285],"alterations":[147],"were":[148],"dynamic":[149,294],"reversible:":[151],"activation":[152],"Rho/ROCK":[154,166,194,279],"wild-type":[156,173],"cells":[157],"reproduced":[158],"the":[159,266],"mutant":[160,176],"state,":[162],"while":[163],"inhibition":[164],"or":[167],"signaling":[169],"restored":[170],"condensation":[171],"levels":[174],"cells.":[177],"Together,":[178],"these":[179],"findings":[180],"establish":[181],"landscape":[189],"through":[190,275],"convergent":[191],"signaling,":[195,280],"predisposing":[196],"progenitors":[197],"differentiation":[200],"trajectories.":[201],"Our":[202],"study":[203],"reframes":[204],"FOP":[205],"as":[206],"persistent,":[210],"but":[211],"reversible,":[212],"states":[214],"identifies":[216],"novel":[217],"therapeutic":[218,302],"opportunities":[219],"restore":[221,305],"mesenchymal":[222,306],"homeostasis":[224],"prevent":[226,310],"pathological":[227,311],"bone":[228,312],"formation.":[229,313],"Significance":[230],"Statement":[231],"ACVR1/ALK2":[246],"ossification.":[250],"However,":[251],"show":[264],"architecture":[272],"hyperactive":[276],"activating":[281],"transcription":[282],"factor":[283],"drive":[286],"expression.":[289],"These":[290],"changes":[292],"are":[293],"reversible":[296],"targeted":[298],"pathway":[299],"inhibition,":[300],"revealing":[301],"potential":[303],"plasticity":[308]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-01-08T00:00:00"}
